经皮椎体成形术联合表阿霉素局部化疗治疗51例脊柱转移瘤患者的短期随访研究
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摘要
目的:研究经皮椎体成形术(PVP)联合表阿霉素局部化疗治疗脊柱转移瘤患者的短期随访效果。方法:选取我院102例脊柱转移瘤患者作为研究对象,按照随机抽签法分组,各51例。对照组采取开放性手术治疗,观察组采取PV+表阿霉素局部化疗治疗。比较两组手术前后疼痛(VAS)评分、手术前后日常生活能力(ODI)评分及预后情况。结果:观察组术后1d、术后10d、术后1个月、术后3个月、术后6个月VAS评分较对照组低(P<0.05);观察组术后1个月、术后3个月、术后6个月ODI评分较对照组低(P<0.05);观察组术后6个月生存率72.55%(37/51)较对照组50.98%(26/51)高,病死率27.45%(14/51)较对照组49.02%(25/51)低(P<0.05)。结论:PVP联合表阿霉素局部化疗治疗脊柱转移瘤患者,可明显减轻疼痛程度,改善日常生活能力,还可显著提高生存率,降低病死率。
Objective: To study the short-term follow-up effect of percutaneous vertebroplasty(PVP) in patients with spinal metastases. Methods: A total of 102 patients with spinal metastases in our hospital were selected as subjects. Each group was randomly divided into 51 cases. The control group was treated with open surgery and the observation group was treated with PVP. Before and after surgery, the pain(VAS) scores, the ability of daily living(ODI), and the prognosis were compared between the two groups. Results: The VAS scores of the observation group were lower than those of the control group at 1 day, 10 days after surgery, 1 month after operation, 3 months after operation and 6 months after operation(P<0.05). The ODI scores of the 3 months and 6 months after operation were lower than those of the control group(P<0.05). The survival rate of the observation group at 7 months was 72.55%(37/51) higher than that of the control group(50.98%(26/51)). The case fatality rate was 27.45%(14/51), which was lower than that of the control group(49.02%(25/51))(P<0.05). Conclusion: PVP in patients with spinal metastases can significantly reduce the degree of pain, improve the ability of daily living, and significantly improve the survival rate and mortality, which is worthy of clinical promotion.
Objective: To study the short-term follow-up effect of percutaneous vertebroplasty(PVP) in patients with spinal metastases. Methods: A total of 102 patients with spinal metastases in our hospital were selected as subjects. Each group was randomly divided into 51 cases. The control group was treated with open surgery and the observation group was treated with PVP. Before and after surgery, the pain(VAS) scores, the ability of daily living(ODI), and the prognosis were compared between the two groups. Results: The VAS scores of the observation group were lower than those of the control group at 1 day, 10 days after surgery, 1 month after operation, 3 months after operation and 6 months after operation(P<0.05). The ODI scores of the 3 months and 6 months after operation were lower than those of the control group(P<0.05). The survival rate of the observation group at 7 months was 72.55%(37/51) higher than that of the control group(50.98%(26/51)). The case fatality rate was 27.45%(14/51), which was lower than that of the control group(49.02%(25/51))(P<0.05). Conclusion: PVP in patients with spinal metastases can significantly reduce the degree of pain, improve the ability of daily living, and significantly improve the survival rate and mortality, which is worthy of clinical promotion.
引文
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[2]张计超,宁宇,崔冰,等.经皮椎体成形术在脊柱转移瘤中的临床应用研究[J].中国医学创新, 2016, 13(2):41-43.
[3]刘勇,夏波,李新福.椎体后凸成形骨水泥注入治疗脊柱转移瘤:脊柱稳定性与疼痛的变化[J].中国组织工程研究, 2015, 19(16):2484-2488.
[4]黄霖,陈铿,蔡兆鹏,等.微创穿刺Intrabeam(R)术中放疗联合椎体强化治疗脊柱转移瘤的近期疗效分析[J].中华骨科杂志, 2016, 36(4):215-223.
[5]赵锡江,齐新生,茅治湘,等.经皮椎体成形术与开放性椎体成形术治疗脊柱转移瘤[J].中国骨伤, 2017, 30(2):115-120.
[6]李涛,张延,杨妮,等.微创经皮椎体成形术治疗脊柱转移性肿瘤的临床疗效分析[J].现代生物医学进展, 2017, 17(28):5582-5584.
[7]张贤俊,齐新生,茅治湘,等.经皮椎体成形术治疗多节段脊柱转移性肿瘤的疗效观察[J].江苏医药, 2014, 40(18):2182-2184.
[8]康展荣,黄秋英,黄建明,等.经皮椎体成形术在脊柱转移瘤中的应用现状[J].脊柱外科杂志, 2017, 15(5):308-313.
[9]钟世寿,李国苗,徐建.表阿霉素加环磷酰胺方案与蒽环类加多西紫杉醇方案治疗三阴乳腺癌的临床疗效比较[J].中国肿瘤临床与康复, 2015, 22(1):37-39.
[10]李海涛,胡成栋,陈怀志,等.经皮椎体成形术联合局部化疗治疗脊柱转移瘤的疗效分析[J].中国肿瘤临床与康复, 2013, 20(5):530-532.