他卡西醇软膏联合窄谱中波紫外线治疗白癜风疗效观察
|
摘要
目的:探讨他卡西醇软膏联合窄谱中波紫外线治疗白癜风的临床疗效。方法:随机选取2013年4月-2015年1月笔者科室接受治疗的白癜风患者60例,根据其临床治疗方法的不同随机分为研究组和对照组。对照组:30例,采用窄谱中波紫外线治疗;研究组:30例,采用他卡西醇软膏联合窄谱中波紫外线治疗,两组患者均以照射紫外线10次为1个疗程,共治疗4个疗程后对比两组患者临床疗效。结果:研究组患者经过4个疗程的治疗后总有效率为96.67%,高于对照组的73.33%,组间比较差异显著,具有统计学意义(P<0.05),两组患者在治疗期间和治疗后均无其他并发症发生。结论:他卡西醇软膏联合窄谱中波紫外线治疗白癜风疗效显著、安全可靠,值得临床推广应用。
Objective The study of the treatment of vitiligo by Tacalcitol ointment and Narrow-band ultraviolet. Methods 60 vitiligo patients were randomly selected in our hospital from April 2013 to January 2015. They were divided into study group and control group by depending on the clinical treatment. 30 cases in the control group of patients were treated by narrowspectrum ultraviolet,and 30 cases of study group patients were treated by tacalcitol ointment and narrow-band ultraviolet. Clinical efficacy of two groups were compared after four courses of treatment(Two groups of patients were irradiated with ultraviolet light 10 times as a course). Results 30 cases of study group patients after four courses of treatment efficacy was assessed after clinical cure, effective,effective and ineffective patients were 13 cases, 10 cases, 6 cases and 1 case, clinical total effective rate was 96.67%, higher than 73.33%(The cured,effective, effective and ineffective patients were 5 cases, 8, 9 and 8) of the control group clinical total efficiency, significantly between the two groups was statistically significant difference(P<0.05). They were no complication being appeared on the two groups of patients during and after treatment and therapy. Conclusion The treatment of vitiligo by tacalcitol ointment and narrow-band ultraviolet was significant effect, safe and reliable,worthy of promotion.
Objective The study of the treatment of vitiligo by Tacalcitol ointment and Narrow-band ultraviolet. Methods 60 vitiligo patients were randomly selected in our hospital from April 2013 to January 2015. They were divided into study group and control group by depending on the clinical treatment. 30 cases in the control group of patients were treated by narrowspectrum ultraviolet,and 30 cases of study group patients were treated by tacalcitol ointment and narrow-band ultraviolet. Clinical efficacy of two groups were compared after four courses of treatment(Two groups of patients were irradiated with ultraviolet light 10 times as a course). Results 30 cases of study group patients after four courses of treatment efficacy was assessed after clinical cure, effective,effective and ineffective patients were 13 cases, 10 cases, 6 cases and 1 case, clinical total effective rate was 96.67%, higher than 73.33%(The cured,effective, effective and ineffective patients were 5 cases, 8, 9 and 8) of the control group clinical total efficiency, significantly between the two groups was statistically significant difference(P<0.05). They were no complication being appeared on the two groups of patients during and after treatment and therapy. Conclusion The treatment of vitiligo by tacalcitol ointment and narrow-band ultraviolet was significant effect, safe and reliable,worthy of promotion.
引文
[1]Keller BA,Kathryn V,Droppelmann CA,et al.Tofacitinib Citrate for the Treatment of Vitiligo:A Pathogenesis-Directed Therapy[J].Acta Neuropathologica,2015,151(5):1110-1112.
[2]张峥,肖风丽,杜文辉,等.中国汉族人白癜风伴发自身免疫疾病与遗传关系[J].安徽医科大学学报,2008,43(2):194-196.
[3]中国中西医结合学会皮肤性病专业委员会色素病学组.白癜风临床分型及疗效标准(2003年修订稿)[J].中华皮肤科杂志,2005,18(1):54-54.
[4]黄星涛,叶蓉,林琦,等.中西医药物治疗白癜风研究进展[J].内蒙古中医药,2012,31(12):115-116.
[5]Laddha NC,Mitesh D,Mansuri MS,et al.Vitiligo:interplay between oxidative stress and immune system.[J].Exp Dermatol,2013,22(4):245-250.
[6]陈玉华.窄谱中波紫外线治疗白癜风的临床疗效[J].中国社区医师,2015,21(13):61-62.
[7]孙慧,杨莉佳,李明,等.他卡西醇软膏联合窄谱UVB治疗面部白癜风疗效观察[J].中国麻风皮肤病杂志,2008,24(4):321-322.
[8]于叶,闵仲生.他卡西醇软膏联合窄谱中波紫外线治疗白癜风临床疗效观察[J].临床皮肤科杂志,2007,13(7):465-466.
[9]李超.窄谱中波紫外线联合他卡西醇软膏治疗白癜风疗效观察[J].现代中西医结合杂志,2011,20(36):4681-4682.
[10]张文强.他卡西醇软膏联合窄谱中波紫外线治疗白癜风的临床疗效观察[J].中国医药指南,2012,7(32):470-471.
[2]张峥,肖风丽,杜文辉,等.中国汉族人白癜风伴发自身免疫疾病与遗传关系[J].安徽医科大学学报,2008,43(2):194-196.
[3]中国中西医结合学会皮肤性病专业委员会色素病学组.白癜风临床分型及疗效标准(2003年修订稿)[J].中华皮肤科杂志,2005,18(1):54-54.
[4]黄星涛,叶蓉,林琦,等.中西医药物治疗白癜风研究进展[J].内蒙古中医药,2012,31(12):115-116.
[5]Laddha NC,Mitesh D,Mansuri MS,et al.Vitiligo:interplay between oxidative stress and immune system.[J].Exp Dermatol,2013,22(4):245-250.
[6]陈玉华.窄谱中波紫外线治疗白癜风的临床疗效[J].中国社区医师,2015,21(13):61-62.
[7]孙慧,杨莉佳,李明,等.他卡西醇软膏联合窄谱UVB治疗面部白癜风疗效观察[J].中国麻风皮肤病杂志,2008,24(4):321-322.
[8]于叶,闵仲生.他卡西醇软膏联合窄谱中波紫外线治疗白癜风临床疗效观察[J].临床皮肤科杂志,2007,13(7):465-466.
[9]李超.窄谱中波紫外线联合他卡西醇软膏治疗白癜风疗效观察[J].现代中西医结合杂志,2011,20(36):4681-4682.
[10]张文强.他卡西醇软膏联合窄谱中波紫外线治疗白癜风的临床疗效观察[J].中国医药指南,2012,7(32):470-471.