甲状腺疾病患者血清超氧化物歧化酶、维生素E与甲状腺激素的相关性研究
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摘要
目的探讨甲状腺疾病患者血清超氧化物歧化酶(SOD)、维生素E(VitE)与甲状腺激素的相关性。方法疾病组选自佛山市禅城区中心医院2018年1-2月甲状腺疾病患者136例,对照组选自门诊健康体检者100例,分别抽取静脉血5mL检测各项实验室指标。采用电化学发光法检测甲状腺激素,采用邻苯三酚自氧化法检测SOD活力,采用酶联免疫吸附试验检测VitE水平。结果疾病组血清SOD水平为143.50(134.00,156.75)U/mL,低于对照组的162.00(154.00,168.00)U/mL,差异有统计学意义(P<0.05)。疾病组血清VitE水平[(339±129)mmol/L]明显高于对照组[(245±84)mmol/L],差异有统计学意义(P<0.05);疾病组SOD与FT3(r=0.199,P=0.020)、FT4(r=0.169,P=0.049)呈正相关;与TSH(r=-0.291,P=0.001)呈负相关。疾病组VitE与FT3(r=-0.392,P<0.01)、FT4(r=-0.384,P<0.01)呈负相关;与TSH(r=0.384,P<0.01)呈正相关。结论甲状腺疾病患者血清SOD、VitE水平与甲状腺激素具有相关性,检测甲状腺疾病患者血清SOD、VitE可为临床治疗甲状腺疾病提供新线索。
Objective To investigate the correlation between serum superoxide dismutase(SOD),vitamin E(VitE)and thyroid hormone in patients with thyroid disease.Methods The disease group was selected from136 of thyroid disease patients from January to February in 2018 in the central hospital of Chancheng District,Foshan City,and the control group was selected from 100 outpatients at the same time.Venous blood was extracted from all the subjects.Thyroid hormones were detected by electrochemiluminescence.SOD activity was measured by pyrogallol auto-oxidation.VitE concentration was detected by ELISA.Results The median serum SOD concentration in the disease group was 143.50(134.00,156.75)U/mL,which was lower than that in the control group[162.00(154.00,168.00)U/mL],difference was statistically significant(P<0.05).The serum VitE concentration in the disease group[(339±129)mmol/L]was significantly higher than that in the control group[(245±84)mmol/L],and the difference was statistically significant(P<0.05).There was a positive correlation between SOD and FT3(r=0.199,P=0.020)and FT4(r=0.169,P=0.049)in the disease group and a negative correlation with thyrotrophin(TSH)(r=-0.291,P=0.001).VitE was negatively correlated with FT3(r=-0.392,P<0.01),FT4(r=-0.384,P<0.01)and positively correlated with TSH(r=0.384,P<0.01).Conclusion Serum SOD,VitE and thyroid hormone are related in patients with thyroid disease.Detection of serum SOD and VitE concentrations in patients with thyroid disease can provide new clues for the treatment of thyroid disease.
Objective To investigate the correlation between serum superoxide dismutase(SOD),vitamin E(VitE)and thyroid hormone in patients with thyroid disease.Methods The disease group was selected from136 of thyroid disease patients from January to February in 2018 in the central hospital of Chancheng District,Foshan City,and the control group was selected from 100 outpatients at the same time.Venous blood was extracted from all the subjects.Thyroid hormones were detected by electrochemiluminescence.SOD activity was measured by pyrogallol auto-oxidation.VitE concentration was detected by ELISA.Results The median serum SOD concentration in the disease group was 143.50(134.00,156.75)U/mL,which was lower than that in the control group[162.00(154.00,168.00)U/mL],difference was statistically significant(P<0.05).The serum VitE concentration in the disease group[(339±129)mmol/L]was significantly higher than that in the control group[(245±84)mmol/L],and the difference was statistically significant(P<0.05).There was a positive correlation between SOD and FT3(r=0.199,P=0.020)and FT4(r=0.169,P=0.049)in the disease group and a negative correlation with thyrotrophin(TSH)(r=-0.291,P=0.001).VitE was negatively correlated with FT3(r=-0.392,P<0.01),FT4(r=-0.384,P<0.01)and positively correlated with TSH(r=0.384,P<0.01).Conclusion Serum SOD,VitE and thyroid hormone are related in patients with thyroid disease.Detection of serum SOD and VitE concentrations in patients with thyroid disease can provide new clues for the treatment of thyroid disease.
引文
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[13]徐艳秋,刘斌,常媛,等.超氧化物歧化酶在甲状腺相关疾病外周血中的水平及意义[J].中国现代普通外科进展,2017,20(9):680-683.
[14]孙全贵,龙子,张晓迪,等.抗氧化系统研究新进展[J].现代生物医学进展,2016,16(11):2197-2200.
[15]刘国安,李杰林,李双越,等.维生素C和VitE的联合抗氧化活性研究[J].西北师范大学学报(自然科学版),2015,51(2):66-72.
[16]仓宝成,宫璀璀,王莉,等.维生素E在体内外具有抗氧化作用[J].基础医学与临床,2016,36(1):80-84.
[2]ZAMPETAKI A,DUDEK K,MAYR M.Oxidative stress in atherosclerosis:the role of microRNAs in arterial remodeling[J].Free Radic Biol Med,2013,64:69-77.
[3]BABIZHAYEV M A,VISHNYAKOVA K S,YEGOR-OV Y E.Oxidative damage impact on aging and age-related diseases:drug targeting of telomere attrition and dynamic telomerase activity flirting with imidazole-containing dipeptides[J].Recent Pat Drug Deliv Formul,2014,8(3):163-192.
[4]YANG Y H,LI B,ZHENG X F,et al.Oxidative damage to osteoblasts can be alleviated by early autophagy through the endoplasmic reticulum stress pathway--implications for the treatment of osteoporosis[J].Free Radic Biol Med,2014,77:10-20.
[5]WEBER C,SCHOBER A,ZERNECKE A.MicroRNAs in arterial remodelling,inflammation and atherosclerosis[J].Curr Drug Targets,2010,11(8):950-956.
[6]VENDITTI P,NAPOLITANO G,BARONE D,et al.Effect of thyroid state on enzymatic and non-enzymatic processes in H2O2removal by liver mitochondria of male rats[J].Mol Cell Endocrinol,2015,403:57-63.
[7]陈威,滕晓春,单忠艳,等.慢性碘过量对大鼠甲状腺细胞凋亡的影响[J].中华内分泌代谢杂志,2008,24(6):649-653.
[8]谭开卷,王文健,黄太伟,等.早产儿甲状腺功能低下研究[J].现代医院,2012,12(6):69-70.
[9]任利民,袁晓辉,王雅贤,等.参芪王浆制剂对老龄大鼠皮肤和血清SOD的影响[J].中医药学报,2005,33(4):41-42.
[10]徐艳秋,刘斌,常媛,等.超氧化物歧化酶在乙型肝炎和肝细胞癌中的应用价值[J].中国现代普通外科进展,2017,20(11):841-844.
[11]刘凤英,蔡学坤,张琪,等.成人癫痫患者血清超氧化物歧化酶的水平变化及意义[J].山东医药,2013,53(12):12-14.
[12]阮华玲,赵黎,郭昆全,等.甲状腺功能亢进症患者氧自由基代谢及游离氨基酸变化研究[J].海南医学院学报,2016,22(8):768-770.
[13]徐艳秋,刘斌,常媛,等.超氧化物歧化酶在甲状腺相关疾病外周血中的水平及意义[J].中国现代普通外科进展,2017,20(9):680-683.
[14]孙全贵,龙子,张晓迪,等.抗氧化系统研究新进展[J].现代生物医学进展,2016,16(11):2197-2200.
[15]刘国安,李杰林,李双越,等.维生素C和VitE的联合抗氧化活性研究[J].西北师范大学学报(自然科学版),2015,51(2):66-72.
[16]仓宝成,宫璀璀,王莉,等.维生素E在体内外具有抗氧化作用[J].基础医学与临床,2016,36(1):80-84.