神经纤维瘤病Ⅰ型的MRI影像学表现
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摘要
目的分析神经纤维瘤病I型(NF1)的MRI影像学表现,提高对本病的认识。方法回顾性分析26例确诊神经纤维瘤病I型患者的临床及影像学资料,26例患者均接受MRI的检查,3例患者同时接受了CT的检查,1例患者同时接受了X线检查。结果 26例神经纤维瘤病I型(NF1)中有16例颅内中枢神经系统肿瘤,5例椎管内肿瘤,1例腹腔及腹膜后内肿瘤,1例臀部丛状神经纤维瘤,1例膝关节及2例小腿肿瘤,20例合并有皮肤的咖啡牛乳色斑,12例有家族史。结论神经纤维瘤病I型具有典型MRI表现,与临床表现结合可以确诊该病。
Objective To analyze the MR image findings in patients with neurofibromatosis type I( NF1) and to promote diagnostic accuracy. Methods 26 patients with neurofibromatosis type I proved by clinical manifestations and pathology were reviewed retrospectively. 25 patients were examined by MRI,and 3 patients were examined by CT at the same time,1 patient was examined by X-ray at the same time. Results There were 16 cases of intracranial tumors of the central nervous system,5 cases of intra-spinal canal tumor,1 case of abdominal cavity and retroperitoneal tumor,1 case of hip plexiform neurofibromatosis tumor,1 case of knee joint and 2 cases of crus tumor. 20 patients presented with cutaneous multiple cafe au-lait spots,12 cases had family history. Conclusion Neurofibromatosis type 1( NF1) has typical MRI manifestations,the disease can be diagnosed combined with the clinical manifestations.
Objective To analyze the MR image findings in patients with neurofibromatosis type I( NF1) and to promote diagnostic accuracy. Methods 26 patients with neurofibromatosis type I proved by clinical manifestations and pathology were reviewed retrospectively. 25 patients were examined by MRI,and 3 patients were examined by CT at the same time,1 patient was examined by X-ray at the same time. Results There were 16 cases of intracranial tumors of the central nervous system,5 cases of intra-spinal canal tumor,1 case of abdominal cavity and retroperitoneal tumor,1 case of hip plexiform neurofibromatosis tumor,1 case of knee joint and 2 cases of crus tumor. 20 patients presented with cutaneous multiple cafe au-lait spots,12 cases had family history. Conclusion Neurofibromatosis type 1( NF1) has typical MRI manifestations,the disease can be diagnosed combined with the clinical manifestations.
引文
[1]武刚,高晓龙,黄丙仓,等.神经纤维瘤病的影像学研究[J].同济大学学报(医学版),2011,32(2):76-79.
[2]National institutes of health consensus development.Neurofibromatosis[J].Arch Neurol,1988,45(5):575-578.
[3]吕京光,殷天文,张凤霞,等.神经纤维瘤病的脑部CT评价[J].医学影像学杂志,2001,11(5):299-301.
[4]Thiagalingam S,Flaherty M,Billson F,et al.Neurofibromatosis type I and optic pathway gliomas:follow-up of 54 patients[J].Ophthalmology,2004,111(3):568-577.
[5]包颜明,Albert Lam.神经纤维瘤病Ⅰ型的MRI研究[J].中华放射学杂志,2002,36(4):344-348.
[6]付琳,王振常,李静,等.神经纤维瘤病Ⅰ型患者脑实质T2WI高信号的临床意义[J].磁共振成像,2012,3(5):331-335.
[7]付琳,李季,王振常,等.眶部丛状神经纤维瘤的MRI表现[J].中国医学影像技术,2012,28(7):1299-1302.
[8]Waggoner DJ,Towbin J,Gottesman G,et al.Clinic-based study of plexiform neurofibromas in neurofibromatosis[J].Am J Med Genet,2000,92(2):132-135.
[9]张淑倩,刘连祥,吴晶,等.神经纤维瘤病MR影像表现[J].实用放射学杂志,2003,19(1):12-16.
[10]李跃明,黄飚.丛状神经纤维瘤生长方式的MRI分析[J].中华放射学杂志,2008,42(6):657-659.
[2]National institutes of health consensus development.Neurofibromatosis[J].Arch Neurol,1988,45(5):575-578.
[3]吕京光,殷天文,张凤霞,等.神经纤维瘤病的脑部CT评价[J].医学影像学杂志,2001,11(5):299-301.
[4]Thiagalingam S,Flaherty M,Billson F,et al.Neurofibromatosis type I and optic pathway gliomas:follow-up of 54 patients[J].Ophthalmology,2004,111(3):568-577.
[5]包颜明,Albert Lam.神经纤维瘤病Ⅰ型的MRI研究[J].中华放射学杂志,2002,36(4):344-348.
[6]付琳,王振常,李静,等.神经纤维瘤病Ⅰ型患者脑实质T2WI高信号的临床意义[J].磁共振成像,2012,3(5):331-335.
[7]付琳,李季,王振常,等.眶部丛状神经纤维瘤的MRI表现[J].中国医学影像技术,2012,28(7):1299-1302.
[8]Waggoner DJ,Towbin J,Gottesman G,et al.Clinic-based study of plexiform neurofibromas in neurofibromatosis[J].Am J Med Genet,2000,92(2):132-135.
[9]张淑倩,刘连祥,吴晶,等.神经纤维瘤病MR影像表现[J].实用放射学杂志,2003,19(1):12-16.
[10]李跃明,黄飚.丛状神经纤维瘤生长方式的MRI分析[J].中华放射学杂志,2008,42(6):657-659.