Mg-based absorbable membrane for guided bone regeneration(GBR): a pilot study
|
摘要
A novel calcium-phosphate(Ca–P)-coated magnesium(Mg) membrane used for guided bone regeneration(GBR) was studied.The microstructural characterization, electrochemical test, immersion test,fluorescence labeling analysis and histopathological evaluation were carried out.The results showed that Ca–P coating could obviously improve the corrosion resistance of the pure Mg membrane.The in vivo results showed that Mg membrane coated with Ca–P would take 8 weeks to be completely absorbed.However, Mg membrane was completely absorbed within 1 week.Histopathological evaluation showed that the Ca–P-coated Mg membranes were significantly better than Ti membranes at the early implantation time(4 weeks), and with the time prolonging,the performance of the coated Mg membrane was not as good as pure Ti membranes(but still better than blank group) at 8 and 12 weeks.The coated biodegradable Mg membrane had a good promising application in GBR.But further studies have to be done to further decrease the degradation rate of pure Mg membrane.
A novel calcium-phosphate(Ca–P)-coated magnesium(Mg) membrane used for guided bone regeneration(GBR) was studied.The microstructural characterization, electrochemical test, immersion test,fluorescence labeling analysis and histopathological evaluation were carried out.The results showed that Ca–P coating could obviously improve the corrosion resistance of the pure Mg membrane.The in vivo results showed that Mg membrane coated with Ca–P would take 8 weeks to be completely absorbed.However, Mg membrane was completely absorbed within 1 week.Histopathological evaluation showed that the Ca–P-coated Mg membranes were significantly better than Ti membranes at the early implantation time(4 weeks), and with the time prolonging,the performance of the coated Mg membrane was not as good as pure Ti membranes(but still better than blank group) at 8 and 12 weeks.The coated biodegradable Mg membrane had a good promising application in GBR.But further studies have to be done to further decrease the degradation rate of pure Mg membrane.
A novel calcium-phosphate(Ca–P)-coated magnesium(Mg) membrane used for guided bone regeneration(GBR) was studied.The microstructural characterization, electrochemical test, immersion test,fluorescence labeling analysis and histopathological evaluation were carried out.The results showed that Ca–P coating could obviously improve the corrosion resistance of the pure Mg membrane.The in vivo results showed that Mg membrane coated with Ca–P would take 8 weeks to be completely absorbed.However, Mg membrane was completely absorbed within 1 week.Histopathological evaluation showed that the Ca–P-coated Mg membranes were significantly better than Ti membranes at the early implantation time(4 weeks), and with the time prolonging,the performance of the coated Mg membrane was not as good as pure Ti membranes(but still better than blank group) at 8 and 12 weeks.The coated biodegradable Mg membrane had a good promising application in GBR.But further studies have to be done to further decrease the degradation rate of pure Mg membrane.
引文
[1]Cho KS,Choi SH,Han KH,Chai JK,Wikesjo UME,Kim CK.Alveolar bone formation at dental implant dehiscence defects following guided bone regeneration and xenogeneic freeze-dried demineralized bone matrix.Clin Oral Implants Res.1998;9(6):419.
[2]Arx TV,Cochran DL,Schenk RK,Buser D.Evaluation of a prototype trilayer membrane(PTLM)for lateral ridge augmentation:an experimental study in the canine mandible.Int J Oral Maxillofac Surg.2002;31(2):190.
[3]Vignoletti F,Matesanz P,Rodrigo D,Figuero E,Martin C,Sanz M.Surgical protocols for ridge preservation after tooth extraction.A systematic review.Clin Oral Implants Res.2012;23:22.
[4]Rocchietta I,Fontana F,Simion M.Clinical outcomes of vertical bone augmentation to enable dental implant placement:a systematic review.J Clin Periodontol.2008;35:203.
[5]Aghaloo TL,Moy PK.Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?Int J Oral Maxillofac Implants.2007;22(7):49.
[6]Wessing B,Lettner S,Zechner W.Guided bone regeneration with collagen membranes and particulate graft materials:a systematic review and meta-analysis.Int J Oral Maxillofac Implants.2018;33:87.
[7]Rakhmatia YD,Ayukawa Y,Furuhashi A,Koyano K.Current barrier membranes:titanium mesh and other membranes for guided bone regeneration in dental applications.J Prosthodont Res.2013;57(1):3.
[8]Carpio L,Loza J,Lynch S,Genco R.Guided bone regeneration around endosseous implants with anorganic bovine bone mineral.A randomized controlled trial comparing bioabsorbable versus non-resorbable barriers.J Periodontol.2000;71(11):1743.
[9]Yoshikawa G,Murashima Y,Wadachi R,Sawada N,Suda H.Guided bone regeneration(GBR)using membranes and calcium sulphate after apicectomy:a comparative histomorphometrical study.Int Endod J.2002;35(3):255.
[10]Liu J,Kerns DG.Mechanisms of guided bone regeneration:a review.Open Dent J.2014;8:56.
[11]Mir-Mari J,Benic GI,Valmaseda-Castellon E,Hammerle CHF,Jung RE.Influence of wound closure on the volume stability of particulate and non-particulate GBR materials:an in vitro cone-beam computed tomographic examination.Part Ⅱ.Clin Oral Implants Res.2017;28(6):631.
[12]Sheikh Z,Qureshi J,Alshahrani AM,Nassar H,Ikeda Y,Glogauer M,Ganss B.Collagen based barrier membranes for periodontal guided bone regeneration applications.Odontology.2017;105(1):1.
[13]Hurzeler MB,Kohal RJ,Naghshbandi J,Mota LF,Conradt J,Hutmacher D,Caffesse RG.Evaluation of a new bioresorbable barrier to facilitate guided bone regeneration around exposed implant threads-an experimental study in the monkey.Int JOral Maxillofac Surg.1998;27(4):315.
[14]Zhao DW,Witte F,Lu FQ,Wang JL,Li JL,Qin L.Current status on clinical applications of magnesium-based orthopaedic implants:a review from clinical translational perspective.Biomaterials.2017;112:287.
[15]Kim BJ,Piao Y,Wufuer M,Son WC,Choi TH.Biocompatibility and efficiency of biodegradable magnesium-based plates and screws in the facial fracture model of beagles.J Oral Maxillofac Surg.2018;76(5):1055.
[16]Lin DJ,Hung FY,Yeh ML,Lui TS.Microstructure-modified biodegradable magnesium alloy for promoting cytocompatibility and wound healing in vitro.J Mater Sci Mater Med.2015;26(10):248.
[17]Lavernia EJ,Srivatsan TS.The rapid solidification processing of materials:science,principles,technology,advances,and applications.J Mater Sci.2010;45(2):287.
[18]Zhang CY,Zeng RC,Liu CL,Gao JC.Comparison of calcium phosphate coatings on Mg-Al and Mg-Ca alloys and their corrosion behavior in Hank’s solution.Surf Coat Technol.2010;204:3636.
[19]Elgali I,Turri A,Xia W,Norlindh B,Johansson A,Dahlin C,Thomsen P,Omar O.Guided bone regeneration using resorbable membrane and different bone substitutes:early histological and molecular events.Acta Biomater.2016;29:409.
[20]Chen J,Lu S,Tan L,Etim IP,Yang K.Comparative study on effects of different coatings on biodegradable and wear properties of Mg-2Zn-1Gd-0.5Zr alloy.Surf Coat Technol.2018;352:273.
[21]Chen J,Tan L,Etim IP,Yang K.Comparative study of the effect of Nd and Y content on the mechanical and biodegradable properties of Mg-Zn-Zr-x Nd/Y(x=0.5,1,2)alloys.Mater Technol.2018;33(10):659.
[22]Chen J,Tan L,Yu X,Yang K.Effect of minor content of Gd on the mechanical and degradable properties of as-cast Mg-2Zn-x Gd-0.5Zr alloys.J Mater Sci Technol.2018.https://doi.org/10.1016/j.jmst.2018.10.022.
[23]Xu LP,Pan F,Yu GN,Yang L,Zhang EL,Yang K.In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy.Biomaterials.2009;30(8):1512.
[24]Tan L,Wang Q,Geng F,Xi XS,Qiu JH,Yang K.Preparation and characterization of Ca-P coating on AZ31 magnesium alloy.Trans Nonferr Met Soc.2010;20:648.
[25]Delgado-Ruiz RA,Calvo-Guirado JL,Romanos GE.Critical size defects for bone regeneration experiments in rabbit calvariae:systematic review and quality evaluation using ARRIVEguidelines.Clin Oral Implants Res.2015;26(8):915.
[26]Song GL,Song SZ.A possible biodegradable magnesium implant material.Adv Eng Mater.2007;9(4):298.
[27]Lin DJ,Hung FY,Lee HP,Yeh ML.Development of a novel degradation-controlled magnesium-based regeneration membrane for future guided bone regeneration(GBR)therapy.Met Basel.2017;7(11):481.
[28]Klopfleisch R,Jung F.The pathology of the foreign body reaction against biomaterials.J Biomed Mater Res A.2017;105(3):927.
[29]Franz S,Rammelt S,Scharnweber D,Simon JC.Immune responses to implants-a review of the implications for the design of immunomodulatory biomaterials.Biomaterials.2011;32(28):6692.
[30]Hao YL,Li SJ,Yang R.Biomedical titanium alloys and their additive manufacturing.Rare Met.2016;35(9):661.
[2]Arx TV,Cochran DL,Schenk RK,Buser D.Evaluation of a prototype trilayer membrane(PTLM)for lateral ridge augmentation:an experimental study in the canine mandible.Int J Oral Maxillofac Surg.2002;31(2):190.
[3]Vignoletti F,Matesanz P,Rodrigo D,Figuero E,Martin C,Sanz M.Surgical protocols for ridge preservation after tooth extraction.A systematic review.Clin Oral Implants Res.2012;23:22.
[4]Rocchietta I,Fontana F,Simion M.Clinical outcomes of vertical bone augmentation to enable dental implant placement:a systematic review.J Clin Periodontol.2008;35:203.
[5]Aghaloo TL,Moy PK.Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?Int J Oral Maxillofac Implants.2007;22(7):49.
[6]Wessing B,Lettner S,Zechner W.Guided bone regeneration with collagen membranes and particulate graft materials:a systematic review and meta-analysis.Int J Oral Maxillofac Implants.2018;33:87.
[7]Rakhmatia YD,Ayukawa Y,Furuhashi A,Koyano K.Current barrier membranes:titanium mesh and other membranes for guided bone regeneration in dental applications.J Prosthodont Res.2013;57(1):3.
[8]Carpio L,Loza J,Lynch S,Genco R.Guided bone regeneration around endosseous implants with anorganic bovine bone mineral.A randomized controlled trial comparing bioabsorbable versus non-resorbable barriers.J Periodontol.2000;71(11):1743.
[9]Yoshikawa G,Murashima Y,Wadachi R,Sawada N,Suda H.Guided bone regeneration(GBR)using membranes and calcium sulphate after apicectomy:a comparative histomorphometrical study.Int Endod J.2002;35(3):255.
[10]Liu J,Kerns DG.Mechanisms of guided bone regeneration:a review.Open Dent J.2014;8:56.
[11]Mir-Mari J,Benic GI,Valmaseda-Castellon E,Hammerle CHF,Jung RE.Influence of wound closure on the volume stability of particulate and non-particulate GBR materials:an in vitro cone-beam computed tomographic examination.Part Ⅱ.Clin Oral Implants Res.2017;28(6):631.
[12]Sheikh Z,Qureshi J,Alshahrani AM,Nassar H,Ikeda Y,Glogauer M,Ganss B.Collagen based barrier membranes for periodontal guided bone regeneration applications.Odontology.2017;105(1):1.
[13]Hurzeler MB,Kohal RJ,Naghshbandi J,Mota LF,Conradt J,Hutmacher D,Caffesse RG.Evaluation of a new bioresorbable barrier to facilitate guided bone regeneration around exposed implant threads-an experimental study in the monkey.Int JOral Maxillofac Surg.1998;27(4):315.
[14]Zhao DW,Witte F,Lu FQ,Wang JL,Li JL,Qin L.Current status on clinical applications of magnesium-based orthopaedic implants:a review from clinical translational perspective.Biomaterials.2017;112:287.
[15]Kim BJ,Piao Y,Wufuer M,Son WC,Choi TH.Biocompatibility and efficiency of biodegradable magnesium-based plates and screws in the facial fracture model of beagles.J Oral Maxillofac Surg.2018;76(5):1055.
[16]Lin DJ,Hung FY,Yeh ML,Lui TS.Microstructure-modified biodegradable magnesium alloy for promoting cytocompatibility and wound healing in vitro.J Mater Sci Mater Med.2015;26(10):248.
[17]Lavernia EJ,Srivatsan TS.The rapid solidification processing of materials:science,principles,technology,advances,and applications.J Mater Sci.2010;45(2):287.
[18]Zhang CY,Zeng RC,Liu CL,Gao JC.Comparison of calcium phosphate coatings on Mg-Al and Mg-Ca alloys and their corrosion behavior in Hank’s solution.Surf Coat Technol.2010;204:3636.
[19]Elgali I,Turri A,Xia W,Norlindh B,Johansson A,Dahlin C,Thomsen P,Omar O.Guided bone regeneration using resorbable membrane and different bone substitutes:early histological and molecular events.Acta Biomater.2016;29:409.
[20]Chen J,Lu S,Tan L,Etim IP,Yang K.Comparative study on effects of different coatings on biodegradable and wear properties of Mg-2Zn-1Gd-0.5Zr alloy.Surf Coat Technol.2018;352:273.
[21]Chen J,Tan L,Etim IP,Yang K.Comparative study of the effect of Nd and Y content on the mechanical and biodegradable properties of Mg-Zn-Zr-x Nd/Y(x=0.5,1,2)alloys.Mater Technol.2018;33(10):659.
[22]Chen J,Tan L,Yu X,Yang K.Effect of minor content of Gd on the mechanical and degradable properties of as-cast Mg-2Zn-x Gd-0.5Zr alloys.J Mater Sci Technol.2018.https://doi.org/10.1016/j.jmst.2018.10.022.
[23]Xu LP,Pan F,Yu GN,Yang L,Zhang EL,Yang K.In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy.Biomaterials.2009;30(8):1512.
[24]Tan L,Wang Q,Geng F,Xi XS,Qiu JH,Yang K.Preparation and characterization of Ca-P coating on AZ31 magnesium alloy.Trans Nonferr Met Soc.2010;20:648.
[25]Delgado-Ruiz RA,Calvo-Guirado JL,Romanos GE.Critical size defects for bone regeneration experiments in rabbit calvariae:systematic review and quality evaluation using ARRIVEguidelines.Clin Oral Implants Res.2015;26(8):915.
[26]Song GL,Song SZ.A possible biodegradable magnesium implant material.Adv Eng Mater.2007;9(4):298.
[27]Lin DJ,Hung FY,Lee HP,Yeh ML.Development of a novel degradation-controlled magnesium-based regeneration membrane for future guided bone regeneration(GBR)therapy.Met Basel.2017;7(11):481.
[28]Klopfleisch R,Jung F.The pathology of the foreign body reaction against biomaterials.J Biomed Mater Res A.2017;105(3):927.
[29]Franz S,Rammelt S,Scharnweber D,Simon JC.Immune responses to implants-a review of the implications for the design of immunomodulatory biomaterials.Biomaterials.2011;32(28):6692.
[30]Hao YL,Li SJ,Yang R.Biomedical titanium alloys and their additive manufacturing.Rare Met.2016;35(9):661.