体质量指数对青少年24 h眼压波动的影响
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摘要
目的探讨体质量指数(body mass index,BMI)对青少年24 h眼压波动的影响。方法本研究共纳入90名健康青少年。采用Goldmann压平式眼压计测量受试者24 h眼压波动(5∶00 am、7∶00 am、10∶00 am、2∶00 pm、6∶00 pm、10∶00 pm)。BMI通过体质量(kg)除以身高(m)的平方计算。根据BMI将受试者分为低体质量及正常组(BMI<25 kg·m~(-2))50人,超重组(25 kg·m~(-2)≤BMI<30 kg·m~(-2))22人和肥胖组(BMI≥30 kg·m~(-2))18人。使用SPSS 22.0统计软件对测量值进行统计学分析。结果所有观察对象平均眼压、眼压峰值、眼压谷值和眼压波动值分别为(16.72±3.30)mm Hg(1 k Pa=7.5 mm Hg)、(19.26±3.68)mm Hg、(14.29±3.26)mm Hg和(4.98±1.91)mm Hg。3组间眼压波动值差异比较无统计学意义(均为P>0.05)。低体质量及正常组与肥胖组间平均眼压、眼压峰值和眼压谷值差异比较有统计学意义(均为P<0.05),而低体质量及正常组与超重组、超重组与肥胖组差异比较无统计学意义(均为P>0.05)。Pearson相关分析结果显示,BMI与平均眼压、眼压峰值呈显著正相关(P<0.05)。结论在青少年人群中,BMI较高者具有更高的平均眼压、眼压峰值。
Objective To investigate the effects of body mass index( BMI) on 24-hour intraocular pressure( IOP) fluctuations in adolescences. Methods Totally 90 healthy adolescences were included in the study. Measurements of 24-hour IOP were obtained by Goldmann applanation tonometer on 5∶00 am,7∶00 am,10∶00 am,2∶00 pm,6∶00 pm and 10∶00 pm.BMI was calculated as weight in kilograms divided by the square of height in meters( kg ·m~(-2)). The patients were divided into three groups according to BMI,and they were Group 1( BMI < 25 kg·m~(-2)),Group 2( 25≤BMI < 30 kg·m~(-2)),Group 3( BMI≥30 kg·m~(-2)). Data were analyzed by statistic software SPSS 22. 0. Results The mean of IOP,peak IOP,valley IOP and fluctuation value of IOP were( 16. 72 ± 3. 30) mm Hg( 1 k Pa = 7. 5 mm Hg),( 19. 26 ±3. 68) mm Hg,( 14. 29 ± 3. 26) mm Hg and( 4. 98 ± 1. 91) mm Hg,respectively. And there was no significant differences in the fluctuation value of IOP among the three groups( all P > 0. 05); the differences in mean IOP,peak IOP,valley IOP between group 1 and group 3 were significant( all P < 0. 05). However,the differences between group 1 and group 2,group 2 and group 3 showed no significant differences( all P > 0. 05). Pearson correlation analysis showed that BMI was positively correlated with mean IOP and peak IOP( both P < 0. 05). Conclusion In the adolescent population,individuals with higher BMI tend to have higher mean IOP and peak IOP.
Objective To investigate the effects of body mass index( BMI) on 24-hour intraocular pressure( IOP) fluctuations in adolescences. Methods Totally 90 healthy adolescences were included in the study. Measurements of 24-hour IOP were obtained by Goldmann applanation tonometer on 5∶00 am,7∶00 am,10∶00 am,2∶00 pm,6∶00 pm and 10∶00 pm.BMI was calculated as weight in kilograms divided by the square of height in meters( kg ·m~(-2)). The patients were divided into three groups according to BMI,and they were Group 1( BMI < 25 kg·m~(-2)),Group 2( 25≤BMI < 30 kg·m~(-2)),Group 3( BMI≥30 kg·m~(-2)). Data were analyzed by statistic software SPSS 22. 0. Results The mean of IOP,peak IOP,valley IOP and fluctuation value of IOP were( 16. 72 ± 3. 30) mm Hg( 1 k Pa = 7. 5 mm Hg),( 19. 26 ±3. 68) mm Hg,( 14. 29 ± 3. 26) mm Hg and( 4. 98 ± 1. 91) mm Hg,respectively. And there was no significant differences in the fluctuation value of IOP among the three groups( all P > 0. 05); the differences in mean IOP,peak IOP,valley IOP between group 1 and group 3 were significant( all P < 0. 05). However,the differences between group 1 and group 2,group 2 and group 3 showed no significant differences( all P > 0. 05). Pearson correlation analysis showed that BMI was positively correlated with mean IOP and peak IOP( both P < 0. 05). Conclusion In the adolescent population,individuals with higher BMI tend to have higher mean IOP and peak IOP.
引文
[1]HASLAM DW,JAMES WP.Obesity[J].Lancet,2005,366(9492):1197-1209.
[2]CHEUNG N,WONG TY.Obesity and eye diseases[J].Surv Ophthalmol,2007,52(2):180-195.
[3]KWON YH,FINGERT JH,KUEHN MH,ALWARD WL.Primary open-angle glaucoma[J].N Engl J Med,2009,360(11):1113-1124.
[4]QUIGLEY HA,BROMAN AT.The number of people with glaucoma worldwide in 2010 and 2020[J].Br J Ophthalmol,2006,90(3):262-267.
[5]MORI K,ANDO F,NOMURA H,SATO Y,SHIMOKATA H.Relationship between intraocular pressure and obesity in Japan[J].Int J Epidemiol,2000,29(4):661-666.
[6]ZHENG Y,CHEUNG CY,WONG TY,MITCHELL P,AUNG T.Influence of height,weight,and body mass index on optic disc parameters[J].Invest Ophthalmol Vis Sci,2010,51(6):2998-3002.
[7]YOSHIDA M,ISHIKAWA M,KARITA K,KOKAZE A,HARADA M,TAKE S,et al.Association of blood pressure and body mass index with intraocular pressure in middle-aged and older Japanese residents:a cross-sectional and longitudinal study[J].Acta Med Okayama,2014,8(1):27-34.
[8]WANG YX,XU L,ZHANG XH,YOU QS,ZHAO L,JONAS JB.Five-year change in intraocular pressure associated with changes in arterial blood pressure and body mass index.The Beijing Eye Study[J].PLo S One,2013,8(10):e77180.
[9]AKINCI A,CETINKAYA E,AYCAN Z,ONER O.Relationship between intraocular pressure and obesity in children[J].J Glaucoma,2007,16(7):627-630.
[10]KARADAG R,ARSLANYILMAZ Z,AYDIN B,HEPSEN IF.Effects of body mass index on intraocular pressure and ocular pulse amplitude[J].Int J Ophthalmol,2012,5(5):605-608.
[11]TZAMALOUKAS AH,MURATA GH,HOFFMAN RM,SCHMIDT DW,HILL JE,LEGER A,et al.Classification of the degree of obesity by body mass index or by deviation from ideal weight[J].J Parenter Enteral Nutr,2003,27(5):340-348.
[12]Ophthalmology Branch of Beijing Medical Association.Discussion about monitoring standards of 24-hour intraocular pressure[J].Chin J Ophthalmol,2014,50(5):384-385.北京医学会眼科学分会.关于24 h眼压监测规范的探讨[J].中华眼科杂志,2014,50(5):384-385.
[13]COLE TJ,BELLIZZI MC,FLEGAL KM,DIETZ WH.Establishing a standard definition for child overweight and obesity worldwide:international survey[J].BMJ,2000,320(7244):1240-1243.
[14]ALBUQUERQUE LL,GAETE MI,FIGUEIROA JN,ALVES JG.The correlation between body mass index and intraocular pressure in children[J].Arq Bras Oftalmol,2013,76(1):10-12.
[15]STOJANOV O,STOKIC E,SVELJO O,NAUMOVIC N.The influence of retrobulbar adipose tissue volume upon intraocular pressure in obesity[J].Vojnosanit Pregl,2013,70(5):469-476.
[16]HAN YS,LEE JW,LEE JS.Intraocular pressure and influencing systemic health parameters in a Korean population[J].Indian J Ophthalmol,2014,62(3):305-310.
[17]BULPITT CJ,HODES C,EVERITT MG.Intraocular pressure and systemic blood pressure in the elderly[J].Br J Ophthalmol,1975,59(12):717-720.
[18]OH SW,LEE S,PARK C,KIM DJ.Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome[J].Diabetes Metab Res Rev,2005,21(5):434-440.
[2]CHEUNG N,WONG TY.Obesity and eye diseases[J].Surv Ophthalmol,2007,52(2):180-195.
[3]KWON YH,FINGERT JH,KUEHN MH,ALWARD WL.Primary open-angle glaucoma[J].N Engl J Med,2009,360(11):1113-1124.
[4]QUIGLEY HA,BROMAN AT.The number of people with glaucoma worldwide in 2010 and 2020[J].Br J Ophthalmol,2006,90(3):262-267.
[5]MORI K,ANDO F,NOMURA H,SATO Y,SHIMOKATA H.Relationship between intraocular pressure and obesity in Japan[J].Int J Epidemiol,2000,29(4):661-666.
[6]ZHENG Y,CHEUNG CY,WONG TY,MITCHELL P,AUNG T.Influence of height,weight,and body mass index on optic disc parameters[J].Invest Ophthalmol Vis Sci,2010,51(6):2998-3002.
[7]YOSHIDA M,ISHIKAWA M,KARITA K,KOKAZE A,HARADA M,TAKE S,et al.Association of blood pressure and body mass index with intraocular pressure in middle-aged and older Japanese residents:a cross-sectional and longitudinal study[J].Acta Med Okayama,2014,8(1):27-34.
[8]WANG YX,XU L,ZHANG XH,YOU QS,ZHAO L,JONAS JB.Five-year change in intraocular pressure associated with changes in arterial blood pressure and body mass index.The Beijing Eye Study[J].PLo S One,2013,8(10):e77180.
[9]AKINCI A,CETINKAYA E,AYCAN Z,ONER O.Relationship between intraocular pressure and obesity in children[J].J Glaucoma,2007,16(7):627-630.
[10]KARADAG R,ARSLANYILMAZ Z,AYDIN B,HEPSEN IF.Effects of body mass index on intraocular pressure and ocular pulse amplitude[J].Int J Ophthalmol,2012,5(5):605-608.
[11]TZAMALOUKAS AH,MURATA GH,HOFFMAN RM,SCHMIDT DW,HILL JE,LEGER A,et al.Classification of the degree of obesity by body mass index or by deviation from ideal weight[J].J Parenter Enteral Nutr,2003,27(5):340-348.
[12]Ophthalmology Branch of Beijing Medical Association.Discussion about monitoring standards of 24-hour intraocular pressure[J].Chin J Ophthalmol,2014,50(5):384-385.北京医学会眼科学分会.关于24 h眼压监测规范的探讨[J].中华眼科杂志,2014,50(5):384-385.
[13]COLE TJ,BELLIZZI MC,FLEGAL KM,DIETZ WH.Establishing a standard definition for child overweight and obesity worldwide:international survey[J].BMJ,2000,320(7244):1240-1243.
[14]ALBUQUERQUE LL,GAETE MI,FIGUEIROA JN,ALVES JG.The correlation between body mass index and intraocular pressure in children[J].Arq Bras Oftalmol,2013,76(1):10-12.
[15]STOJANOV O,STOKIC E,SVELJO O,NAUMOVIC N.The influence of retrobulbar adipose tissue volume upon intraocular pressure in obesity[J].Vojnosanit Pregl,2013,70(5):469-476.
[16]HAN YS,LEE JW,LEE JS.Intraocular pressure and influencing systemic health parameters in a Korean population[J].Indian J Ophthalmol,2014,62(3):305-310.
[17]BULPITT CJ,HODES C,EVERITT MG.Intraocular pressure and systemic blood pressure in the elderly[J].Br J Ophthalmol,1975,59(12):717-720.
[18]OH SW,LEE S,PARK C,KIM DJ.Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome[J].Diabetes Metab Res Rev,2005,21(5):434-440.