紫菀化学成分及药理作用研究进展
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摘要
查阅并分析近年来国内外有关紫菀研究的相关文献。紫菀的化学成分有萜类、肽类、黄酮类、蒽醌类、香豆素类、甾醇及有机酸类等,其药理学作用十分广泛,有抗菌、抗肿瘤、镇咳、祛痰、平喘、抗病毒、抗氧化活性等作用。紫菀化学成分丰富,药理活性广泛,目前有关镇咳、祛痰、平喘方面的药理作用较为深入,但通利大小便的药理活性研究不够深入,有待进一步研究。
To review and analyze the related literatures about the research on Aster in China and other countries in recent years.The chemical composition of Aster is terpenoids,peptides,coumarins,flavonoids,anthraquinones,sterols and organic acids,its pharmacological effects are very broad,with antibacterial,antitumor,antitussive,expectorant,Antiasthmatic,anti-virus,anti-oxidant activity and so on.Aster is rich in chemical components and has wide range of pharmacological activities.At present,the pharmacological effects of antitussive,expectorant and antiasthmatic effects are rather in-depth.However,the research on the pharmacological activities of defecation is not deep enough and needs further study.
To review and analyze the related literatures about the research on Aster in China and other countries in recent years.The chemical composition of Aster is terpenoids,peptides,coumarins,flavonoids,anthraquinones,sterols and organic acids,its pharmacological effects are very broad,with antibacterial,antitumor,antitussive,expectorant,Antiasthmatic,anti-virus,anti-oxidant activity and so on.Aster is rich in chemical components and has wide range of pharmacological activities.At present,the pharmacological effects of antitussive,expectorant and antiasthmatic effects are rather in-depth.However,the research on the pharmacological activities of defecation is not deep enough and needs further study.
引文
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[2]贾志新.紫菀通便作用考[J].山西中医学院学报,2008,19(1):12.
[3]NAGAO T,OKABE H,YAMAUCHI T.Studies on the constituents of AstertataricusL.f.I:Structures of shionosides A and B,monoterpene glycosides isolated from the root[J].Chem Pharm Bull,1988,36(2):571-577.
[4]CHENG D L,SHAO Y.Terpenoid glycosides from the roots ofAster tataricus[J].Phytochemistry,1994,35(1):173-176.
[5]WANG C Z,YU D Q.Diterpenoid,Sesquiterpenoid and Secoiridoid Glucosides from Aster auriculatus[J].Phytochemistry,1997,45(7):1483-1487.
[6]UCHIO Y,NAGASAKI M,EGUCHI S,et al.Labdane Diterpene Glycosides with 6-Deoxy-L-Idose from Aster spathulifolius Maxim[J].Tetrahedron Lett,1980,21:3775-3778.
[7]LEE S O,CHOI S Z,CHOI S U,et al.Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines[J].J Nat Prod,2005,68(10):1471-1474.
[8]金晶,张朝凤,张勉,等.紫菀的化学成分研究[J].中国现代中药,2008,10(6):20-22.
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[12]刘可越,张铁军,高文远,等.紫菀中三萜及甾体化合物的研究[J].天然产物研究与开发,2006,18:4-6
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[14]ZHOU W B,ZENG G Z,XU H M,et al.Astataricusones A-D and astataricusol A,five new anti-HBV shionane-type triterpenes from Aster tataricus L.f.[J].Molecules,2013,18(12):14585-14596.
[15]SHAO Y,ZHOU B N,LIN L Z,et al.Triterpene saponins from Aster yunnanensis[J].Phytochemistry,1995,38(4):927-933.
[16]SHAO Y,ZHOU B N,LIN L Z,et al.Glycosides from Aster yunnanensis[J].Phytochemistry,1995,38(3):675-680.
[17]SHAO Y,ZHOU B N,LIN L Z,et al.Asteryunnanosides F and G:two newtriterpenoid saponins from Aster yunnanensis[J].Planta Med,1995,61(5):446-449.
[18]SHAO Y,LI YL,ZHOU BN.Phenolic and triterpenoid glycosides from Asterbatangensis[J].Phytochemistry,1996,41(6):1593-1598.
[19]SHAO Y,ZHOU B N,MA K,et al.New triterpenoid saponins,asterbatanoside D and E,from Aster batangensis[J].Planta Med,1995,61(3):246-249.
[20]SHAO Y,ZHOU B N,LIN L Z,et al.Triterpenoid saponins from Aster batangensis[J].Phytochemistry,1995,38(4):927-933.
[21]SHAO Y,ZHOU B N,MA K,et al.Medicagenic acid saponins from Aster batangensis[J].Phytochemistry,1995,39(4):875-881.
[22]LEE J,LEE Y M,LEE B W,et al.Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities[J].J Nat Prod,2012,75(2):267-270.
[23]XIE W D,WENG C W,NIU Y F,et al.Eudesmane sesquiterpenes and other constituents from Aster himalaicus[J].Chem Biodivers,2010,7(1):221-224.
[24]GAN L S,ZHAN Z J,YANG S P,et al.Two new terpenoid glucosides from Aster flaccidus[J].J Asian Nat Prod Res,2006,8(7):589-594.
[25]CHOI S Z,LEE S O,CHOI S U,et al.A new sesquiterpene hydroperoxide from the aerial parts of Aster oharai[J].Arch Pharm Res,2003,26(7):521-525.
[26]CHENG D L,SHAO Y,HARTMAN R,et al.Olgopeptides from Astertataricus[J].Phytochemistry,1994,36(4):945.
[27]CHENG D L,SHAO Y,HARTMANN R,et al.New pentapeptides from Asterta taricus[J].Phytochemistry,1996,41(1):225-227.
[28]卢艳花,王峥涛,叶文才,等.紫菀化学成分的研究[J].中国药科大学学报,1998,29(2):97-99.
[29]XU H M,ZENG G Z,ZHOU W B,et al.Tataricins A and B,two novel cyclotetrapeptides from Aster tataricus,and their absolute configuration assignment[J].Tetrahedron Letters,2013,54(11):1380-1383.
[30]XU H M,ZENG G Z,ZHOU W B,et al.Astins K-P,six new chlorinated cyclopentapeptides from Aster tatancus[J].Tetrahedron,2013,69(37):7964-7969.
[31]彭文静,辛蕊华,任丽花,等.紫菀化学成分及药理作用研究进展[J].动物医学进展,2015,36(3):3102-3107.
[32]卢艳花,王峥涛,徐珞珊,等.紫菀中的多元酚类化合物[J].中草药,2002,33(1):17-18.
[33]王国艳,吴弢,林平川,等.紫菀酚类化学成分的研究[J].中国中药杂志,2003,28(10):946-948.
[34]KIM A R,JIN Q,JIN H G,et al.Phenolic compounds with IL-6 inhibitory activity from Aster yomena[J].Arch Pharm Res,2014,37(7):845-851.
[35]LIN C F,SHEN C C,CHEN C C,et al.Phenolic derivatives from Aster indicus[J].Phytochemistry,2007,68(19):2450-2454.
[36]牛倩,孙鹏,张慢慢,等.中药紫菀的化学成分研究进展[J].安徽农学通报,2016,22(13):30-31.
[37]元文君,任刚,李文艳,等.三脉紫菀挥发油化学成分的GC-MS分析[J].中国实验方剂学杂志,2015,21(21):47-50.
[38]杨滨,肖永庆,梁日欣,等.紫菀挥发油中祛痰活性化学成分研究[J].中国中药杂志,2008,33(3):281-283.
[39]LIU Z L,LIU Y Q,ZHAO L,et al.The phenylpropanoids of Aster flaccidus[J].Fitoterapia,2010,81(2):140-144.
[40]卢艳花,戴岳,王峥涛,等.紫菀祛痰镇咳作用及其有效部位和有效成分[J].中草药,1999,30(50):360-362.
[41]任丽花,辛蕊华,彭文静,等.紫菀不同极性段提取物的药效比较[J].南方农业学报,2015,46(4):675-679.
[42]刘晓丽,梁羽茜,胡秀华.体外实验探讨蜜炙紫菀水煎剂对人乳腺癌MCF-7细胞的影响[J].世界中西医结合杂志,2017,12(4):496-500.
[43]钱树树,彭林,杨映映,等.蜜炙紫菀水煎剂对大肠癌LOVO细胞凋亡及迁移的影响[J].中华中医药学刊,2015,33(9):2146-2150.
[44]赵晓杰,郭兰青.长毛三脉紫菀萜类成分的提取及抑菌活性[J].新乡医学院学报,2010,27(2):140-142.
[45]黄炜娟,张春,翁城武.耳叶紫菀化学成分及生物活性研究[J].广州化工,2012,40(15):89-91.
[46]张应鹏,张海雷,杨云裳,等.紫菀提取物不同极性部位体外抗氧化活性研究[J].2011,22(11):2799-2800.
[47]景临林,马慧萍,蒙萍,等.藏紫菀醇提物的抗氧化与抗缺氧作用研究[J].中药材,2016,39(2):398-403.
[48]贾志新,王世民,冯五金,等.紫菀通便利尿作用研究[J].中药药理与临床,2012,28(1):109-111.
[2]贾志新.紫菀通便作用考[J].山西中医学院学报,2008,19(1):12.
[3]NAGAO T,OKABE H,YAMAUCHI T.Studies on the constituents of AstertataricusL.f.I:Structures of shionosides A and B,monoterpene glycosides isolated from the root[J].Chem Pharm Bull,1988,36(2):571-577.
[4]CHENG D L,SHAO Y.Terpenoid glycosides from the roots ofAster tataricus[J].Phytochemistry,1994,35(1):173-176.
[5]WANG C Z,YU D Q.Diterpenoid,Sesquiterpenoid and Secoiridoid Glucosides from Aster auriculatus[J].Phytochemistry,1997,45(7):1483-1487.
[6]UCHIO Y,NAGASAKI M,EGUCHI S,et al.Labdane Diterpene Glycosides with 6-Deoxy-L-Idose from Aster spathulifolius Maxim[J].Tetrahedron Lett,1980,21:3775-3778.
[7]LEE S O,CHOI S Z,CHOI S U,et al.Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines[J].J Nat Prod,2005,68(10):1471-1474.
[8]金晶,张朝凤,张勉,等.紫菀的化学成分研究[J].中国现代中药,2008,10(6):20-22.
[9]AKIHISA T,KIMURA Y,KOIKE K,et al.Astertarone A:a triterpenoid ketone isolated from the roots of Aster tataricusL[J].Chem Pharm Bull,1998,46(11):1824-1826.
[10]AKIHISA T,KIMURA Y,TAI T,et al.Astertarone B,a hydroxy-triterpenoid ketone from the roots of Aster tataricusL[J].Chem Pharm Bull,1999,47(8):1161-1163.
[11]房慧勇,单高威,秦桂芳,等.紫菀的化学成分及其药理活性研究进展[J].医学研究与教育,2012,29(5):73-77.
[12]刘可越,张铁军,高文远,等.紫菀中三萜及甾体化合物的研究[J].天然产物研究与开发,2006,18:4-6
[13]ZHOU W B,ZENG G Z,XU H M,et al.Astershionones A-F,six new anti-HBV shionane-triterpenes from Aster tataricus[J].Fitoterapia,2014,93:98-104.
[14]ZHOU W B,ZENG G Z,XU H M,et al.Astataricusones A-D and astataricusol A,five new anti-HBV shionane-type triterpenes from Aster tataricus L.f.[J].Molecules,2013,18(12):14585-14596.
[15]SHAO Y,ZHOU B N,LIN L Z,et al.Triterpene saponins from Aster yunnanensis[J].Phytochemistry,1995,38(4):927-933.
[16]SHAO Y,ZHOU B N,LIN L Z,et al.Glycosides from Aster yunnanensis[J].Phytochemistry,1995,38(3):675-680.
[17]SHAO Y,ZHOU B N,LIN L Z,et al.Asteryunnanosides F and G:two newtriterpenoid saponins from Aster yunnanensis[J].Planta Med,1995,61(5):446-449.
[18]SHAO Y,LI YL,ZHOU BN.Phenolic and triterpenoid glycosides from Asterbatangensis[J].Phytochemistry,1996,41(6):1593-1598.
[19]SHAO Y,ZHOU B N,MA K,et al.New triterpenoid saponins,asterbatanoside D and E,from Aster batangensis[J].Planta Med,1995,61(3):246-249.
[20]SHAO Y,ZHOU B N,LIN L Z,et al.Triterpenoid saponins from Aster batangensis[J].Phytochemistry,1995,38(4):927-933.
[21]SHAO Y,ZHOU B N,MA K,et al.Medicagenic acid saponins from Aster batangensis[J].Phytochemistry,1995,39(4):875-881.
[22]LEE J,LEE Y M,LEE B W,et al.Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities[J].J Nat Prod,2012,75(2):267-270.
[23]XIE W D,WENG C W,NIU Y F,et al.Eudesmane sesquiterpenes and other constituents from Aster himalaicus[J].Chem Biodivers,2010,7(1):221-224.
[24]GAN L S,ZHAN Z J,YANG S P,et al.Two new terpenoid glucosides from Aster flaccidus[J].J Asian Nat Prod Res,2006,8(7):589-594.
[25]CHOI S Z,LEE S O,CHOI S U,et al.A new sesquiterpene hydroperoxide from the aerial parts of Aster oharai[J].Arch Pharm Res,2003,26(7):521-525.
[26]CHENG D L,SHAO Y,HARTMAN R,et al.Olgopeptides from Astertataricus[J].Phytochemistry,1994,36(4):945.
[27]CHENG D L,SHAO Y,HARTMANN R,et al.New pentapeptides from Asterta taricus[J].Phytochemistry,1996,41(1):225-227.
[28]卢艳花,王峥涛,叶文才,等.紫菀化学成分的研究[J].中国药科大学学报,1998,29(2):97-99.
[29]XU H M,ZENG G Z,ZHOU W B,et al.Tataricins A and B,two novel cyclotetrapeptides from Aster tataricus,and their absolute configuration assignment[J].Tetrahedron Letters,2013,54(11):1380-1383.
[30]XU H M,ZENG G Z,ZHOU W B,et al.Astins K-P,six new chlorinated cyclopentapeptides from Aster tatancus[J].Tetrahedron,2013,69(37):7964-7969.
[31]彭文静,辛蕊华,任丽花,等.紫菀化学成分及药理作用研究进展[J].动物医学进展,2015,36(3):3102-3107.
[32]卢艳花,王峥涛,徐珞珊,等.紫菀中的多元酚类化合物[J].中草药,2002,33(1):17-18.
[33]王国艳,吴弢,林平川,等.紫菀酚类化学成分的研究[J].中国中药杂志,2003,28(10):946-948.
[34]KIM A R,JIN Q,JIN H G,et al.Phenolic compounds with IL-6 inhibitory activity from Aster yomena[J].Arch Pharm Res,2014,37(7):845-851.
[35]LIN C F,SHEN C C,CHEN C C,et al.Phenolic derivatives from Aster indicus[J].Phytochemistry,2007,68(19):2450-2454.
[36]牛倩,孙鹏,张慢慢,等.中药紫菀的化学成分研究进展[J].安徽农学通报,2016,22(13):30-31.
[37]元文君,任刚,李文艳,等.三脉紫菀挥发油化学成分的GC-MS分析[J].中国实验方剂学杂志,2015,21(21):47-50.
[38]杨滨,肖永庆,梁日欣,等.紫菀挥发油中祛痰活性化学成分研究[J].中国中药杂志,2008,33(3):281-283.
[39]LIU Z L,LIU Y Q,ZHAO L,et al.The phenylpropanoids of Aster flaccidus[J].Fitoterapia,2010,81(2):140-144.
[40]卢艳花,戴岳,王峥涛,等.紫菀祛痰镇咳作用及其有效部位和有效成分[J].中草药,1999,30(50):360-362.
[41]任丽花,辛蕊华,彭文静,等.紫菀不同极性段提取物的药效比较[J].南方农业学报,2015,46(4):675-679.
[42]刘晓丽,梁羽茜,胡秀华.体外实验探讨蜜炙紫菀水煎剂对人乳腺癌MCF-7细胞的影响[J].世界中西医结合杂志,2017,12(4):496-500.
[43]钱树树,彭林,杨映映,等.蜜炙紫菀水煎剂对大肠癌LOVO细胞凋亡及迁移的影响[J].中华中医药学刊,2015,33(9):2146-2150.
[44]赵晓杰,郭兰青.长毛三脉紫菀萜类成分的提取及抑菌活性[J].新乡医学院学报,2010,27(2):140-142.
[45]黄炜娟,张春,翁城武.耳叶紫菀化学成分及生物活性研究[J].广州化工,2012,40(15):89-91.
[46]张应鹏,张海雷,杨云裳,等.紫菀提取物不同极性部位体外抗氧化活性研究[J].2011,22(11):2799-2800.
[47]景临林,马慧萍,蒙萍,等.藏紫菀醇提物的抗氧化与抗缺氧作用研究[J].中药材,2016,39(2):398-403.
[48]贾志新,王世民,冯五金,等.紫菀通便利尿作用研究[J].中药药理与临床,2012,28(1):109-111.