高敏C反应蛋白与载脂蛋白A-1、甘油三酯联合检测在心血管疾病中的临床价值
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摘要
目的分析在心血管疾病中联合应用hs-CRP、apo A-1及TRi检测的临床价值。方法选取我院2016年5月～2018年6月收治的患有心血管疾病患者90例进行研究,根据疾病的不同,将其分为急性心肌梗死组30例、稳定型心绞痛组30例、不稳定型心绞痛组30例,并选取同期健康体检结果为正常的患者29例,将其作为对照组。收集所有患者的临床资料,并对其hs-CRP、apo A-1及TRi进行检测。观察并比较各组患者的hs-CRP、apo A-1、TRi水平,并分析hs-CRP、apo A-1、TRi联合检测对心血管疾病诊断的敏感性、特异性。结果稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组的hs-CRP、TRi水平显著高于对照组;稳定型心绞痛组、急性心肌梗死组的hs-CRP显著高于稳定型心绞痛组;稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组的apo A-1水平显著低于对照组;hs-CRP、apo A-1、Tri联合检测对稳定性心绞痛组、不稳定型心绞痛组、急性心肌梗死组的敏感性、特异性显著高于hs-CRP、apo A-1、Tri单独检测的敏感性、特异性,差异有统计学意义(t=1.225,P <0.05)。结论心血管疾病患者的高敏C反应蛋白、甘油三酯水平显著升高,而载脂蛋白A-1显著降低,联合检测hs-CRP、apo A-1、TRi对心血管诊断有一定的临床价值。
Objective To analyze the clinical value of combined test of high-sensitivity C-reactive protein(hsCRP),apolipoprotein A-1(apo A-1),triglyceride(TRi) in cardiovascular diseases. Methods Ninety patients with cardiovascular diseases in hospital from May 2016 to June 2018 were selected and divided into acute myocardial infarction group(30 cases),stable angina pectoris group(30 cases) and unstable angina pectoris group(30 cases),and 29 patients with normal physical examination results were selected as control group.The clinical data of all patients were collected, and hs-CRP,apo A-1 and TRi were detected.The levels of hs-CRP,apoA-1 and TRi in each group were observed and compared,and the sensitivity and specificity of combined test of hs-CRP,apoA-1 and TRi in the diagnosis of cardiovascular diseases were analyzed. Results The levels of hs-CRP and TRi in stable angina pectoris group,unstable angina pectoris group and acute myocardial infarction group were significantly higher than those in control group.The levels of hs-CRP in stable angina pectoris group and acute myocardial infarction group were significantly higher than that in stable angina pectoris group.The levels of apo A-1 in stable angina pectoris group,unstable angina pectoris group and acute myocardial infarction group were significantly higher than that in stable angina pectoris group.The sensitivity and specificity of combined test of hs-CRP,apo A-1 and Tri for stable angina pectoris,unstable angina pectoris and acute myocardial infarction were significantly higher than those of hs-CRP,apo A-1 and Tri alone(t=1.225,P=0.01). Conclusion The levels of hs-CRP and TRi in patients with cardiovascular diseases are significantly increased,while apo A-1 is significantly decreased.Combined testof hsCRP,apo A-1 and TRi has certain clinical value in cardiovascular diagnosis.
Objective To analyze the clinical value of combined test of high-sensitivity C-reactive protein(hsCRP),apolipoprotein A-1(apo A-1),triglyceride(TRi) in cardiovascular diseases. Methods Ninety patients with cardiovascular diseases in hospital from May 2016 to June 2018 were selected and divided into acute myocardial infarction group(30 cases),stable angina pectoris group(30 cases) and unstable angina pectoris group(30 cases),and 29 patients with normal physical examination results were selected as control group.The clinical data of all patients were collected, and hs-CRP,apo A-1 and TRi were detected.The levels of hs-CRP,apoA-1 and TRi in each group were observed and compared,and the sensitivity and specificity of combined test of hs-CRP,apoA-1 and TRi in the diagnosis of cardiovascular diseases were analyzed. Results The levels of hs-CRP and TRi in stable angina pectoris group,unstable angina pectoris group and acute myocardial infarction group were significantly higher than those in control group.The levels of hs-CRP in stable angina pectoris group and acute myocardial infarction group were significantly higher than that in stable angina pectoris group.The levels of apo A-1 in stable angina pectoris group,unstable angina pectoris group and acute myocardial infarction group were significantly higher than that in stable angina pectoris group.The sensitivity and specificity of combined test of hs-CRP,apo A-1 and Tri for stable angina pectoris,unstable angina pectoris and acute myocardial infarction were significantly higher than those of hs-CRP,apo A-1 and Tri alone(t=1.225,P=0.01). Conclusion The levels of hs-CRP and TRi in patients with cardiovascular diseases are significantly increased,while apo A-1 is significantly decreased.Combined testof hsCRP,apo A-1 and TRi has certain clinical value in cardiovascular diagnosis.
引文
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[11]Wu L,Chen Y,Zhong S,et al.Blood N-terminal probrain natriuretic peptide and interleukin-17for distinguishing incomplete kawasaki disease from infectious diseases[J].Indian Pediatr,2015,52(6):477-480.
[12]赵丽华,杜卉莲,姜秀春,等.终末期肾衰竭患儿血清脑钠肽水平与心血管疾病相关性研究[J].医学综述,2015,22(5):933-934.
[13]李红艳,凌凯.CRP及BNP与高龄尿毒症患儿心血管疾病发病的相关性[J].中国医药导刊,2013,15(12):2010-2011.
[14]刘华,杨敏,高小夏,等.成纤维细胞生长因子23与血液透析患儿心血管疾病的关系[J].临床和实验医学杂志,2014,(19):1591-1593.
[2]吴利伟,王凤鸣.脑钠肽在患儿心血管疾病诊治中的研究进展[J].临床儿科杂志,2013,31(7):679-682.
[3]吴凤丽,马晓光.联合检测慢性心力衰竭患儿血清NTproBNP?hs-CR和cTnI的临床意义[J].中国实用医药,2014,9(5):12-13.
[4]张冲,聂娜娜,李伟,等.BNP对左向右分流型小儿先天性心脏病心功能评价[J].青岛大学医学院学报,2014,4(15):333-335.
[5]张英波.BNP?Hcy和Cys-C在糖尿病肾病中的变化及其与心血管疾病的关系[J].重庆医学,2013,42(15):1759-1761.
[6]宋颖飞.BNP升高程度与充血性心力衰竭严重程度的相关性分析[J].中西医结合心血管病杂志,2014,5(10):106.
[7]王美方,王忠,王丽,等.原发性高血压患者血浆SCUBE1的水平变化及临床意义[J].中国动脉硬化杂志,2016,24(1):63-66.
[8]Kitagawa A,Okan,Kimura S,et al.Clinical utili-ty of the plasma brain natriuretic peptide level in monito-ring tetralogy of fallot patients over the long term after initial intracardiac repair:considerations for pulmonaryvalve replacement[J].Pediatr Cardiol,2015,36(4):752-758.
[9]Miyaji Y,Iwanaga Y,Nnkamura T,et al.Inter-relationship between the Myocardial Mass,Fibrosis,BNP,and Clinical Outcomes in Hypertrophic Cardiomy-opathy[J].Intern Med,2016,55(10):1261-1268.
[10]罗友军,周新媚,肖嫒.BNP?cTnI?T3联合检测对老年心力衰竭的临床意义[J].中国现代医生,2014,52(18):60-62.
[11]Wu L,Chen Y,Zhong S,et al.Blood N-terminal probrain natriuretic peptide and interleukin-17for distinguishing incomplete kawasaki disease from infectious diseases[J].Indian Pediatr,2015,52(6):477-480.
[12]赵丽华,杜卉莲,姜秀春,等.终末期肾衰竭患儿血清脑钠肽水平与心血管疾病相关性研究[J].医学综述,2015,22(5):933-934.
[13]李红艳,凌凯.CRP及BNP与高龄尿毒症患儿心血管疾病发病的相关性[J].中国医药导刊,2013,15(12):2010-2011.
[14]刘华,杨敏,高小夏,等.成纤维细胞生长因子23与血液透析患儿心血管疾病的关系[J].临床和实验医学杂志,2014,(19):1591-1593.