半夏白术天麻汤加减联合银杏叶提取物注射液治疗突发性耳聋临床观察
|
摘要
目的:观察半夏白术天麻汤加减联合银杏叶提取物注射液对突发性耳聋患者血清高迁移率族蛋白-1 (HMGB1)、过氧化脂质(LPO)水平变化及听力改善的影响。方法:选取突发性耳聋患者93例,均为单侧发病。对照组46例予以银杏叶提取物注射液治疗,研究组47例予以半夏白术天麻汤加减联合银杏叶提取物注射液治疗,均治疗2周。分析比较2组治疗前后血清HMGB1、LPO、一氧化氮(NO)水平、血液流变学及生活质量(SF-36)变化情况,统计比较2组听力改善、不良反应发生的情况。结果:治疗后,研究组听力改善情况优于对照组,差异有统计学意义(P <0.05);研究组血清HMGB1、LPO、NO水平情况优于对照组,差异均有统计学意义(P <0.05);研究组血浆黏度、全血低切黏度、全血高切黏度均低于对照组,差异均有统计学意义(P <0.05);不良反应总发生率研究组14.89%,与对照组8.70%比较,差异无统计学意义(P> 0.05);研究组SF-36评分高于对照组,差异有统计学意义(P <0.05)。结论:运用半夏白术天麻汤加减联合银杏叶提取物注射液治疗突发性耳聋,与单纯采用银杏叶提取物注射液治疗比较,可明显改善患者听力、血液流变学及血清HMGB1、LPO、NO水平,提高预后,且安全性较高。
Objective: To observe the effect of modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection on changes of levels of high mobility group box protein 1(HMGB1) and lipid peroxide(LPO) in serum as well as the improvement of hearing of patients with sudden deafness. Methods:Selected 93 cases of patients with sudden deafness whose unilateral ears were affected,46 cases in the control group were treated with ginkgo biloba leaves extract injection,while 47 cases in the study group were treated with modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection. The treatment in the two groups lasted for two weeks. Analyzed and compared the changes of levels of HMGB1, LPO and nitric oxide(NO) in serum,hemorheology and short form 36 questionnaire(SF-36),and calculated and compared the improvement of hearing and the incidence of adverse reactions in the two groups. Results:After treatment,the improvement of hearing in the study group was better than that in the control group,the difference being significant(P < 0.05). Levels of HMGB1,LPO and NO in serum in the study group were better than those in the control group,differences being significant(P < 0.05). The plasma viscosity,the whole low blood viscosity and the whole high blood viscosity in the study group were lower than those in the control group,differences being significant(P < 0.05). The incidence of adverse reactions was 14.89% in the study group and 8.70% in the control group,there being no significance in the difference(P >0.05). Scores of SF-36 in the study group were higher than those in the control group, the difference being significant(P < 0.05).Conclusion: Compared with the simple ginkgo biloba leaves extract injection, the therapy of modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection for sudden deafness can significantly improve the hearing,hemorheology and levels of HMGB1,LPO and NO in serum of patients,and improve the prognosis with higher safety.
Objective: To observe the effect of modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection on changes of levels of high mobility group box protein 1(HMGB1) and lipid peroxide(LPO) in serum as well as the improvement of hearing of patients with sudden deafness. Methods:Selected 93 cases of patients with sudden deafness whose unilateral ears were affected,46 cases in the control group were treated with ginkgo biloba leaves extract injection,while 47 cases in the study group were treated with modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection. The treatment in the two groups lasted for two weeks. Analyzed and compared the changes of levels of HMGB1, LPO and nitric oxide(NO) in serum,hemorheology and short form 36 questionnaire(SF-36),and calculated and compared the improvement of hearing and the incidence of adverse reactions in the two groups. Results:After treatment,the improvement of hearing in the study group was better than that in the control group,the difference being significant(P < 0.05). Levels of HMGB1,LPO and NO in serum in the study group were better than those in the control group,differences being significant(P < 0.05). The plasma viscosity,the whole low blood viscosity and the whole high blood viscosity in the study group were lower than those in the control group,differences being significant(P < 0.05). The incidence of adverse reactions was 14.89% in the study group and 8.70% in the control group,there being no significance in the difference(P >0.05). Scores of SF-36 in the study group were higher than those in the control group, the difference being significant(P < 0.05).Conclusion: Compared with the simple ginkgo biloba leaves extract injection, the therapy of modified Banxia Baizhu Tianma tang combined with ginkgo biloba leaves extract injection for sudden deafness can significantly improve the hearing,hemorheology and levels of HMGB1,LPO and NO in serum of patients,and improve the prognosis with higher safety.
引文
[1]谢凤梅.鼠神经生长因子治疗突发性耳聋临床观察[J].国际医药卫生导报,2015,21(3):364-366.
[2]王淑芳,张莉,张雯雯,等.鼠神经生长因子在突发性耳聋中的疗效观察[J].中华耳科学杂志,2016,14(2):223-228.
[3]韩倩,渠晓丽,刘平,等.银杏叶提取物对突发性耳聋患者免疫功能的影响及疗效观察[J].临床误诊误治,2015,28(2):106-108.
[4]柴卫芳,余志能,郭仪.圆窗置管微泵灌注鼠神经生长因子治疗难治性老年突发性耳聋疗效观察[J].中华实用诊断与治疗杂志,2014,28(4):381-382.
[5]景阳,张文,王宇娟,等.鼠神经生长因子不同给药方式治疗突发性耳聋的效果比较[J].中国医药导报,2016,13(15):127-130.
[6]罗宏伟,李玉环,李阳阳,等.银杏叶提取物注射液联合鼠神经生长因子治疗突发性耳聋56例[J].中国药业,2014,23(10):71-72.
[7]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科分会.突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻咽喉头颈外科杂志,2006,41(5):325.
[8]武敬参,鄢秀英,王羽,等.健康调查简表与世界卫生组织生存质量测定量表简表在评价肺结核患者生存质量中的应用比较[J].华西医学,2016,31(3):463-466.
[9]中华医学会耳鼻咽喉科学会,中华耳鼻咽喉科杂志编辑委员会.突发性聋诊断依据和疗效分级[J].中华耳鼻咽喉科杂志,1997,32(2):72.
[10]王丽芳.鼠神经生长因子联合地塞米松乳突骨膜下注射治疗突发性耳聋效果评价[J].广西医学,2017,39(1):61-64.
[11]许航宇,舒海荣,宋建新.老年突发性耳聋患者血清可溶性血管细胞黏附分子-1水平及其影响因素[J].中国老年学杂志,2017,37(2):452-453.
[12] Koo JW, Chang MY, Yun SC, et al. The efficacy and safety of systemic injection of Ginkgo biloba extract,EGb761,in idiopathic sudden sensorineural hearing loss:a randomized placebo-controlled clinical trial[J]. Eur Arch Otorhinolaryngol,2016,273(9):2433-2441.
[13]王洪波,常艳,蒋丽艳.银杏叶提取物注射液治疗突发性耳聋的临床研究[J].中国临床药理学杂志,2016,32(21):1946-1949.
[14] Han Q,Zhang S,Yuan H,et al. Effect of ginkgo biloba extract on concentration of homocysteine and lipid in patients with sudden hearing loss[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2015, 22(4):191-193.
[15]王丽,关淑芬,孙慧子,等.巴曲酶和银杏叶提取物注射液治疗高龄患者突发性耳聋的疗效[J].中国老年学杂志,2014,34(8):2103-2105.
[16]廖威,戴嵩,贾建平,等.中西医结合治疗突发性耳聋34例[J].针灸临床杂志,2015,31(1):35-37.
[17]雷霞,吴俊慧,任全伟.中西医联合治疗高频下降型突聋的临床观察[J].中国中医急症,2016,25(8):1598-1600.
[18]李彬.周德安教授“耳聋治肺”新解在治疗突发性耳聋中的应用[J].环球中医药,2015,8(6):741-742.
[19]彭桂原,李云英,杨黎,等.金针联合药物治疗气虚血瘀证突发性耳聋36例临床观察[J].中医杂志,2015,56(23):2036-2038.
[2]王淑芳,张莉,张雯雯,等.鼠神经生长因子在突发性耳聋中的疗效观察[J].中华耳科学杂志,2016,14(2):223-228.
[3]韩倩,渠晓丽,刘平,等.银杏叶提取物对突发性耳聋患者免疫功能的影响及疗效观察[J].临床误诊误治,2015,28(2):106-108.
[4]柴卫芳,余志能,郭仪.圆窗置管微泵灌注鼠神经生长因子治疗难治性老年突发性耳聋疗效观察[J].中华实用诊断与治疗杂志,2014,28(4):381-382.
[5]景阳,张文,王宇娟,等.鼠神经生长因子不同给药方式治疗突发性耳聋的效果比较[J].中国医药导报,2016,13(15):127-130.
[6]罗宏伟,李玉环,李阳阳,等.银杏叶提取物注射液联合鼠神经生长因子治疗突发性耳聋56例[J].中国药业,2014,23(10):71-72.
[7]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科分会.突发性聋的诊断和治疗指南(2005年,济南)[J].中华耳鼻咽喉头颈外科杂志,2006,41(5):325.
[8]武敬参,鄢秀英,王羽,等.健康调查简表与世界卫生组织生存质量测定量表简表在评价肺结核患者生存质量中的应用比较[J].华西医学,2016,31(3):463-466.
[9]中华医学会耳鼻咽喉科学会,中华耳鼻咽喉科杂志编辑委员会.突发性聋诊断依据和疗效分级[J].中华耳鼻咽喉科杂志,1997,32(2):72.
[10]王丽芳.鼠神经生长因子联合地塞米松乳突骨膜下注射治疗突发性耳聋效果评价[J].广西医学,2017,39(1):61-64.
[11]许航宇,舒海荣,宋建新.老年突发性耳聋患者血清可溶性血管细胞黏附分子-1水平及其影响因素[J].中国老年学杂志,2017,37(2):452-453.
[12] Koo JW, Chang MY, Yun SC, et al. The efficacy and safety of systemic injection of Ginkgo biloba extract,EGb761,in idiopathic sudden sensorineural hearing loss:a randomized placebo-controlled clinical trial[J]. Eur Arch Otorhinolaryngol,2016,273(9):2433-2441.
[13]王洪波,常艳,蒋丽艳.银杏叶提取物注射液治疗突发性耳聋的临床研究[J].中国临床药理学杂志,2016,32(21):1946-1949.
[14] Han Q,Zhang S,Yuan H,et al. Effect of ginkgo biloba extract on concentration of homocysteine and lipid in patients with sudden hearing loss[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2015, 22(4):191-193.
[15]王丽,关淑芬,孙慧子,等.巴曲酶和银杏叶提取物注射液治疗高龄患者突发性耳聋的疗效[J].中国老年学杂志,2014,34(8):2103-2105.
[16]廖威,戴嵩,贾建平,等.中西医结合治疗突发性耳聋34例[J].针灸临床杂志,2015,31(1):35-37.
[17]雷霞,吴俊慧,任全伟.中西医联合治疗高频下降型突聋的临床观察[J].中国中医急症,2016,25(8):1598-1600.
[18]李彬.周德安教授“耳聋治肺”新解在治疗突发性耳聋中的应用[J].环球中医药,2015,8(6):741-742.
[19]彭桂原,李云英,杨黎,等.金针联合药物治疗气虚血瘀证突发性耳聋36例临床观察[J].中医杂志,2015,56(23):2036-2038.