中西医结合治疗溃疡性结肠炎的疗效及对凝血和炎性因子水平的影响
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摘要
目的:分析中西医结合疗法治疗非特异性溃疡性结肠炎(ulcerative colitis,UC)的疗效及对凝血功能、炎性因子水平的影响。方法:先抽取220名实验对象,要求其是UC活动期患者,并将实验对象随机平均分成对照组和实验组两组。对照组采用单纯西药治疗,实验组在对照组疗法基础上加用中药灌肠治疗。对两组临床疗效进行评价和比较。比较两组在治疗前及治疗后凝血酶原时间(PT)、凝血活酶时间(APTT)、D-二聚体(D-D)、血浆纤维蛋白原(Fib)等凝血指标;比较两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)等血清炎性因子含量。结果:试验组和对照组在临床期间达到预想效果的概率分别达到了97%和75%,可以看出实验组的效果是比对照组要好的试验组的临床有效率和疗效均优于对照组,两组之间存在着不同,有统计学意义(P<0.05)。两组治疗后的血浆Fib水平和血浆D-D水平均较治疗前显著降低,差异有统计学意义(P<0.05),而且观察组治疗后的血浆Fib水平和血浆D-D水平均低于对照组,差异有统计学意义(P<0.05)。两组治疗后的各项血清炎性因子水平均较治疗前降低,差异有统计学意义(P<0.05),而且观察组治疗后的各项血清炎性因子水平均低于对照组,差异有统计学意义(P<0.05)。结论:中西医结合治疗UC患者疗效显著,解决凝血纤溶功能的失衡,有效降低炎症反应程及并发症发生率,促进患者康复。
Objective:To analyze the therapeutic effects of integrated traditional Chinese and Western medicine on ulcerative colitis(UC)and its effects on coagulation function and inflammatory factors.Methods:A total of 220 cases of patients with UC were selected as the research subjects and randomly divided into the observation group and the control group,with 110 cases in each group.The patients in the control group were treated with single Western medicine,while the patients in the observation group were treated with enema treatment of traditional Chinese medicine.The clinical therapeutic effects of the two groups were evaluated and compared.The blood coagulation indexes of the activated partial thromboplastin time(APTT),prothrombin time(PT),the plasma fibrinogen(Fib),the D dimer(D-D)of two groups patients were detected and compared before and after treatment.The serum tumor necrosis factorα(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)levels of the patients in the two groups were measured and compared.Results:The clinical efficiencies of the observation group and the control group were 97% and 75%,respectively.The clinical efficiencies and the therapeutic effects of the observation group were better than those in the control group;there were statistically significant differences between the two groups(P<0.05).The plasma Fib levels and the plasma D-D levels after the treatment of the patients in the two groups were significantly lower than those before the treatment,and the difference was statistically significant(P<0.05).The plasma Fib levels and the plasma DD levels after the treatment of the patients in the observation group were lower than those in the control group;the difference was statistically significant(P<0.05).The serum inflammatory factors levels after the treatment of the patients in the two groups were significantly lower than those before the treatment;the difference was statistically significant(P<0.05).The serum inflammatory factors levels after the treatment of the patients in the observation group were lower than those in the control group;the difference was statistically significant(P<0.05).Conclusion:The application of integrated traditional Chinese and Western medicine in the treatment of UC can significantly improve the therapeutic effect,correct imbalance of the patients' coagulation dissolution function,and reduce the degree of inflammatory reaction,which benefits to promote the patients' rehabilitation,reduce the incidence of complications and improve the prognosis of patients.
Objective:To analyze the therapeutic effects of integrated traditional Chinese and Western medicine on ulcerative colitis(UC)and its effects on coagulation function and inflammatory factors.Methods:A total of 220 cases of patients with UC were selected as the research subjects and randomly divided into the observation group and the control group,with 110 cases in each group.The patients in the control group were treated with single Western medicine,while the patients in the observation group were treated with enema treatment of traditional Chinese medicine.The clinical therapeutic effects of the two groups were evaluated and compared.The blood coagulation indexes of the activated partial thromboplastin time(APTT),prothrombin time(PT),the plasma fibrinogen(Fib),the D dimer(D-D)of two groups patients were detected and compared before and after treatment.The serum tumor necrosis factorα(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)levels of the patients in the two groups were measured and compared.Results:The clinical efficiencies of the observation group and the control group were 97% and 75%,respectively.The clinical efficiencies and the therapeutic effects of the observation group were better than those in the control group;there were statistically significant differences between the two groups(P<0.05).The plasma Fib levels and the plasma D-D levels after the treatment of the patients in the two groups were significantly lower than those before the treatment,and the difference was statistically significant(P<0.05).The plasma Fib levels and the plasma DD levels after the treatment of the patients in the observation group were lower than those in the control group;the difference was statistically significant(P<0.05).The serum inflammatory factors levels after the treatment of the patients in the two groups were significantly lower than those before the treatment;the difference was statistically significant(P<0.05).The serum inflammatory factors levels after the treatment of the patients in the observation group were lower than those in the control group;the difference was statistically significant(P<0.05).Conclusion:The application of integrated traditional Chinese and Western medicine in the treatment of UC can significantly improve the therapeutic effect,correct imbalance of the patients' coagulation dissolution function,and reduce the degree of inflammatory reaction,which benefits to promote the patients' rehabilitation,reduce the incidence of complications and improve the prognosis of patients.
引文
1陈章风,刘宏岩.溃疡性结肠炎的中医研究进展[J].长春中医药大学学报,2018,34(1):196-198.
2王玉芳,欧阳钦.糖皮质激素抵抗的重度溃疡性结肠炎的诊治进展[J].中华消化杂志,2016,36(7):447-452.
3周凤,吴静.溃疡性结肠炎内科治疗的进展[J].世界华人消化杂志,2016,24(20):3149-3158.
4裴银奇,赵党生.溃疡性结肠炎中医药治疗研究进展[J].中医研究,2016,29(9):77-78.
5任彦,王文荣,林瑜,等.溃疡性结肠炎中医治疗方案优化研究[J].中华中医药学刊,2016,34(10):2481-2484.
6李毅,刘艳,刘力.溃疡性结肠炎的中医辨证分型统计分析[J].中医药导报,2016,22(11):94-95.
7王坤.复方黄柏液保留灌肠联合美沙拉嗪栓剂治疗溃疡性直肠炎疗效观察[J].中华消化病与影像杂志(电子版),2016,6(5):229-231.
8张串串,张相安.复方黄柏液保留灌肠治疗湿热下注型溃疡性结肠炎45例临床观察[J].中医临床研究,2015,7(25):107-108.
9李敬峰,张鹏飞,姜红英,等.复方黄柏液保留灌肠治疗溃疡性结肠炎的疗效[J].实用临床医学,2013,14(4):12-13.
10万文静,刘福平.白及愈疡汤对溃疡性结肠炎患者免疫调节作用的影响[J].中国医药指南,2014,12(25):312-313.
11李伟.血竭联合地榆局部保留灌肠治疗溃疡性结肠炎(UC)的内镜下黏膜临床分析[J].世界最新医学信息文摘(电子版),2015,15(10):90-91.
12孙静.康复新液联合三七粉直肠滴注治疗溃疡性结肠炎60例疗效观察[J].中国现代药物应用,2015,9(9):167-168.
13安毅,康凯,贺亚妮.炎症性肠病患者凝血指标变化及其临床意义研究[J].检验医学与临床,2016,13(16):2306-2308.
14 Samsami-kor M,Daryani NE,Asl PR,et al.Anti-inflammatory effects of resveratrol in patients with ulcerativecolitis:a randomized,double-blind,placebo-controlled pilot study[J].Arch Med Res,2015,46(4):280-285.
15 Han J,Wang J,Wang JH.Effects of jianpi herbalsuppository on hemorheology and CD62p in patients with ulcerative colitis[J].J Tradit Chin Med,2014,34(2):155-158.
16刘闻莺,刘欣艳,杨根妹,等.活动期溃疡性结肠炎凝血功能分析[J].胃肠病学,2013,18(10):615-618.
17李丽萍.活动期不同中医证型溃疡性结肠炎患者血清干扰素和白细胞介素-4水平的变化[J].中国药业,2016,25(19):30-32.
18邓台燕,全大祥,吴彬.复方黄柏液联合美沙拉嗪对溃疡性结肠炎及肠道菌群和血清炎症因子的影响[J].中国现代医学杂志,2016,26(9):124-127.
19张苏闽,刘轩良.溃结灌肠液对溃疡性结肠炎模型大鼠结肠组织中set9及血清TNF-α的影响[J].山东中医药大学学报,2014,38(5):477-479.
20倪广林,孔令霞,张润莲.白及愈疡汤对溃疡性结肠炎患者免疫调节作用的影响[J].长春中医药大学学报,2012,26(3):404-405.
21郑烈,戴彦成,张亚利,等.中医药对NF-κB信号通路介导溃疡性结肠炎治疗进展[J].中华中医药学刊,2016,34(7):1585-1587.
2王玉芳,欧阳钦.糖皮质激素抵抗的重度溃疡性结肠炎的诊治进展[J].中华消化杂志,2016,36(7):447-452.
3周凤,吴静.溃疡性结肠炎内科治疗的进展[J].世界华人消化杂志,2016,24(20):3149-3158.
4裴银奇,赵党生.溃疡性结肠炎中医药治疗研究进展[J].中医研究,2016,29(9):77-78.
5任彦,王文荣,林瑜,等.溃疡性结肠炎中医治疗方案优化研究[J].中华中医药学刊,2016,34(10):2481-2484.
6李毅,刘艳,刘力.溃疡性结肠炎的中医辨证分型统计分析[J].中医药导报,2016,22(11):94-95.
7王坤.复方黄柏液保留灌肠联合美沙拉嗪栓剂治疗溃疡性直肠炎疗效观察[J].中华消化病与影像杂志(电子版),2016,6(5):229-231.
8张串串,张相安.复方黄柏液保留灌肠治疗湿热下注型溃疡性结肠炎45例临床观察[J].中医临床研究,2015,7(25):107-108.
9李敬峰,张鹏飞,姜红英,等.复方黄柏液保留灌肠治疗溃疡性结肠炎的疗效[J].实用临床医学,2013,14(4):12-13.
10万文静,刘福平.白及愈疡汤对溃疡性结肠炎患者免疫调节作用的影响[J].中国医药指南,2014,12(25):312-313.
11李伟.血竭联合地榆局部保留灌肠治疗溃疡性结肠炎(UC)的内镜下黏膜临床分析[J].世界最新医学信息文摘(电子版),2015,15(10):90-91.
12孙静.康复新液联合三七粉直肠滴注治疗溃疡性结肠炎60例疗效观察[J].中国现代药物应用,2015,9(9):167-168.
13安毅,康凯,贺亚妮.炎症性肠病患者凝血指标变化及其临床意义研究[J].检验医学与临床,2016,13(16):2306-2308.
14 Samsami-kor M,Daryani NE,Asl PR,et al.Anti-inflammatory effects of resveratrol in patients with ulcerativecolitis:a randomized,double-blind,placebo-controlled pilot study[J].Arch Med Res,2015,46(4):280-285.
15 Han J,Wang J,Wang JH.Effects of jianpi herbalsuppository on hemorheology and CD62p in patients with ulcerative colitis[J].J Tradit Chin Med,2014,34(2):155-158.
16刘闻莺,刘欣艳,杨根妹,等.活动期溃疡性结肠炎凝血功能分析[J].胃肠病学,2013,18(10):615-618.
17李丽萍.活动期不同中医证型溃疡性结肠炎患者血清干扰素和白细胞介素-4水平的变化[J].中国药业,2016,25(19):30-32.
18邓台燕,全大祥,吴彬.复方黄柏液联合美沙拉嗪对溃疡性结肠炎及肠道菌群和血清炎症因子的影响[J].中国现代医学杂志,2016,26(9):124-127.
19张苏闽,刘轩良.溃结灌肠液对溃疡性结肠炎模型大鼠结肠组织中set9及血清TNF-α的影响[J].山东中医药大学学报,2014,38(5):477-479.
20倪广林,孔令霞,张润莲.白及愈疡汤对溃疡性结肠炎患者免疫调节作用的影响[J].长春中医药大学学报,2012,26(3):404-405.
21郑烈,戴彦成,张亚利,等.中医药对NF-κB信号通路介导溃疡性结肠炎治疗进展[J].中华中医药学刊,2016,34(7):1585-1587.