巨噬细胞移动抑制因子在慢性阻塞性肺疾病发病中的作用及机制研究进展
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摘要
<正>慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是以持续的呼吸道症状和气流受限为特征的一种气道疾病,钟南山院士指出,在中国主要致死病因中COPD排第三位(17.6%),仅次为肿瘤和脑血管疾病(19.3%和19.1%)[1-2],由此可见COPD严重危害我国公众健康。COPD可防可控,了解其发病机制对于防治至关重要。目前
引文
1任成山,钱桂生.慢性阻塞性肺疾病发病机制研究现状与展望[J/CD].中华肺部疾病杂志(电子版),2009,2(2):104-115.
2钟南山.2017年慢性气道疾病防治研究进展[J].华西医学,2018,33(1):1-7.
3樊迪,张爽,张凡,等.巨噬细胞在慢性阻塞性肺疾病发病机制中作用的研究进展[J].医学综述,2017,23(13):2526-2530.
4陈亚红.2017年GOLD慢性阻塞性肺疾病诊断、治疗及预防的全球策略解读[J/CD].中国医学前沿杂志(电子版),2017,9(1):37-47.
5 Sarir H,Mortaz E,Karimi K,et al.Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages[J].J Inflamm(Lond),2009,6:12.
6 Wallace AM,Sandford AJ,English JC,et al.Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema[J].COPD,2008,5(1):13-23.
7 Allinson JP,Hardy R,Donaldson GC,et al.Combined impact of smoking and early-life exposures on adult lung function trajectories[J].Am J Respir Crit Care Med,2017,196(8):1021-1030.
8陈亚红.2018年GOLD慢性阻塞性肺疾病诊断、治疗及预防全球策略解读[J/CD].中国医学前沿杂志(电子版),2017,9(12):15-22.
9 Harvey CJ,Thimmulappa RK,Sethi S,et al.Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model[J].Sci Transl Med,2011,3(78):78ra32.
10 Lofdahl MJ,Roos-Engstrand E,Pourazar J,et al.Increased intraepithelial T-cells in stable COPD[J].Respir Med,2008,102(12):1812-1818.
11武广华,臧益秀,刘运祥,等.医学免疫学[M].北京:中国科学技术出版社,2001.
12 Miller EJ,Li J,Leng L,et al.Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart[J].Nature,2008,451(7178):578-582.
13 Wang Y,Luo G,Chen J,et al.Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGFfactor 8(MFG-E8)expressions[J].Sci Rep,2017,7:42642.
14朱惠源.巨噬细胞移动抑制因子在过敏性哮喘中的表达及意义[D].郑州大学,2016.
15聂树涛,刘茂峰.矽肺患者肺泡灌洗液中巨噬细胞游走抑制因子和活化因子的观察[J].中华劳动卫生职业病杂志,2008,26(10):614-615.
16 Bloom BR,Bennett B.Mechanism of a reaction in vitro associated with delayed-type hypersensitivity[J].Science,1966,153(3731):80-82.
17 Sun HW,Bernhagen J,Bucala R,et al.Crystal structure at 2.6-Aresolution of human macrophage mig ration inhibitory factor[J].Proc Natl Acad Sci USA,1996,28,93(11):5191-5196.
18 Husebo GR,Bakke PS,Gronseth R,et al.Macrophage migration inhibitory factor,a role in COPD[J].Am J Physiol Lung Cell Mol Physiol,2016,311(1):L1-L7.
19 Oikonomidi A,Tautvydaite D,Gholamrezaee MM,et al.Macrophage migration inhibitory factor is associated with biomarkers of alzheimer's disease pathology and predicts cognitive decline in mild cognitive impairment and mild dementia[J].J Alzheimers Dis,2017,60(1):273-281.
20 Kim JS,Choi J,Hahn HJ,et al.Association of macrophage migration inhibitory factor polymorphisms with total plasma Ig E levels in patients with atopic dermatitis in Korea[J].PLoS One,2016,11(9):e162477.
21 Abraham EJ,Morris-Hardeman JN,Swenson LM,et al.Pituitary function in the acute phase response in domestic farm animals:cytokines,prostaglandins,and secretion of ACTH[J].Domest Anim Endocrinol,1998,15(5):389-396.
22 Calandra T,Bernhagen J,Metz CN,et al.Macrophage migration inhibitory factor:a regulator of innate im munity[J].Nature,1995,377(6544):68-71.
23张淑文,赵国锋,刘亚辉,等.OSAHS患者血清MIF和IL-18水平变化[J].大连医科大学学报,2015,37(4):372-375.
24朱惠源,薛永志,闫少峰.钝化NF-κB的活化对哮喘大鼠肺组织MIF及血清IL-4的影响[J].中国药理学通报,2011,27(7):1011-1014.
25许志明,王东,谢美强,等.非小细胞肺癌患者血清中MIF表达的临床意义[J].热带医学杂志,2016,16(3):333-335.
26罗泽如.COPD患者外周血巨噬细胞移动抑制因子的表达及意义[D].南方医科大学,2013.
27 Foschino Barbaro MP,Carpagnano GE,Spanevello A,et al.Inflammation,oxidative stress and systemic effects in mild chronic obstructive pulmonary disease[J].Int J immunopathol pharmacol,2007,20(4):753-763.
28 Linder R,Rnmark E,Pourazar J,et al.Serum metalloproteinase-9is related to COPD severity and symptoms-cross-sectional datafrom a population based cohort-study[J].Respir Res,2015,16:28.
29 Verschu ren L,Lindem an JH,van Bockel JH,et al.Upregu lation and coexpression of MIF and matrix metallop roteinases in human abdominal aortic aneurysms[J].Antioxid Redox Signal,2005,7(9-10):1195-1202.
30 Papakonstantinou E,Klagas I,Karakiulakis G,et al.Activation of MMP-9 in BAL is increased in COPD exacerbation independently of smoking,lung function,microbiology and treatment[J].Eur Respir J,2014,44(58):4855.
31陈培芬,罗雅玲,赖文岩,等.巨噬细胞移动抑制因子经Rho途径促进人肺成纤维细胞Ⅰ型胶原合成[J].医学理论与实践,2011,24(14):1621-1624.
32 Leung JC,Chan LY,Tsang AW,et al.Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta1 expression in experimental Ig A nephropathy[J].Nephrol Dial Transplant,2004,19(8):1976-1985.
33刘琛琛,高兴林,罗泽如.慢性阻塞性肺疾病患者诱导痰T细胞巨噬细胞移动抑制因子的表达及其意义[J].实用医学杂志,2014,30(8):1238-1242.
34佘惟槟,刘先胜,倪望,等.吸烟患或未患慢性阻塞性肺疾病患者肺组织中巨噬细胞移动抑制因子表达[J].中华内科杂志,2012,51(11):863-866.
35郁昊达,范晓东,殷波,等.慢性阻塞性肺疾病患者血清巨噬细胞移动抑制因子的表达[J].江苏医药,2016,42(4):432-435.
2钟南山.2017年慢性气道疾病防治研究进展[J].华西医学,2018,33(1):1-7.
3樊迪,张爽,张凡,等.巨噬细胞在慢性阻塞性肺疾病发病机制中作用的研究进展[J].医学综述,2017,23(13):2526-2530.
4陈亚红.2017年GOLD慢性阻塞性肺疾病诊断、治疗及预防的全球策略解读[J/CD].中国医学前沿杂志(电子版),2017,9(1):37-47.
5 Sarir H,Mortaz E,Karimi K,et al.Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages[J].J Inflamm(Lond),2009,6:12.
6 Wallace AM,Sandford AJ,English JC,et al.Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema[J].COPD,2008,5(1):13-23.
7 Allinson JP,Hardy R,Donaldson GC,et al.Combined impact of smoking and early-life exposures on adult lung function trajectories[J].Am J Respir Crit Care Med,2017,196(8):1021-1030.
8陈亚红.2018年GOLD慢性阻塞性肺疾病诊断、治疗及预防全球策略解读[J/CD].中国医学前沿杂志(电子版),2017,9(12):15-22.
9 Harvey CJ,Thimmulappa RK,Sethi S,et al.Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model[J].Sci Transl Med,2011,3(78):78ra32.
10 Lofdahl MJ,Roos-Engstrand E,Pourazar J,et al.Increased intraepithelial T-cells in stable COPD[J].Respir Med,2008,102(12):1812-1818.
11武广华,臧益秀,刘运祥,等.医学免疫学[M].北京:中国科学技术出版社,2001.
12 Miller EJ,Li J,Leng L,et al.Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart[J].Nature,2008,451(7178):578-582.
13 Wang Y,Luo G,Chen J,et al.Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGFfactor 8(MFG-E8)expressions[J].Sci Rep,2017,7:42642.
14朱惠源.巨噬细胞移动抑制因子在过敏性哮喘中的表达及意义[D].郑州大学,2016.
15聂树涛,刘茂峰.矽肺患者肺泡灌洗液中巨噬细胞游走抑制因子和活化因子的观察[J].中华劳动卫生职业病杂志,2008,26(10):614-615.
16 Bloom BR,Bennett B.Mechanism of a reaction in vitro associated with delayed-type hypersensitivity[J].Science,1966,153(3731):80-82.
17 Sun HW,Bernhagen J,Bucala R,et al.Crystal structure at 2.6-Aresolution of human macrophage mig ration inhibitory factor[J].Proc Natl Acad Sci USA,1996,28,93(11):5191-5196.
18 Husebo GR,Bakke PS,Gronseth R,et al.Macrophage migration inhibitory factor,a role in COPD[J].Am J Physiol Lung Cell Mol Physiol,2016,311(1):L1-L7.
19 Oikonomidi A,Tautvydaite D,Gholamrezaee MM,et al.Macrophage migration inhibitory factor is associated with biomarkers of alzheimer's disease pathology and predicts cognitive decline in mild cognitive impairment and mild dementia[J].J Alzheimers Dis,2017,60(1):273-281.
20 Kim JS,Choi J,Hahn HJ,et al.Association of macrophage migration inhibitory factor polymorphisms with total plasma Ig E levels in patients with atopic dermatitis in Korea[J].PLoS One,2016,11(9):e162477.
21 Abraham EJ,Morris-Hardeman JN,Swenson LM,et al.Pituitary function in the acute phase response in domestic farm animals:cytokines,prostaglandins,and secretion of ACTH[J].Domest Anim Endocrinol,1998,15(5):389-396.
22 Calandra T,Bernhagen J,Metz CN,et al.Macrophage migration inhibitory factor:a regulator of innate im munity[J].Nature,1995,377(6544):68-71.
23张淑文,赵国锋,刘亚辉,等.OSAHS患者血清MIF和IL-18水平变化[J].大连医科大学学报,2015,37(4):372-375.
24朱惠源,薛永志,闫少峰.钝化NF-κB的活化对哮喘大鼠肺组织MIF及血清IL-4的影响[J].中国药理学通报,2011,27(7):1011-1014.
25许志明,王东,谢美强,等.非小细胞肺癌患者血清中MIF表达的临床意义[J].热带医学杂志,2016,16(3):333-335.
26罗泽如.COPD患者外周血巨噬细胞移动抑制因子的表达及意义[D].南方医科大学,2013.
27 Foschino Barbaro MP,Carpagnano GE,Spanevello A,et al.Inflammation,oxidative stress and systemic effects in mild chronic obstructive pulmonary disease[J].Int J immunopathol pharmacol,2007,20(4):753-763.
28 Linder R,Rnmark E,Pourazar J,et al.Serum metalloproteinase-9is related to COPD severity and symptoms-cross-sectional datafrom a population based cohort-study[J].Respir Res,2015,16:28.
29 Verschu ren L,Lindem an JH,van Bockel JH,et al.Upregu lation and coexpression of MIF and matrix metallop roteinases in human abdominal aortic aneurysms[J].Antioxid Redox Signal,2005,7(9-10):1195-1202.
30 Papakonstantinou E,Klagas I,Karakiulakis G,et al.Activation of MMP-9 in BAL is increased in COPD exacerbation independently of smoking,lung function,microbiology and treatment[J].Eur Respir J,2014,44(58):4855.
31陈培芬,罗雅玲,赖文岩,等.巨噬细胞移动抑制因子经Rho途径促进人肺成纤维细胞Ⅰ型胶原合成[J].医学理论与实践,2011,24(14):1621-1624.
32 Leung JC,Chan LY,Tsang AW,et al.Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta1 expression in experimental Ig A nephropathy[J].Nephrol Dial Transplant,2004,19(8):1976-1985.
33刘琛琛,高兴林,罗泽如.慢性阻塞性肺疾病患者诱导痰T细胞巨噬细胞移动抑制因子的表达及其意义[J].实用医学杂志,2014,30(8):1238-1242.
34佘惟槟,刘先胜,倪望,等.吸烟患或未患慢性阻塞性肺疾病患者肺组织中巨噬细胞移动抑制因子表达[J].中华内科杂志,2012,51(11):863-866.
35郁昊达,范晓东,殷波,等.慢性阻塞性肺疾病患者血清巨噬细胞移动抑制因子的表达[J].江苏医药,2016,42(4):432-435.