康复新液联合光动力疗法治疗玫瑰痤疮疗效研究
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摘要
目的:研究康复新液联合光动力疗法治疗玫瑰痤疮的临床疗效。方法:选取2017年3月-2018年3月笔者科室确诊的玫瑰痤疮患者107例。按照随机数表法分为联合组(n=37)、康复新液组(n=36)、光动力学组(n=34),其中联合组采用康复新液联合光动力疗法治疗,康复新液组采用单独康复新液治疗,光动力学组采用单独光动力学治疗。观察三组治疗疗效情况,临床症状积分(红斑、丘疹脓疱、瘙痒、毛细血管扩张),皮肤病生活质量量表(DLQI)评分,不良反应发生率。结果:治疗后,联合组总有效率显著高于康复新液组和光动力学组(P<0.05);红斑、丘疹脓疱、瘙痒、毛细血管扩张积分及DLQI评分均显著低于康复新液组和光动力学组,差异有统计学意义(P<0.05);三组不良反应总发生率无统计学意义(P>0.05)。结论:康复新液联合光动力疗法治疗玫瑰痤疮临床疗效肯定,可有效改善患者的临床症状,不良反应少,安全可靠,可提高患者的生活质量。
Objective To study clinical effect of kangfuxin solution combined with photodynamic therapy on rosacea. Methods 107 Rosacea who received therapy from March 2017 to March 2018 in our hospital were selected as research objects. According to random number table,those patients were divided into the Combined group(n=37), kangfuxin solution group(n=36), photodynamic group(n=34). The combined group was treated with kangfuxin solution combined with photodynamic therapy. kangfuxin solution group was treated with kangfuxin solution alone. Photodynamic group was treated with photodynamic therapy alone. Then the therapeutic efficacy, clinical symptom score(erythema, papule pustules, pruritus, telangiectasia), Skin Disease Quality of Life Scale(DLQI) score, incidence of adverse reactions of three groups after treatment were compared. Results After treatment, the total effective rate of combined group was significantly higher than that of kangfuxin solution group and photodynamic group(P<0.05). The scores of erythema, papule pustules, pruritus and telangiectasia were significantly lower than those of kangfuxin solution group and photodynamic group(P<0.05). DLQI score was significantly lower than that of kangfuxin solution group and photodynamic group The difference was statistically significant(P <0.05). There was no significant difference in the total incidence of adverse reactions among the three groups(P>0.05). Conclusion Kangfuxin solution combined with photodynamic therapy for rosacea has a definite clinical effect. It can effectively improve the clinical symptoms of patients with rosacea, with fewer adverse reactions, safety and reliability, and can improve the quality of life of patients.
Objective To study clinical effect of kangfuxin solution combined with photodynamic therapy on rosacea. Methods 107 Rosacea who received therapy from March 2017 to March 2018 in our hospital were selected as research objects. According to random number table,those patients were divided into the Combined group(n=37), kangfuxin solution group(n=36), photodynamic group(n=34). The combined group was treated with kangfuxin solution combined with photodynamic therapy. kangfuxin solution group was treated with kangfuxin solution alone. Photodynamic group was treated with photodynamic therapy alone. Then the therapeutic efficacy, clinical symptom score(erythema, papule pustules, pruritus, telangiectasia), Skin Disease Quality of Life Scale(DLQI) score, incidence of adverse reactions of three groups after treatment were compared. Results After treatment, the total effective rate of combined group was significantly higher than that of kangfuxin solution group and photodynamic group(P<0.05). The scores of erythema, papule pustules, pruritus and telangiectasia were significantly lower than those of kangfuxin solution group and photodynamic group(P<0.05). DLQI score was significantly lower than that of kangfuxin solution group and photodynamic group The difference was statistically significant(P <0.05). There was no significant difference in the total incidence of adverse reactions among the three groups(P>0.05). Conclusion Kangfuxin solution combined with photodynamic therapy for rosacea has a definite clinical effect. It can effectively improve the clinical symptoms of patients with rosacea, with fewer adverse reactions, safety and reliability, and can improve the quality of life of patients.
引文
[1]朱金鸽.氨基酮戊酸光动力疗法与红蓝光治疗中重度痤疮疗效观察[J].皮肤病与性病,2018,40(1):86-88.
[2]Stein-Gold L,Kircik L,Draelos ZD,et al.Topical oxymetazoline cream1.0%for persistent facial erythema associated with rosacea:pooled analysis of the two phase 3,29-day,randomized,controlled REVEAL trials[J].J Drugs Dermatol,2018,17(11):1201-1208.
[3]杜丹,杨笛,郝丹,等.玫瑰痤疮发病机制和治疗的最新进展[J].中国美容医学,2016,25(6):112-115.
[4]曾永芳,鲁元刚,杨洋,等.光动力疗法与红蓝光治疗中、重度痤疮疗效比较[J].中国医疗美容,2016,6(6):43-44.
[5]郝飞.玫瑰痤疮的发病机制[J].皮肤病与性病,2017,39(2):91-92.
[6]胡彩霞,张国强,崔瑜,等.康复新液联合强脉冲光治疗玫瑰痤疮的临床观察[J].中国药房,2017,28(17):2399-2402.
[7]Bilgin B, Karadag AS.Effects of combined oral doxycycline and topical cyclosporine treatment on ocular signs, symptoms,and tear film parameters in rosacea patients[J].Arq Bras Oftalmol,2018,81(6):466-470.
[8]Sinha P,Sinha A,Raman DK,et al.Unilateral facial telangiectasia macularis eruptiva perstansmimicking as rosacea[J].Indian Dermatol Online J,2018,9(5):351-353.
[9]万勃,邓文婷.光动力疗法的研究进展[J].广东化工,2019,46(7):124-127,119.
[10]Garcia C,Birch M.Oxymetazoline hydrochloride 1%cream(rhofade)for persistent facial erythema associated with rosacea[J].Am Fam Physician,2018,97(12):808-810.
[11]李明凤,蒋娟.玫瑰痤疮发病的免疫机制研究进展[J].中国麻风皮肤病杂志,2017,33(11):690-692,697.
[12]李玲.康复新液联合甲硝唑及强脉冲光疗法治疗玫瑰痤疮的疗效[J].医疗装备,2018,31(12):110-111.
[13]张馨中.5-氨基酮戊酸光动力疗法联合康复新液治疗痤疮[J].中国药物与临床,2017,17(12):1814-1815.
[14]李敏.康复新液加减治疗痤疮及酒渣鼻临床研究[J].潍坊医学院学报,2014,36(1):31-32.
[15]万建勣,肖洁平,丁街生,等.双波长强脉冲光联合0.1%他克莫司软膏治疗玫瑰痤疮疗效观察[J].中国美容医学,2015,24(5):47-51.
[2]Stein-Gold L,Kircik L,Draelos ZD,et al.Topical oxymetazoline cream1.0%for persistent facial erythema associated with rosacea:pooled analysis of the two phase 3,29-day,randomized,controlled REVEAL trials[J].J Drugs Dermatol,2018,17(11):1201-1208.
[3]杜丹,杨笛,郝丹,等.玫瑰痤疮发病机制和治疗的最新进展[J].中国美容医学,2016,25(6):112-115.
[4]曾永芳,鲁元刚,杨洋,等.光动力疗法与红蓝光治疗中、重度痤疮疗效比较[J].中国医疗美容,2016,6(6):43-44.
[5]郝飞.玫瑰痤疮的发病机制[J].皮肤病与性病,2017,39(2):91-92.
[6]胡彩霞,张国强,崔瑜,等.康复新液联合强脉冲光治疗玫瑰痤疮的临床观察[J].中国药房,2017,28(17):2399-2402.
[7]Bilgin B, Karadag AS.Effects of combined oral doxycycline and topical cyclosporine treatment on ocular signs, symptoms,and tear film parameters in rosacea patients[J].Arq Bras Oftalmol,2018,81(6):466-470.
[8]Sinha P,Sinha A,Raman DK,et al.Unilateral facial telangiectasia macularis eruptiva perstansmimicking as rosacea[J].Indian Dermatol Online J,2018,9(5):351-353.
[9]万勃,邓文婷.光动力疗法的研究进展[J].广东化工,2019,46(7):124-127,119.
[10]Garcia C,Birch M.Oxymetazoline hydrochloride 1%cream(rhofade)for persistent facial erythema associated with rosacea[J].Am Fam Physician,2018,97(12):808-810.
[11]李明凤,蒋娟.玫瑰痤疮发病的免疫机制研究进展[J].中国麻风皮肤病杂志,2017,33(11):690-692,697.
[12]李玲.康复新液联合甲硝唑及强脉冲光疗法治疗玫瑰痤疮的疗效[J].医疗装备,2018,31(12):110-111.
[13]张馨中.5-氨基酮戊酸光动力疗法联合康复新液治疗痤疮[J].中国药物与临床,2017,17(12):1814-1815.
[14]李敏.康复新液加减治疗痤疮及酒渣鼻临床研究[J].潍坊医学院学报,2014,36(1):31-32.
[15]万建勣,肖洁平,丁街生,等.双波长强脉冲光联合0.1%他克莫司软膏治疗玫瑰痤疮疗效观察[J].中国美容医学,2015,24(5):47-51.