摘要
目的:观察半夏白术天麻汤加减联合银杏叶提取物注射液对突发性耳聋患者血清高迁移率族蛋白-1 (HMGB1)、过氧化脂质(LPO)水平变化及听力改善的影响。方法:选取突发性耳聋患者93例,均为单侧发病。对照组46例予以银杏叶提取物注射液治疗,研究组47例予以半夏白术天麻汤加减联合银杏叶提取物注射液治疗,均治疗2周。分析比较2组治疗前后血清HMGB1、LPO、一氧化氮(NO)水平、血液流变学及生活质量(SF-36)变化情况,统计比较2组听力改善、不良反应发生的情况。结果:治疗后,研究组听力改善情况优于对照组,差异有统计学意义(P <0.05);研究组血清HMGB1、LPO、NO水平情况优于对照组,差异均有统计学意义(P <0.05);研究组血浆黏度、全血低切黏度、全血高切黏度均低于对照组,差异均有统计学意义(P <0.05);不良反应总发生率研究组14.89%,与对照组8.70%比较,差异无统计学意义(P> 0.05);研究组SF-36评分高于对照组,差异有统计学意义(P <0.05)。结论:运用半夏白术天麻汤加减联合银杏叶提取物注射液治疗突发性耳聋,与单纯采用银杏叶提取物注射液治疗比较,可明显改善患者听力、血液流变学及血清HMGB1、LPO、NO水平,提高预后,且安全性较高。
Objective: To observe the effect of modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection on changes of levels of high mobility group box protein 1(HMGB1) and lipid peroxide(LPO) in serum as well as the improvement of hearing of patients with sudden deafness. Methods:Selected 93 cases of patients with sudden deafness whose unilateral ears were affected,46 cases in the control group were treated with ginkgo biloba leaves extract injection,while 47 cases in the study group were treated with modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection. The treatment in the two groups lasted for two weeks. Analyzed and compared the changes of levels of HMGB1, LPO and nitric oxide(NO) in serum,hemorheology and short form 36 questionnaire(SF-36),and calculated and compared the improvement of hearing and the incidence of adverse reactions in the two groups. Results:After treatment,the improvement of hearing in the study group was better than that in the control group,the difference being significant(P < 0.05). Levels of HMGB1,LPO and NO in serum in the study group were better than those in the control group,differences being significant(P < 0.05). The plasma viscosity,the whole low blood viscosity and the whole high blood viscosity in the study group were lower than those in the control group,differences being significant(P < 0.05). The incidence of adverse reactions was 14.89% in the study group and 8.70% in the control group,there being no significance in the difference(P >0.05). Scores of SF-36 in the study group were higher than those in the control group, the difference being significant(P < 0.05).Conclusion: Compared with the simple ginkgo biloba leaves extract injection, the therapy of modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection for sudden deafness can significantly improve the hearing,hemorheology and levels of HMGB1,LPO and NO in serum of patients,and improve the prognosis with higher safety.
引文
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