中国早泄患者与健康男性的性激素水平比较
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摘要
目的了解中国早泄(PE)患者的性激素水平。方法对156例原发性PE组患者和76例健康对照组人群给予性激素检测,并填写早泄诊断工具(PEDT)和中国早泄患者性功能评价表-5(CIPE-5)量表,比较PE组患者与健康对照组的性激素水平差异。结果 PE组与对照组相比,PEDT评分和CIPE-5评分均有统计学差异(P<0.001);与对照组相比,PE组及轻、中、重度PE患者的游离睾酮水平显著增高,均有统计学意义(P<0.05);两组间雌二醇、总睾酮、促黄体生成素、促卵泡生成素、孕酮和催乳素水平无显著统计学差异;PE各组间性激素均无统计学差异。结论原发性PE患者具有较高的游离睾酮水平,游离睾酮可能在PE的发生、发展中发挥重要作用,但具体的作用形式仍需进一步研究。
Objective To investigate the sexual hormone levels in Chinese patients with premature ejaculation(PE).Methods Sexual hormones were detected in 156 primary PE patients and 76 healthy controls,who also filled in the PEDT and CIPE-5 scales.The differences in sexual hormones were compared between PE patients and healthy controls.Results There were significant differences in the scores of PEDT and CIPE-5 between PE patients and healthy controls(P<0.001).Free testosterone level was significantly higher in PE group than in the control group(P<0.05).There were no significant statistical differences in estradiol,total testosterone,luteinizing hormone,follicle stimulating hormone,progesterone or prolactin levels between the two groups.There were no significant differences in the sexual hormones among the different PE groups.Conclusion Primary PE patients have higher level of free testosterone,indicating that free testosterone may play an important role in the occurrence and development of PE,but the underlying mechanism still needs further research.
Objective To investigate the sexual hormone levels in Chinese patients with premature ejaculation(PE).Methods Sexual hormones were detected in 156 primary PE patients and 76 healthy controls,who also filled in the PEDT and CIPE-5 scales.The differences in sexual hormones were compared between PE patients and healthy controls.Results There were significant differences in the scores of PEDT and CIPE-5 between PE patients and healthy controls(P<0.001).Free testosterone level was significantly higher in PE group than in the control group(P<0.05).There were no significant statistical differences in estradiol,total testosterone,luteinizing hormone,follicle stimulating hormone,progesterone or prolactin levels between the two groups.There were no significant differences in the sexual hormones among the different PE groups.Conclusion Primary PE patients have higher level of free testosterone,indicating that free testosterone may play an important role in the occurrence and development of PE,but the underlying mechanism still needs further research.
引文
[1]MERCER CH,FENTON KA,JOHNSON AM,et al.Sexual function problems and help seeking behaviour in Britain:national,probability sample survey[J].BMJ,2003,327(7412):426-427.
[2]SEREFOGLU EC,SAITZ TR.New insights on premature ejaculation:a review of definition,classification,prevalence and treatment[J].Asian J Androl,2012,14(6):822-829.
[3]GAO J,ZHANG X,SU P,et al.Prevalence and factors associated with the complaint of premature ejaculation and the four premature ejaculation syndromes:a large observational study in China[J].J Sex Med,2013,10(7):1874-1881.
[4]PORST H,R0SEN RC,GAYNOR L,et al.The premature ejaculation prevalence and attitudes(pepa)survey:prevalence,comorbidities,and professional help-seeking[J].Eur Urol,2007,51(3):816-823.
[5]SYMONDS T,ROBLIN D,HART K,et al.How does premature ejaculation impact a man s life?[J].J Sex&Marital Therapy,2003,29(5):361-370.
[6]CIHAN A,DEMIR O,DEMIR T,et al.The relationship between premature ejaculation and hyperthyroidism[J].J Urol,2009,181(3):1273-1280.
[7]VIGNOZZI L,CORONA G,PETRONE L,et al.Testosterone and sexual activity[J].J Endocrinol Invest,2005,28(3Suppl):39-44.
[8]SYMONDS T,PERELMAN MA,ALTHOF S,et al.Development and validation of a premature ejaculation diagnostic tool[J].Eur Urol,2007,52(2):565-573.
[9]袁亦铭,辛钟成,金泰乙,等.中国早泄患者性功能评价表对早泄患者的多维评估[J].中国男科学杂志,2003,17(5):302-306.
[10]ALTHOF SE,SYMONDS T.Patient reported outcomes used in the assessment of premature ejaculation[J].Urol Clin North Am,2007,34(4):581-589.
[11]HUANGYP,CHEN B,PING P,et al.The premature ejaculation diagnostic tool(PEDT):linguistic validity of the Chinese version[J].J Sex Med,2015,11(9):2232-2238.
[12]YUAN YM,XIN ZC,JIANG H,et al.Sexual function of premature ejaculation patients assayed with Chinese Index of Premature Ejaculation[J].Asian J Androl,2004,6(2):121-126.
[13]WALDINGER MD,MCLNTOSH J,SCHWEITZER DH.AFive-nation survey to assess the distribution of the intravaginal ejaculatory latency time among the general male population[J].JSex Med,2009,6(10):2888-2895.
[14]MHAOUTY-KODJA S.Role of the androgen receptor in the central nervous system[J].Molec&Cell Endocrinol,2018,465:103-112.
[15]KELETA YB,LUMIA AR,ANDERSON GM,et al.Behavioral effects of pubertal anabolic androgenic steroid exposure in male rats with low serotonin[J].Brain Res,2007,1132(1):129-138.
[16]DE-JONG TR,VEENING JG,OLIVIER B,et al.Oxytocin involvement in SSRI-induced delayed ejaculation:a review of animal studies[J].J Sex Med,2007,4(1):14-28.
[17]WALDINGER MD,SCHWEITZER DH,OLIVIER B.On-demand SSRI treatment of premature ejaculation:pharmacodynamic limitations for relevant ejaculation delay and consequent solutions[J].J Sex Med,2005,2(1):121-131.
[18]MOHSENI MG,HOSSEINI SR,ALIZADEH F,et al.Serum testosterone and gonadotropins levels in patients with premature ejaculation:A comparison with normal men[J].Adv Biomed Res,2014,3(1):6.
[19]CORONA G,JANNINI EA,MANNUCCI E,et al.Different testosterone levels are associated with ejaculatory dysfunction[J].JSex Med,2008,5(8):1991-1998.
[20]HULL EM,DU J,LORRAIN DS,et al.Testosterone,preoptic dopamine,and copulation in male rats[J].Brain Res Bull,1997,44(4):327-333.
[2]SEREFOGLU EC,SAITZ TR.New insights on premature ejaculation:a review of definition,classification,prevalence and treatment[J].Asian J Androl,2012,14(6):822-829.
[3]GAO J,ZHANG X,SU P,et al.Prevalence and factors associated with the complaint of premature ejaculation and the four premature ejaculation syndromes:a large observational study in China[J].J Sex Med,2013,10(7):1874-1881.
[4]PORST H,R0SEN RC,GAYNOR L,et al.The premature ejaculation prevalence and attitudes(pepa)survey:prevalence,comorbidities,and professional help-seeking[J].Eur Urol,2007,51(3):816-823.
[5]SYMONDS T,ROBLIN D,HART K,et al.How does premature ejaculation impact a man s life?[J].J Sex&Marital Therapy,2003,29(5):361-370.
[6]CIHAN A,DEMIR O,DEMIR T,et al.The relationship between premature ejaculation and hyperthyroidism[J].J Urol,2009,181(3):1273-1280.
[7]VIGNOZZI L,CORONA G,PETRONE L,et al.Testosterone and sexual activity[J].J Endocrinol Invest,2005,28(3Suppl):39-44.
[8]SYMONDS T,PERELMAN MA,ALTHOF S,et al.Development and validation of a premature ejaculation diagnostic tool[J].Eur Urol,2007,52(2):565-573.
[9]袁亦铭,辛钟成,金泰乙,等.中国早泄患者性功能评价表对早泄患者的多维评估[J].中国男科学杂志,2003,17(5):302-306.
[10]ALTHOF SE,SYMONDS T.Patient reported outcomes used in the assessment of premature ejaculation[J].Urol Clin North Am,2007,34(4):581-589.
[11]HUANGYP,CHEN B,PING P,et al.The premature ejaculation diagnostic tool(PEDT):linguistic validity of the Chinese version[J].J Sex Med,2015,11(9):2232-2238.
[12]YUAN YM,XIN ZC,JIANG H,et al.Sexual function of premature ejaculation patients assayed with Chinese Index of Premature Ejaculation[J].Asian J Androl,2004,6(2):121-126.
[13]WALDINGER MD,MCLNTOSH J,SCHWEITZER DH.AFive-nation survey to assess the distribution of the intravaginal ejaculatory latency time among the general male population[J].JSex Med,2009,6(10):2888-2895.
[14]MHAOUTY-KODJA S.Role of the androgen receptor in the central nervous system[J].Molec&Cell Endocrinol,2018,465:103-112.
[15]KELETA YB,LUMIA AR,ANDERSON GM,et al.Behavioral effects of pubertal anabolic androgenic steroid exposure in male rats with low serotonin[J].Brain Res,2007,1132(1):129-138.
[16]DE-JONG TR,VEENING JG,OLIVIER B,et al.Oxytocin involvement in SSRI-induced delayed ejaculation:a review of animal studies[J].J Sex Med,2007,4(1):14-28.
[17]WALDINGER MD,SCHWEITZER DH,OLIVIER B.On-demand SSRI treatment of premature ejaculation:pharmacodynamic limitations for relevant ejaculation delay and consequent solutions[J].J Sex Med,2005,2(1):121-131.
[18]MOHSENI MG,HOSSEINI SR,ALIZADEH F,et al.Serum testosterone and gonadotropins levels in patients with premature ejaculation:A comparison with normal men[J].Adv Biomed Res,2014,3(1):6.
[19]CORONA G,JANNINI EA,MANNUCCI E,et al.Different testosterone levels are associated with ejaculatory dysfunction[J].JSex Med,2008,5(8):1991-1998.
[20]HULL EM,DU J,LORRAIN DS,et al.Testosterone,preoptic dopamine,and copulation in male rats[J].Brain Res Bull,1997,44(4):327-333.