薄芝糖肽联合尼麦角林治疗突聋伴眩晕患者的疗效观察
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摘要
目的观察薄芝糖肽与尼麦角林联合应用对突聋伴眩晕患者的治疗效果。方法选择内蒙古医科大学附属医院2015年7月至2017年7月收治的29例突聋伴眩晕患者,分为试验组和对照组,均以金纳多作为基础药物治疗,试验组加用尼麦角林和薄芝糖肽,对照组加用倍他司汀。结果 2组患者治疗后均无听力痊愈者,仅部分患者听力得到有效的改善,2组听力改善的有效率差异无统计学意义(52.9%vs. 41.7%,P>0.05);2组患者治疗后眩晕症状获明显改善,但治疗后的眩晕等级评分(DARS)或眩晕残障量表(dizziness handicap inventory, DHI)评分在2组间差异均无统计学意义(P>0.05),试验组患者眩晕症状改善所需时间明显短于对照组(2.2 d vs. 4.0 d,P <0.001)。结论突聋伴眩晕患者在应用金纳多的基础上辅以尼麦角林和薄芝糖肽治疗可使其眩晕症状更快地得到控制。
Objective To investigate the efficacy of bozhi glycopeptide combined with nicergoline for patients with sudden hearing loss with vertigo.Methods Twenty-nine patients diagnosed as sudden hearing loss with vertigo and treated between July 2015 and July 2017 were included.Patients were divided into experimental group(n=17) and control group(n=12).All patients received primary treatment with kinadol,with additional application of bozhi glycopeptides plus nicergoline in the patients of experimental group or betahistine in the patients of control group.Results No patient of both groups was completely cured for hearing loss of recovery and only part of patients in each group were effectively treated.There was no significant difference in effective rates between two groups(52.9% vs.41.7%,P>0.05).After individual treatments,significant resolution of vertigo symptom was obtained in patients of both groups,but no statistically significant difference in the vertigo grade scores(P>0.05) nor dizziness handicap inventory scores between two groups(P>0.05).The time required for the resolution of vertigo symptom was shorter in patients of experimental group than that in control group(2.2 days vs.4.0 days,P < 0.001).Conclusion Less time is required for resolution of vertigo in patients with sudden hearing loss with vertigo treated with kinadol plus bozhi glycopeptide and nicergoline.
Objective To investigate the efficacy of bozhi glycopeptide combined with nicergoline for patients with sudden hearing loss with vertigo.Methods Twenty-nine patients diagnosed as sudden hearing loss with vertigo and treated between July 2015 and July 2017 were included.Patients were divided into experimental group(n=17) and control group(n=12).All patients received primary treatment with kinadol,with additional application of bozhi glycopeptides plus nicergoline in the patients of experimental group or betahistine in the patients of control group.Results No patient of both groups was completely cured for hearing loss of recovery and only part of patients in each group were effectively treated.There was no significant difference in effective rates between two groups(52.9% vs.41.7%,P>0.05).After individual treatments,significant resolution of vertigo symptom was obtained in patients of both groups,but no statistically significant difference in the vertigo grade scores(P>0.05) nor dizziness handicap inventory scores between two groups(P>0.05).The time required for the resolution of vertigo symptom was shorter in patients of experimental group than that in control group(2.2 days vs.4.0 days,P < 0.001).Conclusion Less time is required for resolution of vertigo in patients with sudden hearing loss with vertigo treated with kinadol plus bozhi glycopeptide and nicergoline.
引文
[1]中华耳鼻咽喉头颈外科杂志编委会,中华医学会耳鼻咽喉头颈外科分会.突发性聋诊断和治疗指南(2015)[J].中华耳鼻喉头颈外科杂志, 2015, 50:443-447.
[2]中国突发性聋多中心临床研究协作组.中国突发性聋分型治疗的多中心临床研究[J].中华耳鼻喉头颈外科杂志, 2013, 48:355-361.
[3] Yu H, Li H. Association of vertigo with hearing outcomes in pa-tients with sudden sensorineural hearing loss:a systematic reviewand meta-analysis[J]. JAMA Otolarygol Head Neck Surg, 2018,144:677-683.
[4]陈海英,缪亚琴.尼麦角林联合天麻治疗后循环缺血性眩晕31例疗效观察[J].北方药学, 2016, 13:29.
[5]杨清,高鹏,郭振鑫,等.天麻活血汤联合西药治疗风痰瘀阻型后循环缺血性眩晕40例[J].中医研究, 2016, 29:18-20.
[6]于峰.氟桂利嗪联合银杏达莫治疗老年后循环缺血性眩晕的疗效[J].中国老年学杂志, 2012, 32:1172-1173.
[7]单希征.眩晕的精准治疗[J].北京医学, 2017, 39:755-757.
[8]刘博,韩德民,张祎,等.伴有眩晕或头晕的突发性聋患者的临床疗效分析[J].中华耳鼻喉头颈外科杂志, 2015, 50:463-467.
[9]姜桂菊.探析薄芝糖肽注射液在肾小球肾炎治疗的有效观察[J].中国继续医学教育, 2015, 7:225-226.
[10]张雯雯,张莉,王淑芳,等.薄芝糖肽治疗前庭性眩晕的疗效分析[J].中国耳鼻喉颅底外科杂志, 2015, 106:313-316.
[11] Lacour M. Betahistine treatment in managing vertigo and improvingvestibular compensation clarification[J]. J Vestib Res, 2013, 23:139-151.
[2]中国突发性聋多中心临床研究协作组.中国突发性聋分型治疗的多中心临床研究[J].中华耳鼻喉头颈外科杂志, 2013, 48:355-361.
[3] Yu H, Li H. Association of vertigo with hearing outcomes in pa-tients with sudden sensorineural hearing loss:a systematic reviewand meta-analysis[J]. JAMA Otolarygol Head Neck Surg, 2018,144:677-683.
[4]陈海英,缪亚琴.尼麦角林联合天麻治疗后循环缺血性眩晕31例疗效观察[J].北方药学, 2016, 13:29.
[5]杨清,高鹏,郭振鑫,等.天麻活血汤联合西药治疗风痰瘀阻型后循环缺血性眩晕40例[J].中医研究, 2016, 29:18-20.
[6]于峰.氟桂利嗪联合银杏达莫治疗老年后循环缺血性眩晕的疗效[J].中国老年学杂志, 2012, 32:1172-1173.
[7]单希征.眩晕的精准治疗[J].北京医学, 2017, 39:755-757.
[8]刘博,韩德民,张祎,等.伴有眩晕或头晕的突发性聋患者的临床疗效分析[J].中华耳鼻喉头颈外科杂志, 2015, 50:463-467.
[9]姜桂菊.探析薄芝糖肽注射液在肾小球肾炎治疗的有效观察[J].中国继续医学教育, 2015, 7:225-226.
[10]张雯雯,张莉,王淑芳,等.薄芝糖肽治疗前庭性眩晕的疗效分析[J].中国耳鼻喉颅底外科杂志, 2015, 106:313-316.
[11] Lacour M. Betahistine treatment in managing vertigo and improvingvestibular compensation clarification[J]. J Vestib Res, 2013, 23:139-151.