替莫唑胺联合放疗对脑肿瘤疗效的临床研究
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摘要
目的评价替莫唑胺联合放疗治疗脑肿瘤的效果以及安全性,为脑肿瘤临床治疗提供参考。方法选择我院2015年6月至2017年8月收治住院治疗的60例脑肿瘤患者,综合治疗方法随机分为对照组、试验组,各30例。对照组脑肿瘤患者接受放疗治疗,试验组联合替莫唑胺治疗,对比2组脑肿瘤患者治疗效果、无进展生存时间以及不良反应情况。结果 2组脑肿瘤患者有胃肠道反应,无严重毒副反应问题。组间治疗效果对比,试验组脑肿瘤患者治疗总有效率明显高于对照组,P<0.05。组间无进展生存时间对比,试验组脑肿瘤患者无进展生存时间明显长于对照组,P<0.05。结论替莫唑胺联合放疗治疗脑肿瘤在保证安全性的基础上可以提高治疗效果、延长生存时间。
Objective To evaluate effect and safety of temozolomide combined with radiotherapy in treatment of brain tumors, to provide reference for clinical treatment. Methods Choose 60 cases brain tumors patients treated in our hospital from June 2015 to August 2017, divide into control and experimental group randomly based on treatment methods, 30 cases in each. Control group was treated with radiotherapy and experimental group with radiotherapy combined with temozolomide. Compare curative effect, progression-free survival time and adverse reactions of two groups. Results Both groups had gastrointestinal reactions and no serious side effects. Comparison of curative effects between groups showed, total effective rate of experimental group was significantly higher than control group(P< 0.05).Compared with control group, progression-free survival time of experimental group was significantly longer than control group(P< 0.05). Conclusion Temozolamide combined with radiotherapy can improve curative effect and prolong survival time of brain tumors patients on the basis of ensuring safety.
Objective To evaluate effect and safety of temozolomide combined with radiotherapy in treatment of brain tumors, to provide reference for clinical treatment. Methods Choose 60 cases brain tumors patients treated in our hospital from June 2015 to August 2017, divide into control and experimental group randomly based on treatment methods, 30 cases in each. Control group was treated with radiotherapy and experimental group with radiotherapy combined with temozolomide. Compare curative effect, progression-free survival time and adverse reactions of two groups. Results Both groups had gastrointestinal reactions and no serious side effects. Comparison of curative effects between groups showed, total effective rate of experimental group was significantly higher than control group(P< 0.05).Compared with control group, progression-free survival time of experimental group was significantly longer than control group(P< 0.05). Conclusion Temozolamide combined with radiotherapy can improve curative effect and prolong survival time of brain tumors patients on the basis of ensuring safety.
引文
[1]谷田露.非小细胞肺癌脑转移者应用替莫唑胺联合全脑放疗的随机对照研究[J].现代仪器与医疗,2015,(1):36-38,52.
[2]贾敬好,王静,王巍等.Ⅲ级和Ⅳ级脑胶质瘤术后放疗联合替莫唑胺化疗的疗效观察[J].河北医药,2017,39(3):337-341.
[3]刘哲.替莫唑胺联合放疗治疗非小细胞肺癌脑转移瘤的临床研究[J].中国现代药物应用,2016,10(2):114-115.
[4]倪峰,何晓军,陆美芹等.替莫唑胺联合放疗对脑肿瘤疗效的临床研究[J].实用临床医药杂志,2017,21(11):166-167.
[5]徐润,张君.替莫唑胺联合放疗对脑肿瘤疗效的临床研究[J].养生保健指南,2017,(50):8.
[2]贾敬好,王静,王巍等.Ⅲ级和Ⅳ级脑胶质瘤术后放疗联合替莫唑胺化疗的疗效观察[J].河北医药,2017,39(3):337-341.
[3]刘哲.替莫唑胺联合放疗治疗非小细胞肺癌脑转移瘤的临床研究[J].中国现代药物应用,2016,10(2):114-115.
[4]倪峰,何晓军,陆美芹等.替莫唑胺联合放疗对脑肿瘤疗效的临床研究[J].实用临床医药杂志,2017,21(11):166-167.
[5]徐润,张君.替莫唑胺联合放疗对脑肿瘤疗效的临床研究[J].养生保健指南,2017,(50):8.