腹腔镜与开腹手术治疗卵巢良性肿瘤对患者卵巢功能及神经内分泌功能的影响
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摘要
目的研究腹腔镜与开腹手术治疗卵巢良性肿瘤对患者卵巢功能及神经内分泌功能的影响。方法选取80例卵巢良性肿瘤患者为研究对象。将80例患者按照随机数字表法分为2组。腹腔镜手术组(Minimally invasive operation)的40例患者进行腹腔镜手术治疗,开腹手术组(Open surgery)的40例患者选择开腹手术。检测比较2组患者治疗前与治疗后的血清中卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、β-内啡肽、胰高血糖素、皮质醇(COR)、TSH水平变化。结果治疗前2组血清中卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、β-内啡肽、胰高血糖素、皮质醇(COR)、TSH指标比较,P均>0.05;而治疗后腹腔镜手术组各激素水平波动均显著小于开腹手术组,P均<0.05;2组患者手术前后的激素水平有统计学差异。结论腹腔镜手术对良性卵巢肿瘤患者的卵巢功能、神经内分泌功能的影响明显小于开腹手术,术后激素波动水平更低,短期内卵巢、神经内分泌功能恢复更快,值得推广应用。
Objective To observe the effect of laparoscopy and open surgery on ovarian function and neuroendocrine function in patients with benign ovarian tumor. Methods 80 cases of ovarian benign tumor patients as the research object,the 80 patients were divided into 2 groups according to the random number table method,Minimally invasive operation group( 40 patients) received laparoscopic surgery,open surgery group( 40 patients) received traditional open surgery. Before and after treatment,the serum follicle stimulating hormone( FSH) and luteinizing hormone( LH),estradiol( E2),beta endorphin,glucagon,cortisol( COR),the change of TSH level of the 2 groups were detected. Results Before treatment,serum follicle stimulating hormone( FSH) and luteinizing hormone( LH),estradiol( E2),beta endorphin,glucagon,cortisol( COR),TSH index of the 2 groups were compared,P > 0. 05,and after treatment,the fluctuations in hormone levels in M group were significantly less than the S group,P < 0. 05,hormone levels in the 2 groups before and after surgery had significant difference. Conclusion The effect of laparoscopic surgery on ovarian function and neuroendocrine function in patients with benign ovarian tumor is significantly less than that of traditional open surgery. Hormone levels fluctuation is small,short-term ovarian function and neuroendocrine function have faster recovery. It is worthy of clinical application.
Objective To observe the effect of laparoscopy and open surgery on ovarian function and neuroendocrine function in patients with benign ovarian tumor. Methods 80 cases of ovarian benign tumor patients as the research object,the 80 patients were divided into 2 groups according to the random number table method,Minimally invasive operation group( 40 patients) received laparoscopic surgery,open surgery group( 40 patients) received traditional open surgery. Before and after treatment,the serum follicle stimulating hormone( FSH) and luteinizing hormone( LH),estradiol( E2),beta endorphin,glucagon,cortisol( COR),the change of TSH level of the 2 groups were detected. Results Before treatment,serum follicle stimulating hormone( FSH) and luteinizing hormone( LH),estradiol( E2),beta endorphin,glucagon,cortisol( COR),TSH index of the 2 groups were compared,P > 0. 05,and after treatment,the fluctuations in hormone levels in M group were significantly less than the S group,P < 0. 05,hormone levels in the 2 groups before and after surgery had significant difference. Conclusion The effect of laparoscopic surgery on ovarian function and neuroendocrine function in patients with benign ovarian tumor is significantly less than that of traditional open surgery. Hormone levels fluctuation is small,short-term ovarian function and neuroendocrine function have faster recovery. It is worthy of clinical application.
引文
[1]王丽芳.腹腔镜卵巢囊肿剔除术对患者卵巢功能的影响[J].中国医学工程,2015,23(2):178.
[2]Izzard AS,Rizzoni D,Agabiti-Rosei E,et al.Small artery structureand hypertension:adaptive changes and target organ damage[J].J Hypertens,2005,23(2):247-250.
[3]徐祥梅,丁秀丽.腹腔镜治疗卵巢良性肿瘤患者的临床分析[J].中国医刊,2013,48(1):75-76.
[4]Takashima A,Takeshita N,Otaka K,et al.Effects of bipolare lectrocoagulation versus suture after laparoscopic excision of ovarian endometrioma on the ovarian reserve and outcome of in vitrofertilization[J].J Obstet Gynaecol Res,2013,39(7):1246-1252.
[5]Zhao S,Wang H,Nie Y,et al.Midkine upregulates MICA/B ex pression in human gastric cancer cells and decreases natural killer cell eytotoxicity[J].Cancer lmmunol Immunother,2012,61(10):1745-1753.
[6]Shiota M,Kotani Y,Umemoto M,et al.Preoperative differentiation between tumor-related ovarian torsion and rupture of ovariancyst preoperatively diagnosed as benign:a retrospective study[J].J Obstet Gynaecol Res,2013,39(1):326-329.
[7]李金波.腹腔镜卵巢囊肿剔除术对卵巢功能的影响[J].求医问药,2013,11(5):65.
[8]吴燕祯,秦福杰,李玉香,等.腹腔镜下卵巢囊肿剥除创面双极电凝止血与缝合止血对卵巢功能影响[J].中国医刊,2015,50(4):66-69.
[9]Galetke W,Ghassemi BM,Priegnitz C,et al.Anticyclie modulated ventilation versus continuous positive airway pressure inpatients with coexisting obstructive sleep apnea and Cheyne Stokes respiration:a randomized crossover trial[J].Sleep Med,2014,15(8):874-879.
[10]葛静,刘晶,都治香,等.腹腔镜卵巢囊肿剥除术对患者术后卵巢功能的近期和远期影响研究[J].中国内镜杂志,2013,19(9):927-931.
[11]宋娟,吴丽英,姚芹雪,等.腹腔镜联合促性腺激素释放激素激动剂治疗卵巢囊肿的疗效观察[J].成都医学院学报,2015,10(4):475-478.
[12]黄玲,刘明娟,宋芳.腹腔镜手术和开腹术治疗早期卵巢癌的临床对比研究[J].中国实用医药,2012,7(14):136-137.
[2]Izzard AS,Rizzoni D,Agabiti-Rosei E,et al.Small artery structureand hypertension:adaptive changes and target organ damage[J].J Hypertens,2005,23(2):247-250.
[3]徐祥梅,丁秀丽.腹腔镜治疗卵巢良性肿瘤患者的临床分析[J].中国医刊,2013,48(1):75-76.
[4]Takashima A,Takeshita N,Otaka K,et al.Effects of bipolare lectrocoagulation versus suture after laparoscopic excision of ovarian endometrioma on the ovarian reserve and outcome of in vitrofertilization[J].J Obstet Gynaecol Res,2013,39(7):1246-1252.
[5]Zhao S,Wang H,Nie Y,et al.Midkine upregulates MICA/B ex pression in human gastric cancer cells and decreases natural killer cell eytotoxicity[J].Cancer lmmunol Immunother,2012,61(10):1745-1753.
[6]Shiota M,Kotani Y,Umemoto M,et al.Preoperative differentiation between tumor-related ovarian torsion and rupture of ovariancyst preoperatively diagnosed as benign:a retrospective study[J].J Obstet Gynaecol Res,2013,39(1):326-329.
[7]李金波.腹腔镜卵巢囊肿剔除术对卵巢功能的影响[J].求医问药,2013,11(5):65.
[8]吴燕祯,秦福杰,李玉香,等.腹腔镜下卵巢囊肿剥除创面双极电凝止血与缝合止血对卵巢功能影响[J].中国医刊,2015,50(4):66-69.
[9]Galetke W,Ghassemi BM,Priegnitz C,et al.Anticyclie modulated ventilation versus continuous positive airway pressure inpatients with coexisting obstructive sleep apnea and Cheyne Stokes respiration:a randomized crossover trial[J].Sleep Med,2014,15(8):874-879.
[10]葛静,刘晶,都治香,等.腹腔镜卵巢囊肿剥除术对患者术后卵巢功能的近期和远期影响研究[J].中国内镜杂志,2013,19(9):927-931.
[11]宋娟,吴丽英,姚芹雪,等.腹腔镜联合促性腺激素释放激素激动剂治疗卵巢囊肿的疗效观察[J].成都医学院学报,2015,10(4):475-478.
[12]黄玲,刘明娟,宋芳.腹腔镜手术和开腹术治疗早期卵巢癌的临床对比研究[J].中国实用医药,2012,7(14):136-137.