补阳疗嚏汤联合粉尘螨滴剂对虚寒型变应性鼻炎患者血清IL-4、IFN-γ水平和免疫功能的影响
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摘要
目的观察补阳疗嚏汤联合粉尘螨滴剂对虚寒型变应性鼻炎(AR)患者血清白介素-4(IL-4)、干扰素-γ(IFN-γ)水平和免疫功能的影响。方法将余姚市人民医院耳鼻喉科收治的虚寒型AR患者102例按照随机数字表法分为观察组和对照组各51例,对照组给予粉尘螨滴剂治疗,观察组在对照组基础上联合补阳疗嚏汤治疗。观察两组临床症状评分、临床疗效,并检测血清IL-4、IFN-γ水平和免疫功能。结果两组治疗后喷嚏、鼻塞、鼻痒、流涕评分显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05);观察组总有效率92.16%显著高于对照组74.51%(P<0.05);治疗后两组IFN-γ及CD3~+、CD4~+、CD4~+/CD8~+水平显著高于治疗前(P<0.05),IL-4、CD8~+水平显著低于治疗前(P<0.05),观察组各项指标改善效果均优于对照组(P<0.05)。结论补阳疗嚏汤联合粉尘螨滴剂可有效改善虚寒型AR患者血清IL-4、IFN-γ水平,提高免疫功能和临床疗效。
Objective: To observe the influence of Buyang Liaoti Decoction combined with dermatophagoides farinae drops on serum IL-4,IFN-γ levels and immunologic function of patients with Allergic Rhinitis of deficiency-cold type. Methods: 102 cases of patients with allergic rhinitis of deficiency-cold type were divided into the observation group and the control group according to random number table method,51 cases in each group.The control group was treated with dermatophagoides farinae drops,and the observation group was treated with Buyang Liaoti Decoction on the basis of the control group. Clinical symptom score and clinical efficacy were observed in the two groups;the levels of IL-4 and IFN-γ and immunologic function were detected in the two groups.Results: After treatment,sneezing,stuffy nose,runny nose,nasal itching score were significantly lower than those before treatment in the two groups(P < 0.05),and those in the observation group were significantly lower than those in the control group(P < 0.05). Total effective rate of the observation group was 92.16%,significantly higher than that of the control group(74.51%)(P < 0.05). After treatment,the levels of IFN-γ,CD3~+,CD4~+and CD4~+/CD8~+in the 2 groups were significantly higher than those before treatment(P < 0.05);the levels of IL-4 and CD8~+were significantly lower than those before treatment(P < 0.05),and the improvement effect of the indexes in the observation group was better than that in the control group(P < 0.05). Conclusion: Buyang Liaoti Decoction combined with dermatophagoides farinae drops can improve serum IL-4 and IFN-γ levels of AR patients of deficiency-cold type,and improve immunologic function and clinical efficacy.
Objective: To observe the influence of Buyang Liaoti Decoction combined with dermatophagoides farinae drops on serum IL-4,IFN-γ levels and immunologic function of patients with Allergic Rhinitis of deficiency-cold type. Methods: 102 cases of patients with allergic rhinitis of deficiency-cold type were divided into the observation group and the control group according to random number table method,51 cases in each group.The control group was treated with dermatophagoides farinae drops,and the observation group was treated with Buyang Liaoti Decoction on the basis of the control group. Clinical symptom score and clinical efficacy were observed in the two groups;the levels of IL-4 and IFN-γ and immunologic function were detected in the two groups.Results: After treatment,sneezing,stuffy nose,runny nose,nasal itching score were significantly lower than those before treatment in the two groups(P < 0.05),and those in the observation group were significantly lower than those in the control group(P < 0.05). Total effective rate of the observation group was 92.16%,significantly higher than that of the control group(74.51%)(P < 0.05). After treatment,the levels of IFN-γ,CD3~+,CD4~+and CD4~+/CD8~+in the 2 groups were significantly higher than those before treatment(P < 0.05);the levels of IL-4 and CD8~+were significantly lower than those before treatment(P < 0.05),and the improvement effect of the indexes in the observation group was better than that in the control group(P < 0.05). Conclusion: Buyang Liaoti Decoction combined with dermatophagoides farinae drops can improve serum IL-4 and IFN-γ levels of AR patients of deficiency-cold type,and improve immunologic function and clinical efficacy.
引文
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[2]杨姜德,徐挺兰,张敏,等.百令胶囊联合粉尘螨滴剂治疗变应性鼻炎的疗效观察[J].中国药师,2016,19(5):947-949.
[3]张军华,田浩,谢飞,等.针药结合治疗肺脾虚寒型变应性鼻炎临床研究[J].河南中医,2016,36(12):2208-2210.
[4]蔡纪堂,王俊杰,王慧敏,等.补阳疗嚏汤治疗虚寒型变应性鼻炎51例[J].中医研究,2016,29(8):16-18.
[5]中华耳鼻咽喉头颈外科杂志编委会.变应性鼻炎诊断和治疗指南[J].中国临床医生杂志,2010,38(6):67-68.
[6]中华人民共和国卫生部.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:228-229.
[7]张志敏,李国义,陈向军,等.特异性免疫治疗对变应性鼻炎患者免疫功能的影响[J].现代中西医结合杂志,2015,24(3):281-283.
[8]岑士青.舌下含服粉尘螨滴剂特异性免疫对变应性鼻炎患者生存质量的影响[J].实用药物与临床,2013,16(11):1043-1045.
[9]国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994.
[10]徐崟,蒙珊,吕计宝,等.穴位埋线治疗对变应性鼻炎患者血清IL-4、IFN-γ的影响[J].中医药导报,2014,20(2):30-33.
[11]刘鸿.发泡灸治疗变应性鼻炎患者临床观察及对血清Ig E、IL-4、IFN-γ的影响[J].贵州医药,2013,37(02):177-178.
[12]徐桂容,杜晓东.舌下含服粉尘螨滴剂治疗变应性鼻炎的疗效[J].江苏医药,2013,39(1):78-80.
[13]周丽枫,王洁,陈彦球,等.舌下含服粉尘螨滴剂治疗多种变应原过敏的变应性鼻炎儿童的疗效与安全性评估[J].临床耳鼻咽喉头颈外科杂志,2012,26(20):913-916.
[14]胡海慈,任璐璐,孙麦青.温肺健脾益气法治疗变应性鼻炎临床研究[J].中医学报,2016,31(2):279-281.
[15]罗恬,吴秦川,王乃平.桂枝加黄芪汤对肺气虚寒型变应性鼻炎的疗效及部分机制分析[J].世界中医药,2016,11(12):2584-2587.