扶正祛邪方治疗病毒性脑炎的疗效及对脑脊液神经元烯醇化酶、脑血流指标水平的影响
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摘要
目的:研究扶正祛邪方治疗病毒性脑炎的疗效及对脑脊液神经元烯醇化酶NSE、脑血流指标水平的影响。方法:病毒性脑炎患者74例,根据治疗方法不同分为对照组和观察组。对照组患者采用常规治疗,观察组患者采用常规治疗+扶正祛邪方治疗,分析两组患者治疗后的临床效果。结果:观察组患者治疗后发热、头晕头疼、呕吐、抽搐及意识障碍持续时间均短于对照组,脑电图分级情况优于对照组差异有统计学意义(P<0.05)。治疗前,两组患者脑脊液蛋白定量、NSE、S-100β、CRP水平及大脑前、后动脉血流指标水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者蛋白定量、NSE、S-100β、CRP水平及大脑前、后动脉血流指标水平低于对照组,差异有统计学意义(P<0.05)。结论:扶正祛邪方治疗病毒性脑炎可缩短临床症状持续时间,降低脑脊液中NSE、S-100β、CRP的表达水平,改善患者脑血流状态。
Objective:To study the effect of Fuzheng Quxie Recipe on the level and effect of neuronal enolase(NSE) in cerebrospinal fluid(CSF) and cerebral blood flow(CBF) in patients with viral encephalitis. Methods:74 patients with viral encephalitis were divided into control group and observation group. The patients in the control group were treated with routine therapy and those in the observation group were treated with Fuzheng Quxie Recipe and the clinical effects of the two groups were analyzed. Results:The duration of fever, dizziness, vomiting, convulsion and disturbance of consciousness in the observation group was shorter than those in the control group, and the EEG grading was better than that in the control group(P<0.05). Before treatment, there was no significant difference between the two groups in cerebrospinal fluid protein(CSF) protein quantification,the levels of NSES-100 β-CRP,the blood flow index of the anterior or posterior cerebral arteries(P>0.05). After treatment, the levels of NSES-100 β-CRP and the blood flow index of the anterior and posterior arteries in the observation group were lower than those in the control group(P<0.05). Conclusion:The treatment of viral encephalitis with Fuzheng Quxie Recipe can shorten the duration of clinical symptoms, reduce the expression of NSES-100 β-CRP in cerebrospinal fluid and improve the cerebral blood flow status of patients with viral encephalitis.
Objective:To study the effect of Fuzheng Quxie Recipe on the level and effect of neuronal enolase(NSE) in cerebrospinal fluid(CSF) and cerebral blood flow(CBF) in patients with viral encephalitis. Methods:74 patients with viral encephalitis were divided into control group and observation group. The patients in the control group were treated with routine therapy and those in the observation group were treated with Fuzheng Quxie Recipe and the clinical effects of the two groups were analyzed. Results:The duration of fever, dizziness, vomiting, convulsion and disturbance of consciousness in the observation group was shorter than those in the control group, and the EEG grading was better than that in the control group(P<0.05). Before treatment, there was no significant difference between the two groups in cerebrospinal fluid protein(CSF) protein quantification,the levels of NSES-100 β-CRP,the blood flow index of the anterior or posterior cerebral arteries(P>0.05). After treatment, the levels of NSES-100 β-CRP and the blood flow index of the anterior and posterior arteries in the observation group were lower than those in the control group(P<0.05). Conclusion:The treatment of viral encephalitis with Fuzheng Quxie Recipe can shorten the duration of clinical symptoms, reduce the expression of NSES-100 β-CRP in cerebrospinal fluid and improve the cerebral blood flow status of patients with viral encephalitis.
引文
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[2] 潘可达,方慧,郑默,等.大剂量丙种球蛋白对病毒性脑炎患者脑脊液中血清神经功能指标及相关炎症因子表达水平的影响[J].中华医院感染学杂志,2017,27(9):1929-1932.
[3] 沈月红,汪娅蓓,汪永胜,等.符为民教授开窍化痰通瘀法治疗病毒性脑炎后遗症经验[J].浙江中医药大学学报,2017,41(8):682-684.
[4] 中华医学会.临床诊疗指南-神经病学分册[M].北京:人民卫生出版社,2010:125.
[5] 赵传丽.神经节苷脂联合更昔洛韦对病毒性脑炎患者血清及脑脊液指标影响的研究[J].神经损伤与功能重建,2017,12(2):159-160.
[6] Mohammadzadeh I,Noei S,Babazadeh K,et al.Comparison of early and late intravenous gamma globulin treatment of kawasaki disease on fever and cardiovascular complications[J].Caspian J Intern Med,2016,7(3):211-216.
[7] 申辛欣,马学军.病毒性脑炎脑膜炎症候群病原学研究进展[J].中华实验和临床病毒学杂志,2017,31(1):75-78.
[8] Muller WJ.Treatment of perinatal viral infections to improve neurologic outcomes[J].Pediatr Res,2017,35(81):162-169.
[9] 肖喜庆.喜炎平注射液联合清热解毒合剂治疗手足口病合并脑炎患儿疗效观察[J].北方药学,2017,14(9):118-119.
[10] 王英旭,刘智,牛兰清,等.小儿癫痫散验案举隅[J].山西中医,2017,33(12):35-36.
[11] 高峰,聂莹雪.自拟扶正祛邪方联合西药治疗病毒性脑炎的临床观察[J].中国中医急症,2016,25(6):1253-1255.
[12] 董民,李玉卿.清热解毒法治疗轻型、普通型流行性乙型脑炎的临床观察[J].临床研究,2016,24(10):174-175.
[13] 王光明,李绍林,蔡琳,等.石菖蒲对慢性应激小鼠记忆的影响及其机制[J].实用医学杂志,2017,33(16):2650-2652.
[14] 高鑫,杨志仙,薛姣,等.儿童抗N-甲基-D-天冬氨酸受体脑炎的脑电图特征[J].中华儿科杂志,2016,54(3):192-196.
[15] 黄日荷,汪渊,吴巧云,等.感染性脑炎患儿脑电图对预后评价的临床研究[J].中华医院感染学杂志,2016,26(11):2599-2601.
[16] 杨柳,张义生,徐惠芳等.矿物类中药石膏清热作用研究进展[J].中国药师,2016,19(10):1943-1945.
[17] 卢蓉,赵力芳,贾鲲鹏,等.小儿病毒性脑炎患儿心肌酶谱、血浆超敏 C 反应蛋白和胱抑素 C 水平变化及其临床意义[J].实用心脑肺血管病杂志,2016,24(7):77-80.
[18] 赵秋菊,张晓红,赵玉歧,等.小儿肺炎支原体脑炎和病毒性脑炎血清NSE、S100-B水平比较分析[J].母婴世界,2016,6(19):21-23.
[19] 柴巧利.手足口病并发脑炎患儿血清NSE、S100β含量与炎症反应、免疫应答的相关性[J].海南医学院学报,2017,23(13):1815-1818.
[20] 季梅.基于明清医著数据挖掘的温病养阴药及其组方运用规律研究[D].南京:南京中医药大学,2016.
[21] 臧泽林,祝瑞,雷霆.醒脑静注射液对病毒性脑炎患者脑血流状态的影响[J].实用心脑肺血管病杂志,2016,24(10):88-90.
[22] 刘翠翠,陈诗赟,朴月善,等.难治性癫痫相关脑炎的临床病理学观察[J].中华病理学杂志,2016,45(5):318-323.