大孔硼酸亲和材料的制备及其对左旋多巴的分离纯化性能研究
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摘要
利用两步种球溶胀法制备带环氧基团的大孔树脂,将3-氨基苯硼酸修饰在大孔树脂表面,得到大孔硼酸亲和材料P_(GMA-HEMA-EGDMA)@APBA。使用扫描电镜,红外光谱对所制备材料进行表征,并通过静态吸附、动态吸附考察其吸附性能。结果表明,硼酸亲和材料对左旋多巴的最大吸附容量可达22.81μmol/g,具有较好的特异性吸附能力。动力学显示,材料对左旋多巴的吸附在50 min内迅速达到平衡,吸附行为符合准二级动力学方程。吸附等温线研究表明,实验数据拟合更符合Langmuir吸附等温模型,且吸附过程为放热。硼酸亲和材料对猫豆中左旋多巴的回收率可达88.9%,再生性能良好,有望应用于左旋多巴的分离与纯化。
The two-step seeded swelling polymerization was used to prepare epoxy macroporous resin,epoxy resin were modified with 3-aminophenylboronic acid( APBA),so that the macroporous boronic acid affinity materials P_(GMA-HEMA-EGDMA)@APBA was gained. The composite material was characterized by Fourier transform infrared( FT-IR) spectroscopy and scanning electron microscope( SEM),and the adsorption performance was investigated by static adsorption and dynamic adsorption. The results showed that the maximum adsorption capacity of levodopa on boronate affinity materials was22. 81μmol/g,and the boronate affinity materials exhibited good specific adsorption capacity. Kinetic studies showed that the boronate affinity materials could adsorb levodopa rapidly and reached the equilibrium in 50 min,the adsorption behavior could be described by the pseuso-second-order kinetic model. The adsorption iso-therms data indicated that the experimental data fit well with the Langmuir isotherm model,and the process is exothermic. The removal rate of levodopa by boronate affinity materials could reach 88. 9% in the seed of stizolobium,and the regeneration property is favorable,so it could be used for the separation and purification of levodopa.
The two-step seeded swelling polymerization was used to prepare epoxy macroporous resin,epoxy resin were modified with 3-aminophenylboronic acid( APBA),so that the macroporous boronic acid affinity materials P_(GMA-HEMA-EGDMA)@APBA was gained. The composite material was characterized by Fourier transform infrared( FT-IR) spectroscopy and scanning electron microscope( SEM),and the adsorption performance was investigated by static adsorption and dynamic adsorption. The results showed that the maximum adsorption capacity of levodopa on boronate affinity materials was22. 81μmol/g,and the boronate affinity materials exhibited good specific adsorption capacity. Kinetic studies showed that the boronate affinity materials could adsorb levodopa rapidly and reached the equilibrium in 50 min,the adsorption behavior could be described by the pseuso-second-order kinetic model. The adsorption iso-therms data indicated that the experimental data fit well with the Langmuir isotherm model,and the process is exothermic. The removal rate of levodopa by boronate affinity materials could reach 88. 9% in the seed of stizolobium,and the regeneration property is favorable,so it could be used for the separation and purification of levodopa.
引文
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