乌贼墨抗氧化活性研究进展
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摘要
乌贼墨是1味传统中药,近年来的研究显示其具有较强的抗氧化活性。本文在查阅大量文献资料的基础上,归纳总结了2008-2018年国内外对乌贼墨总提取物、乌贼墨无黑色素提取物、乌贼墨黑色素、乌贼墨多肽及乌贼墨多糖抗氧化活性的研究概况,旨在为进一步研究乌贼墨抗氧化活性提供依据。
Squid ink,as a traditional Chinese medicine,has been reported to possess strong antioxidant activity.In order to provide a theoretical and evidential basis for the deeper study of antioxidant activity of squid ink,the researches on antioxidant activities of total extract,melanin-free extract,melanin,polypeptide and polysaccharide from squid ink were summarized after consulting a large number of references published from 2008 to 2018.
Squid ink,as a traditional Chinese medicine,has been reported to possess strong antioxidant activity.In order to provide a theoretical and evidential basis for the deeper study of antioxidant activity of squid ink,the researches on antioxidant activities of total extract,melanin-free extract,melanin,polypeptide and polysaccharide from squid ink were summarized after consulting a large number of references published from 2008 to 2018.
引文
[1]Golden T R,Hinerfeld D A,Melov S.Oxidative stress and aging:beyond correlation[J].Aging Cell,2002,1(2):117-123.
[2]张佳艳,熊建文.多糖抗氧化能力体外测定方法研究进展[J].粮食科技与经济,2013,38(6):26-29.
[3]刘爱敬.黄秋葵抗氧化研究[D].沈阳:沈阳药科大学,2015.
[4]孟祥云,汪永锋,杨丽霞,等.中药多糖抗氧化作用及其机制研究进展[J].中华中医药杂志,2018,33(8):3504-3509.
[5]Vandghanooni S,Forouharmehr A,Eskandani M,et al.Cytotoxicity and DNA fragmentation properties of butylated hydroxyanisole[J].DNA Cell Biol,2013,32(3):98-103.
[6]Meier B W,Gomez J D,Kirichenko O V,et al.Mechanistic basis for inflammation and tumor promotion in lungs of 2,6-di-tert-butyl-4-methylphenol-treated mice:electrophilic metabolites alkylate and inactivate antioxidant enzymes[J].Chem Res Toxicol,2007,20(2):199-207.
[7]Gharavi N,Haggarty S,El-Kadi A O.Chemoprotective and carcinogenic effects of tert-butylhydroquinone and its metabolites[J].Curr Drug Metab,2007,8(1):1-7.
[8]Taghvaei M,Jafari S M.Application and stability of natural antioxidants in edible oils in order to substitute synthetic additives[J].J Food Sci Tech,2015,52(3):1272-1282.
[9]黄韵璇,李海峰,黄泽波.天然药物抗氧化活性物质研究进展[J].广东药科大学学报,2016,32(4):532-536.
[10]Kim S M.Reduction and utilization of squid wastes[D].Gangneung:Gangneung-Wonju National University,2013.
[11]Neifar A,Ben Abdelmalek I,Bouajila G,et al.Purification and incorporation of the black ink of cuttlefish Sepia officinalis in eye cosmetic products[J].Color Technol,2013,129(2):150-154.
[12]李孝东.乌贼墨糖胺聚糖的制备、理化性质、结构与生物活性研究[D].济南:山东大学,2004.
[13]Jose J,Krishnakumar K,Dineshkumar B.Squid ink and its pharmacological activities[J].GSC Bio Pharm Sci,2018,2(3):17-22.
[14]Lopez-González A,Tehozol-Sanchez B,García-Ignacio HM,et al.Antioxidant activity of water-soluble proteins and peptides obtained from the squid ink[J/OL].https://smbb.mx/congresos%20smbb/cancun13/TRABAJOS/SMBB/BiotecnologiaMarina/VII-C04.pdf,2014.
[15]江茂旺,蒋霞敏,高晓兰,等.野生与人工养殖虎斑乌贼墨的生化组分分析与比较[J].生物学杂志,2016,33(4):29-33.
[16]Zhong J P,Wang G,Shang J H,et al.Protective effects of squid ink extract towards hemopoietic injuries induced by cyclophosphamine[J].Mar Drugs,2009,7(1):9-18.
[17]Lucero M T,Farrington H,Gilly W F.Quantification of L-dopa and dopamine in squid ink:implications for chemoreception[J].Biol Bull,1994,187(1):55-63.
[18]Liu H Z,Luo P,Chen S G,et al.Effects of squid ink on growth performance,antioxidant functions and immunity in growing broiler chickens[J].Asian Austral J Anim,2011,24(12):1752-1756.
[19]Saleh H,Soliman A M,Mohamed A S,et al.Antioxidant effect of sepia ink extract on extrahepatic cholestasis induced by bile duct ligation in rats[J].Biomed Environ Sci,2015,28(8):582-594.
[20]Fahmy S R,Soliman A M.In vitro antioxidant,analgesic and cytotoxic activities of Sepia officinalis ink and Coelatura aegyptiaca extracts[J].Afr J Pharm Pharmaco,2013,7(22):1512-1522.
[21]Nisha N,Suja S.Phyto chemical evalution and antioxidant activity of methanol extract of Loligo duvauceli Ink[J].JPharm Phytochem,2018,7(1):1764-1767.
[22]黄银燕,杨翠玲,李伟东,等.乌贼墨提取物对环磷酰胺致肝损伤小鼠肝功能的保护作用研究[J].食品研究与开发,2010,31(4):13-16.
[23]雷敏,王静凤,逄龙,等.乌贼墨对高脂血症大鼠血脂代谢和抗氧化能力的影响[J].中国海洋药物,2007,26(3):30-33.
[24]师莉莎.乌贼墨提取物对白鲷的冷藏保鲜作用[D].湛江:广东海洋大学,2012.
[25]刘岩莲.影响食品色、香、味的物质[J].粮食流通技术,2017,5(9):15-17.
[26]Thanasak S L,Natchaphol B,Kumar V N,et al.Effect of squid melanin-free ink and pre-emulsification on properties and stability of surimi gel fortified with seabass oil during refrigerated storage[J].J Aquat Food Prod T,2018,27(8):919-933.
[27]Vate N K.Antioxidative activity of melanin-free ink from splendid squid(Loligo formosana)[J].Int Aquat Res,2013,5(9):1-12.
[28]Vate N K,Benjakul S,Prodpran T.Effect of melanin-free ink on mechanical properties and yellow discolouration of protein film from washed sardine mince[J].Food Biophys,2017,12(2):164-171.
[29]Agustini T W,Wijayanti I,Amalia U,et al.Effect of melanin free ink extracted from squid(Loligo sp.)on proximate and sensory characteristics of soft-bone milkfish(Chanos chanos)during storage[C]//3rd international conference on tropical and coastal region eco development,2017:1-8.
[30]Nicy A B,Velayutham P,Shakila R J,et al.Antioxidative activity of melanin free ink from cuttlefish,Sepia prabahari[J].J Exp Zool,2017,20(2):867-871.
[31]Vate N K,Benjakul S,Agustini T W.Application of melanin‐free ink as a new antioxidative gel enhancer in sardine surimi gel[J].J Sci Food Agr,2015,95(11):2201-2207.
[32]Duan Z H,Liu H Z,Luo P,et al.The effect of melaninfree extract fromSepia esculentaink on lipid peroxidation,protein oxidation and water-holding capacity of tilapia fillet during cold storage[J].Chem Cent J,2018,12(1):30-36.
[33]伍革民,彭光旭.动物黑色素研究进展[J].甘肃畜牧兽医,2005,35(1):39-41.
[34]Nasti T H,Timares L.MC1R,eumelanin and pheomelanin:their role in determining the susceptibility to skin cancer[J].Photochem Photobiol,2015,91(1):188-200.
[35]Meredith P,Sarna T.The physical and chemical properties of eumelanin[J].Pigm Cell Melanoma R,2006,19(6):572-594.
[36]甄天元,赵梦醒,雷敏.鱿鱼墨黑色素对亚急性衰老模型小鼠抗氧化功能的影响[J].中国食品学报,2012,12(5):61-65.
[37]李和生,李晓,董亚辉,等.乌贼墨黑色素的超微结构及抗氧化活性研究[J].中国食品学报,2012,12(10):62-66.
[38]Guo X,Chen S G,Hu Y Q,et al.Preparation of watersoluble melanin from squid ink using ultrasound-assisted degradation and its anti-oxidant activity[J].J Food Sci Tech,2014,51(12):3680-3690.
[39]景奕文,杨最素,丁国芳,等.乌贼墨多肽体外抗氧化活性研究[J].安徽农业科学,2013,41(27):10971-10973.
[40]Rangasamy T,Cho C Y,Thimmulappa R K,et al.Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice[J].J Clin Invest,2004,114(9):1248-1259.
[41]李慧,杨林.Nrf2抗氧化的分子调控机制[J].生物信息学,2018,16(1):1-6.
[42]Buendia I,Michalska P,Navarro E,et al.Nrf2-AREpathway:an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases[J].Pharmacol Therapeut,2016,157(1):84-104.
[43]Le X Y,Luo P,Gu Y P,et al.Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice[J].Iran J Basic Med Sci,2015,18(8):827-831.
[44]Liu C H,Li X D,Li Y H,et al.Structural characterisation and antimutagenic activity of a novel polysaccharide isolated fromSepiella maindroni ink[J].Food Chem,2008,110(4):807-813.
[45]罗萍,师莉莎,刘华忠.乌贼墨多糖的体外抗氧化作用[J].食品研究与开发,2013,34(8):1-4.
[46]牛庆凤,王斌,李涛,等.1种新型乌贼墨糖胺聚糖的分离纯化、理化性质及其抗氧化活性研究[J].中国海洋药物,2015,34(3):59-64.
[47]杨丽芝.南海鸢乌贼墨汁多糖分离纯化与活性研究[D].上海:上海海洋大学,2016.
[48]Luo P,Liu H Z.Antioxidant ability of squid ink polysaccharides as well as their protective effects on deoxyribonucleic acid DNA damage in vitro[J].Afr J Pharm Pharmaco,2013,7(21):1382-1388.
[49]Gu Y P,Yang X M,Duan Z H,et al.Squid ink polysaccharide prevents autophagy and oxidative stress affected by cyclophosphamide in Leydig cells of mice:apilot study[J].Iran J Basic Med Sci,2017,20(11):1194-1199.
[50]乐小炎,刘华忠.乌贼墨多糖对环磷酰胺介导雄性小鼠生殖能力损伤的保护作用[C]//环北部湾高校研究生海洋论坛,2013:239-243.
[51]谷毅鹏,张云波,刘华忠,等.乌贼墨多糖对环磷酰胺致小鼠卵巢损伤的保护作用[J].食品工业科技,2014,35(17):358-361.
[52]张云波,刘华忠,谷毅鹏,等.乌贼墨多糖对环磷酰胺介导小鼠卵巢氧化应激损伤的干预效应[J].广东农业科学,2015,42(14):90-93.
[53]刘华忠,王光,吴金龙,等.乌贼墨多糖对环磷酰胺致小鼠部分脏器损伤的缓解效应[J].中国现代应用药学,2012,29(2):89-93.
[54]闵诗刚,王光,钟杰平,等.乌贼墨多糖对大鼠外周血及血液中抗氧化能力影响[J].食品研究与开发,2011,32(1):123-125.
[55]陈颖.乌贼墨多糖通过调节Connexin43和NADPH氧化酶改善成纤维细胞氧化损伤的研究[D].广州:南方医科大学,2016.
[2]张佳艳,熊建文.多糖抗氧化能力体外测定方法研究进展[J].粮食科技与经济,2013,38(6):26-29.
[3]刘爱敬.黄秋葵抗氧化研究[D].沈阳:沈阳药科大学,2015.
[4]孟祥云,汪永锋,杨丽霞,等.中药多糖抗氧化作用及其机制研究进展[J].中华中医药杂志,2018,33(8):3504-3509.
[5]Vandghanooni S,Forouharmehr A,Eskandani M,et al.Cytotoxicity and DNA fragmentation properties of butylated hydroxyanisole[J].DNA Cell Biol,2013,32(3):98-103.
[6]Meier B W,Gomez J D,Kirichenko O V,et al.Mechanistic basis for inflammation and tumor promotion in lungs of 2,6-di-tert-butyl-4-methylphenol-treated mice:electrophilic metabolites alkylate and inactivate antioxidant enzymes[J].Chem Res Toxicol,2007,20(2):199-207.
[7]Gharavi N,Haggarty S,El-Kadi A O.Chemoprotective and carcinogenic effects of tert-butylhydroquinone and its metabolites[J].Curr Drug Metab,2007,8(1):1-7.
[8]Taghvaei M,Jafari S M.Application and stability of natural antioxidants in edible oils in order to substitute synthetic additives[J].J Food Sci Tech,2015,52(3):1272-1282.
[9]黄韵璇,李海峰,黄泽波.天然药物抗氧化活性物质研究进展[J].广东药科大学学报,2016,32(4):532-536.
[10]Kim S M.Reduction and utilization of squid wastes[D].Gangneung:Gangneung-Wonju National University,2013.
[11]Neifar A,Ben Abdelmalek I,Bouajila G,et al.Purification and incorporation of the black ink of cuttlefish Sepia officinalis in eye cosmetic products[J].Color Technol,2013,129(2):150-154.
[12]李孝东.乌贼墨糖胺聚糖的制备、理化性质、结构与生物活性研究[D].济南:山东大学,2004.
[13]Jose J,Krishnakumar K,Dineshkumar B.Squid ink and its pharmacological activities[J].GSC Bio Pharm Sci,2018,2(3):17-22.
[14]Lopez-González A,Tehozol-Sanchez B,García-Ignacio HM,et al.Antioxidant activity of water-soluble proteins and peptides obtained from the squid ink[J/OL].https://smbb.mx/congresos%20smbb/cancun13/TRABAJOS/SMBB/BiotecnologiaMarina/VII-C04.pdf,2014.
[15]江茂旺,蒋霞敏,高晓兰,等.野生与人工养殖虎斑乌贼墨的生化组分分析与比较[J].生物学杂志,2016,33(4):29-33.
[16]Zhong J P,Wang G,Shang J H,et al.Protective effects of squid ink extract towards hemopoietic injuries induced by cyclophosphamine[J].Mar Drugs,2009,7(1):9-18.
[17]Lucero M T,Farrington H,Gilly W F.Quantification of L-dopa and dopamine in squid ink:implications for chemoreception[J].Biol Bull,1994,187(1):55-63.
[18]Liu H Z,Luo P,Chen S G,et al.Effects of squid ink on growth performance,antioxidant functions and immunity in growing broiler chickens[J].Asian Austral J Anim,2011,24(12):1752-1756.
[19]Saleh H,Soliman A M,Mohamed A S,et al.Antioxidant effect of sepia ink extract on extrahepatic cholestasis induced by bile duct ligation in rats[J].Biomed Environ Sci,2015,28(8):582-594.
[20]Fahmy S R,Soliman A M.In vitro antioxidant,analgesic and cytotoxic activities of Sepia officinalis ink and Coelatura aegyptiaca extracts[J].Afr J Pharm Pharmaco,2013,7(22):1512-1522.
[21]Nisha N,Suja S.Phyto chemical evalution and antioxidant activity of methanol extract of Loligo duvauceli Ink[J].JPharm Phytochem,2018,7(1):1764-1767.
[22]黄银燕,杨翠玲,李伟东,等.乌贼墨提取物对环磷酰胺致肝损伤小鼠肝功能的保护作用研究[J].食品研究与开发,2010,31(4):13-16.
[23]雷敏,王静凤,逄龙,等.乌贼墨对高脂血症大鼠血脂代谢和抗氧化能力的影响[J].中国海洋药物,2007,26(3):30-33.
[24]师莉莎.乌贼墨提取物对白鲷的冷藏保鲜作用[D].湛江:广东海洋大学,2012.
[25]刘岩莲.影响食品色、香、味的物质[J].粮食流通技术,2017,5(9):15-17.
[26]Thanasak S L,Natchaphol B,Kumar V N,et al.Effect of squid melanin-free ink and pre-emulsification on properties and stability of surimi gel fortified with seabass oil during refrigerated storage[J].J Aquat Food Prod T,2018,27(8):919-933.
[27]Vate N K.Antioxidative activity of melanin-free ink from splendid squid(Loligo formosana)[J].Int Aquat Res,2013,5(9):1-12.
[28]Vate N K,Benjakul S,Prodpran T.Effect of melanin-free ink on mechanical properties and yellow discolouration of protein film from washed sardine mince[J].Food Biophys,2017,12(2):164-171.
[29]Agustini T W,Wijayanti I,Amalia U,et al.Effect of melanin free ink extracted from squid(Loligo sp.)on proximate and sensory characteristics of soft-bone milkfish(Chanos chanos)during storage[C]//3rd international conference on tropical and coastal region eco development,2017:1-8.
[30]Nicy A B,Velayutham P,Shakila R J,et al.Antioxidative activity of melanin free ink from cuttlefish,Sepia prabahari[J].J Exp Zool,2017,20(2):867-871.
[31]Vate N K,Benjakul S,Agustini T W.Application of melanin‐free ink as a new antioxidative gel enhancer in sardine surimi gel[J].J Sci Food Agr,2015,95(11):2201-2207.
[32]Duan Z H,Liu H Z,Luo P,et al.The effect of melaninfree extract fromSepia esculentaink on lipid peroxidation,protein oxidation and water-holding capacity of tilapia fillet during cold storage[J].Chem Cent J,2018,12(1):30-36.
[33]伍革民,彭光旭.动物黑色素研究进展[J].甘肃畜牧兽医,2005,35(1):39-41.
[34]Nasti T H,Timares L.MC1R,eumelanin and pheomelanin:their role in determining the susceptibility to skin cancer[J].Photochem Photobiol,2015,91(1):188-200.
[35]Meredith P,Sarna T.The physical and chemical properties of eumelanin[J].Pigm Cell Melanoma R,2006,19(6):572-594.
[36]甄天元,赵梦醒,雷敏.鱿鱼墨黑色素对亚急性衰老模型小鼠抗氧化功能的影响[J].中国食品学报,2012,12(5):61-65.
[37]李和生,李晓,董亚辉,等.乌贼墨黑色素的超微结构及抗氧化活性研究[J].中国食品学报,2012,12(10):62-66.
[38]Guo X,Chen S G,Hu Y Q,et al.Preparation of watersoluble melanin from squid ink using ultrasound-assisted degradation and its anti-oxidant activity[J].J Food Sci Tech,2014,51(12):3680-3690.
[39]景奕文,杨最素,丁国芳,等.乌贼墨多肽体外抗氧化活性研究[J].安徽农业科学,2013,41(27):10971-10973.
[40]Rangasamy T,Cho C Y,Thimmulappa R K,et al.Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice[J].J Clin Invest,2004,114(9):1248-1259.
[41]李慧,杨林.Nrf2抗氧化的分子调控机制[J].生物信息学,2018,16(1):1-6.
[42]Buendia I,Michalska P,Navarro E,et al.Nrf2-AREpathway:an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases[J].Pharmacol Therapeut,2016,157(1):84-104.
[43]Le X Y,Luo P,Gu Y P,et al.Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice[J].Iran J Basic Med Sci,2015,18(8):827-831.
[44]Liu C H,Li X D,Li Y H,et al.Structural characterisation and antimutagenic activity of a novel polysaccharide isolated fromSepiella maindroni ink[J].Food Chem,2008,110(4):807-813.
[45]罗萍,师莉莎,刘华忠.乌贼墨多糖的体外抗氧化作用[J].食品研究与开发,2013,34(8):1-4.
[46]牛庆凤,王斌,李涛,等.1种新型乌贼墨糖胺聚糖的分离纯化、理化性质及其抗氧化活性研究[J].中国海洋药物,2015,34(3):59-64.
[47]杨丽芝.南海鸢乌贼墨汁多糖分离纯化与活性研究[D].上海:上海海洋大学,2016.
[48]Luo P,Liu H Z.Antioxidant ability of squid ink polysaccharides as well as their protective effects on deoxyribonucleic acid DNA damage in vitro[J].Afr J Pharm Pharmaco,2013,7(21):1382-1388.
[49]Gu Y P,Yang X M,Duan Z H,et al.Squid ink polysaccharide prevents autophagy and oxidative stress affected by cyclophosphamide in Leydig cells of mice:apilot study[J].Iran J Basic Med Sci,2017,20(11):1194-1199.
[50]乐小炎,刘华忠.乌贼墨多糖对环磷酰胺介导雄性小鼠生殖能力损伤的保护作用[C]//环北部湾高校研究生海洋论坛,2013:239-243.
[51]谷毅鹏,张云波,刘华忠,等.乌贼墨多糖对环磷酰胺致小鼠卵巢损伤的保护作用[J].食品工业科技,2014,35(17):358-361.
[52]张云波,刘华忠,谷毅鹏,等.乌贼墨多糖对环磷酰胺介导小鼠卵巢氧化应激损伤的干预效应[J].广东农业科学,2015,42(14):90-93.
[53]刘华忠,王光,吴金龙,等.乌贼墨多糖对环磷酰胺致小鼠部分脏器损伤的缓解效应[J].中国现代应用药学,2012,29(2):89-93.
[54]闵诗刚,王光,钟杰平,等.乌贼墨多糖对大鼠外周血及血液中抗氧化能力影响[J].食品研究与开发,2011,32(1):123-125.
[55]陈颖.乌贼墨多糖通过调节Connexin43和NADPH氧化酶改善成纤维细胞氧化损伤的研究[D].广州:南方医科大学,2016.