308 nm准分子光联合祛白酊治疗进展期白癜风97例临床观察
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摘要
目的观察308 nm准分子光联合祛白酊治疗进展期白癜风临床疗效。方法选取南昌白癜风医院2016年3 12月收治的97例进展期白癜风病人,采用随机自身对照法,将相邻或对称部位皮损分为联合治疗组和对照组。联合治疗组:采用308 nm准分子光联合祛白酊治疗;对照组:单用308 nm准分子光局部单一照射治疗。对其疗效和可能发生的不良反应进行临床观察。治疗12周后对两组数据进行统计分析。结果联合治疗组有效率为72. 3%,对照组有效率为50. 9%,两组间差异有统计学意义(χ2=11. 179,P <0. 05)。结论 308 nm准分子光联合祛白酊治疗进展期白癜风疗效优于单一光照,值得在临床推广。
Objective To evaluate the therapeutic efficacy of 308-nm excimer light combined with Qu-Bai tincture in the treatment of active vitiligo. Methods A randomized self-controlled study was performed. A total of 97 patients with active vitiligo were enrolled from Department of Dermatology of Nanchang Vitiligo Hospital between March 2016 and December 2016,with contralateral or nearby lesions and divided into test group and control group. In the test group,target lesions were treated by 308-nm excimer light combined with QuBai tincture. In th control group,target lesions received only 308-nm excimer light monotherapy. The efficacy and safety were evaluated after 12 weeks. Results Effective rate was 72. 3% in the test group and 50. 9% in the control group. Conclusion The test group was better than the control group.
Objective To evaluate the therapeutic efficacy of 308-nm excimer light combined with Qu-Bai tincture in the treatment of active vitiligo. Methods A randomized self-controlled study was performed. A total of 97 patients with active vitiligo were enrolled from Department of Dermatology of Nanchang Vitiligo Hospital between March 2016 and December 2016,with contralateral or nearby lesions and divided into test group and control group. In the test group,target lesions were treated by 308-nm excimer light combined with QuBai tincture. In th control group,target lesions received only 308-nm excimer light monotherapy. The efficacy and safety were evaluated after 12 weeks. Results Effective rate was 72. 3% in the test group and 50. 9% in the control group. Conclusion The test group was better than the control group.
引文
[1]赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2013:1268-1274.
[2]中国中西医结合学会皮肤性病专业委员会色素病学组.白癜风诊疗共识(2014版)[J].中华皮肤科杂志,2014,47(1):69-71.
[3]中国中西医结合学会皮肤性病专业委员会色素病学组.黄褐斑和白癜风的诊疗标准(2010年版)[J].中华皮肤科杂志,2010,43(6):373-373.
[4] BLOMHOFF A,KEMP EH,GAWKRODGER DJ,et al. CTLA4polymorphisms are associated with vitiligo,in patients with concomitant autoimmune diseases[J]. Pigment Cell Research,2005,18(1):55-58.
[5] AUFIERO BM,TALWAR H,YOUNG C,et al. Narrow-band UVB induces apoptosis in human keratinocytes[J]. J Photochem Photobiol B,2006,82(2):132-139.
[6]陶莉,项蕾红,金以,等.准分子激光治疗白癜风的临床疗效与安全性研究[J].国际皮肤性病学杂志,2009,35(4):204-206.
[7]隋·巢元方.诸病源候论(卷三十一)[M].北京:人民卫生出版社,1955:163.
[8]李曰庆,何清湖.中医外科学[M]. 3版.北京:中国中医药出版社2012:192.
[9]雷铁池,朱文元,夏明玉,等. 8-甲氧补骨脂素对小鼠黑素瘤细胞黑素生成的调节及相关信号转导研究[J].中华皮肤科杂志,1999,32(2):115.
[2]中国中西医结合学会皮肤性病专业委员会色素病学组.白癜风诊疗共识(2014版)[J].中华皮肤科杂志,2014,47(1):69-71.
[3]中国中西医结合学会皮肤性病专业委员会色素病学组.黄褐斑和白癜风的诊疗标准(2010年版)[J].中华皮肤科杂志,2010,43(6):373-373.
[4] BLOMHOFF A,KEMP EH,GAWKRODGER DJ,et al. CTLA4polymorphisms are associated with vitiligo,in patients with concomitant autoimmune diseases[J]. Pigment Cell Research,2005,18(1):55-58.
[5] AUFIERO BM,TALWAR H,YOUNG C,et al. Narrow-band UVB induces apoptosis in human keratinocytes[J]. J Photochem Photobiol B,2006,82(2):132-139.
[6]陶莉,项蕾红,金以,等.准分子激光治疗白癜风的临床疗效与安全性研究[J].国际皮肤性病学杂志,2009,35(4):204-206.
[7]隋·巢元方.诸病源候论(卷三十一)[M].北京:人民卫生出版社,1955:163.
[8]李曰庆,何清湖.中医外科学[M]. 3版.北京:中国中医药出版社2012:192.
[9]雷铁池,朱文元,夏明玉,等. 8-甲氧补骨脂素对小鼠黑素瘤细胞黑素生成的调节及相关信号转导研究[J].中华皮肤科杂志,1999,32(2):115.