传统针灸联合药物治疗寻常性痤疮疗效及患者满意度分析
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摘要
目的:分析传统针灸联合药物治疗寻常性痤疮的疗效及患者满意度情况。方法:选取笔者医院2017年10月-2018年3月收治的60例青春期痤疮患者,根据治疗方法不同分为对照组(药物治疗)和观察组(药物治疗基础上联合传统针灸治疗),分析两组患者治疗后的临床疗效。结果:两组治疗前中医证候评分、皮损评分及满意度评分组间比较,差异不具有统计学意义(P>0.05)。治疗后观察组面部潮红、口干口臭、小便短赤、大便秘结评分、皮损评分及满意评分均低于对照组(P<0.05)。两组治疗前炎症因子水平组间比较,差异不具有统计学意义(P>0.05);治疗后观察组干扰素-γ(IFN-γ)水平高于对照组,白介素-8(IL-8)、白介素-17(IL-17)水平低于对照组(P<0.05)。观察组患者总有效率(96.67%)高于对照组(76.67%),复发率(6.67%)低于对照组(26.67%),差异有统计学意义(P<0.05)。结论:传统针灸联合药物治疗青春期痤疮疗效显著,可改善患者临床症状,调节炎症因子的表达,提高满意度。
Objective To analyze the efficacy and satisfaction of traditional acupuncture and moxibustion combined with drugs in the treatment of acne vulgaris. Methods From October 2017 to March 2018, 60 patients with adolescent acne were divided into two groups: control group(drug therapy) and observation group(combined with traditional acupuncture therapy).To analyze the clinical effect of two groups of patients after treatment. Results There was no significant difference in TCM syndrome score, skin lesion score and satisfactory score between the two groups before treatment(P>0.05). After treatment,the scores of flushed face, bad breath of dry mouth, short redness of urine, constipation score, skin lesion score and satisfaction score in the observation group were lower than those in the control group(P<0.05), and the levels of inflammatory factors in the two groups before treatment were lower than those in the control group(P<0.05). The difference was not statistically significant(P>0.05). The levels of interferon-γ(IFN-γ), interleukin-8(IL-8) and interleukin-17(IL-17) in the observation group were higher than those in the control group(P<0.05).The total effective rate(96.67%) in the observation group was higher than that in the control group(76.67%), and the recurrence rate(6.67%) was lower than that in the control group(26.67%)(P<0.05). Conclusion Traditional acupuncture and moxibustion can improve the clinical symptoms, regulate the expression of inflammatory factors and improve satisfaction.
Objective To analyze the efficacy and satisfaction of traditional acupuncture and moxibustion combined with drugs in the treatment of acne vulgaris. Methods From October 2017 to March 2018, 60 patients with adolescent acne were divided into two groups: control group(drug therapy) and observation group(combined with traditional acupuncture therapy).To analyze the clinical effect of two groups of patients after treatment. Results There was no significant difference in TCM syndrome score, skin lesion score and satisfactory score between the two groups before treatment(P>0.05). After treatment,the scores of flushed face, bad breath of dry mouth, short redness of urine, constipation score, skin lesion score and satisfaction score in the observation group were lower than those in the control group(P<0.05), and the levels of inflammatory factors in the two groups before treatment were lower than those in the control group(P<0.05). The difference was not statistically significant(P>0.05). The levels of interferon-γ(IFN-γ), interleukin-8(IL-8) and interleukin-17(IL-17) in the observation group were higher than those in the control group(P<0.05).The total effective rate(96.67%) in the observation group was higher than that in the control group(76.67%), and the recurrence rate(6.67%) was lower than that in the control group(26.67%)(P<0.05). Conclusion Traditional acupuncture and moxibustion can improve the clinical symptoms, regulate the expression of inflammatory factors and improve satisfaction.
引文
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[12]Melnik BC.Acne vulgaris:the metabolic syndrome of the pilosebaceous follicle[J].Clin Dermatol,2018,36(1):29-40.
[13]张新峰,王虹,贵明俊,等.基于中医舌象特征的痤疮证型分类的初步研究[J].北京生物医学工程,2016,35(5):464-468.
[14]王东平,刘岩.潘星宇针药结合治疗痤疮经验[J].江西中医药,2018,49(6):21-23.
[15]于小普.粉刺清除术配合刺络拔罐治疗痤疮临床观察[J].实用中医药杂志,2017,33(4):415.
[16]王广建,韩呈明,毕晓涛,等.李波教授运用桂枝茯苓丸经验研究[J].河北中医药学报,2017,32(1):52-54.
[17]张倩,石红乔,周莉,等.痤疮一号散治疗寻常痤疮的临床疗效观察[J].内蒙古中医药,2017,36(20):43.
[18]张莉,胡志帮.痤疮炎症的发生机制研究进展[J].山东医药,2018,58(34):110-112.
[19]孙欣荣,刘志宏,黄爱文,等.痤疮发病机制及其药物治疗的研究进展[J].中国药房,2017,28(20):2868-2871.
[20]陆威,周炳荣,汤怡,等.Th17细胞在痤疮发病中的作用及与痤疮严重度相关性的功能研究[J].中国临床药理学与治疗学,2018,23(1):83-87.
[21]耿春杰,张国强,李会申,等.地氯雷他定分散片联合小剂量异维A酸胶丸治疗痤疮的疗效及对炎性因子的影响[J].河北医药,2018,40(16):2449-2452,2456.
[2]黄鹂,刘江山.不同治疗方案在面部痤疮凹陷性瘢痕患者中的疗效对比[J].医学临床研究,2016,33(5):922-925.
[3]燕群,董心亚.异维A酸胶囊联合丹参酮胶囊治疗中重度痤疮的疗效观察[J].中华疾病控制杂志,2016,20(7):752-754.
[4]周涛,杨岚,刘清,等.清肺解毒饮治疗肺胃蕴热型痤疮临床研究[J].国际中医中药杂志,2017,39(7):597-600.
[5]李文龙,何海龙,黄智兼.中医内外结合治疗青春期痤疮疗效观察[J].山西中医,2017,33(3):28-29.
[6]赵辨.中国临床皮肤病学[M]..南京:江苏科学技术出版社,2009:1165-1169.
[7]范瑞强,廖元兴.中西医结合临床皮肤性病学[M].广州:广东世界图书出版有限公司,2003:637.
[8]邵蕾,梁景耀,陈丽洁,等.痤疮发病机制的免疫学研究进展[J].国际皮肤性病学杂志,2017,43(6):78-82.
[9]Skroza N,Tolino E,Mambrin A,et al.Adult acne versus adolescent acne:a retrospective study of 1 167 patients[J].J Clin Aesthet Dermatol,2018,11(1):21-25.
[10]曹燕,王林,贾虹,等.米诺环素在皮肤科临床中的应用[J].实用皮肤病学杂志,2016,9(2):120-123.
[11]周建华,毛玉春.维胺酯联合安体舒通治疗痤疮临床应用效果观察[J].临床医药文献电子杂志,2017,4(96):18966.
[12]Melnik BC.Acne vulgaris:the metabolic syndrome of the pilosebaceous follicle[J].Clin Dermatol,2018,36(1):29-40.
[13]张新峰,王虹,贵明俊,等.基于中医舌象特征的痤疮证型分类的初步研究[J].北京生物医学工程,2016,35(5):464-468.
[14]王东平,刘岩.潘星宇针药结合治疗痤疮经验[J].江西中医药,2018,49(6):21-23.
[15]于小普.粉刺清除术配合刺络拔罐治疗痤疮临床观察[J].实用中医药杂志,2017,33(4):415.
[16]王广建,韩呈明,毕晓涛,等.李波教授运用桂枝茯苓丸经验研究[J].河北中医药学报,2017,32(1):52-54.
[17]张倩,石红乔,周莉,等.痤疮一号散治疗寻常痤疮的临床疗效观察[J].内蒙古中医药,2017,36(20):43.
[18]张莉,胡志帮.痤疮炎症的发生机制研究进展[J].山东医药,2018,58(34):110-112.
[19]孙欣荣,刘志宏,黄爱文,等.痤疮发病机制及其药物治疗的研究进展[J].中国药房,2017,28(20):2868-2871.
[20]陆威,周炳荣,汤怡,等.Th17细胞在痤疮发病中的作用及与痤疮严重度相关性的功能研究[J].中国临床药理学与治疗学,2018,23(1):83-87.
[21]耿春杰,张国强,李会申,等.地氯雷他定分散片联合小剂量异维A酸胶丸治疗痤疮的疗效及对炎性因子的影响[J].河北医药,2018,40(16):2449-2452,2456.