2型糖尿病合并无症状冠心病的危险因素分析
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摘要
目的探讨T2DM合并无症状冠心病(CAD)的危险因素。方法选取328例既往无CAD病史,亦无胸闷、胸痛等CAD相关症状的T2DM患者为研究对象,根据冠状动脉CTA检查结果分为单纯T2DM组(T2DM)和合并无症状CAD组(ACAD)。结果 ACAD组年龄、糖尿病病程、吸烟、高血压病、入院前服用降压药及他汀类药物比例高于T2DM组(P<0.05或P<0.01)。Logistic回归分析显示,年龄、糖尿病病程增加、有高血压病及吸烟为T2DM合并ACAD的独立危险因素。结论T2DM合并ACAD的危险因素是年龄、糖尿病病程、高血压病和吸烟。
Objective To explore the risk factors for type 2 diabetes mellitus(T2DM)complicated with asymptomatic coronary artery disease(ACAD). Methods A total of 328 patients with T2DM were enrolled in this study.All the patients were without CAD history,chest tightness,chest pain or other symptoms related to CAD.All the patients were divided into two groups according to the results of coronary CTA examination:T2DM with asymptomatic CAD group and T2DM without CAD group.Results The age,diabetic duration,the proportions of smoking,hypertension history,and the proportion of statins and antihypertensive drugs before admission were all higher in T2DM with asymptomatic CAD group than in T2DM without CAD group(P<0.05 or P<0.01).Logistic regression analysis showed that age,diabetic duration,hypertension,and smoking were independent risk factors for T2DM with asymptomatic CAD. Conclusion Age,diabetic duration,hypertension,and smoking are independent risk factors for T2DM with asymptomatic CAD.
Objective To explore the risk factors for type 2 diabetes mellitus(T2DM)complicated with asymptomatic coronary artery disease(ACAD). Methods A total of 328 patients with T2DM were enrolled in this study.All the patients were without CAD history,chest tightness,chest pain or other symptoms related to CAD.All the patients were divided into two groups according to the results of coronary CTA examination:T2DM with asymptomatic CAD group and T2DM without CAD group.Results The age,diabetic duration,the proportions of smoking,hypertension history,and the proportion of statins and antihypertensive drugs before admission were all higher in T2DM with asymptomatic CAD group than in T2DM without CAD group(P<0.05 or P<0.01).Logistic regression analysis showed that age,diabetic duration,hypertension,and smoking were independent risk factors for T2DM with asymptomatic CAD. Conclusion Age,diabetic duration,hypertension,and smoking are independent risk factors for T2DM with asymptomatic CAD.
引文
[1]Xu Y,Bi Y,Li M,et al.Significant coronary stenosis in asymptomatic Chinese with different glycemic status.Diabetes Care,2013,36:1687-1694.
[2]Goraya TY,Leibson CL,Palumbo PJ,et al.Coronary atherosclerosis in diabetes mellitus:apopulation-based autopsy study.J Am Coll Cardiol,2002,40:946-953.
[3]王淑玲,郭玉岩.糖尿病无症状性心肌缺血研究进展.实用糖尿病杂志,2016,2:63-64.
[4]崔艳玲,王广志,周茂义,等.64MDCT冠状动脉成像对隐匿性冠心病的诊断价值.医学影像学杂志,2009,11:1405-1408.
[5]宋宏宾,张伟民,陈大楸,等.1872例冠心病增龄性临床研究.实用临床医药杂志,2016,20:109-113.
[6]侯晓沛,陈燕燕.老年糖尿病与大血管并发症.中华内分泌代谢杂志,2014,30:882-885.
[7]洪靖,张金萍,赵文惠,等.门诊2型糖尿病合并冠心病患者临床特点分析.中华糖尿病杂志,2013,5:297-300.
[8]王志军,吴寿岭.糖尿病合并高血压病患者的危险因素及随访分析.中华内分泌代谢杂志,2013,29:120-124.
[9]Lehmann N,M9hlenkamp S,Mahabadi AA,et al.Effect of smoking and other traditional risk factors on the onset of coronary artery calcification:results of the Heinz Nixdorf recall study.Atherosclerosi,2014,232:339-345.
[10]Messner B,Bernhard D.Smoking and cardiovascular disease:mechanisms of endothelial dysfunction and early atherogenesis.Arterioscler Thromb Vasc Biol,2014,34:509-515.
[11]Turner RC,Millns H,Neil HA,et al.Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus:United Kingdom Prospective Diabetes Study(UKPDS:23).BMJ,1998,316:823-828.
[2]Goraya TY,Leibson CL,Palumbo PJ,et al.Coronary atherosclerosis in diabetes mellitus:apopulation-based autopsy study.J Am Coll Cardiol,2002,40:946-953.
[3]王淑玲,郭玉岩.糖尿病无症状性心肌缺血研究进展.实用糖尿病杂志,2016,2:63-64.
[4]崔艳玲,王广志,周茂义,等.64MDCT冠状动脉成像对隐匿性冠心病的诊断价值.医学影像学杂志,2009,11:1405-1408.
[5]宋宏宾,张伟民,陈大楸,等.1872例冠心病增龄性临床研究.实用临床医药杂志,2016,20:109-113.
[6]侯晓沛,陈燕燕.老年糖尿病与大血管并发症.中华内分泌代谢杂志,2014,30:882-885.
[7]洪靖,张金萍,赵文惠,等.门诊2型糖尿病合并冠心病患者临床特点分析.中华糖尿病杂志,2013,5:297-300.
[8]王志军,吴寿岭.糖尿病合并高血压病患者的危险因素及随访分析.中华内分泌代谢杂志,2013,29:120-124.
[9]Lehmann N,M9hlenkamp S,Mahabadi AA,et al.Effect of smoking and other traditional risk factors on the onset of coronary artery calcification:results of the Heinz Nixdorf recall study.Atherosclerosi,2014,232:339-345.
[10]Messner B,Bernhard D.Smoking and cardiovascular disease:mechanisms of endothelial dysfunction and early atherogenesis.Arterioscler Thromb Vasc Biol,2014,34:509-515.
[11]Turner RC,Millns H,Neil HA,et al.Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus:United Kingdom Prospective Diabetes Study(UKPDS:23).BMJ,1998,316:823-828.