滋肾疏肝、活血祛瘀法干预滑胎患者血栓前状态的疗效观察
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摘要
目的:探讨滋肾疏肝、活血祛瘀法干预滑胎患者血栓前状态的临床效果。方法:滑胎患者100例根据数字表法随机分成观察组和对照组,每组50例,对照组采用低分子肝素组进行治疗,观察组采用滋肾活血安胎方进行治疗,比较分析两组的临床效果。结果:观察组的临床治疗总有效率与对照组相比无明显差异,不具有统计学意义(P>0.05)。两组患者在干预前凝血功能各项指标,血P值,症状积分和β-HCG值相比无明显差异,无统计学意义(P>0.05),通过不同方式进行治疗后,观察组除PT和BPC两项以外,其余凝血功能各项指标,β-HCG和症状积分均明显优于对照组,两组相比差异有统计学意义(P<0.05),但两组患者治疗后血P值无明显差异(P>0.05)。结论:滋肾疏肝,活血祛瘀法可以通过对以下方面的调节,提高胚胎存活率,如:调节纤溶功能,改变复发性流产血栓前状态,调节胎盘血液循环等多方面。滋肾活血安胎方因其疗效好、安全,提高胚胎存活率,所以有推广的价值。
Objective: To explore the clinical effect of nourishing kidney and dredging liver and activating blood circulation and removing blood stasis on the prethrombosis of synovial patients.Method:100 patients with habitual abortion according to the digital table method were randomly divided into observation group and control group, 50 cases in each group. The control group's patients were treated with low molecular heparinand the observation group usedself-made Zishen Huoxue Antai Formula. We compared the clinical effect of two groups. Results:There was no significant difference in the total effective rate between the observation group and the control group(P>0.05).Before intervention,blood coagulation function,blood P values, symptom integral and beta HCG value in two groups had no obvious difference(P>0.05). After treatment by different ways,in the observation group, except PT and BPC, the rest of the blood coagulation function indicators, beta HCG and symptom score were significantly better than those of the control group(P<0.05). But the two groups' blood P values after intervention had no obvious difference(P>0.05). Conclusion:The nourishing kidney and dredging liver and activating blood circulation and removing blood stasis method can improve the survival rate of embryonic through adjusting the fibrinolytic function, change of recurrent miscarriage before thrombus state, regulating placental blood circulation, etc.Because of its good effect and safety, it can improve the survival rate of embryo.
Objective: To explore the clinical effect of nourishing kidney and dredging liver and activating blood circulation and removing blood stasis on the prethrombosis of synovial patients.Method:100 patients with habitual abortion according to the digital table method were randomly divided into observation group and control group, 50 cases in each group. The control group's patients were treated with low molecular heparinand the observation group usedself-made Zishen Huoxue Antai Formula. We compared the clinical effect of two groups. Results:There was no significant difference in the total effective rate between the observation group and the control group(P>0.05).Before intervention,blood coagulation function,blood P values, symptom integral and beta HCG value in two groups had no obvious difference(P>0.05). After treatment by different ways,in the observation group, except PT and BPC, the rest of the blood coagulation function indicators, beta HCG and symptom score were significantly better than those of the control group(P<0.05). But the two groups' blood P values after intervention had no obvious difference(P>0.05). Conclusion:The nourishing kidney and dredging liver and activating blood circulation and removing blood stasis method can improve the survival rate of embryonic through adjusting the fibrinolytic function, change of recurrent miscarriage before thrombus state, regulating placental blood circulation, etc.Because of its good effect and safety, it can improve the survival rate of embryo.
引文
[1] 臧玲,孟安琪,张凤暖.自拟滑胎补肾Ⅲ号膏方治疗抗心磷脂阳性所致复发性流产临床观察[J].辽宁中医药大学学报,2017,19(8):122-124.
[2] 黄紫微,王希浩,赵嘉梅,等.从妇人病质角度浅述《妇人规》论治滑胎特色[J].光明中医,2017,32(6):781-782.
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[4] 姚美玉,马静,付丽媛,等.辨证治疗滑胎1例[J].光明中医,2016,31(14):2104-2105.
[5] 郝海霞.中西医防治滑胎研究进展[J].内蒙古中医药,2016,35(7):118-119.
[6] 章刚.113例滑胎史患者中医证型分布及相关因素研究[D].成都:成都中医药大学,2016.
[7] 李文红.滑胎患者的辨证施护体会[J].云南中医中药杂志,2016,37(2):80-81.
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[10] 李邹.益气升举安胎方联合黄体酮治疗滑胎67例[J].河南中医,2014,34(6):1153-1154.
[11] 刘筱茂.胎宝汤治疗脾肾阳虚型滑胎疗效观察[J].山东中医杂志,2013,32(5):315-317.
[12] 陈文英,赵旭辉.应用中医扶阳法治疗妇科疾病的体会[J].贵阳中医学院学报,2013,35(2):142-143.
[13] 雷婕.补肾健脾化瘀汤治疗ACA阳性滑胎的临床研究[D].昆明:云南中医学院,2012.
[14] 从蓉俊.补肾养肝法联合黄体酮治疗不明原因复发性自然流产的临床研究[D].南京:南京中医药大学,2012.
[15] 姜丽娟,张良英.保胎饮治疗滑胎再妊娠后的保胎临床研究[C]//第十一次全国中医妇科学术大会论文集.中华中医药学会,2011:2.
[16] 张丹,洪家铁.中药防治结合治疗滑胎30例疗效观察[J].长春中医药大学学报,2010,26(5):733-734.
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[18] 周征,王欣,舒荣梅.滋肾育胎丸治疗先兆流产56例疗效观察[J].中医药导报,2012,8(1):89-91.
[19] 刘新玉,郜洁,罗颂平.中医药防治自然流产的研究思路及进展[J].现代中西医结合杂志,2011,15(11):187-189.
[20] 李微.中西医结合治疗先兆流产的疗效观察[J].中国煤炭工业医学杂志, 2011,29(6):278-280.
[21] 邹琦,王如萍.滋肾育胎丸[J].广东药学,2002,9(2):95-96.
[22] 崔轶凡.补肾固胎汤治疗脾肾两虚型滑胎的临床观察[D].济南:山东中医药大学,2004.
[23] 庞震苗,梁菁,钟秀驰,等.滋肾育胎丸治疗卵巢储备功能下降300例临床研究[J].中国中医药现代远程教育,2017,21(24):244-246.
[24] 周征,王欣,舒荣梅.滋肾育胎丸治疗先兆流产56例疗效观察[J].中医药导报,2012,6(1):87-89.
[25] 刘新玉,郜洁,罗颂平.中医药防治自然流产的研究思路及进展[J].现代中西医结合杂志,2011,14(11):154-156.
[26] 方如丹,赵春玲.滋肾育胎丸临床验证探析[J].辽宁中医杂志,2008,33(5):99-101.
[27] 许海鸥,骆玉兰.滋肾育胎丸在多囊卵巢综合征促排卵方案中的应用[J].中国中医药信息杂志,2008,13(7):121-123.
[28] 褚蕴,赵宏利.血栓前状态所致复发性流产的中西医研究进展[J].黑龙江中医药,2015,15(4):166-168.
[29] 李亚,王俊玲,刘昱磊,等.活血化瘀法治疗血栓前状态所致复发性流产的临床观察[J].广州中医药大学学报,2015,21(6):178-180.
[30] 罗辉,杨国彦,刘建平.应用活血化瘀法治疗复发性流产文献评价[J].中医杂志,2012,24(16):265-267.
[2] 黄紫微,王希浩,赵嘉梅,等.从妇人病质角度浅述《妇人规》论治滑胎特色[J].光明中医,2017,32(6):781-782.
[3] 刘筱茂.胎宝汤治疗脾肾阳虚型滑胎临床研究[J].陕西中医,2016,37(11):1506-1507.
[4] 姚美玉,马静,付丽媛,等.辨证治疗滑胎1例[J].光明中医,2016,31(14):2104-2105.
[5] 郝海霞.中西医防治滑胎研究进展[J].内蒙古中医药,2016,35(7):118-119.
[6] 章刚.113例滑胎史患者中医证型分布及相关因素研究[D].成都:成都中医药大学,2016.
[7] 李文红.滑胎患者的辨证施护体会[J].云南中医中药杂志,2016,37(2):80-81.
[8] 罗纳新.滋养肝肾活血祛瘀法干预滑胎患者血栓前状态临床研究[J].新中医,2016,48(1):134-136.
[9] 刘巴宁.用于治疗滑胎的中药组合物[P].广东:CN104274516A,2015-01-14.
[10] 李邹.益气升举安胎方联合黄体酮治疗滑胎67例[J].河南中医,2014,34(6):1153-1154.
[11] 刘筱茂.胎宝汤治疗脾肾阳虚型滑胎疗效观察[J].山东中医杂志,2013,32(5):315-317.
[12] 陈文英,赵旭辉.应用中医扶阳法治疗妇科疾病的体会[J].贵阳中医学院学报,2013,35(2):142-143.
[13] 雷婕.补肾健脾化瘀汤治疗ACA阳性滑胎的临床研究[D].昆明:云南中医学院,2012.
[14] 从蓉俊.补肾养肝法联合黄体酮治疗不明原因复发性自然流产的临床研究[D].南京:南京中医药大学,2012.
[15] 姜丽娟,张良英.保胎饮治疗滑胎再妊娠后的保胎临床研究[C]//第十一次全国中医妇科学术大会论文集.中华中医药学会,2011:2.
[16] 张丹,洪家铁.中药防治结合治疗滑胎30例疗效观察[J].长春中医药大学学报,2010,26(5):733-734.
[17] 曾元儿.中国药典(2010年版1部) 化学成分分析简明手册[M].广州:中山大学出版社,2010: 11-12.
[18] 周征,王欣,舒荣梅.滋肾育胎丸治疗先兆流产56例疗效观察[J].中医药导报,2012,8(1):89-91.
[19] 刘新玉,郜洁,罗颂平.中医药防治自然流产的研究思路及进展[J].现代中西医结合杂志,2011,15(11):187-189.
[20] 李微.中西医结合治疗先兆流产的疗效观察[J].中国煤炭工业医学杂志, 2011,29(6):278-280.
[21] 邹琦,王如萍.滋肾育胎丸[J].广东药学,2002,9(2):95-96.
[22] 崔轶凡.补肾固胎汤治疗脾肾两虚型滑胎的临床观察[D].济南:山东中医药大学,2004.
[23] 庞震苗,梁菁,钟秀驰,等.滋肾育胎丸治疗卵巢储备功能下降300例临床研究[J].中国中医药现代远程教育,2017,21(24):244-246.
[24] 周征,王欣,舒荣梅.滋肾育胎丸治疗先兆流产56例疗效观察[J].中医药导报,2012,6(1):87-89.
[25] 刘新玉,郜洁,罗颂平.中医药防治自然流产的研究思路及进展[J].现代中西医结合杂志,2011,14(11):154-156.
[26] 方如丹,赵春玲.滋肾育胎丸临床验证探析[J].辽宁中医杂志,2008,33(5):99-101.
[27] 许海鸥,骆玉兰.滋肾育胎丸在多囊卵巢综合征促排卵方案中的应用[J].中国中医药信息杂志,2008,13(7):121-123.
[28] 褚蕴,赵宏利.血栓前状态所致复发性流产的中西医研究进展[J].黑龙江中医药,2015,15(4):166-168.
[29] 李亚,王俊玲,刘昱磊,等.活血化瘀法治疗血栓前状态所致复发性流产的临床观察[J].广州中医药大学学报,2015,21(6):178-180.
[30] 罗辉,杨国彦,刘建平.应用活血化瘀法治疗复发性流产文献评价[J].中医杂志,2012,24(16):265-267.