摘要
查阅并分析近年来国内外有关紫菀研究的相关文献。紫菀的化学成分有萜类、肽类、黄酮类、蒽醌类、香豆素类、甾醇及有机酸类等,其药理学作用十分广泛,有抗菌、抗肿瘤、镇咳、祛痰、平喘、抗病毒、抗氧化活性等作用。紫菀化学成分丰富,药理活性广泛,目前有关镇咳、祛痰、平喘方面的药理作用较为深入,但通利大小便的药理活性研究不够深入,有待进一步研究。
To review and analyze the related literatures about the research on Aster in China and other countries in recent years.The chemical composition of Aster is terpenoids,peptides,coumarins,flavonoids,anthraquinones,sterols and organic acids,its pharmacological effects are very broad,with antibacterial,antitumor,antitussive,expectorant,Antiasthmatic,anti-virus,anti-oxidant activity and so on.Aster is rich in chemical components and has wide range of pharmacological activities.At present,the pharmacological effects of antitussive,expectorant and antiasthmatic effects are rather in-depth.However,the research on the pharmacological activities of defecation is not deep enough and needs further study.
引文
[1]尹浩,骆建平,王鑫,等.士材学派医家妙用紫菀治疗癃闭[J].江苏中医药,2017,49(8):66-68.
[2]贾志新.紫菀通便作用考[J].山西中医学院学报,2008,19(1):12.
[3]NAGAO T,OKABE H,YAMAUCHI T.Studies on the constituents of AstertataricusL.f.I:Structures of shionosides A and B,monoterpene glycosides isolated from the root[J].Chem Pharm Bull,1988,36(2):571-577.
[4]CHENG D L,SHAO Y.Terpenoid glycosides from the roots ofAster tataricus[J].Phytochemistry,1994,35(1):173-176.
[5]WANG C Z,YU D Q.Diterpenoid,Sesquiterpenoid and Secoiridoid Glucosides from Aster auriculatus[J].Phytochemistry,1997,45(7):1483-1487.
[6]UCHIO Y,NAGASAKI M,EGUCHI S,et al.Labdane Diterpene Glycosides with 6-Deoxy-L-Idose from Aster spathulifolius Maxim[J].Tetrahedron Lett,1980,21:3775-3778.
[7]LEE S O,CHOI S Z,CHOI S U,et al.Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines[J].J Nat Prod,2005,68(10):1471-1474.
[8]金晶,张朝凤,张勉,等.紫菀的化学成分研究[J].中国现代中药,2008,10(6):20-22.
[9]AKIHISA T,KIMURA Y,KOIKE K,et al.Astertarone A:a triterpenoid ketone isolated from the roots of Aster tataricusL[J].Chem Pharm Bull,1998,46(11):1824-1826.
[10]AKIHISA T,KIMURA Y,TAI T,et al.Astertarone B,a hydroxy-triterpenoid ketone from the roots of Aster tataricusL[J].Chem Pharm Bull,1999,47(8):1161-1163.
[11]房慧勇,单高威,秦桂芳,等.紫菀的化学成分及其药理活性研究进展[J].医学研究与教育,2012,29(5):73-77.
[12]刘可越,张铁军,高文远,等.紫菀中三萜及甾体化合物的研究[J].天然产物研究与开发,2006,18:4-6
[13]ZHOU W B,ZENG G Z,XU H M,et al.Astershionones A-F,six new anti-HBV shionane-triterpenes from Aster tataricus[J].Fitoterapia,2014,93:98-104.
[14]ZHOU W B,ZENG G Z,XU H M,et al.Astataricusones A-D and astataricusol A,five new anti-HBV shionane-type triterpenes from Aster tataricus L.f.[J].Molecules,2013,18(12):14585-14596.
[15]SHAO Y,ZHOU B N,LIN L Z,et al.Triterpene saponins from Aster yunnanensis[J].Phytochemistry,1995,38(4):927-933.
[16]SHAO Y,ZHOU B N,LIN L Z,et al.Glycosides from Aster yunnanensis[J].Phytochemistry,1995,38(3):675-680.
[17]SHAO Y,ZHOU B N,LIN L Z,et al.Asteryunnanosides F and G:two newtriterpenoid saponins from Aster yunnanensis[J].Planta Med,1995,61(5):446-449.
[18]SHAO Y,LI YL,ZHOU BN.Phenolic and triterpenoid glycosides from Asterbatangensis[J].Phytochemistry,1996,41(6):1593-1598.
[19]SHAO Y,ZHOU B N,MA K,et al.New triterpenoid saponins,asterbatanoside D and E,from Aster batangensis[J].Planta Med,1995,61(3):246-249.
[20]SHAO Y,ZHOU B N,LIN L Z,et al.Triterpenoid saponins from Aster batangensis[J].Phytochemistry,1995,38(4):927-933.
[21]SHAO Y,ZHOU B N,MA K,et al.Medicagenic acid saponins from Aster batangensis[J].Phytochemistry,1995,39(4):875-881.
[22]LEE J,LEE Y M,LEE B W,et al.Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities[J].J Nat Prod,2012,75(2):267-270.
[23]XIE W D,WENG C W,NIU Y F,et al.Eudesmane sesquiterpenes and other constituents from Aster himalaicus[J].Chem Biodivers,2010,7(1):221-224.
[24]GAN L S,ZHAN Z J,YANG S P,et al.Two new terpenoid glucosides from Aster flaccidus[J].J Asian Nat Prod Res,2006,8(7):589-594.
[25]CHOI S Z,LEE S O,CHOI S U,et al.A new sesquiterpene hydroperoxide from the aerial parts of Aster oharai[J].Arch Pharm Res,2003,26(7):521-525.
[26]CHENG D L,SHAO Y,HARTMAN R,et al.Olgopeptides from Astertataricus[J].Phytochemistry,1994,36(4):945.
[27]CHENG D L,SHAO Y,HARTMANN R,et al.New pentapeptides from Asterta taricus[J].Phytochemistry,1996,41(1):225-227.
[28]卢艳花,王峥涛,叶文才,等.紫菀化学成分的研究[J].中国药科大学学报,1998,29(2):97-99.
[29]XU H M,ZENG G Z,ZHOU W B,et al.Tataricins A and B,two novel cyclotetrapeptides from Aster tataricus,and their absolute configuration assignment[J].Tetrahedron Letters,2013,54(11):1380-1383.
[30]XU H M,ZENG G Z,ZHOU W B,et al.Astins K-P,six new chlorinated cyclopentapeptides from Aster tatancus[J].Tetrahedron,2013,69(37):7964-7969.
[31]彭文静,辛蕊华,任丽花,等.紫菀化学成分及药理作用研究进展[J].动物医学进展,2015,36(3):3102-3107.
[32]卢艳花,王峥涛,徐珞珊,等.紫菀中的多元酚类化合物[J].中草药,2002,33(1):17-18.
[33]王国艳,吴弢,林平川,等.紫菀酚类化学成分的研究[J].中国中药杂志,2003,28(10):946-948.
[34]KIM A R,JIN Q,JIN H G,et al.Phenolic compounds with IL-6 inhibitory activity from Aster yomena[J].Arch Pharm Res,2014,37(7):845-851.
[35]LIN C F,SHEN C C,CHEN C C,et al.Phenolic derivatives from Aster indicus[J].Phytochemistry,2007,68(19):2450-2454.
[36]牛倩,孙鹏,张慢慢,等.中药紫菀的化学成分研究进展[J].安徽农学通报,2016,22(13):30-31.
[37]元文君,任刚,李文艳,等.三脉紫菀挥发油化学成分的GC-MS分析[J].中国实验方剂学杂志,2015,21(21):47-50.
[38]杨滨,肖永庆,梁日欣,等.紫菀挥发油中祛痰活性化学成分研究[J].中国中药杂志,2008,33(3):281-283.
[39]LIU Z L,LIU Y Q,ZHAO L,et al.The phenylpropanoids of Aster flaccidus[J].Fitoterapia,2010,81(2):140-144.
[40]卢艳花,戴岳,王峥涛,等.紫菀祛痰镇咳作用及其有效部位和有效成分[J].中草药,1999,30(50):360-362.
[41]任丽花,辛蕊华,彭文静,等.紫菀不同极性段提取物的药效比较[J].南方农业学报,2015,46(4):675-679.
[42]刘晓丽,梁羽茜,胡秀华.体外实验探讨蜜炙紫菀水煎剂对人乳腺癌MCF-7细胞的影响[J].世界中西医结合杂志,2017,12(4):496-500.
[43]钱树树,彭林,杨映映,等.蜜炙紫菀水煎剂对大肠癌LOVO细胞凋亡及迁移的影响[J].中华中医药学刊,2015,33(9):2146-2150.
[44]赵晓杰,郭兰青.长毛三脉紫菀萜类成分的提取及抑菌活性[J].新乡医学院学报,2010,27(2):140-142.
[45]黄炜娟,张春,翁城武.耳叶紫菀化学成分及生物活性研究[J].广州化工,2012,40(15):89-91.
[46]张应鹏,张海雷,杨云裳,等.紫菀提取物不同极性部位体外抗氧化活性研究[J].2011,22(11):2799-2800.
[47]景临林,马慧萍,蒙萍,等.藏紫菀醇提物的抗氧化与抗缺氧作用研究[J].中药材,2016,39(2):398-403.
[48]贾志新,王世民,冯五金,等.紫菀通便利尿作用研究[J].中药药理与临床,2012,28(1):109-111.