地佐辛在学龄前儿童全麻下部分睫毛切除术中的应用效果及对苏醒期躁动的影响
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摘要
目的:探讨地佐辛在学龄前儿童全麻下部分睫毛切除术中的应用效果及对苏醒期躁动的影响。方法:选取笔者医院2016年1月-2017年12月收治的110例拟实施全麻术下部分睫毛切除术治疗的倒睫患儿,采用随机数字表法分为研究组(手术结束前10min给予地佐辛0.1mg/kg静滴)和对照组(给予等量生理盐水),每组55例。对比两组拔管前后不同时间点的心率(HR)、平均动脉压(MAP)及术后不同时间点患儿苏醒期躁动评分。结果:研究组HR测定值T1～T2时刻均较T0时刻升高,MAP测定值T1时刻高于T0时刻,且HR、MAP测定值T0～T3时刻均显著低于对照组,差异均有统计学意义(P<0.05)。拔管前、拔管后10min、拔管后30min、拔管后60min,研究组患儿躁动评分均显著低于对照组,差异有统计学意义(P<0.05)。结论:全麻术下部分睫毛切除术治疗学龄前儿童倒睫术中应用地佐辛有利于维持患儿拔管期血流动力学稳定、减轻苏醒期患儿躁动。
Objective To explore the effect of dizocine in partial eyelash resection under pre-school children under general anesthesia and its effect on wakefulness. Methods Selected 110 patients with trichiasis who were treated with partial eyelash resection under general anesthesia from January 2016 to December 2017. The randomized digital table method was divided into the study group(0.1 mg/kg intravenous infusion of dextrozine 10 min before the end of surgery) and the control group(administered with the same amount of normal saline), 55 patients in each group. The heart rate(HR), mean arterial pressure(MAP) at different time points before and after extubation, and the agitation scores of the children at different time points after operation were compared. Results The HR values at T1-T2 were higher than those at T0, and MAP values at T1 were higher than those at T0, HR and MAP values at T0-T3 were signi? cantly lower in the study group than those in the control group, the differences were statistically signi? cant(P<0.05). Before extubation, 10 minutes after extubation, 30 minutes after extubation and 60 minutes after extubation, the scores of restlessness in the study group were significantly lower than those in the control group(P <0.05). Conclusion Partial eyelash resection under general anesthesia for the treatment of preschool children with trichiasis in the treatment of diazepam is bene? cial to maintain hemodynamic stability during the extubation period and reduce the agitation of children in the recovery period.
Objective To explore the effect of dizocine in partial eyelash resection under pre-school children under general anesthesia and its effect on wakefulness. Methods Selected 110 patients with trichiasis who were treated with partial eyelash resection under general anesthesia from January 2016 to December 2017. The randomized digital table method was divided into the study group(0.1 mg/kg intravenous infusion of dextrozine 10 min before the end of surgery) and the control group(administered with the same amount of normal saline), 55 patients in each group. The heart rate(HR), mean arterial pressure(MAP) at different time points before and after extubation, and the agitation scores of the children at different time points after operation were compared. Results The HR values at T1-T2 were higher than those at T0, and MAP values at T1 were higher than those at T0, HR and MAP values at T0-T3 were signi? cantly lower in the study group than those in the control group, the differences were statistically signi? cant(P<0.05). Before extubation, 10 minutes after extubation, 30 minutes after extubation and 60 minutes after extubation, the scores of restlessness in the study group were significantly lower than those in the control group(P <0.05). Conclusion Partial eyelash resection under general anesthesia for the treatment of preschool children with trichiasis in the treatment of diazepam is bene? cial to maintain hemodynamic stability during the extubation period and reduce the agitation of children in the recovery period.
引文
[1]王越.皮肤眼轮匝肌切除联合睫毛外翻褥式缝合矫正儿童下睑倒睫的疗效观察[J].眼科,2017,3(6):404-408.
[2]马涛,翁瑞,郑永生,等.内眦皮肤重置法对伴有内眦赘皮的下睑倒睫患者的矫治效果[J].中华医学杂志,2016,96(36):2906-2908.
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[4]章艳君,李榕,刘金柱.不同剂量地佐辛对小儿七氟醚复合麻醉苏醒期躁动的影响[J].重庆医学,2016,7(1):74-76.
[5]纪怀珠,欧阳碧山,宁巧明.地佐辛预防小儿全身麻醉苏醒期躁动的临床研究[J].中国现代医学杂志,2017,27(17):108-112.
[6]罗林,张越茗,李美胜,等.右美托咪定对儿童牙科日间全麻手术苏醒期躁动的影响[J].华西口腔医学杂志,2017,35(6):613-617.
[7]曾晓燕,李正芬.丙泊酚预防小儿全麻术后苏醒期躁动的剂量探讨[J].山东医药,2017,57(33):96-97.
[8]张磊,吴裕超.不同浓度七氟醚喉罩吸入联合瑞芬太尼应用于新生儿麻醉的效果分析[J].重庆医学,2016,45(36):5161-5163.
[9]李颖,李翔,罗欢,等.基因多态性对阿片类药物疼痛治疗影响的研究进展[J].中国医院药学杂志,2018,8(2):203-208.
[10]曾彦茹,佘守章,黄宇光.阿片类药物地佐辛临床应用研究现状[J].广东医学,2018,5(1):6-9.
[11]赵保建,董迎春,王新河,等.诱导前给予地佐辛对口腔癌患者术后镇痛效果的影响[J].临床麻醉学杂志,2016,32(11):1073-1075.
[12]丁翠青,刘志永.地佐辛超前应用对瑞芬太尼复合全身麻醉患者术后躁动的疗效分析[J].重庆医学,2016,45(5):680-682.
[13]胡铮,王建设,赵龙德,等.地佐辛对小儿腹腔镜阑尾术后苏醒及镇痛的影响[J].中国内镜杂志,2016,22(7):22-25.
[14]李富强,邸海鹏,戴云.术中应用地佐辛对气管拔管时血流动力学影响的观察[J].现代中西医结合杂志,2013,22(29):3270-3272.
[15]Hatzichristodoulou G.Partial plaque excision and grafting with collagen?eece in peyronie disease[J].J Sex Med,2016,13(2):277-281.
[2]马涛,翁瑞,郑永生,等.内眦皮肤重置法对伴有内眦赘皮的下睑倒睫患者的矫治效果[J].中华医学杂志,2016,96(36):2906-2908.
[3]倪如飞,刘吉平,黄海文,等.右美托咪定预防儿童全麻苏醒期躁动和谵妄的安全有效剂量[J].广东医学,2017,38(11):1750-1753.
[4]章艳君,李榕,刘金柱.不同剂量地佐辛对小儿七氟醚复合麻醉苏醒期躁动的影响[J].重庆医学,2016,7(1):74-76.
[5]纪怀珠,欧阳碧山,宁巧明.地佐辛预防小儿全身麻醉苏醒期躁动的临床研究[J].中国现代医学杂志,2017,27(17):108-112.
[6]罗林,张越茗,李美胜,等.右美托咪定对儿童牙科日间全麻手术苏醒期躁动的影响[J].华西口腔医学杂志,2017,35(6):613-617.
[7]曾晓燕,李正芬.丙泊酚预防小儿全麻术后苏醒期躁动的剂量探讨[J].山东医药,2017,57(33):96-97.
[8]张磊,吴裕超.不同浓度七氟醚喉罩吸入联合瑞芬太尼应用于新生儿麻醉的效果分析[J].重庆医学,2016,45(36):5161-5163.
[9]李颖,李翔,罗欢,等.基因多态性对阿片类药物疼痛治疗影响的研究进展[J].中国医院药学杂志,2018,8(2):203-208.
[10]曾彦茹,佘守章,黄宇光.阿片类药物地佐辛临床应用研究现状[J].广东医学,2018,5(1):6-9.
[11]赵保建,董迎春,王新河,等.诱导前给予地佐辛对口腔癌患者术后镇痛效果的影响[J].临床麻醉学杂志,2016,32(11):1073-1075.
[12]丁翠青,刘志永.地佐辛超前应用对瑞芬太尼复合全身麻醉患者术后躁动的疗效分析[J].重庆医学,2016,45(5):680-682.
[13]胡铮,王建设,赵龙德,等.地佐辛对小儿腹腔镜阑尾术后苏醒及镇痛的影响[J].中国内镜杂志,2016,22(7):22-25.
[14]李富强,邸海鹏,戴云.术中应用地佐辛对气管拔管时血流动力学影响的观察[J].现代中西医结合杂志,2013,22(29):3270-3272.
[15]Hatzichristodoulou G.Partial plaque excision and grafting with collagen?eece in peyronie disease[J].J Sex Med,2016,13(2):277-281.