洁身洗液的含量测定方法及工艺优化研究
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摘要
目的考察洁身洗液工艺改进后对其主要成分苦参碱的影响。方法含量测定采用液-液自动萃取设备改进检测方法;水提工艺改进为雾化提取;醇沉工艺改进了乙醇体积分数及加醇的速度。结果含量检测方法改进后稳定性大幅提高,RSD值由2.74%变为0.76%。工艺改进后,有效提高了苦参碱和氧化苦参碱的转移率。水提、醇沉工艺使苦参碱转移率提高15%以上。结论改变该工艺过程的工艺参数可提高该产品的质量。
Objective To study the influence of the improvement of Jieshen Lotion on matrine,the main content of the Jieshen Lotion.Methods The liquid-liquid automatic extraction equipment was used to improve the detection method;the water extraction process was improved by atomization extraction,and the alcohol precipitation process was improved by changing the ethanol concentration and the speed of alcohol addition.Results The stability of the method was improved greatly,RSD changed from 2.74%to 0.76%.The transfer rate of matrine and oxymatrine was increased effectively after the process improved.The transfer rate of matrine by water extraction and alcohol precipitation was increased more than 15%.Conclusion This experiment can improve the quality of the product by changing the technological parameters of the process.
Objective To study the influence of the improvement of Jieshen Lotion on matrine,the main content of the Jieshen Lotion.Methods The liquid-liquid automatic extraction equipment was used to improve the detection method;the water extraction process was improved by atomization extraction,and the alcohol precipitation process was improved by changing the ethanol concentration and the speed of alcohol addition.Results The stability of the method was improved greatly,RSD changed from 2.74%to 0.76%.The transfer rate of matrine and oxymatrine was increased effectively after the process improved.The transfer rate of matrine by water extraction and alcohol precipitation was increased more than 15%.Conclusion This experiment can improve the quality of the product by changing the technological parameters of the process.
引文
[1]朱晨.高秉钧《疡科心得集》学术思想浅析[J].湖南中医杂志,2015,31(5):142-143.
[2]蒋燕.《医林改错》瘀血病证的初步探讨[J].北京中医药大学学报,2014,37(3):152-155,164.
[3]陈爱玲.《医林改错》之瘀血观阐释[J].北京中医药,2016,35(11):1046-1047.
[4]朱丽君.苦参有效部位化学研究[D].北京:北京中医药大学,2007.
[5]高红宁,殷奕.苦参药材中氧化苦参碱和苦参总黄酮含量比较[J].中国实验方剂学杂志,2013,19(17):66-69.
[6]陈静.苦参饮片规格及其质量评价标准研究[D].广州:广东药学院,2013.
[7]于海红.苦参粗提液中氧化苦参碱和苦参碱的分离与纯化[D].沈阳:辽宁科技大学,2013.
[8]田娟,王智民,王维皓.HPLC测定苦参药材中苦参碱和氧化苦参碱的含量[J].中国实验方剂学杂志,2006,12(2):23-24.
[9]黄华树,叶能胜,郝晓丽,等.HPLC检测苦参中苦参碱和氧化苦参碱的含量[J].现代仪器,2009,(5):43-45.
[10]佘志华,王秀梅,吴雅莉,等.反相高效液相色谱法同时测定阴炎净洗液中苦参碱和氧化苦参碱含量[J].中国药业,2013,22(19):33-35.
[11]侯杰荣,柯发敏,侯思奎.HPLC法同时测定苦参中3种生物碱的含量[J].中药材,2014,37(2):273-275.
[12]张为,谭璐,张广求,等.高效液相色谱法同时测定参菊洗剂中苦参碱和蛇床子素的含量[J].西北药学杂志,2016,31(1):40-42.
[13]郭倩倩.液液萃取技术在低浓度乙醇水溶液样品检测前处理中的应用探讨[J].山东工业技术,2015,(21):35.
[14]朱颖,刘沛,秦迪岚,等.液液萃取-高效液相色谱法测定水中的苯胺和联苯胺[J].理化检验-化学分册,2016,52(7):840-842.
[15]王璐.超声雾化提取植物中化学成分的研究[D].长春:吉林大学,2010.
[16]张培旭.超声雾化提取中药有效成份及有害残留的研究[D].长春:吉林大学,2014.
[17]梅明,伍振峰,韩丽,等.苦参常压提取与减压提取的工艺效果比较[J].中国实验方剂学杂志,2014,20(22):16-19.
[18]周佳,朱目成.离心式雾化喷嘴参数优化分析[J].中国粉体技术,2016,22(6):7-11.
[19]陈晨,杨样,高宏力,等.敞口式离心喷嘴内部及近喷口区域的流动特性[J].航空动力学报,2016,31(12):2988-2995.
[20]陈梦钰,牛倩倩,焦海胜.正交实验法优选健肾Ⅰ号胶囊水煎提取工艺[J].西北药学杂志,2016,31(5):451-455.
[21]李锋,吕付国,罗卫东,等.超声速气流中液体横向射流的破碎特性[J].北京航空航天大学学报,2015,41(12):2356-2362.
[22]马尧,王旭,胡宇,等.惰气雾化过程中粉末破碎机理研究[J].热喷涂技术,2017,9(1):34-36,11.
[2]蒋燕.《医林改错》瘀血病证的初步探讨[J].北京中医药大学学报,2014,37(3):152-155,164.
[3]陈爱玲.《医林改错》之瘀血观阐释[J].北京中医药,2016,35(11):1046-1047.
[4]朱丽君.苦参有效部位化学研究[D].北京:北京中医药大学,2007.
[5]高红宁,殷奕.苦参药材中氧化苦参碱和苦参总黄酮含量比较[J].中国实验方剂学杂志,2013,19(17):66-69.
[6]陈静.苦参饮片规格及其质量评价标准研究[D].广州:广东药学院,2013.
[7]于海红.苦参粗提液中氧化苦参碱和苦参碱的分离与纯化[D].沈阳:辽宁科技大学,2013.
[8]田娟,王智民,王维皓.HPLC测定苦参药材中苦参碱和氧化苦参碱的含量[J].中国实验方剂学杂志,2006,12(2):23-24.
[9]黄华树,叶能胜,郝晓丽,等.HPLC检测苦参中苦参碱和氧化苦参碱的含量[J].现代仪器,2009,(5):43-45.
[10]佘志华,王秀梅,吴雅莉,等.反相高效液相色谱法同时测定阴炎净洗液中苦参碱和氧化苦参碱含量[J].中国药业,2013,22(19):33-35.
[11]侯杰荣,柯发敏,侯思奎.HPLC法同时测定苦参中3种生物碱的含量[J].中药材,2014,37(2):273-275.
[12]张为,谭璐,张广求,等.高效液相色谱法同时测定参菊洗剂中苦参碱和蛇床子素的含量[J].西北药学杂志,2016,31(1):40-42.
[13]郭倩倩.液液萃取技术在低浓度乙醇水溶液样品检测前处理中的应用探讨[J].山东工业技术,2015,(21):35.
[14]朱颖,刘沛,秦迪岚,等.液液萃取-高效液相色谱法测定水中的苯胺和联苯胺[J].理化检验-化学分册,2016,52(7):840-842.
[15]王璐.超声雾化提取植物中化学成分的研究[D].长春:吉林大学,2010.
[16]张培旭.超声雾化提取中药有效成份及有害残留的研究[D].长春:吉林大学,2014.
[17]梅明,伍振峰,韩丽,等.苦参常压提取与减压提取的工艺效果比较[J].中国实验方剂学杂志,2014,20(22):16-19.
[18]周佳,朱目成.离心式雾化喷嘴参数优化分析[J].中国粉体技术,2016,22(6):7-11.
[19]陈晨,杨样,高宏力,等.敞口式离心喷嘴内部及近喷口区域的流动特性[J].航空动力学报,2016,31(12):2988-2995.
[20]陈梦钰,牛倩倩,焦海胜.正交实验法优选健肾Ⅰ号胶囊水煎提取工艺[J].西北药学杂志,2016,31(5):451-455.
[21]李锋,吕付国,罗卫东,等.超声速气流中液体横向射流的破碎特性[J].北京航空航天大学学报,2015,41(12):2356-2362.
[22]马尧,王旭,胡宇,等.惰气雾化过程中粉末破碎机理研究[J].热喷涂技术,2017,9(1):34-36,11.