MicroRNA-155在结核分支杆菌与巨噬细胞互作中调控作用的研究进展
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摘要
microRNAs是广泛存在于真核生物中的小分子非编码RNA,在转录后水平调节多种生物进程,包括细胞分化和发育、免疫反应、凋亡等。microRNA-155是一个多功能的microRNA,研究发现microRNA-155在结核分支杆菌与巨噬细胞互作中发挥着重要的调控作用,巨噬细胞是结核分支杆菌在体内的主要宿主细胞,结核分支杆菌与巨噬细胞互作的结果与结核病的发展密切相关。论文对结核分支杆菌与巨噬细胞互作中microRNA-155调控细胞自噬、细胞凋亡、细胞杀菌能力等作用的研究进展进行综述,以期为结核病的诊断和治疗提供新的思路。
MicroRNAs are a kind of short non-coding RNAs which widely present in eukaryotes,and can regulate a variety of biological processes at post-transcriptional levels,including cell differentiation and development,immune response,and apoptosis.MicroRNA-155 is a multifunctional microRNA and plays an important role in regulating the interaction between Mycobacterium tuberculosis and macrophages.Macrophage is the main host cell of Mycobacterium tuberculosis,the interaction between Mycobacterium tuberculosis and macrophages is closely related to the development of tuberculosis.Therefore,this review summarized the advances in the roles of microRNA-155 regulated cellular autophagy,apoptosis and bactericidal activity in the interaction between Mycobacterium tuberculosis and macrophages,hoping to provide new thought for the therapy and diagnosis of tuberculosis.
MicroRNAs are a kind of short non-coding RNAs which widely present in eukaryotes,and can regulate a variety of biological processes at post-transcriptional levels,including cell differentiation and development,immune response,and apoptosis.MicroRNA-155 is a multifunctional microRNA and plays an important role in regulating the interaction between Mycobacterium tuberculosis and macrophages.Macrophage is the main host cell of Mycobacterium tuberculosis,the interaction between Mycobacterium tuberculosis and macrophages is closely related to the development of tuberculosis.Therefore,this review summarized the advances in the roles of microRNA-155 regulated cellular autophagy,apoptosis and bactericidal activity in the interaction between Mycobacterium tuberculosis and macrophages,hoping to provide new thought for the therapy and diagnosis of tuberculosis.
引文
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[24]张妍,宋纪伟,曾范利,等.不同毒力结核分枝杆菌对THP-1细胞凋亡及细胞因子表达的影响[J].畜牧兽医学报,2015,46(9):1600-1605.
[25]Yang S,Li F,Jia S,et al.Early secreted antigen ESAT-6of Mycobacterium tuberculosis promotes apoptosis of macrophages via targeting the microRNA155-SOCS1interaction[J].Cell Physiol Biochem,2015,35(4):1276-1288.
[26]Qin Y,Wang Q,Zhou Y,et al.Inhibition of IFN-gamma-induced nitric oxide dependent antimycobacterial activity by miR-155and C/EBPβ[J].Int J Mol Sci,2016,17(4):535.
[27]Wang J,Wu M,Wen J,et al.MicroRNA-155induction by Mycobacterium bovis BCG enhances ROS production through targeting SHIP1[J].Mol Immunol,2014,62(1):29-36.
[28]Wu J,Lu C,Diao N,et al.Analysis of microRNA expression profiling identifies miR-155and miR-155*as potential diagnostic markers for active tuberculosis:apreliminary study[J].Hum immunol,2012,73(1):31-37.
[29]Zheng M L,Zhou N K,Luo C H.MiRNA-155and miRNA-132as potential diagnostic biomarkers for pulmonary tuberculosis:A preliminary study[J].Microb pathog,2016,100:78-83.
[30]高丽,贺蕾,田慎谦,等.结核与非结核分枝杆菌感染者血浆中差异表达micro RNAs筛选[J].现代预防医学,2016,43(7):1295-1299.
[2]Faraoni I,Antonetti F R,Cardone J,et al.miR-155gene:a typical multifunctional microRNA[J].Biochim Biophys Acta,2009,1792(6):497-505.
[3]马春燕.miRNA-124在肺泡上皮细胞和巨噬细胞抗结核分枝杆菌感染中的免疫调控机制研究[D].宁夏银川:宁夏大学,2014.
[4]Shukla G C,Singh J,Barik S.MicroRNAs:processing,maturation,target recognition and regulatory functions[J].Mol cell pharmacol,2011,3(3):83-92.
[5]苏乃芳.转录因子和microRNA组成的基因调控网络的生物信息学分析[D].北京:北京大学,2013.
[6]Ovcharenko D,Kelnar K,Johnson C,et al.Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathway[J].Cancer Res,2007,67(22):10782-10788.
[7]Pang W,Su J,Wang Y,et al.Pancreatic cancer‐secreted miR-155implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts[J].Cancer Sci,2015,106(10):1362-1369.
[8]Zhang P,Wang H,Luo X,et al.MicroRNA-155inhibits polarization of macrophages to M2-type and suppresses choroidal neovascularization[J].Inflammation,2018,41(1):143-153.
[9]Banerjee A,Schambach F,DeJong C S,et al.Micro-RNA-155inhibits IFN-γsignaling in CD4+T cells[J].Eur J Immunol,2010,40(1):225-231.
[10]Gracias D T,Stelekati E,Hope J L,et al.The microRNA miR-155controls CD8+T cell responses by regulating interferon signaling[J].Nat immunol,2013,14(6):593-602.
[11]Cremer T J,Ravneberg D H,Clay C D,et al.MiR-155induction by F.novicida but not the virulent F.tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response[J].PLoS One,2009,4(12):e8508.
[12]Tang B,Xiao B,Liu Z,et al.Identification of MyD88as a novel target of miR-155,involved in negative regulation of Helicobacter pylori induced inflammation[J].FEBS lett,2010,584(8):1481-1486.
[13]Teng Y,Miao J,Shen X,et al.The modulation of miR-155and miR-23amanipulates Klebsiella pneumoniae adhesion on human pulmonary epithelial cells via integrinα5β1signaling[J].Sci Rep,2016,6:31918.
[14]Abdalla A E,Duan X,Deng W,et al.MicroRNAs play big roles in modulating macrophages response toward mycobacteria infection[J].Infect Genet Evol,2016,45:378-382.
[15]陈艳清,张林波.结核分枝杆菌免疫逃逸分子机制的研究进展[J].免疫学杂志,2014,30(1):84-88.
[16]Wang J,Yang K,Zhou L,et al.MicroRNA-155promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb[J].PLoS Pathog,2013,9(10):e1003697.
[17]Rothchild A C,Sissons J R,Shafiani S,et al.MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis[J].Proc Natl Acad Sci U S A,2016,113(41):E6172-E6181.
[18]Kumar R,Halder P,Sahu S K,et al.Identification of a novel role of ESAT-6-dependent miR-155induction during infection of macrophages with Mycobacterium tuberculosis[J].Cell Microbiol,2012,14(10):1620-1631.
[19]Kuijl C,Savage N D,Marsman M,et al.Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1[J].Nature,2007,450(7170):725-730.
[20]Etna M P,Sinigaglia A,Grassi A,et al.Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3in human dendritic cells[J].PLoS Pathogens,2018,14(1):e1006790.
[21]向文玉,徐军发.MicroRNAs在抗结核相关的巨噬细胞及树突状细胞中的研究进展[J].国际检验医学杂志,2015,36(2):237-239.
[22]Huang J,Jiao J,Xu W,et al.MiR-155is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO3[J].Mol Med Rep,2015,12(5):7102-7108.
[23]Ghorpade D S,Leyland R,Kurowska-Stolarska M,et al.MicroRNA-155is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages[J].Mol Cell Biol,2012,32(12):2239-2253.
[24]张妍,宋纪伟,曾范利,等.不同毒力结核分枝杆菌对THP-1细胞凋亡及细胞因子表达的影响[J].畜牧兽医学报,2015,46(9):1600-1605.
[25]Yang S,Li F,Jia S,et al.Early secreted antigen ESAT-6of Mycobacterium tuberculosis promotes apoptosis of macrophages via targeting the microRNA155-SOCS1interaction[J].Cell Physiol Biochem,2015,35(4):1276-1288.
[26]Qin Y,Wang Q,Zhou Y,et al.Inhibition of IFN-gamma-induced nitric oxide dependent antimycobacterial activity by miR-155and C/EBPβ[J].Int J Mol Sci,2016,17(4):535.
[27]Wang J,Wu M,Wen J,et al.MicroRNA-155induction by Mycobacterium bovis BCG enhances ROS production through targeting SHIP1[J].Mol Immunol,2014,62(1):29-36.
[28]Wu J,Lu C,Diao N,et al.Analysis of microRNA expression profiling identifies miR-155and miR-155*as potential diagnostic markers for active tuberculosis:apreliminary study[J].Hum immunol,2012,73(1):31-37.
[29]Zheng M L,Zhou N K,Luo C H.MiRNA-155and miRNA-132as potential diagnostic biomarkers for pulmonary tuberculosis:A preliminary study[J].Microb pathog,2016,100:78-83.
[30]高丽,贺蕾,田慎谦,等.结核与非结核分枝杆菌感染者血浆中差异表达micro RNAs筛选[J].现代预防医学,2016,43(7):1295-1299.