阿司匹林联合偏瘫活络片治疗脑血栓临床效果及对D-二聚体水平的影响
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摘要
目的:观察阿司匹林联合偏瘫活络片治疗脑血栓的临床效果及对D-二聚体水平的影响。方法:将收治的脑血栓患者148例采用随机数字法分为2组各74例,对照组采用单一的阿司匹林进行治疗,研究组在此基础上联合偏瘫活络片进行治疗,对2组患者的临床治疗效果、治疗前后动脉斑块情况、神经功能缺损评估量表(NIHSS)评分和Barthel指数、D-二聚体以及血浆N端前脑钠肽(NT-proBNP)的水平。结果:治疗后,研究组总有效率为93.2%,对照组为84.5%,2组比较,差异有统计学意义(P <0.05)。治疗前,2组间动脉斑块面积及颈动脉内膜厚度比较,差异无统计学意义(P> 0.05)。经治疗,2组动脉斑块面积及颈动脉内膜厚度较前改善(P <0.05)。治疗3个月后,2组间动脉斑块面积及颈动脉内膜厚度比较,差异有统计学意义(P <0.05)。治疗前,2组间NIHSS评分、Barthel指数比较,差异无统计学意义(P> 0.05)。经治疗,2组NIHSS评分、Barthel指数较前改善(P <0.05)。治疗3个月后,2组间NIHSS评分、Barthel指数比较,差异有统计学意义(P <0.05)。治疗前,2组间D-二聚体、血浆NT-proBNP比较,差异无统计学意义(P> 0.05)。经治疗,2组D-二聚体、血浆NT-proBNP较前改善(P <0.05)。治疗3个月后,2组间D-二聚体、血浆NT-proBNP比较,差异有统计学意义(P <0.05)。结论:对脑血栓患者采用阿司匹林联合偏瘫活络片进行治疗,可提高临床治疗效果,改善相关指标水平。
Objective: To observe the clinical effect of aspirin combined with Piantan Huoluo tablets for patients with cerebral thrombosis and its effect on D-dimer level. Methods:148 cases of patients with cerebral thrombosis admitted and treated in our hospital were divided into the control group and the study group randomly,74 cases in each group. The control group received the single administration of aspirin, while the study group additionally received Piantan Huoluo tablets.Observed the clinical effect of patients in both group, and compared the condition of arterial plaque, scores of national institutes of health stroke scale(NIHSS),Barthel index and levels of D-dimer and plasma NT-pro B-type natriuretic peptide(NT-pro BNP) before and after treatment. Results:After treatment,the total effective rate was 93.2% in the study group and84.5% in the control group,difference being significant(P < 0.05). Before treatment,comparing the area of arterial plaque and carotid intimal thickness in-between the two groups, there was no significant difference being found(P > 0.05). After treatment,the area of arterial plaque and carotid intimal thickness in both groups were improved when comparing with those before treatment(P < 0.05). After 3 months of treatment,comparing the area of arterial plaque and carotid intimal thickness in-between the two groups,there was significant difference being found(P < 0.05). Before treatment,comparing the scores of NIHSS and Barthel index in-between the two group s, there was no significant difference being found(P > 0.05). After treatment, the scores of NIHSS and Barthel index in both groups were improved when comparing with those before treatment(P < 0.05). After 3 months of treatment, comparing the scores of NIHSS and Barthel index in-between the two groups, there was significant difference being found(P < 0.05). Before treatment, comparing the levels of D-dimer and plasma NT-pro BNP in-between the two groups,there was no significant difference being found(P > 0.05). After treatment,the levels of D-dimer and plasma NT-pro BNP in both groups were improved when comparing with those before treatment(P < 0.05). After 3 months of treatment, comparing the levels of D-dimer and plasma NT-pro BNP in-between the two groups,there was significant difference being found(P < 0.05). Conclusion:The application of aspirin combined with Piantan Huoluo tablets for patients with cerebral thrombosis can enhance the clinical effect and improve the levels of relevant indexes.
Objective: To observe the clinical effect of aspirin combined with Piantan Huoluo tablets for patients with cerebral thrombosis and its effect on D-dimer level. Methods:148 cases of patients with cerebral thrombosis admitted and treated in our hospital were divided into the control group and the study group randomly,74 cases in each group. The control group received the single administration of aspirin, while the study group additionally received Piantan Huoluo tablets.Observed the clinical effect of patients in both group, and compared the condition of arterial plaque, scores of national institutes of health stroke scale(NIHSS),Barthel index and levels of D-dimer and plasma NT-pro B-type natriuretic peptide(NT-pro BNP) before and after treatment. Results:After treatment,the total effective rate was 93.2% in the study group and84.5% in the control group,difference being significant(P < 0.05). Before treatment,comparing the area of arterial plaque and carotid intimal thickness in-between the two groups, there was no significant difference being found(P > 0.05). After treatment,the area of arterial plaque and carotid intimal thickness in both groups were improved when comparing with those before treatment(P < 0.05). After 3 months of treatment,comparing the area of arterial plaque and carotid intimal thickness in-between the two groups,there was significant difference being found(P < 0.05). Before treatment,comparing the scores of NIHSS and Barthel index in-between the two group s, there was no significant difference being found(P > 0.05). After treatment, the scores of NIHSS and Barthel index in both groups were improved when comparing with those before treatment(P < 0.05). After 3 months of treatment, comparing the scores of NIHSS and Barthel index in-between the two groups, there was significant difference being found(P < 0.05). Before treatment, comparing the levels of D-dimer and plasma NT-pro BNP in-between the two groups,there was no significant difference being found(P > 0.05). After treatment,the levels of D-dimer and plasma NT-pro BNP in both groups were improved when comparing with those before treatment(P < 0.05). After 3 months of treatment, comparing the levels of D-dimer and plasma NT-pro BNP in-between the two groups,there was significant difference being found(P < 0.05). Conclusion:The application of aspirin combined with Piantan Huoluo tablets for patients with cerebral thrombosis can enhance the clinical effect and improve the levels of relevant indexes.
引文
[1]陈璐菡,潘涛.辛伐他汀联合阿司匹林治疗脑血栓的效果及对神经功能缺损的影响[J].中国医药导报,2016,13(23):161-164.
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[3]惠振,佟朝霞,张敬华,等.通脑活络针刺法联合复方通络饮治疗脑梗死急性期患者临床观察[J].辽宁中医药大学学报,2017,25(11):169-171.
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[5]吴丹.阿司匹林肠溶片联合双嘧达莫对脑血栓患者神经功能恢复及血液流变学的影响[J].潍坊医学院学报,2017,67(2):79-81.
[6] MIN G, SIWEI L, BAOJIN L I, et al.Effect of motor relearning programme on motor function recovery of acute stroke patients with hemiplegia[J].Chinese Journal of Contemporary Neurology&Neurosurgery,2017,17(3):197-201.
[7]姚珊,周静.阿司匹林联合辛伐他汀治疗脑血栓的临床疗效及对血液流变学指标的影响[J].沈阳医学院学报,2017,18(3):59-61.
[8]吴裕勇.阿司匹林联合他汀类药物对老年脑血栓患者预后的影响分析[J].世界最新医学信息文摘,2016,16(5):41-42.
[9]陈翔.浅析脑血栓患者运用双嘧达莫和阿司匹林肠溶片联合治疗的临床疗效[J].中国实用医药,2016,11(9):174-175.
[10] JIANG Y,ZHOU Y,WANG B,et al.Clinical research of scalp acupuncture combined with rehabilitation training treating patients with cerebral infarction in recovery period based on1H-MRS[J].Rehabilitation Medicine,2016,26(1):10.
[11]赵展宁.阿司匹林肠溶片与双嘧达莫联合用于脑血栓治疗的临床效果评价[J].中国医药指南,2016,26(14):136-137.
[12]武艳娥,冯晔,徐鹏.辛伐他汀联合阿司匹林治疗脑血栓的效果及对神经功能缺损的影响[J].临床医药文献(电子杂志),2017,69(11):13600.
[13] DU X,BAO C,DONG G,et al.Immediate effects of scalp acupuncture with twirling reinforcing manipulation on hemiplegia following acute ischemic stroke:a hidden association study[J].Neural Regeneration Research,2016,11(5):758-764.
[2] SI Z,HU K,WANG C,et al.The effects of neuromuscular facilitation techniques on osteoporosis of hemiplegia limbs and serum leptin level in patients or rats with cerebral infarction[J].Brain Injury,2016,30(4):6.
[3]惠振,佟朝霞,张敬华,等.通脑活络针刺法联合复方通络饮治疗脑梗死急性期患者临床观察[J].辽宁中医药大学学报,2017,25(11):169-171.
[4] ZHOU Y, PAN Y, WU Y, et al.Effect of estimated glomerular filtration rate decline on the efficacy and safety of clopidogrel with aspirin in minor Stroke or transient ischemic attack:CHANCE substudy(clopidogrel in high-risk patients with Acute nondisabling cerebrovascular events)[J].Stroke,2016,47(11):2791-2796.
[5]吴丹.阿司匹林肠溶片联合双嘧达莫对脑血栓患者神经功能恢复及血液流变学的影响[J].潍坊医学院学报,2017,67(2):79-81.
[6] MIN G, SIWEI L, BAOJIN L I, et al.Effect of motor relearning programme on motor function recovery of acute stroke patients with hemiplegia[J].Chinese Journal of Contemporary Neurology&Neurosurgery,2017,17(3):197-201.
[7]姚珊,周静.阿司匹林联合辛伐他汀治疗脑血栓的临床疗效及对血液流变学指标的影响[J].沈阳医学院学报,2017,18(3):59-61.
[8]吴裕勇.阿司匹林联合他汀类药物对老年脑血栓患者预后的影响分析[J].世界最新医学信息文摘,2016,16(5):41-42.
[9]陈翔.浅析脑血栓患者运用双嘧达莫和阿司匹林肠溶片联合治疗的临床疗效[J].中国实用医药,2016,11(9):174-175.
[10] JIANG Y,ZHOU Y,WANG B,et al.Clinical research of scalp acupuncture combined with rehabilitation training treating patients with cerebral infarction in recovery period based on1H-MRS[J].Rehabilitation Medicine,2016,26(1):10.
[11]赵展宁.阿司匹林肠溶片与双嘧达莫联合用于脑血栓治疗的临床效果评价[J].中国医药指南,2016,26(14):136-137.
[12]武艳娥,冯晔,徐鹏.辛伐他汀联合阿司匹林治疗脑血栓的效果及对神经功能缺损的影响[J].临床医药文献(电子杂志),2017,69(11):13600.
[13] DU X,BAO C,DONG G,et al.Immediate effects of scalp acupuncture with twirling reinforcing manipulation on hemiplegia following acute ischemic stroke:a hidden association study[J].Neural Regeneration Research,2016,11(5):758-764.