帕金森病冻结步态的扩散张量成像研究进展
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摘要
脚桥核虽然在帕金森病冻结步态(FOG)发生中起着重要的作用,但越来越多研究表明FOG的发生是认知和运动功能损害相互作用导致的,其中认知功能受损起主导作用。扩散张量成像(DTI)的基于体素分析(VBA)方法和基于纤维束骨架的空间统计方法 (TBSS)具有客观性、全面性和可重复性的特点,是研究神经系统疾病的常用方法,对于探究FOG的发病机制具有重要价值。就近年来DTI技术在PD病人FOG中的研究进展予以综述。
Pedunculopontine nucleus plays an important role in the pathophysiological mechanism of freezing of gait(FOG) in patients with Parkinson's disease, but accumulative evidences have shown that the occurrence of FOG is the interaction of cognitive malfunction and motor malfunction, especially the impairment of cognitive function. Owing to their objectivity, comprehensiveness and repeatability, voxel-based analysis(VBA) and tract-based spatial statistics(TBSS) based on diffusion tensor imaging(DTI) are the useful methods for the study of pathophysiological mechanisms in central nervous system diseases. We reviewed the research progress of DTI techniques in FOG.
Pedunculopontine nucleus plays an important role in the pathophysiological mechanism of freezing of gait(FOG) in patients with Parkinson's disease, but accumulative evidences have shown that the occurrence of FOG is the interaction of cognitive malfunction and motor malfunction, especially the impairment of cognitive function. Owing to their objectivity, comprehensiveness and repeatability, voxel-based analysis(VBA) and tract-based spatial statistics(TBSS) based on diffusion tensor imaging(DTI) are the useful methods for the study of pathophysiological mechanisms in central nervous system diseases. We reviewed the research progress of DTI techniques in FOG.
引文
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[20]Tessitore A,Amboni M,Esposito F,et al.Resting-state brain connectivity in patients with Parkinson’s disease and freezing of gait[J].Parkinsonism Relat Disord,2012,18:781-787.
[21]Snijders AH,Leunissen I,Bakker M,et al.Gait-related cerebral alterations in patients with Parkinson’s disease with freezing of gait[J].Brain,2011,134:59-72.
[22]Iseki K,Fukuyama H,Oishi N,et al.Freezing of gait and white matter changes:a tract-based spatial statistics study[J].J Clin Mov Disord,2015,2:1.
[23]Wang M,Jiang S,Yuan Y,et al.Alterations of functional and structural connectivity of freezing of gait in Parkinson’s disease[J].J Neurol,2016,263:1583-1592.
[24]Vercruysse S,Leunissen I,Vervoort G,et al.Microstructural changes in white matter associated with freezing of gait in Parkinson’s disease[J].Mov Disord,2015,30:567-576.
[25]Canu E,Agosta F,Sarasso E,et al.Brain structural and functional connectivity in Parkinson’s disease with freezing of gait[J].Hum Brain Mapp,2015,36:5064-5078.
[2]Walton CC,Shine JM,Mowszowski L,et al.Freezing of gait in Parkinson’s disease:current treatments and the potential role for cognitive training[J].Restor Neurol Neurosci,2014,32:411-422.
[3]Thevathasan W,Debu B,Aziz T,et al.Pedunculopontine nucleus deep brain stimulation in Parkinson’s disease:A clinical review[J].Mov Disord,2018,33:10-20.
[4]Follett KA,Weaver FM,Stern M,et al.Pallidal versus subthalamic deep-brain stimulation for Parkinson’s disease[J].N Engl J Med,2010,362:2077-2091.
[5]Ou R,Guo X,Song W,et al.Freezing of gait in Chinese patients with Parkinson disease[J].J Neurol Sci,2014,345:56-60.
[6]Zhang H,Yin X,Ouyang Z,et al.A prospective study of freezing of gait with early Parkinson disease in Chinese patients[J].Medicine(Baltimore),2016,95:e4056.
[7]Gray WK,Hildreth A,Bilclough JA,et al.Physical assessment as a predictor of mortality in people with parkinson’s disease:a study over 7 years[J].Mov Disord,2009,24:1934-1940.
[8]Fling BW,Cohen RG,Mancini M,et al.Asymmetric pedunculopontine network connectivity in parkinsonian patients with freezing of gait[J].Brain,2013,136:2405-2418.
[9]Youn J,Lee JM,Kwon H,et al.Alterations of mean diffusivity of pedunculopontine nucleus pathway in Parkinson’s disease patients with freezing of gait[J].Parkinsonism Relat Disord,2015,21:12-17.
[10]Youn J,Cho JW,Lee WY,et al.Diffusion tensor imaging of freezing of gait in patients with white matter changes[J].Mov Disord,2012,27:760-764.
[11]Zhou C,Zhong X,Yang Y,et al.Alterations of regional homogeneity in freezing of gait in Parkinson’s disease[J].J Neurol Sci,2018,387:54-59.
[12]Yao Z,Shao Y,Han X Freezing of gait is associated with cognitive impairment in patients with Parkinson disease[J].Neurosci Lett,2017,656:126-130.
[13]Lenka A,Naduthota RM,Jha M,et al.Freezing of gait in Parkinson's disease is associated with altered functional brain connectivity[J].Parkinsonism Relat Disord,2016,24:100-106.
[14]Jha M,Jhunjhunwala K,Sankara BB,et al.Neuropsychological and imaging profile of patients with Parkinson's disease and freezing of gait[J].Parkinsonism Relat Disord,2015,21:1184-1190.
[15]Karachi C,Grabli D,Bernard FA,et al.Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease[J].J Clin Invest,2010,120:2745-2754.
[16]Hamani C,Aziz T,Bloem BR,et al.Pedunculopontine nucleus region deep brain stimulation in parkinson disease:surgical anatomy and terminology[J].Stereotact Funct Neurosurg,2016,94:298-306.
[17]Profice P,Mazzone P,Pilato F,et al.Neurophysiological evaluation of the pedunculopontine nucleus in humans[J].J Neural Transm(Vienna),2011,118:1423-1429.
[18]Xiao H,Li M,Cai J,et al.Selective cholinergic depletion of pedunculopontine tegmental nucleus aggravates freezing of gait in parkinsonian rats[J].Neurosci Lett,2017,659:92-98.
[19]Chawla H,Walia S,Behari M,et al.Effect of type of secondary task on cued gait on people with idiopathic Parkinson’s disease[J].J Neurosci Rural Pract,2014,5:18-23.
[20]Tessitore A,Amboni M,Esposito F,et al.Resting-state brain connectivity in patients with Parkinson’s disease and freezing of gait[J].Parkinsonism Relat Disord,2012,18:781-787.
[21]Snijders AH,Leunissen I,Bakker M,et al.Gait-related cerebral alterations in patients with Parkinson’s disease with freezing of gait[J].Brain,2011,134:59-72.
[22]Iseki K,Fukuyama H,Oishi N,et al.Freezing of gait and white matter changes:a tract-based spatial statistics study[J].J Clin Mov Disord,2015,2:1.
[23]Wang M,Jiang S,Yuan Y,et al.Alterations of functional and structural connectivity of freezing of gait in Parkinson’s disease[J].J Neurol,2016,263:1583-1592.
[24]Vercruysse S,Leunissen I,Vervoort G,et al.Microstructural changes in white matter associated with freezing of gait in Parkinson’s disease[J].Mov Disord,2015,30:567-576.
[25]Canu E,Agosta F,Sarasso E,et al.Brain structural and functional connectivity in Parkinson’s disease with freezing of gait[J].Hum Brain Mapp,2015,36:5064-5078.