平衡针联合生活方式干预对糖耐量降低患者的影响研究
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摘要
目的:探究平衡针联合生活方式干预对糖耐量降低(IGT)患者的影响。方法:将460例IGT患者按照随机对照法分为生活方式干预组和联合治疗组各230例。生活方式干预组给予生活方式干预,联合治疗组在生活方式干预的基础上,采用平衡针针刺降糖穴治疗。分别在治疗3月后、9月后、1年后检测空腹血糖(FBG)、餐后2h血糖(P2hBG)、高密度脂蛋白(HDL)以及体质量指数(BMI),并且随访6月、1年以及2年后糖尿病的发病率。结果:2组经过3月治疗后,2组P2hBG比较,差异有统计学意义(P <0.05)。其他指标比较,差异无统计学意义(P> 0.05)。干预9月后,2组FBG、P2hBG、BMI比较,差异有统计学意义(P <0.05)。2组HDL比较,差异无统计学意义(P> 0.05)。干预1年后,2组FBG、P2hBG、HDL及BMI比较,差异有统计学意义(P <0.05)。干预6月后生活方式干预组的糖尿病发病率为4.78%,联合治疗组的为2.61%,2组比较,差异无统计学意义(P> 0.05)。干预1年、2年后,生活方式干预组的糖尿病发病率分别为32.61%、59.13%,联合治疗组分别为21.30%、32.17%,2组比较,差异均有统计学意义(P <0.05)。结论:平衡针联合生活方式干预IGT,能有效预防、延缓糖尿病的发生。
Objective: To explore the effect of balance acupuncture combined with life style intervention on patients with impaired glucose tolerance(IGT). Methods: Divided 460 cases of patients with IGT into two groups randomly, namely the life style intervention group and the combined treatment group,230 cases in each group. The life style intervention group received life style intervention, while the combined treatment group additionally received balance acupuncture at the glucose-lowering acupoints. After treatment for 3 months, 9 months and 1 year,detected levels of fasting blood glucose(FBG), 2-hour postprandial blood glucose(P2 hBG), high density lipoprotein(HDL) and body mass index(BMI) respectively, and followed up the incidence of diabetes after treatment for 6 months, 1 year and 2 years. Results: After 3 months of treatment, comparing the level of P2 hBG in both groups, there was significant difference being found(P < 0.05); comparing other indexes in-between the two groups,there was no significant difference being found(P > 0.05). After 9 months of intervention, comparing the levels of FBG, P2 hBG and BMI in both groups, there was significant difference being found(P <0.05); comparing the level of HDL in-between the two groups, there was no significant difference being found(P > 0.05).After 1 year of intervention, comparing the levels of FBG, P2 hBG, HDL and BMI in both groups, there was significant difference being found(P < 0.05). After 6 months of intervention, the incidence of diabetes was 4.78% in the life style intervention group and 2.61% in the combined treatment group, difference being insignificant(P > 0.05). After 1 year of intervention, the incidence of diabetes was 32.61% in the life style intervention group and 21.30% in the combined treatment group; after 2 years of intervention, the incidence of diabetes was 59.13% in the life style intervention group and 32.17% in the combined treatment group, differences being significant found(P < 0.05). Conclusion: Balance acupuncture combined with life style intervention for IGT can effectively prevent and prolong the occurrence of diabetes.
Objective: To explore the effect of balance acupuncture combined with life style intervention on patients with impaired glucose tolerance(IGT). Methods: Divided 460 cases of patients with IGT into two groups randomly, namely the life style intervention group and the combined treatment group,230 cases in each group. The life style intervention group received life style intervention, while the combined treatment group additionally received balance acupuncture at the glucose-lowering acupoints. After treatment for 3 months, 9 months and 1 year,detected levels of fasting blood glucose(FBG), 2-hour postprandial blood glucose(P2 hBG), high density lipoprotein(HDL) and body mass index(BMI) respectively, and followed up the incidence of diabetes after treatment for 6 months, 1 year and 2 years. Results: After 3 months of treatment, comparing the level of P2 hBG in both groups, there was significant difference being found(P < 0.05); comparing other indexes in-between the two groups,there was no significant difference being found(P > 0.05). After 9 months of intervention, comparing the levels of FBG, P2 hBG and BMI in both groups, there was significant difference being found(P <0.05); comparing the level of HDL in-between the two groups, there was no significant difference being found(P > 0.05).After 1 year of intervention, comparing the levels of FBG, P2 hBG, HDL and BMI in both groups, there was significant difference being found(P < 0.05). After 6 months of intervention, the incidence of diabetes was 4.78% in the life style intervention group and 2.61% in the combined treatment group, difference being insignificant(P > 0.05). After 1 year of intervention, the incidence of diabetes was 32.61% in the life style intervention group and 21.30% in the combined treatment group; after 2 years of intervention, the incidence of diabetes was 59.13% in the life style intervention group and 32.17% in the combined treatment group, differences being significant found(P < 0.05). Conclusion: Balance acupuncture combined with life style intervention for IGT can effectively prevent and prolong the occurrence of diabetes.
引文
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[11] Qiu Q, Gong Y, Liu X, et al. Serum Uric Acid andImpaired Glucose Tolerance:The Cardiometabolic Risk inChinese(CRC)Study[J].Cell Biochemistry&Biophysics,2015,73(1):155-162.
[12]王文远,马忠立,郑欣杰,等.平衡针灸对2型糖尿病血脂疗效观察[J].中国中医药现代远程教育,2012,10(2):96-105.
[2] Nagi DK,Pettitt DJ,Bennett PH,et al.Diabetic retinopathyassessed by fundus photography in Pima Indians with impairedglucose tolerance and NIDDM[J].Diabetic Medicine,2015,14(6):449-456.
[3] Irimia JM, Meyer CM, Peper CL, et al.Impaired GlucoseTolerance and Predisposition to the Fasted State in LiverGlycogen Synthase Knock-out Mice[J].Journal of BiologicalChemistry,2015,285(17):12851-12861.
[4]蒋喜平.糖耐量受损患者强化干预的临床研究及评估分析[J].实用糖尿病杂志,2008,4(1):37-38
[5] Satin LS,Butler PC,Ha J,et al.Pulsatile insulin secretion,impaired glucose tolerance and type 2 diabetes[J].MolecularAspects of Medicine,2015,42:61-77.
[6] Gong QH,Kang JF,Ying YY,et al.Lifestyle interventionsfor adults with impaired glucose tolerance:a systematic reviewand meta-analysis of the effects on glycemic control[J].Internal Medicine,2015,54(3):303-310.
[7]林芹.糖耐量减低患者健康干预前瞻性效果评价[J].中国热带医学,2008,8(5):874-875.
[8]张海燕,邬伟魁,李芳,等.针药结合治疗糖尿病及其并发症研究进展[J].中国实验方剂学杂志,2012,18(4):260-264.
[9] Asghar O,Petropoulos IN,Alam U,et al.Corneal ConfocalMicroscopy Detects Neuropathy in Subjects With ImpairedGlucose Tolerance[J].Diabetes Care, 2014, 37(9):2643-2646.
[10]王文远,马忠立,张利芳.平衡针灸降糖穴治疗2型糖尿病的临床研究[J].中国老年学杂志,2015,35(7):1767-1768.
[11] Qiu Q, Gong Y, Liu X, et al. Serum Uric Acid andImpaired Glucose Tolerance:The Cardiometabolic Risk inChinese(CRC)Study[J].Cell Biochemistry&Biophysics,2015,73(1):155-162.
[12]王文远,马忠立,郑欣杰,等.平衡针灸对2型糖尿病血脂疗效观察[J].中国中医药现代远程教育,2012,10(2):96-105.