酪酸梭菌肠球菌三联活菌片对晚期非小细胞肺癌患者吉西他滨联合铂类化疗方案影响的回顾性分析
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摘要
目的通过相关回顾性病例收集研究,探究使用酪酸梭菌肠球菌三联活菌片是否具有提高晚期非小细胞肺癌(NSCLC)患者吉西他滨联合铂类(GP)化疗方案的疗效,减轻化疗带来的毒副作用。方法调取2014年1月至2018年7月在福州某三甲医院肿瘤科接受GP化疗方案治疗的晚期NSCLC患者的医疗记录,纳入78例患者的相关数据,采用SPSS 25.0软件进行数据统计分析。结果与对照组相比,使用酪酸梭菌肠球菌三联活菌片对患者的疾病控制率、无进展生存时间的影响具有显著性差异(P值分别为0.048、0.012),对疾病缓解率和不良反应风险的影响均无显著性差异(P>0.05)。结论在晚期NSCLC患者中,GP化疗方案治疗联合使用酪酸梭菌肠球菌三联活菌片可能提高患者的疗效。
Objective To explore the effect of clostridium butyricum enterococcus triple viable tablet on the efficacy and adverse reactions of gemcitabine plus platinum(GP) regimen for the patients with advanced non-small cell lung cancer(NSCLC).Methods The records of 78 NSCLC patients who treated with GP regimen as first-line palliative chemotherapy were reviewed,and the related data were recorded.Statistical analyses were performed with SPSS 25.0.Results Compared with the control group,the probiotic preparation group showed a significant difference in disease control rate and progression-free survival(P value are 0.048 and 0.012 respectively),while there were no significant differences in objective response rate and the risk of adverse reaction events(P>0.05).Conclusion The clostridium butyricum enterococcus triple viable tablet might improve the efficacy of GP regimen as a first-line palliative chemotherapy for advanced NSCLC patients.
Objective To explore the effect of clostridium butyricum enterococcus triple viable tablet on the efficacy and adverse reactions of gemcitabine plus platinum(GP) regimen for the patients with advanced non-small cell lung cancer(NSCLC).Methods The records of 78 NSCLC patients who treated with GP regimen as first-line palliative chemotherapy were reviewed,and the related data were recorded.Statistical analyses were performed with SPSS 25.0.Results Compared with the control group,the probiotic preparation group showed a significant difference in disease control rate and progression-free survival(P value are 0.048 and 0.012 respectively),while there were no significant differences in objective response rate and the risk of adverse reaction events(P>0.05).Conclusion The clostridium butyricum enterococcus triple viable tablet might improve the efficacy of GP regimen as a first-line palliative chemotherapy for advanced NSCLC patients.
引文
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[5] FUHRMANB J,FEIGELSON H S,FLORES R,et al.Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women[J].J Clin Endocrinol Metab,2014,99(12):4632-4640.
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[7] SCHWABER F,JOBIN C.The microbiome and cancer[J].Nat Rev Cancer,2013,13(11):800-812.
[8] ZACKULARJ P,BAXTER N T,IVERSON K D,et al.The gut microbiome modulates colon tumorigenesis[J].mBio,2013,4(6):e613-e692.
[9] IIDA N,DZUTSEV A,STEWARTC A,et al.Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment[J].Science,2013,342(6161):967-970.
[10] PEREZ-CHANONA E,TRINCHIERI G.The role of microbiota in cancer therapy[J].Curr Opin Immunol,2016,39:75-81.
[11] VIAUD S,SACCHERI F,MIGNOT G,et al.Theintestinal microbiota modulates the anticancer immune effects of cyclophosphamide[J].Science,2013,342(6161):971-976.[LinkOut]
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[13] CRONIN K A,LAKE A J,SCOTT S,et al.Annual report to the Nation on the status of cancer,part I:national cancer statistics[J].Cancer,2018,124(13):2785-2800.
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[19] PALA V,SIERI S,BERRINO F,et al.Yogurt consumption and risk of colorectal cancer in the Italian European prospective investigation into cancer and nutrition cohort[J].Int J Cancer,2011,129(11):2712-2719.
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