脑钠尿肽的表达调控机制及其法医学应用
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摘要
脑钠尿肽是主要由心肌细胞分泌的钠尿肽类激素,通常在心肌细胞受到牵拉时产生,具有利钠、利尿、舒张血管、调节血压等功能。临床上BNP是反映心功能的重要指标之一,近年的研究表明,BNP在法医学中对心源性猝死的诊断也具有十分重要的价值。本文综述了BNP的分子结构、表达调控及法医学应用的进展。
Brain natriuretic peptide(BNP), a natriuretic peptide hormone, is mainly secreted by cardiomyocytes when they are pulled by mechanical force. BNP acts to increase natriuresis and decrease vascular resistance, thereby decreasing blood volume, systemic blood pressure and afterload. It is not only the main indicators of cardiac function which is widely used in clinical, recent studies have also shown that it has a very important value in identifying sudden cardiac death(SCD). However, the exact expression of the regulation mechanism is still unknown. This paper reviewed the structure, expression of the regulation mechanism of BNP, and the application progress in clinical and forensic.
Brain natriuretic peptide(BNP), a natriuretic peptide hormone, is mainly secreted by cardiomyocytes when they are pulled by mechanical force. BNP acts to increase natriuresis and decrease vascular resistance, thereby decreasing blood volume, systemic blood pressure and afterload. It is not only the main indicators of cardiac function which is widely used in clinical, recent studies have also shown that it has a very important value in identifying sudden cardiac death(SCD). However, the exact expression of the regulation mechanism is still unknown. This paper reviewed the structure, expression of the regulation mechanism of BNP, and the application progress in clinical and forensic.
引文
[1]高卫民,毛瑞明,杜中波,等.脑钠尿肽作为心功能评价指标在法医学上的应用价值[J].法医学杂志,2011,27(5):369-371.
[2]Sudoh T,Kangawa K,Minamino N,et al.A new natriuretic peptide in porcine brain[J].Nature,1988,332(6159):78-81.
[3]Carvajal J A,Delpiano A M,Cuello M A,et al.Mechanical stretch increases brain natriuretic peptide production and secretion in the human fetal membranes[J].Reprod Sci,2013,20(5):597-604.
[4]Bielmann C,Rignault-Clerc S,Liaudet L,et al.Brain natriuretic peptide is able to stimulate cardiac progenitor cell proliferation and differentiation in murine hearts after birth[J].Basic Res Cardiol,2015,110(1):455.
[5]Caselli C,Ragusa R,Prontera C,et al.Distribution of circulating cardiac biomarkers in healthy children:from birth through adulthood[J].Biomark Med,2016,10(4):357-365.
[6]林良烽.B型脑钠肽与兔急性心肌梗死并房性快速型心律失常关系的研究[D].福建:福建医科大学,2013:23-28.
[7]高卫民,曹志鹏,米丽,等.急性心功能障碍大鼠心肌中BNP的表达[J].法医学杂志,2013,29(2):86-90.
[8]Brown L A,Nunez D J,Wilkins M R.Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat[J].J Clin Invest,1993,92(6):2702-2712.
[9]Shimoike H,Iwai N,Kinoshita M.Differential regulation of natriuretic peptide genes in infarcted rat hearts[J].Clin Exp Pharmacol Physiol,1997,24(1):23-30.
[10]Xia W J,Huang Y Y,Chen Y L,et al.Acute myocardial is chemia directly modulates the expression of brai nnatriu retic peptide at the t ranscr iptional and translational levels via inf lammatory cytokines[J].Eur J Pharmacol,2011,670(1):7-12.
[11]Hama N,Itoh H,Shirakami G,et al.Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction[J].Circulation,1995,92(6):1558-1564.
[12]Chandrakala A N,Kwiatkowski P,Sai-Sudhakar C B,et al.Induction of early biomarkers in a thrombus-induced sheep model of ischemic heart failure[J].Tex Heart Inst J,2013,40(5):511-520.
[13]Cameron V A,Rademaker M T,Ellmers L J,et al.Atrial(ANP)and brain natriuretic peptide(BNP)expression after myocardial infarction in sheep:ANP is synthesized by fibroblasts infiltrating the infarct[J].Endocrinology,2000,141(12):4690-4697.
[14]Cao Z P,Zhang Y,Mi L,et al.The expression of B-type natriuretic peptide after Ca Cl2-induced arrhythmias in rats[J].Am J Forensic Med Pathol,2016,37(3):133-140.
[15]Liang F,Lu S,Gardner D G.Endothelin-dependent and-i nde pe nde nt compone nt s of st r ai n-a ct ivat ed br ai n natriuretic peptide gene transcription require extracellular signal regulated kinase and p38 mitogen-activated protein kinase[J].Hypertension,2000,35(1/2):188-192.
[16]Koiv isto E,K ai k konen L,Tokola H,et al.Dist i nct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms[J].Mol Cell Endocrinol,2011,338(1/2):18-27.
[17]Piuhola J,Szokodi I,Ruskoaho H.Endothelin-1 and angiotensin II contribute to BNP but not c-fos gene expression response to elevated load in isolated mice hearts[J].Biochim Biophys Acta,2007,1772(3):338-344.
[18]Sergeeva I A,Christoffels V M.Regulation of expression of atrial and brain natriuretic peptide,biomarkers for heart development and disease[J].Biochim Biophys Acta,2013,1832(12):2403-2413.
[19]Majalahti T,Suo-Palosaari M,Sarman B,et al.Cardiac BNP gene activation by angiotensin II in vivo[J].Mol Cell Endocrinol,2007,273(1/2):59-67.
[20]Cheng T H,Cheng P Y,Shih N L,et al.Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts[J].J Am Coll Cardiol,2003,42(10):1845-1854.
[21]Rosenkranz S.TGF-beta1 and angiotensin networking in cardiac remodeling[J].Cardiovasc Res,2004,63(3):423-432.
[22]Su Z,Wei G,Wei L,et al.Effects of rh BNP on myocardial fibrosis after myocardial infarction in rats[J].Int J Clin Exp Pathol,2015,8(6):6407-6415.
[23]Ayca B,Sahin I,Kucuk S H,et al.Increased transforming growth factor-beta levels associated with cardiac adverse events in hypertrophic cardiomyopathy[J].Clin Cardiol,2015,38(6):371-377.
[24]陈玲,侯娟,张旸,等.B型钠尿肽抑制心成纤维细胞增殖与转化生长因子-β1/Smad信号传导途径的关系[J].临床心血管病杂志,2009,25(5):388-389.
[25]Selvaraj S,Klein I,Danzi S,et al.Association of serum triiodothyronine with B-ty pe natriuretic peptide and severe left ventricular diastolic dysfunction in heart failure with preserved ejection fraction[J].Am J Cardiol,2012,110(2):234-239.
[26]刘奇,王杰,于燕妮,等.300例心源性猝死案例的法医学鉴定分析[J].中国法医学杂志,2015,30(3):283-285.
[2]Sudoh T,Kangawa K,Minamino N,et al.A new natriuretic peptide in porcine brain[J].Nature,1988,332(6159):78-81.
[3]Carvajal J A,Delpiano A M,Cuello M A,et al.Mechanical stretch increases brain natriuretic peptide production and secretion in the human fetal membranes[J].Reprod Sci,2013,20(5):597-604.
[4]Bielmann C,Rignault-Clerc S,Liaudet L,et al.Brain natriuretic peptide is able to stimulate cardiac progenitor cell proliferation and differentiation in murine hearts after birth[J].Basic Res Cardiol,2015,110(1):455.
[5]Caselli C,Ragusa R,Prontera C,et al.Distribution of circulating cardiac biomarkers in healthy children:from birth through adulthood[J].Biomark Med,2016,10(4):357-365.
[6]林良烽.B型脑钠肽与兔急性心肌梗死并房性快速型心律失常关系的研究[D].福建:福建医科大学,2013:23-28.
[7]高卫民,曹志鹏,米丽,等.急性心功能障碍大鼠心肌中BNP的表达[J].法医学杂志,2013,29(2):86-90.
[8]Brown L A,Nunez D J,Wilkins M R.Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat[J].J Clin Invest,1993,92(6):2702-2712.
[9]Shimoike H,Iwai N,Kinoshita M.Differential regulation of natriuretic peptide genes in infarcted rat hearts[J].Clin Exp Pharmacol Physiol,1997,24(1):23-30.
[10]Xia W J,Huang Y Y,Chen Y L,et al.Acute myocardial is chemia directly modulates the expression of brai nnatriu retic peptide at the t ranscr iptional and translational levels via inf lammatory cytokines[J].Eur J Pharmacol,2011,670(1):7-12.
[11]Hama N,Itoh H,Shirakami G,et al.Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction[J].Circulation,1995,92(6):1558-1564.
[12]Chandrakala A N,Kwiatkowski P,Sai-Sudhakar C B,et al.Induction of early biomarkers in a thrombus-induced sheep model of ischemic heart failure[J].Tex Heart Inst J,2013,40(5):511-520.
[13]Cameron V A,Rademaker M T,Ellmers L J,et al.Atrial(ANP)and brain natriuretic peptide(BNP)expression after myocardial infarction in sheep:ANP is synthesized by fibroblasts infiltrating the infarct[J].Endocrinology,2000,141(12):4690-4697.
[14]Cao Z P,Zhang Y,Mi L,et al.The expression of B-type natriuretic peptide after Ca Cl2-induced arrhythmias in rats[J].Am J Forensic Med Pathol,2016,37(3):133-140.
[15]Liang F,Lu S,Gardner D G.Endothelin-dependent and-i nde pe nde nt compone nt s of st r ai n-a ct ivat ed br ai n natriuretic peptide gene transcription require extracellular signal regulated kinase and p38 mitogen-activated protein kinase[J].Hypertension,2000,35(1/2):188-192.
[16]Koiv isto E,K ai k konen L,Tokola H,et al.Dist i nct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms[J].Mol Cell Endocrinol,2011,338(1/2):18-27.
[17]Piuhola J,Szokodi I,Ruskoaho H.Endothelin-1 and angiotensin II contribute to BNP but not c-fos gene expression response to elevated load in isolated mice hearts[J].Biochim Biophys Acta,2007,1772(3):338-344.
[18]Sergeeva I A,Christoffels V M.Regulation of expression of atrial and brain natriuretic peptide,biomarkers for heart development and disease[J].Biochim Biophys Acta,2013,1832(12):2403-2413.
[19]Majalahti T,Suo-Palosaari M,Sarman B,et al.Cardiac BNP gene activation by angiotensin II in vivo[J].Mol Cell Endocrinol,2007,273(1/2):59-67.
[20]Cheng T H,Cheng P Y,Shih N L,et al.Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts[J].J Am Coll Cardiol,2003,42(10):1845-1854.
[21]Rosenkranz S.TGF-beta1 and angiotensin networking in cardiac remodeling[J].Cardiovasc Res,2004,63(3):423-432.
[22]Su Z,Wei G,Wei L,et al.Effects of rh BNP on myocardial fibrosis after myocardial infarction in rats[J].Int J Clin Exp Pathol,2015,8(6):6407-6415.
[23]Ayca B,Sahin I,Kucuk S H,et al.Increased transforming growth factor-beta levels associated with cardiac adverse events in hypertrophic cardiomyopathy[J].Clin Cardiol,2015,38(6):371-377.
[24]陈玲,侯娟,张旸,等.B型钠尿肽抑制心成纤维细胞增殖与转化生长因子-β1/Smad信号传导途径的关系[J].临床心血管病杂志,2009,25(5):388-389.
[25]Selvaraj S,Klein I,Danzi S,et al.Association of serum triiodothyronine with B-ty pe natriuretic peptide and severe left ventricular diastolic dysfunction in heart failure with preserved ejection fraction[J].Am J Cardiol,2012,110(2):234-239.
[26]刘奇,王杰,于燕妮,等.300例心源性猝死案例的法医学鉴定分析[J].中国法医学杂志,2015,30(3):283-285.