尖锐湿疣患者采用派特灵结合肌注干扰素治疗的临床效果
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摘要
目的探究尖锐湿疣患者采用派特灵结合肌注干扰素治疗的临床效果。方法选取2015年1月至2017年1月榆林市第一医院诊治的60例尖锐湿疣患者作为研究对象。根据入院先后实施分组,对照组30例,给予单纯干扰素肌注治疗;观察组30例,在对照组治疗方法的基础上加用派特灵治疗。对两组患者治疗前后的免疫学指标、不良反应发生情况以及临床治疗效果进行综合评价。结果观察组患者治疗后白细胞介素2(IL-2)、肿瘤坏死因子(TNF-a)以及CD_(4+)/CD_(8+)免疫学指标均得到显著改善,与对照组比较差异具有统计学意义(P<0.05);观察组治疗后不良反应率为6.7%,较对照组的26.7%低,差异具有统计学意义(P<0.05);观察组治疗后有27例患者显示有效,占90.0%,显著高于对照组的66.7%,差异具有统计学意义(P<0.05)。结论尖锐湿疣患者采用派特灵结合肌注干扰素治疗,能够促进患者免疫功能改善,减少不良反应的发生,效果显著,值得推广应用。
Objective To explore the clinical effect of the treatment of patients with condyloma acuminata combined with the treatment of interferon. Methods From January 2015 to January 2015 in our hospital for treatment of 60 patients with condyloma acuminatum were as the research object, according to hospital has implemented group, 30 cases of control group given interferon alone intramuscular injection treatment; In the observation group, 30 patients were treated with petronic therapy on the basis of control group, and the immunological indexes, adverse reactions and clinical therapeutic effects of the two groups before and after treatment were comprehensively evaluated. Results The observation group after treatment in patients with interleukin 2(IL-2), tumor necrosis factor(TNF-a) and CD4 +/CD8 + immunological indexes were improved significantly, compared with the control group there is statistical significance difference(P<0.05); After treatment, the adverse reaction rate was 6.7%, which was lower than 26.7% in the control group(P<0.05), and there was statistical significance. After treatment, 27 patients were shown to be effective, accounting for 90.0%, significantly higher than 66.7% in the control group, and the difference between the two groups was statistically significant(P<0.05). Conclusions The treatment of patients with condyloma acuminata combined with the treatment of interferon, can promote the improvement of immune function, reduce the occurrence of adverse reactions, and the effect is remarkable, and it is worth populating and applying.
Objective To explore the clinical effect of the treatment of patients with condyloma acuminata combined with the treatment of interferon. Methods From January 2015 to January 2015 in our hospital for treatment of 60 patients with condyloma acuminatum were as the research object, according to hospital has implemented group, 30 cases of control group given interferon alone intramuscular injection treatment; In the observation group, 30 patients were treated with petronic therapy on the basis of control group, and the immunological indexes, adverse reactions and clinical therapeutic effects of the two groups before and after treatment were comprehensively evaluated. Results The observation group after treatment in patients with interleukin 2(IL-2), tumor necrosis factor(TNF-a) and CD4 +/CD8 + immunological indexes were improved significantly, compared with the control group there is statistical significance difference(P<0.05); After treatment, the adverse reaction rate was 6.7%, which was lower than 26.7% in the control group(P<0.05), and there was statistical significance. After treatment, 27 patients were shown to be effective, accounting for 90.0%, significantly higher than 66.7% in the control group, and the difference between the two groups was statistically significant(P<0.05). Conclusions The treatment of patients with condyloma acuminata combined with the treatment of interferon, can promote the improvement of immune function, reduce the occurrence of adverse reactions, and the effect is remarkable, and it is worth populating and applying.
引文
[1] 王立新,刘龙,曹志强,等.派特灵与电灼结合干扰素治疗阴茎尖锐湿疣的临床效果对比观察[J].中国性科学,2016,25(8):68-71.
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[5] 张超,伍洲炜,施伟民,等.派特灵外涂联合光动力疗法治疗阴茎尖锐湿疣的疗效及对患者局部HPV病毒载量水平的影响[J].中国性科学,2017,26(11):106-107.
[6] 华鹏,林召,杨秀莲,等.胸腺五肽联合干扰素治疗复发性尖锐湿疣疗效分析及对T细胞亚群影响的研究[J].中国性科学,2014,23(8):42-44.
[7] 李志瑜,陶玥,包军,等.多功能电离子联合ALA-PDT及干扰素治疗宫颈尖锐湿疣疗效评价[J].中国麻风皮肤病杂志,2017,33(5):272-275.
[8] 周秋霞,陶茂灿.卡介菌多糖核酸联合重组人干扰素α-2b凝胶对尖锐湿疣CO_2激光治疗术后复发预防作用[J].中国微生态学杂志,2014,26(8):921-923.
[9] 贾四友,张静,张云风.CO2激光联合半枝莲膏、IL-2治疗尖锐湿疣复发的疗效观察[J].山东医药,2014,54(1):90-91.
[10] 芦洁.卡介菌多糖核酸注射液联合派特灵治疗尖锐湿疣的临床分析[J].医学理论与实践,2016,29(10):1340-1341.
[11] Lai J,Li CX.Observation on clinical effect of orally-taking guben xiaoyou decoction combined with interferon hypodermic injection in operative region for patients with postoperative recurrence of anus condyloma acuminata[J].Journal of Chengdu University of Traditional Chinese Medicine,2017,21(3):384-385.
[12] 张启国,王勉,黄一锦,等.中药派特灵三阶段疗法治疗儿童尖锐湿疣的临床疗效和安全性观察[J].中国卫生标准管理,2017,8(24):114-116.
[13] 周渐云,梁裕华,陈秀琼,等.中药外用联合解毒消疣方治疗尖锐湿疣临床研究[J].中医学报,2017,32(7):1316-1318.
[14] 顾艳伟,方恒.胸腺五肽肌注治疗复发性尖锐湿疣的临床疗效及对免疫学指标影响的研究[J].中国性科学,2015,24(8):63-65.
[15] 毕淑萍.二氧化碳激光联合草分枝杆菌F.U.36注射液肌注治疗尖锐湿疣临床效果分析[J].中国继续医学教育,2017,21(21):173-174.
[16] 黄伟.胸腺五肽联合重组人干扰素α-2b凝胶灌注疗法预防男性尿道口尖锐湿疣复发的疗效观察[J].皮肤病与性病,2015,21(3):174-175.
[17] 刘畅,张莹莹,王宇,等.疣必治治疗尖锐湿疣的疗效观察及对患者血清IL-2的影响[J].中国中医药科技,2016,23(2):208-209.
[18] Chen Q,Yang R,Gao A,et al.Efficacy of fulguration combined with imiquimod cream on condyloma acuminatum,and the effect on immune functions and serums levels of IL-2 and IL-10[J].Experimental & Therapeutic Medicine,2017,14(1):131-134.
[2] Du J,Cheng Q,Zhang Z,et al.5-Aminolevulinic acid photodynamic therapy stimulates local immunity in patients with condylomata acuminata via activation of T lymphocytes[J].European Review for Medical & Pharmacological Sciences,2017,21(10):2302-2303.
[3] 张晶,扈容英,赵倩颖,等.派特灵与微波联合重组人干扰素α-2b乳膏治疗不同亚型HPV感染尖锐湿疣的临床疗效观察[J].中国艾滋病性病,2017,21(11):163-164.
[4] Shan X,Wang N,Li Z,et al.An open uncontrolled trial of topical 5-aminolevulinic acid photodynamic therapy for the treatment of urethral condylomata acuminata in male patients[J].Indian Journal of Dermatology Venereology & Leprology,2016,82(1):65-67.
[5] 张超,伍洲炜,施伟民,等.派特灵外涂联合光动力疗法治疗阴茎尖锐湿疣的疗效及对患者局部HPV病毒载量水平的影响[J].中国性科学,2017,26(11):106-107.
[6] 华鹏,林召,杨秀莲,等.胸腺五肽联合干扰素治疗复发性尖锐湿疣疗效分析及对T细胞亚群影响的研究[J].中国性科学,2014,23(8):42-44.
[7] 李志瑜,陶玥,包军,等.多功能电离子联合ALA-PDT及干扰素治疗宫颈尖锐湿疣疗效评价[J].中国麻风皮肤病杂志,2017,33(5):272-275.
[8] 周秋霞,陶茂灿.卡介菌多糖核酸联合重组人干扰素α-2b凝胶对尖锐湿疣CO_2激光治疗术后复发预防作用[J].中国微生态学杂志,2014,26(8):921-923.
[9] 贾四友,张静,张云风.CO2激光联合半枝莲膏、IL-2治疗尖锐湿疣复发的疗效观察[J].山东医药,2014,54(1):90-91.
[10] 芦洁.卡介菌多糖核酸注射液联合派特灵治疗尖锐湿疣的临床分析[J].医学理论与实践,2016,29(10):1340-1341.
[11] Lai J,Li CX.Observation on clinical effect of orally-taking guben xiaoyou decoction combined with interferon hypodermic injection in operative region for patients with postoperative recurrence of anus condyloma acuminata[J].Journal of Chengdu University of Traditional Chinese Medicine,2017,21(3):384-385.
[12] 张启国,王勉,黄一锦,等.中药派特灵三阶段疗法治疗儿童尖锐湿疣的临床疗效和安全性观察[J].中国卫生标准管理,2017,8(24):114-116.
[13] 周渐云,梁裕华,陈秀琼,等.中药外用联合解毒消疣方治疗尖锐湿疣临床研究[J].中医学报,2017,32(7):1316-1318.
[14] 顾艳伟,方恒.胸腺五肽肌注治疗复发性尖锐湿疣的临床疗效及对免疫学指标影响的研究[J].中国性科学,2015,24(8):63-65.
[15] 毕淑萍.二氧化碳激光联合草分枝杆菌F.U.36注射液肌注治疗尖锐湿疣临床效果分析[J].中国继续医学教育,2017,21(21):173-174.
[16] 黄伟.胸腺五肽联合重组人干扰素α-2b凝胶灌注疗法预防男性尿道口尖锐湿疣复发的疗效观察[J].皮肤病与性病,2015,21(3):174-175.
[17] 刘畅,张莹莹,王宇,等.疣必治治疗尖锐湿疣的疗效观察及对患者血清IL-2的影响[J].中国中医药科技,2016,23(2):208-209.
[18] Chen Q,Yang R,Gao A,et al.Efficacy of fulguration combined with imiquimod cream on condyloma acuminatum,and the effect on immune functions and serums levels of IL-2 and IL-10[J].Experimental & Therapeutic Medicine,2017,14(1):131-134.