羊水HPV感染检测方法及临床意义的研究进展
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摘要
近年来研究发现宫内感染是围生期人乳头瘤病毒(HPV)母婴传播途径之一,以往人们认为HPV是通过胎儿与产道接触而传播的,目前研究发现非经阴道分娩的新生儿仍会感染HPV,由此提出HPV宫内感染的假设。后羊水中检测出HPV DNA进一步证实宫内感染的存在。目前HPV宫内感染的机制主要有血-胎盘途径和上行感染途径,具体机制尚不十分清楚,现应用的羊水HPV检测方法以聚合酶链反应和核酸杂交为基础。HPV感染可能造成不良妊娠结局,并影响婴儿健康。剖宫产能降低新生儿HPV感染率,但是不能有效阻止HPV传播,因此HPV感染不作为剖宫产指征。
In recent years,it is found that intrauterine infection is one of human papilloma virus( HPV) mother-to-fetus transmission in perinatal period. In the past,people thought the HPV is spread by contact with the birth canal. However,it's found that the newborns would be infected with HPV by the non-vaginal delivery,thus it is put forward the hypothesis of HPV intrauterine infection. HPV DNA later detected in amniotic fluid confirms the possibility of intrauterine infection. At present,main mechanisms of HPV intrauterine infection are blood-placenta and ascending infection,while the specific mechanism has not been very clear. Now the application of amniotic fluid HPV detection method is based on polymerase chain reaction and nucleic acid hybridization. HPV infection may cause adverse pregnancy outcomes and can affect the health of the baby. Cesarean section can reduce the infection rate of HPV in newborns,but it cannot effectively prevent the transmission of HPV,so HPV infection is not an indication of cesarean section.
In recent years,it is found that intrauterine infection is one of human papilloma virus( HPV) mother-to-fetus transmission in perinatal period. In the past,people thought the HPV is spread by contact with the birth canal. However,it's found that the newborns would be infected with HPV by the non-vaginal delivery,thus it is put forward the hypothesis of HPV intrauterine infection. HPV DNA later detected in amniotic fluid confirms the possibility of intrauterine infection. At present,main mechanisms of HPV intrauterine infection are blood-placenta and ascending infection,while the specific mechanism has not been very clear. Now the application of amniotic fluid HPV detection method is based on polymerase chain reaction and nucleic acid hybridization. HPV infection may cause adverse pregnancy outcomes and can affect the health of the baby. Cesarean section can reduce the infection rate of HPV in newborns,but it cannot effectively prevent the transmission of HPV,so HPV infection is not an indication of cesarean section.
引文
[1]郑晓霞,王谢桐,于珊.妊娠期人乳头瘤病毒感染对母儿影响的探讨[J].实用妇产科杂志,2011,27(3):223-226.
[2]徐倏,刘兰青,吕绳敏,等.人乳头状瘤病毒母婴垂直传播的临床观察[J].中华妇产科杂志,1995,30(8):457-459.
[3]王卡娜,郄明蓉. HPV感染对妊娠及结局的影响[J].实用妇产科杂志,2017,33(4):241-243.
[4]马骏.妊娠期下生殖道人乳头瘤病毒感染48例临床分析[J].中国血液流变学杂志,2009,19(4):610-612.
[5]梁云萍.合并下生殖道人乳头瘤病毒感染妊娠结局和新生儿近期的影响[J].中国妇产科临床杂志,2012,13(5):331-333.
[6]郑华丽,王喜.复发性流产者妊娠早期E-钙粘素的表达及其与HPV感染的相关性[J].慢性病学杂志,2014,15(5):417-418.
[7]祝圆红,张玮.胎盘人膜联蛋白Ⅴ和β2糖蛋白Ⅰ在乙型肝炎病毒宫内感染胎盘组织中的表达及意义[J].中国妇幼保健,2016,31(1):164-166.
[8]邓东锐,闻良珍.妊娠期人乳头瘤病毒的感染状况及母婴传播的研究[J].中华实验和临床病毒学杂志,1997,11(4):369-371.
[9]丁锋,高锦声,马旭,等.人乳头瘤病毒宫内感染的分子生物学研究[J].中国优生与遗传杂志,2002,10(2):20-22.
[10]姚天一.妊娠期尖锐湿疣的诊断和治疗进展[J].中国实用妇科与产科杂志,2001,17(12):707-709.
[11]李源,向阳. HPV感染检测方法及相关问题[J].国际生殖健康/计划生育杂志,2015,34(6):457-461.
[12]邓东锐,闻良珍,凌霞珍,等.亚临床型人乳头瘤病毒感染垂直传播途径的研究[J].中国实用妇科与产科杂志,2005,21(1):45-46.
[13]宋歌,刘静,吴焱. HPV检测方法的研究进展[J].国际病毒学杂志,2017,24(4):280-284.
[14]李莉,陈汶,杨欢,等. HPV检测技术在宫颈癌中的研究进展[J].癌症进展,2018,16(3):278-282.
[15]吴杨,王振美.关于女性生殖道HPV感染的研究进展[J].黑龙江医学,2017,41(9):916-917.
[16]张媛媛,古扎努尔·阿不都西库尔,古扎丽努尔·阿不力孜,等. Cervista法与HPV快速筛查法检测高危型HPV在宫颈癌早期筛查中的应用[J].中国临床研究,2017,30(6):770-772.
[17] Syrjnen S. Current concepts on human papillomavirus infectionsin children[J]. APMIS,2010,118(6/7):494-509.
[18] Lmm A,Leonhard AK,Zakhary CW,et al. Human papillomavirusinfects placental trophoblast and Hofbauer cells,but appears notto play a causal role in miscarriage and preterm labor[J]. ActaObstet Gynecol Scand,2017,96(10):1188-1196.
[19] Worda C,Huber A,Hudelist G,et al. Prevalence of cervical andintrauterine human papillomavirus infection in the third trimesterin asymptomatic women[J]. J Soc Gynecol Investig,2005,12(6):440-444.
[20] Ruffin MT,Bailey JM,Roulston D,et al. Human papillomavirus inamniotic fluid[J]. BMC Pregnancy Childbirth,2006,6:28.
[21]卢丹妮,张为远.人乳头瘤病毒感染对母婴健康影响的研究进展[J].中国计划生育和妇产科,2017,9(5):26-28,35.
[22]刘建华.妊娠期生殖道HPV感染及其对妊娠的影响[J].国际生殖健康/计划生育杂志,2015,34(6):467-470.
[23]周静,欧荣英,周美茜,等. HPV感染与不良妊娠结局的关系研究[J].预防医学,2018,30(1):12-15.
[24]蔡际. HPV感染对产后出血与围产儿结局的对照研究[J].赣南医学院学报,2017,37(3):376-378.
[25]陈慧军,陈敏玲.妊娠期生殖道人乳头瘤病毒感染对妊娠结局和新生儿的影响[J].中国农村卫生事业管理,2015,35(10):1306-1307.
[26]庹闽,李枫光.妊娠期生殖道人乳头瘤病毒感染对妊娠结局和新生儿的影响[J].河南医学研究,2016,25(7):1179-1180.
[27] Naresh A,Simhan H. Absence of viruses in amniotic fluid ofwomen with PPROM:A case series[J]. J Reprod Immunol,2012,96(1/2):79-83.
[28] Boulenouar S,Weyn C,Van NM,et al. Effects of HPV-16 E5,E6and E7 proteins on survival,adhesion,migration and invasion oftrophoblastic cells[J]. Carcinogenesis,2010,31(3):473-480.
[29]周静,欧荣英,周美茜,等. HPV感染与不良妊娠结局的关系研究[J].预防医学,2018,30(1):12-15.
[30] Ambühl LM,Baandrup U,Dybkr K,et al. Human papillomavirusinfection as a possible cause of spontaneous abortion and sponta-neous preterm delivery[J]. Infect Dis Obstet Gynecol,2016,2016:3086036.
[31]张静,范海波,张双婕,等.南京地区妊娠期妇女高危型人乳头瘤病毒感染率及其对妊娠结局的影响[J].标记免疫分析与临床,2017,24(1):37-40.
[32]夏蕾,于娟.妊娠合并下生殖道人乳头瘤病毒感染对妊娠结局和新生儿的近期影响[J].临床和实验医学杂志,2016,15(1):72-74.
[33] Nimrodi M,Kleitman V,Wainstock T,et al. The associationbetween cervical inflammation and histologic evidence of HPV inPAP smears and adverse pregnancy outcome in low risk popula-tion[J]. Eur J Obstet Gynecol Reprod Biol,2018,225:160-165.
[34] Chatzistamatiou K,Sotiriadis A,Agorastos T. Effect of mode ofdelivery on vertical human papillomavirus transmission-A meta-analysis[J]. J Obstet Gynaecol,2016,36(1):10-17.
[35] Mammas IN,Sourvinos G,Giamarelou P,et al. Human papilloma-virus in the oral cavity of children and mode of delivery:A retro-spective study[J]. Int J STD AIDS,2012,23(3):185.
[36]于松,臧春逸,李守柔,等.孕妇人乳头状瘤病毒感染与新生儿感染关系的研究[J].中国实用妇科与产科杂志,2000,16(3):167-168.
[37]廖琪.妊娠期孕妇HPV病毒感染的分型及母婴妊娠结局的影响[J].中国性科学,2017,26(6):127-129.
[38]米辰.妊娠期人乳头瘤病毒感染的诊治评价[J].实用妇产科杂志,2016,32(2):99-102.
[2]徐倏,刘兰青,吕绳敏,等.人乳头状瘤病毒母婴垂直传播的临床观察[J].中华妇产科杂志,1995,30(8):457-459.
[3]王卡娜,郄明蓉. HPV感染对妊娠及结局的影响[J].实用妇产科杂志,2017,33(4):241-243.
[4]马骏.妊娠期下生殖道人乳头瘤病毒感染48例临床分析[J].中国血液流变学杂志,2009,19(4):610-612.
[5]梁云萍.合并下生殖道人乳头瘤病毒感染妊娠结局和新生儿近期的影响[J].中国妇产科临床杂志,2012,13(5):331-333.
[6]郑华丽,王喜.复发性流产者妊娠早期E-钙粘素的表达及其与HPV感染的相关性[J].慢性病学杂志,2014,15(5):417-418.
[7]祝圆红,张玮.胎盘人膜联蛋白Ⅴ和β2糖蛋白Ⅰ在乙型肝炎病毒宫内感染胎盘组织中的表达及意义[J].中国妇幼保健,2016,31(1):164-166.
[8]邓东锐,闻良珍.妊娠期人乳头瘤病毒的感染状况及母婴传播的研究[J].中华实验和临床病毒学杂志,1997,11(4):369-371.
[9]丁锋,高锦声,马旭,等.人乳头瘤病毒宫内感染的分子生物学研究[J].中国优生与遗传杂志,2002,10(2):20-22.
[10]姚天一.妊娠期尖锐湿疣的诊断和治疗进展[J].中国实用妇科与产科杂志,2001,17(12):707-709.
[11]李源,向阳. HPV感染检测方法及相关问题[J].国际生殖健康/计划生育杂志,2015,34(6):457-461.
[12]邓东锐,闻良珍,凌霞珍,等.亚临床型人乳头瘤病毒感染垂直传播途径的研究[J].中国实用妇科与产科杂志,2005,21(1):45-46.
[13]宋歌,刘静,吴焱. HPV检测方法的研究进展[J].国际病毒学杂志,2017,24(4):280-284.
[14]李莉,陈汶,杨欢,等. HPV检测技术在宫颈癌中的研究进展[J].癌症进展,2018,16(3):278-282.
[15]吴杨,王振美.关于女性生殖道HPV感染的研究进展[J].黑龙江医学,2017,41(9):916-917.
[16]张媛媛,古扎努尔·阿不都西库尔,古扎丽努尔·阿不力孜,等. Cervista法与HPV快速筛查法检测高危型HPV在宫颈癌早期筛查中的应用[J].中国临床研究,2017,30(6):770-772.
[17] Syrjnen S. Current concepts on human papillomavirus infectionsin children[J]. APMIS,2010,118(6/7):494-509.
[18] Lmm A,Leonhard AK,Zakhary CW,et al. Human papillomavirusinfects placental trophoblast and Hofbauer cells,but appears notto play a causal role in miscarriage and preterm labor[J]. ActaObstet Gynecol Scand,2017,96(10):1188-1196.
[19] Worda C,Huber A,Hudelist G,et al. Prevalence of cervical andintrauterine human papillomavirus infection in the third trimesterin asymptomatic women[J]. J Soc Gynecol Investig,2005,12(6):440-444.
[20] Ruffin MT,Bailey JM,Roulston D,et al. Human papillomavirus inamniotic fluid[J]. BMC Pregnancy Childbirth,2006,6:28.
[21]卢丹妮,张为远.人乳头瘤病毒感染对母婴健康影响的研究进展[J].中国计划生育和妇产科,2017,9(5):26-28,35.
[22]刘建华.妊娠期生殖道HPV感染及其对妊娠的影响[J].国际生殖健康/计划生育杂志,2015,34(6):467-470.
[23]周静,欧荣英,周美茜,等. HPV感染与不良妊娠结局的关系研究[J].预防医学,2018,30(1):12-15.
[24]蔡际. HPV感染对产后出血与围产儿结局的对照研究[J].赣南医学院学报,2017,37(3):376-378.
[25]陈慧军,陈敏玲.妊娠期生殖道人乳头瘤病毒感染对妊娠结局和新生儿的影响[J].中国农村卫生事业管理,2015,35(10):1306-1307.
[26]庹闽,李枫光.妊娠期生殖道人乳头瘤病毒感染对妊娠结局和新生儿的影响[J].河南医学研究,2016,25(7):1179-1180.
[27] Naresh A,Simhan H. Absence of viruses in amniotic fluid ofwomen with PPROM:A case series[J]. J Reprod Immunol,2012,96(1/2):79-83.
[28] Boulenouar S,Weyn C,Van NM,et al. Effects of HPV-16 E5,E6and E7 proteins on survival,adhesion,migration and invasion oftrophoblastic cells[J]. Carcinogenesis,2010,31(3):473-480.
[29]周静,欧荣英,周美茜,等. HPV感染与不良妊娠结局的关系研究[J].预防医学,2018,30(1):12-15.
[30] Ambühl LM,Baandrup U,Dybkr K,et al. Human papillomavirusinfection as a possible cause of spontaneous abortion and sponta-neous preterm delivery[J]. Infect Dis Obstet Gynecol,2016,2016:3086036.
[31]张静,范海波,张双婕,等.南京地区妊娠期妇女高危型人乳头瘤病毒感染率及其对妊娠结局的影响[J].标记免疫分析与临床,2017,24(1):37-40.
[32]夏蕾,于娟.妊娠合并下生殖道人乳头瘤病毒感染对妊娠结局和新生儿的近期影响[J].临床和实验医学杂志,2016,15(1):72-74.
[33] Nimrodi M,Kleitman V,Wainstock T,et al. The associationbetween cervical inflammation and histologic evidence of HPV inPAP smears and adverse pregnancy outcome in low risk popula-tion[J]. Eur J Obstet Gynecol Reprod Biol,2018,225:160-165.
[34] Chatzistamatiou K,Sotiriadis A,Agorastos T. Effect of mode ofdelivery on vertical human papillomavirus transmission-A meta-analysis[J]. J Obstet Gynaecol,2016,36(1):10-17.
[35] Mammas IN,Sourvinos G,Giamarelou P,et al. Human papilloma-virus in the oral cavity of children and mode of delivery:A retro-spective study[J]. Int J STD AIDS,2012,23(3):185.
[36]于松,臧春逸,李守柔,等.孕妇人乳头状瘤病毒感染与新生儿感染关系的研究[J].中国实用妇科与产科杂志,2000,16(3):167-168.
[37]廖琪.妊娠期孕妇HPV病毒感染的分型及母婴妊娠结局的影响[J].中国性科学,2017,26(6):127-129.
[38]米辰.妊娠期人乳头瘤病毒感染的诊治评价[J].实用妇产科杂志,2016,32(2):99-102.