Octavius 4D电离室探头特性及在RapidArc剂量验证中的应用研究
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摘要
目的研究Octavius 4D电离室探头特性及在快速旋转调强(Rapid Arc)剂量验证中的应用研究。方法测量Octavius 729和1000SRS探头的稳定性、剂量响应、剂量率依赖性、角度依赖性,并与PTW31010型0.125 cm~3指形电离室测量值比较。选取20例患者Rapid Arc计划,其中10例鼻咽癌和10例直肠癌,分别采用729和1000SRS电离室矩阵进行剂量验证,两两比较分析其γ通过率差异。结果 Octavius 729和1000SRS探头特性均符合临床验证要求,20例Rapid Arc计划3%/3 mm的γ平均通过率分别为鼻咽癌(96.2%和99.3%)、直肠癌(98.4%和99.7%),两两比较P<0.05,均具有统计学意义。结论 Octavius 4D验证系统(729和1000SRS)都能满足临床多病种Rapid Arc计划剂量验证要求,且测量平面始终随机架旋转与射线束相垂直,无角度依赖性,可行性值得认可。计划复杂度是影响Rapid Arc计划验证通过率的主要因素,1000SRS液体电离室矩阵具有更大的优势。
Objective To evaluate the characteristics and clinical application of the Octavius 4 D ionization chamber arrays in RapidArc dose verification. Methods The reproducibility, dose and dose rate dependence, field sizes dependence of the Octavius 729 and 1000 SRS ionization chamber were measured. The results were compared with the measurement results of PTW31010 0.125 cm~3 ionization chamber. Gamma rate was used to analyze the dose difference between selected 20 RapidArc plans by the Octavius 729 and 1000 SRS two-dimensional ionization chamber array respectively, which included 10 nasopharyngeal cancer and 10 rectal cancer. Results The Octavius 729 and 1000 SRS performed well for all tests. Average Gamma analysis passing rates with 3%/3 mm for 20 RapidArc plans were nasopharyngeal cancer( 96.2% and 99.3%) and rectal cancer( 98.4%and 99.7%) respectively, statistical significance has been found between either two of the groups(P<0.05). Conclusion Octavius4 D system(729 and 1000 SRS) can meet the dose verfication for RapidArc plans of multiple cancer. The measured plane is always rotated in a random frame and perpendicular to the beam, which hasn't directional dependence. The complexity of VMAT plan is the main factor affecting the passing rate, 1000 SRS liquid ionization chamber array has great advantages.
Objective To evaluate the characteristics and clinical application of the Octavius 4 D ionization chamber arrays in RapidArc dose verification. Methods The reproducibility, dose and dose rate dependence, field sizes dependence of the Octavius 729 and 1000 SRS ionization chamber were measured. The results were compared with the measurement results of PTW31010 0.125 cm~3 ionization chamber. Gamma rate was used to analyze the dose difference between selected 20 RapidArc plans by the Octavius 729 and 1000 SRS two-dimensional ionization chamber array respectively, which included 10 nasopharyngeal cancer and 10 rectal cancer. Results The Octavius 729 and 1000 SRS performed well for all tests. Average Gamma analysis passing rates with 3%/3 mm for 20 RapidArc plans were nasopharyngeal cancer( 96.2% and 99.3%) and rectal cancer( 98.4%and 99.7%) respectively, statistical significance has been found between either two of the groups(P<0.05). Conclusion Octavius4 D system(729 and 1000 SRS) can meet the dose verfication for RapidArc plans of multiple cancer. The measured plane is always rotated in a random frame and perpendicular to the beam, which hasn't directional dependence. The complexity of VMAT plan is the main factor affecting the passing rate, 1000 SRS liquid ionization chamber array has great advantages.
引文
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[18]岳海振,张艺宝,胡俏俏,等.PTW1000 SRS与7 2 9矩阵在非均整模式下剂量验证对比[J].中国医学物理学杂志,2016,33(1).19-23.C
[2]Low DA,Moran JM,Dempsey JF,et al.Dosimetry tools and techniques for IMRT[J].Med Phys,2011,38(3):1313.
[3]戴立言,王占宇,谭军文,等.调强放疗计划设计参数对剂量验证结果影响的初步研究[J].中华放射肿瘤学杂志,2018,27(10):933.
[4]牛振洋,费振乐,段宗锦,等.VMAT患者剂量验证方法的评价分析[J].中华放射肿瘤学杂志,2017,26(8):929.
[5]Bedford JL,Lee YK,Wai P,et al.Evaluation of the Delta4phantom for IMRT and VMAT verification[J].Phys Med Biol,2009,54(9):167-176.
[6]Zhu JH,Chen LX,Jin GH,et al.A comparison of VMATdosimetric verifications between fixed and rotating gantry positions[J].Phys Med Biol,2013,58(5):1315-22.
[7]Li G,Zhang Y,Jiang X,et al.Evaluation of the ArcCHECK QA system for IMRT and VMAT verification[J].Phys Med,2013,29(3):295-303.
[8]Baeza JA,Wolfs C,Nijsten S,et al.Validation and uncertainty analysis of a pre-treatment 2D dose prediction model.[J].Phys Med Biol,2018,63(3).
[9]Grams MP,de Los Santos LEF.Design and clinical use of a rotational phantom for dosimetric verification of IMRT/VMATtreatments[J].Phys Med,2018,50:59-65.
[10]Yang B,Geng H,Ding Y,et al.Development of a novel methodology for QA of respiratory-gated and VMAT beam delivery using Octavius 4D phantom[J].Med Dosim,2019,44(1):83-90.
[11]Hussein M,Adams EJ,Jordan TJ,et al.A critical evaluation of the PTW2D-ARRAY seven29 and OCTAVIUS II phantom for IMRT and VMAT verification[J].Appl Clin Med Phy,2013,14(6):274-292.
[12]李明,周杰,王忠明,等.Octavius 4D验证系统用于VMAT剂量验证可行性分析[J].中华肿瘤防治杂志,2018,25(14):1028-1030.
[13]Mcgarry CK,O'Connell BF,Grattan MWD,et al.Octavius 4Dcharacterization for flattened and flattening filter free rotational deliveries[J].Med Phys,2013,40(9):1-11.
[14]Ezzell GA,Burmeister JW,Dogan N,et al.IMRT commissioning:Multiple institution planning and dosimetry comparisons,a report from AAPM Task Group 119[J].Med Phys,2009,36(11):5359-5373.
[15]Robar JL,Clark BG.The use of radiographic film for linear accelerator stereotactic radiosurgical dosimetry[J].Med Phys,1999,26(10):2144-2150.
[16]Wagner D,Vorwerk H.Two years experience with quality assurance protocol for patient related Rapid Arc treatment plan verification using a two dimensional ionization chamber array[J].Radiat Oncol,2011,6(1):21.
[17]Poppe B,Stelljes TS,Looe HK,et al.Performance parameters of a liquid filled ionization chamber array[J].Med Phys,2013,40(8):082106.
[18]岳海振,张艺宝,胡俏俏,等.PTW1000 SRS与7 2 9矩阵在非均整模式下剂量验证对比[J].中国医学物理学杂志,2016,33(1).19-23.C