正常体检人群戊型肝炎病毒感染情况分析
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摘要
目的了解正常体检人群戊型肝炎病毒感染情况。方法采用酶联免疫吸附法检测499例正常体检受试者血清HEV IgG和HEV IgM抗体水平。结果在499例受试者中,HEV IgG总阳性率为13.63%(68/499),HEV IgM总阳性率为3.21%(16/499),共同阳性率为1.40%(9/499),共检出9例HEV IgM单阳性样本。男性人群中的抗体阳性率高于女性。体检人群中40岁～59岁HEV IgG阳性率显著高于20岁～39岁。结论正常体检人群中存在HEV感染者,需要加强对正常体检人群的HEV抗体筛查,尤其是联合检测HEV IgG和HEV IgM可以提高检出率,避免漏检。
Objective To investigate hepatitis E virus infection in normal physical examination population. Methods The levels of HEV IgG and HEV IgM antibodies in 499 normal subjects sera were detected by enzyme-linked immunosorbent assay(ELIA). Results Among 499 subjects, the total positive rate of HEV IgG was 13.63%(68/499), the total positive rate of HEV IgM was 3.21%(16/499), and the common positive rate was 1.40%(9/499). Antibody positive rate was higher in men than that in women. The positive rate of HEV IgG in the age group of 40-59 was significantly higher than that in the age group of 20-39. Conclusion There are HEV infected people in normal physical examination population, so it is necessary to strengthen the screening of HEV antibody in normal physical examination population, especially the combined detection of HEV IgG and HEV IgM, which can improve the detection rate and avoid missed detection.
Objective To investigate hepatitis E virus infection in normal physical examination population. Methods The levels of HEV IgG and HEV IgM antibodies in 499 normal subjects sera were detected by enzyme-linked immunosorbent assay(ELIA). Results Among 499 subjects, the total positive rate of HEV IgG was 13.63%(68/499), the total positive rate of HEV IgM was 3.21%(16/499), and the common positive rate was 1.40%(9/499). Antibody positive rate was higher in men than that in women. The positive rate of HEV IgG in the age group of 40-59 was significantly higher than that in the age group of 20-39. Conclusion There are HEV infected people in normal physical examination population, so it is necessary to strengthen the screening of HEV antibody in normal physical examination population, especially the combined detection of HEV IgG and HEV IgM, which can improve the detection rate and avoid missed detection.
引文
[1] Kamar N,Selves J,Mansuy JM,et al.Hepatitis E virus and chronic hepatitis in organ-transplant recipients[J].N Engl J Med,2008,358:811-817.
[2] Colson P,Dhiver C,Poiaot-Martin I,et al.Acute and chronic hepatitis E in patients infected with human immunodeficiency virus[J].J Viral Hepat,2011,18:227-228.
[3] 王金霞,李雯,张云智.戊型肝炎病原学及流行病学研究进展[J].中国热带医学,2018,18(3):277-281.
[4] 朱光泽,李一权,兰添,等.吉林地区人群戊型肝炎病毒感染的流行病学调查[J].中国病原生物学杂志,2015,10(10):919-923.
[5] 任宏.戊型肝炎已成为全球和我国严重的公共卫生问题之一[J].肝脏,2018,23(8):659-660.
[6] Jia Z,Yi Y,Liu J,et al.Epidemiology of hepatitis E virus in China:results from the Third National Viral Hepatitis Prevalence Survey[J].PLoS ONE,2014,9:e110837.
[7] Zhang S,Wang J,Yuan Q,et al.Clinical characteristics and risk factors of sporadic Hepatitis E in central China[J].Virol J,2011,8:152.
[8] 周乙华,庄辉.中国戊型肝炎流行病学研究进展[J].中华流行病学杂志,2010,31(12):1414-1416.
[9] 李美霖,麻静敏,李天君,等.北京部分地区无偿献血者戊型肝炎病毒感染情况研究[J].中国病毒病杂志,2016,9(5):360-362.
[10] 王晓红,王阿蕾.2013-2017年西安市公共食品从业人员戊型肝炎病毒IgM 抗体检测结果分析[J].实用临床医药杂志,2018,22(15):87-90.
[11] 王秀娟,莎日娜,郭强.呼和浩特市从业人员甲肝、戊肝感染现状[J].疾病监测与控制杂志,2018,15(5):372-374.
[12] 刘霞,王帅,武跃明,等.河南省部分地区人群散发戊型肝炎流行病学及病毒基因型分析[J].中国现代医学杂志,2016,26(20):12-15.
[13] 覃江纯,杭惠,陈立凌,等.2007-2016 年苏州市戊型肝炎流行病学特征分析[J].现代预防医学,2018,45(17):3073-3075,3092.
[14] 刘敏,李丽娟,肖文.中国戊型肝炎病毒基因型及其亚型的地理分布[J].中国人兽共患病学报,2016,32(2):182-187.
[2] Colson P,Dhiver C,Poiaot-Martin I,et al.Acute and chronic hepatitis E in patients infected with human immunodeficiency virus[J].J Viral Hepat,2011,18:227-228.
[3] 王金霞,李雯,张云智.戊型肝炎病原学及流行病学研究进展[J].中国热带医学,2018,18(3):277-281.
[4] 朱光泽,李一权,兰添,等.吉林地区人群戊型肝炎病毒感染的流行病学调查[J].中国病原生物学杂志,2015,10(10):919-923.
[5] 任宏.戊型肝炎已成为全球和我国严重的公共卫生问题之一[J].肝脏,2018,23(8):659-660.
[6] Jia Z,Yi Y,Liu J,et al.Epidemiology of hepatitis E virus in China:results from the Third National Viral Hepatitis Prevalence Survey[J].PLoS ONE,2014,9:e110837.
[7] Zhang S,Wang J,Yuan Q,et al.Clinical characteristics and risk factors of sporadic Hepatitis E in central China[J].Virol J,2011,8:152.
[8] 周乙华,庄辉.中国戊型肝炎流行病学研究进展[J].中华流行病学杂志,2010,31(12):1414-1416.
[9] 李美霖,麻静敏,李天君,等.北京部分地区无偿献血者戊型肝炎病毒感染情况研究[J].中国病毒病杂志,2016,9(5):360-362.
[10] 王晓红,王阿蕾.2013-2017年西安市公共食品从业人员戊型肝炎病毒IgM 抗体检测结果分析[J].实用临床医药杂志,2018,22(15):87-90.
[11] 王秀娟,莎日娜,郭强.呼和浩特市从业人员甲肝、戊肝感染现状[J].疾病监测与控制杂志,2018,15(5):372-374.
[12] 刘霞,王帅,武跃明,等.河南省部分地区人群散发戊型肝炎流行病学及病毒基因型分析[J].中国现代医学杂志,2016,26(20):12-15.
[13] 覃江纯,杭惠,陈立凌,等.2007-2016 年苏州市戊型肝炎流行病学特征分析[J].现代预防医学,2018,45(17):3073-3075,3092.
[14] 刘敏,李丽娟,肖文.中国戊型肝炎病毒基因型及其亚型的地理分布[J].中国人兽共患病学报,2016,32(2):182-187.