益气活血清热化湿方联合西药标准三联疗法治疗消化性溃疡的疗效观察
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摘要
目的探讨益气活血清热化湿方联合西药标准三联疗法治疗消化性溃疡的临床疗效。方法选取2015年3月-2016年2月进行治疗的消化性溃疡患者286例,随机分为研究组和对照组,每组143例。其中对照组采用传统西药标准三联治疗方案,研究组采用益气活血清热化湿方联合西药标准三联疗法治疗。观察两种治疗方案的治疗效果及对患者病灶部位幽门螺杆菌(Hp)的清除(即阴性率)情况和不良反应发生情况。结果研究组和对照组治疗后有效率分别为88. 11%和84. 62%,研究组高于对照组,但两组之间差异无统计学意义(P>0. 05)。研究组和对照组的阴性率分别为76. 22%和65. 03%,研究组高于对照组,且组间差异具有统计学意义(P<0. 05)。两组患者在治疗过程中均未出现明显的不良反应。结论益气活血清热化湿方联合西药标准三联疗法对于消化性溃疡疗效显著,能有效根除Hp,降低疾病的复发,对于耐药性较强的患者也具备更好的疗效,值得在临床上进行推广。
Objective To explore the clinical effects on peptic ulcer treated with yiqi huoxue qingre huashi formula( for benefiting qi,activating blood circulation,clearing heat and resolving damp) and the triple therapy with western medication. Methods From March 2015 to February 2016,286 patients with peptic ulcer were collected and randomized into a treatment group and a control group,143 cases in each one. In the control group,the triple therapy with western medication was used. In the treatment group,the combined treatments with yiqi huoxue qingre huashi formula and the triple therapy with western medication were adopted. The therapeutic effects,clearance rate of Hp and adverse reactions were observed in the two groups. Results The effective rates were 88. 11% and 84. 62% in the treatment group and control group successively. The result in the treatment group was higher than the control group,but without statistical significance( P >0. 05). The clearance rates were 76. 22% and 65. 05% in the treatment group and control group successively,and the result in the treatment group was higher thant he control group,indicating the statistical significance( P < 0. 05). During treatment,no obvious adverse reaction was found in the two groups. Conclusion The yiqi huoxue qingre huashi combined with the triple therapy with western medication achieves the better effects on peptic ulcer. Such combined treatment removes Hp and reduces the recurrence more effectively compared with the traditional regimen. It is especially effective for the patients with strong drug tolerance. Hence,it deserves to be promoted in clinical practice.
Objective To explore the clinical effects on peptic ulcer treated with yiqi huoxue qingre huashi formula( for benefiting qi,activating blood circulation,clearing heat and resolving damp) and the triple therapy with western medication. Methods From March 2015 to February 2016,286 patients with peptic ulcer were collected and randomized into a treatment group and a control group,143 cases in each one. In the control group,the triple therapy with western medication was used. In the treatment group,the combined treatments with yiqi huoxue qingre huashi formula and the triple therapy with western medication were adopted. The therapeutic effects,clearance rate of Hp and adverse reactions were observed in the two groups. Results The effective rates were 88. 11% and 84. 62% in the treatment group and control group successively. The result in the treatment group was higher than the control group,but without statistical significance( P >0. 05). The clearance rates were 76. 22% and 65. 05% in the treatment group and control group successively,and the result in the treatment group was higher thant he control group,indicating the statistical significance( P < 0. 05). During treatment,no obvious adverse reaction was found in the two groups. Conclusion The yiqi huoxue qingre huashi combined with the triple therapy with western medication achieves the better effects on peptic ulcer. Such combined treatment removes Hp and reduces the recurrence more effectively compared with the traditional regimen. It is especially effective for the patients with strong drug tolerance. Hence,it deserves to be promoted in clinical practice.
引文
[1]彭兴国,许耿瑞,何晴,等.左氧氟沙星三联疗法与阿莫西林三联疗法治疗消化性溃疡的疗效比较[J].当代医学,2012(21):83-84.
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[8]Kasai C,Sugimoto K,Moritani I,et al. Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection[J]. BMC Gastroenterol,2016,16(1):119.
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[10]Shih HM,Hsu TY,Chen CY,et al. Analysis of Patients with helicobacter pylori infection and the subsequent risk of developing osteoporosis after eradication therapy:a nationwide population-based cohort study[J]. PLo S One,2016,11(9):e0 162 645.
[11]Archampong TN,Asmah RH,Wiredu EK,et al. Factors associated with gastro-duodenal disease in patients undergoing upper GI endoscopy at the Korle-Bu Teaching Hospital,Accra,Ghana[J]. Afr Health Sci,2016,16(2):611-619.
[12]Lee JW,Kim HK,Woo YS,et al. Optimal operational definition of patient with peptic ulcer bleeding for big data analysis using combination of clinical characteristics in a secondary general hospital[J].Korean J Gastroenterol,2016,68(2):77-86.
[13]Chernin VV,Chervinets VM,Bazlov SN. The role of helicobacter pylori in normomicrobiocenosis and dysbacteriosis of mucosal microflora of oesophagogastroduodenal zone in the cases of peptic ulcer,chronic gastritis and oesophagitis[J]. Eksp Klin Gastroenterol,2016(2):79-86.
[14]Carneiro CC,da CSS,de Souza Lino R,et al. Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St-Hil[J]. Toxicol Appl Pharmacol,2016(310):1-8.
[15]Wang S,Li B,Ungvari GS,et al. Poor mental health status and its associations with demographic characteristics and chronic diseases in Chinese elderly[J]. Soc Psychiatry Psychiatr Epidemiol,2016,51(10):1449-1455.
[16]Agarwal A,Jain S,Meena LN,et al. Validation of Boey's score in predicting morbidity and mortality in peptic perforation peritonitis in Northwestern India[J]. Trop Gastroenterol,2015,36(4):256-260.
[17]Peng L,Wang Y,Chang X,et al. Effect of moxa-burning heat stimulating Liangmen(ST 21)and Zusanli(ST 36)on proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer[J]. J Tradit Chin Med,2016,36(3):340-346.
[18]Lee WP,Hou MC,Lan KH,et al. Helicobacter pylori-induced chronic inflammation causes telomere shortening of gastric mucosa by promoting PARP-1-mediated non-homologous end joining of DNA[J]. Arch Biochem Biophys,2016(606):90-98.
[19]Sazonova OV,Davydkin IL,Osadchuk AM,et al. Clinical and endoscopic,morphologic and immunohistochemical features of gastric ulcer in pylori-infected individuals receiving cytotoxic therapy[J].Eksp Klin Gastroenterol,2016(2):18-24.
[20]Nkurunziza A,Dusabejambo V,Everhart K,et al. Validation of the kinyarwanda-version short-form leeds dyspepsia questionnaire and short-form nepean dyspepsia index to assess dyspepsia prevalence and quality-of-life impact in Rwanda[J]. BMJ Open,2016,6(6):e011 018.
[2]Bagheri N,Azadegan-Dehkordi F,Rafieian-Kopaei M,et al. Clinical relevance of Helicobacter pylori virulence factors in Iranian patients with gastrointestinal diseases[J]. Microb Pathog,2016(100):154-162.
[3]Mahmoudi L,Farshad S,Seddigh M,et al. High efficacy of gemifloxacin-containing therapy in Helicobacter Pylori eradication:A pilot empirical second-line rescue therapy[J]. Medicine(Baltimore),2016,95(42):e4410.
[4]Teles SE,Maia L,Salgueiro P,et al. Antiplatelet agents and/or anticoagulants are not associated with worse outcome following nonvariceal upper gastrointestinal bleeding[J]. Rev Esp Enferm Dig,2016(2):108.
[5]Tsai AP,Tsai JP,Stewart L,et al. Prevalence of potential smokingrelated conditions among tobacco users in the emergency department and their perception that their visit may be smoking-related[J].CJEM,2016(2):1-6.
[6]Agaba EA,Klair T,Ikedilo O,et al. A 10-year review of surgical management of complicated peptic ulcer disease from a single center:is laparoscopic approach the future?[J]. Surg Laparosc Endosc Percutan Tech,2016,26(5):385-390.
[7]叶泽辉,温晓雯.泮托拉唑治疗消化性溃疡合并出血48例疗效观察[J].当代医学,2012(14):9-10.
[8]Kasai C,Sugimoto K,Moritani I,et al. Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection[J]. BMC Gastroenterol,2016,16(1):119.
[9]Jiang JX,Liu Q,Mao XY,et al. Downward trend in the prevalence of Helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in Southeastern China between2003 and 2012[J]. Springerplus,2016,5(1):1601.
[10]Shih HM,Hsu TY,Chen CY,et al. Analysis of Patients with helicobacter pylori infection and the subsequent risk of developing osteoporosis after eradication therapy:a nationwide population-based cohort study[J]. PLo S One,2016,11(9):e0 162 645.
[11]Archampong TN,Asmah RH,Wiredu EK,et al. Factors associated with gastro-duodenal disease in patients undergoing upper GI endoscopy at the Korle-Bu Teaching Hospital,Accra,Ghana[J]. Afr Health Sci,2016,16(2):611-619.
[12]Lee JW,Kim HK,Woo YS,et al. Optimal operational definition of patient with peptic ulcer bleeding for big data analysis using combination of clinical characteristics in a secondary general hospital[J].Korean J Gastroenterol,2016,68(2):77-86.
[13]Chernin VV,Chervinets VM,Bazlov SN. The role of helicobacter pylori in normomicrobiocenosis and dysbacteriosis of mucosal microflora of oesophagogastroduodenal zone in the cases of peptic ulcer,chronic gastritis and oesophagitis[J]. Eksp Klin Gastroenterol,2016(2):79-86.
[14]Carneiro CC,da CSS,de Souza Lino R,et al. Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St-Hil[J]. Toxicol Appl Pharmacol,2016(310):1-8.
[15]Wang S,Li B,Ungvari GS,et al. Poor mental health status and its associations with demographic characteristics and chronic diseases in Chinese elderly[J]. Soc Psychiatry Psychiatr Epidemiol,2016,51(10):1449-1455.
[16]Agarwal A,Jain S,Meena LN,et al. Validation of Boey's score in predicting morbidity and mortality in peptic perforation peritonitis in Northwestern India[J]. Trop Gastroenterol,2015,36(4):256-260.
[17]Peng L,Wang Y,Chang X,et al. Effect of moxa-burning heat stimulating Liangmen(ST 21)and Zusanli(ST 36)on proliferation and apoptosis signaling proteins in rats with stress-induced gastric ulcer[J]. J Tradit Chin Med,2016,36(3):340-346.
[18]Lee WP,Hou MC,Lan KH,et al. Helicobacter pylori-induced chronic inflammation causes telomere shortening of gastric mucosa by promoting PARP-1-mediated non-homologous end joining of DNA[J]. Arch Biochem Biophys,2016(606):90-98.
[19]Sazonova OV,Davydkin IL,Osadchuk AM,et al. Clinical and endoscopic,morphologic and immunohistochemical features of gastric ulcer in pylori-infected individuals receiving cytotoxic therapy[J].Eksp Klin Gastroenterol,2016(2):18-24.
[20]Nkurunziza A,Dusabejambo V,Everhart K,et al. Validation of the kinyarwanda-version short-form leeds dyspepsia questionnaire and short-form nepean dyspepsia index to assess dyspepsia prevalence and quality-of-life impact in Rwanda[J]. BMJ Open,2016,6(6):e011 018.