RLPO改性亲水性SIS热熔压敏胶基质配比研究
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摘要
目的优选适宜亲水性物质释放的热熔压敏胶基质的配比。方法采用正交试验法,以胶体的黏性、亲水性药物的释放度为指标,以C_5石油树脂、以苯乙烯-异戊二烯-苯乙烯(SIS)、丙烯酸乙酯-甲基丙烯酸甲酯-甲基丙烯酸氯化三甲胺基乙酯共聚物(RLPO)、液体石蜡、邻苯二甲酸二辛酯(DOP)、聚乙二醇400(PEG 400)、抗氧化剂1010为材料,筛选热熔压敏胶基质的配方。结果最佳基质配比为SIS-C_5石油树脂-RLPO-液体石蜡-PEG 400-DOP-抗氧化剂1010为3∶4∶6∶6∶5∶1∶0.1,所制得的热熔压敏胶黏性适宜,对亲水性药物释放度高。结论本研究制备的热熔压敏胶是制备亲水性药物经皮给药贴剂的良好材料。
Objective To optimize the matrix proportion of SIS hot melt pressure sensitive adhesive suit for hydrophilic material releasing. Methods By orthogonal test method, taking adhesiveness and hydrophilic drug release rate as factors, and C_5 petroleum resin hydrogenate, lanoline styrene-isoprene-styrene(SIS) triblock copolymer, ethyl acrylate-methyl methacrylate-trimethylamino(RLPO), liquid paraffin, dibutyl phthalate(DOP), polyethylene glycol(PEG) 400, and Antioxidant 1010 as materials, the matrix proportion was optimized. Results The optimized formulation was as follows: SIS-C_5 petroleum resin hydrogenate-SIS-RLPO-DOP-PEG 400-Antioxidant 1010 was 3∶4∶6∶6∶5∶1∶0.1. The adhesiveness was proper and shows more release rate for hydrophilic material. Conclusion The SIS hot melt pressure sensitive adhesive shows good property and is suitable to prepare transdermal patch.
Objective To optimize the matrix proportion of SIS hot melt pressure sensitive adhesive suit for hydrophilic material releasing. Methods By orthogonal test method, taking adhesiveness and hydrophilic drug release rate as factors, and C_5 petroleum resin hydrogenate, lanoline styrene-isoprene-styrene(SIS) triblock copolymer, ethyl acrylate-methyl methacrylate-trimethylamino(RLPO), liquid paraffin, dibutyl phthalate(DOP), polyethylene glycol(PEG) 400, and Antioxidant 1010 as materials, the matrix proportion was optimized. Results The optimized formulation was as follows: SIS-C_5 petroleum resin hydrogenate-SIS-RLPO-DOP-PEG 400-Antioxidant 1010 was 3∶4∶6∶6∶5∶1∶0.1. The adhesiveness was proper and shows more release rate for hydrophilic material. Conclusion The SIS hot melt pressure sensitive adhesive shows good property and is suitable to prepare transdermal patch.
引文
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[13]俞振伟,梁漪,梁文权.热熔压敏胶性能与药物释放速率的关系研究[J].中国中药杂志,2011,36(21):2967-2970.
[2]姚譞,沈侃,刘然,等.关节止痛膏橡胶膏与热熔压敏胶剂型的体外透皮特性、药效以及皮肤刺激性比较[J].中草药,2013,44(4):443-448.
[3]张爱清.压敏胶粘剂[M].北京:化学工业出版社,2002.
[4]陆彬.药物新剂型与新技术[M].北京:人民卫生出版社,2005.
[5]闫小平,郑蕊,官仕杰,等.热熔压敏胶在中药透皮吸收制剂中的研究进展[J].中国药学杂志,2009,34(12):1612-1614.
[6]俞振伟,梁漪,梁文权.经皮给药用热熔压敏胶的制备及其体外评价[J].中国药学杂志,2013,48(6):450-455.
[7]高轶.中药浸膏贴片用环氧化SIS热熔压敏胶的制备及其性能研究[D].北京:北京化工大学,2011.
[8]韦异,陈薇,赵文峰,等.SBS的磺化改性[J].精细石油化工,2002,(5):23-25.
[9]华丽丽,李杨,赵忠夫,等.C5树脂对SIS/RLPO基热熔压敏胶性能的影响[J].中国胶黏剂,2011,36(21):27-31.
[10]孟祥乐,李红伟,李颜.栀子化学成分及其药理作用研究进展[J].中国新药杂志,2011,20(11):959-967.
[11]马建芳,罗华菲,王浩.睾酮热熔压敏胶透皮贴剂的研制[J].中国药学杂志,2012,47(21):1727-1731.
[12]张欣.SIS型热熔压敏胶改性研究及性能评价[D].大连:大连理工大学,2010.
[13]俞振伟,梁漪,梁文权.热熔压敏胶性能与药物释放速率的关系研究[J].中国中药杂志,2011,36(21):2967-2970.