解毒活血汤加减保留灌肠治疗急性盆腔炎(湿瘀互结型)的效果及安全性
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摘要
目的分析解毒活血汤加减保留灌肠治疗急性盆腔炎(湿瘀互结型)的效果及安全性。方法选择我院2016年2月至2017年2月收治的急性盆腔炎(湿瘀互结型)患者120例,随机将其分别为观察组和对照组,各60例。对照组采取静脉滴注头孢呋辛钠及奥硝唑治疗,观察组在此基础上加用解毒活血汤加减保留灌肠治疗。1个疗程后比较两组的治疗效果。结果治疗前,两组患者CRP、TNF-α、IL-6水平比较,差异无统计学意义(P>0.05);治疗后,两组CRP、TNF-α、IL-6水平均显著降低,且观察组明显低于对照组(P<0.05)。观察组体温恢复正常时间、腹痛缓解时间、血WBC计数恢复正常时间及住院时间均显著短于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率显著高于对照组(P<0.05)。结论解毒活血汤加减保留灌肠治疗急性盆腔炎(湿瘀互结型)可明显降低患者炎性细胞因子水平、缩短症状缓解时间,提高疗效,且不良反应少。
Objective To analyze the effect and safety of modified Jiedu Huoxue decoction for retention enema in the treatment of acute pelvic inflammation(damp and blood stasis type). Methods A total of 120 patients with acute pelvic inflammatory(damp and blood stasis type) admitted in our hospital from February 2016 to February 2017 were selected and randomly divided into observation group and control group, with 60 cases in each group. The control group was treated with intravenous infusion of cefuroxime sodium and ornidazole. On this basis, the observation group was additionally treated with modified Jiedu Huoxue decoction for retention enema. The treatment effects were compared between the two groups after one course of treatment. Results There were no significant differences in the levels of CRP,TNF-α and IL-6 between the two groups before treatment(P>0.05). After treatment, the levels of CRP, TNF-α and IL-6 of the two groups decreased significantly, and those in the observation group were lower than the control group(P <0.05). The temperature recovery time, abdominal pain relief time, time of blood WBC count returning to normal and hospital stay in the observation group were significantly shorter than those in the control group(P <0.05). The total effective rate of treatment in the observation group was significantly higher than that in the control group(P <0.05).Conclusion Modified Jiedu Huoxue decoction for retention enema for acute pelvic inflammatory(damp and blood stasis type) can significantly reduce the levels of inflammatory cytokines, shorten the time of symptom relief and improve the curative effect, with few adverse reactions.
Objective To analyze the effect and safety of modified Jiedu Huoxue decoction for retention enema in the treatment of acute pelvic inflammation(damp and blood stasis type). Methods A total of 120 patients with acute pelvic inflammatory(damp and blood stasis type) admitted in our hospital from February 2016 to February 2017 were selected and randomly divided into observation group and control group, with 60 cases in each group. The control group was treated with intravenous infusion of cefuroxime sodium and ornidazole. On this basis, the observation group was additionally treated with modified Jiedu Huoxue decoction for retention enema. The treatment effects were compared between the two groups after one course of treatment. Results There were no significant differences in the levels of CRP,TNF-α and IL-6 between the two groups before treatment(P>0.05). After treatment, the levels of CRP, TNF-α and IL-6 of the two groups decreased significantly, and those in the observation group were lower than the control group(P <0.05). The temperature recovery time, abdominal pain relief time, time of blood WBC count returning to normal and hospital stay in the observation group were significantly shorter than those in the control group(P <0.05). The total effective rate of treatment in the observation group was significantly higher than that in the control group(P <0.05).Conclusion Modified Jiedu Huoxue decoction for retention enema for acute pelvic inflammatory(damp and blood stasis type) can significantly reduce the levels of inflammatory cytokines, shorten the time of symptom relief and improve the curative effect, with few adverse reactions.
引文
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[2]孙书青,马秀君,陈凤娟.大黄牡丹汤加减保留灌肠辅助治疗急性盆腔炎热毒炽盛证临床研究[J].国际中医中药杂志,2016,38(10):880-883.
[3]张越.清热解毒活血汤灌肠治疗90例慢性盆腔炎的临床疗效观察[J].中国妇幼健康研究,2017,28(S1):93.
[4]谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:258-262.
[5]傅淑清.中医妇科学[M].北京:人民卫生出版社,2006:314-316.
[6]王璐,徐键,陈学奇.四妙丸加减对湿瘀互结型慢性盆腔炎患者生活质量的影响[J].医药导报,2016,35(6):601-603.
[7]王春环,李维民,靳丽萍,等.克炎灵保留灌肠治疗湿瘀型慢性盆腔炎40例[J].辽宁中医杂志,2016,43(12):2579-2581.
[8]张仙红.血虎汤加减保留灌肠治疗慢性盆腔炎的疗效观察[J].山西医药杂志,2014,43(13):1559-1560.
[9]郝焕妮,蒋海玲,胡晓华.中西医结合治疗急性盆腔炎湿热瘀结证临床研究[J].中医学报,2017,32(4):639-642.
[10]张秀娟,李军.中医药治疗盆腔炎性疾病后遗症[J].吉林中医药,2014,34(4):363-365.