摘要
周细胞与内皮细胞、星形胶质细胞以及胞外间隙共同构成血脑屏障(BBB),周细胞与内皮细胞通过各种机制通路参与多种BBB的功能调节,共同维持神经血管单元(NVU)的稳定。NVU的损伤与修复涉及诸多分子水平的信号传递。血管生成主要是内皮细胞的发生成熟和周细胞的支持黏附过程。本文主要就目前NVU缺血损伤后周细胞与内皮细胞相关的血管生成信号通路研究进行综述。
Pericytes, endothelial cells(EC), astrocytes and extracellular space together constitute the blood-brain barrier. Pericytes and EC participate in the various regulations of blood-brain barriers through many mechanisms to maintain the stability of neurovascular units(NVU). The injury and repair of NVU involve a lot of signal transduction at molecular levels, and angiogenesis is primarily about the generation and maturation of EC and the supporting adhesion process of pericytes.This article briefly reviewed EC-related angiogenesis signaling pathways in pericytes after NVU ischemic injury.
引文
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