急性脑梗死患者血清CRP、Hcy及IL-6水平的表达及临床意义
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摘要
目的探讨急性脑梗死患者血清C反应蛋白(CRP)、同型半胱氨酸(Hcy)、白细胞介素-6(IL-6)水平的表达及临床意义。方法选取2018年1月至2018年6月间在我院进行治疗的急性脑梗死患者80例作为观察组,另选取同期在我院体检的健康志愿者80例作为对照组。比较两组研究对象血清CRP、Hcy、IL-6的表达,比较不同病情急性脑梗死患者血清CRP、Hcy及IL-6水平的表达,并分析各因子之间的相关性。结果治疗前观察组血清CRP、Hcy、IL-6水平明显高于对照组(P<0.05),治疗后观察组患者血清CRP、Hcy、IL-6水平明显低于治疗前(P<0.05)。重型急性脑梗死患者血清CRP、Hcy、IL-6水平明显高于中型、轻型急性脑梗死患者,中型急性脑梗死患者血清CRP、Hcy、IL-6水平明显高于轻型急性脑梗死患者(P<0.05)。急性脑梗死患者血清CRP与Hcy、IL-6呈正相关(P<0.05),血清Hcy与IL-6呈正相关(P<0.05)。结论急性脑梗死患者血清中的CRP、Hcy、IL-6呈高表达,与患者病情严重程度有相关性,且三个指标之间相互呈线性关系。
Objective To investigate the serum levels of C-reactive protein( CRP),homocysteine( Hcy) and interleukin-6( IL-6) in patients with acute cerebral infarction and its clinical significance.Methods 80 patients with acute cerebral infarction who were treated in our hospital from January 2018 to June 2018 were selected as the observation group. Another 80 healthy volunteers in our hospital during the same period were selected as control group. The expressions of serum CRP,Hcy and IL-6 were compared between the two groups,the expressions of serum CRP,Hcy and IL-6 were compared between the patients with different conditions,and the correlation between various factors were analyzed.Results The levels of serum CRP,Hcy and IL-6 in the observation group before treatment were significantly higher than those in the control group( P<0.05). After treatment,the serum levels of CRP,Hcy and IL-6 in the observation group were significantly lower than those before treatment( P<0.05).The serum levels of CRP,Hcy and IL-6 in patients with severe acute cerebral infarction were significantly higher than those in patients with moderate and mild acute cerebral infarction,and the serum levels of CRP,Hcy and IL-6 in patients with moderate acute cerebral infarction were significantly higher than those in patients with mild acute cerebral infarction( P< 0.05). Serum CRP was positively correlated with Hcy and IL-6 in patients with acute cerebral infarction( P<0.05),and serum Hcy was positively correlated with IL-6( P< 0.05). Conclusion The levels of CRP,Hcy and IL-6 in serum of patients with acute cerebral infarction were higher,and the expression level wascorrelated to the severity of the disease,and there was a linear relationship among the three indicators.
Objective To investigate the serum levels of C-reactive protein( CRP),homocysteine( Hcy) and interleukin-6( IL-6) in patients with acute cerebral infarction and its clinical significance.Methods 80 patients with acute cerebral infarction who were treated in our hospital from January 2018 to June 2018 were selected as the observation group. Another 80 healthy volunteers in our hospital during the same period were selected as control group. The expressions of serum CRP,Hcy and IL-6 were compared between the two groups,the expressions of serum CRP,Hcy and IL-6 were compared between the patients with different conditions,and the correlation between various factors were analyzed.Results The levels of serum CRP,Hcy and IL-6 in the observation group before treatment were significantly higher than those in the control group( P<0.05). After treatment,the serum levels of CRP,Hcy and IL-6 in the observation group were significantly lower than those before treatment( P<0.05).The serum levels of CRP,Hcy and IL-6 in patients with severe acute cerebral infarction were significantly higher than those in patients with moderate and mild acute cerebral infarction,and the serum levels of CRP,Hcy and IL-6 in patients with moderate acute cerebral infarction were significantly higher than those in patients with mild acute cerebral infarction( P< 0.05). Serum CRP was positively correlated with Hcy and IL-6 in patients with acute cerebral infarction( P<0.05),and serum Hcy was positively correlated with IL-6( P< 0.05). Conclusion The levels of CRP,Hcy and IL-6 in serum of patients with acute cerebral infarction were higher,and the expression level wascorrelated to the severity of the disease,and there was a linear relationship among the three indicators.
引文
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[1]尚广芹,王志宏,姜积军.颈动脉重度狭窄或闭塞导致脑梗死发病机制的研究[J].中风与神经疾病杂志,2016,33(2):128-130.
[2]ZHAO L,ZHAI Z,HOU W.Analysis of Carotid color ultrasonography and high sensitive C-reactive protein in patients with atherosclerotic cerebral infarction[J].Pak J Med Sci,2016,32(4):931-934.
[3]陈海恋,何超明,庞明武,等.高龄急性脑梗死患者同型半胱氨酸与颈动脉硬化的相关性[J].中国热带医学,2016,16(9):930-933.
[4]路小薇.急性脑梗死患者血清炎性因子及血流动力学变化及意义[J].海南医学院学报,2016,22(1):93-95.
[5]张作念,王志晔,顾伟,等.急性脑梗死患者血清炎症因子与颈动脉粥样硬化斑块性质关系的临床研究[J].重庆医学,2016,45(10):1375-1377.
[6]常虹,卢祖能.miR-151a-3p在急性脑梗死患者血清中的表达及与炎性因子的相关性研究[J].中华危重病急救医学,2016,28(3):272-276.
[7]王迎新,顾志坚,周平.血浆Hcy水平与急性脑梗死TOAST分型和OCSP分型的关系研究[J].河北医学,2016,22(2):258-261.
[8]苏静.脑卒中患者临床神经功能缺损程度评分的信度与效度[J].中国医药指南,2013,11(17):626-627.
[9]中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[10]刘旭,毛玲艳,李鑫,等.急性脑梗死患者高敏C反应蛋白及脂蛋白a表达水平的临床价值[J].中国临床医学,2016,23(2):161-163.
[11]李顺钧,李云霞,王慧,等.老年急性脑梗死患者血清CRP,FG,LP(a)变化研究[J].现代生物医学进展,2016,16(22):4260-4262,4279.
[12]LI Y,WANG L,ZHANG W,et al.No association between elevated homocysteine levels and carotid atherosclerosis in a ruralpopulation in China[J].Stroke Vasc Neurol,2016,1(4):154-160.
[14]HOLTE E,KLEVELAND O,UELANG T,et al.Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction[J].Heart,2017,103(19):1521-1527.
[15]任彩霞,冯丙东,余永平.急性脑梗死患者血清hs-CRP、IL-6和TNF-α测定及其临床意义[J].陕西医学杂志,2016,45(11):1501-1502.
[16]李志国,周霞,文贵斌.急性脑梗死患者血清同型半胱氨酸水平与炎性因子、神经因子及NO代谢的相关性[J].海南医学院学报,2017,23(10):1431-1433.
[1]尚广芹,王志宏,姜积军.颈动脉重度狭窄或闭塞导致脑梗死发病机制的研究[J].中风与神经疾病杂志,2016,33(2):128-130.
[2]ZHAO L,ZHAI Z,HOU W.Analysis of Carotid color ultrasonography and high sensitive C-reactive protein in patients with atherosclerotic cerebral infarction[J].Pak J Med Sci,2016,32(4):931-934.
[3]陈海恋,何超明,庞明武,等.高龄急性脑梗死患者同型半胱氨酸与颈动脉硬化的相关性[J].中国热带医学,2016,16(9):930-933.
[4]路小薇.急性脑梗死患者血清炎性因子及血流动力学变化及意义[J].海南医学院学报,2016,22(1):93-95.
[5]张作念,王志晔,顾伟,等.急性脑梗死患者血清炎症因子与颈动脉粥样硬化斑块性质关系的临床研究[J].重庆医学,2016,45(10):1375-1377.
[6]常虹,卢祖能.miR-151a-3p在急性脑梗死患者血清中的表达及与炎性因子的相关性研究[J].中华危重病急救医学,2016,28(3):272-276.
[7]王迎新,顾志坚,周平.血浆Hcy水平与急性脑梗死TOAST分型和OCSP分型的关系研究[J].河北医学,2016,22(2):258-261.
[8]苏静.脑卒中患者临床神经功能缺损程度评分的信度与效度[J].中国医药指南,2013,11(17):626-627.
[9]中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[10]刘旭,毛玲艳,李鑫,等.急性脑梗死患者高敏C反应蛋白及脂蛋白a表达水平的临床价值[J].中国临床医学,2016,23(2):161-163.
[11]李顺钧,李云霞,王慧,等.老年急性脑梗死患者血清CRP,FG,LP(a)变化研究[J].现代生物医学进展,2016,16(22):4260-4262,4279.
[12]LI Y,WANG L,ZHANG W,et al.No association between elevated homocysteine levels and carotid atherosclerosis in a ruralpopulation in China[J].Stroke Vasc Neurol,2016,1(4):154-160.