脑卒中后少突胶质细胞再生的细胞间相互作用机制
摘要
白质损伤是包括脑卒中在内的很多中枢神经系统疾病的重要临床表现。脑白质由成熟少突胶质细胞形成的髓鞘包绕轴突构成,且作为连接各灰质部位的发挥信号传递作用。在脑卒中的急性阶段,少突胶质细胞死亡、脱髓鞘导致了白质功能失调。而在慢性阶段,白质环境对于神经元修复、血管重塑以及髓鞘再生都起到积极促进作用。少突胶质细胞前体细胞(oligodendrocyte precursor cells,OPCs)能增殖分化为成熟少突胶质细胞完成髓鞘再生,重新包绕轴突进行修复。在这过程中,尤其引人注目的是其他种类的细胞在缺血情况下对OPCs的支持作用。本文聚焦白质损伤或者生理情况下,对OPCs如何获得其周围其他细胞支持,完成少突胶质细胞再生以及髓鞘再生的过程进行综述,为白质损伤后修复的进一步研究提供参考。
引文
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2 Matute C,Domercq M,Perez-Samartin A,et al. Protecting white matter from stroke injury[J]. Stroke,2013,44(4):1204-1211
3 Etxeberria A,Mangin JM,Aguirre A,et al. Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum[J]. Nat Neurosci,2010,13(3):287-289
4 Li Q,Brus-Ramer M,Martin JH,et al. Electrical stimulation of the medullary pyramid promotes proliferation and differentiation of oligodendrocyte progenitor cells in the corticospinal tract of the adult rat[J]. Neurosci Lett,2010,479(2):128-133
5 Zhang Y,Chen K,Sloan SA,et al. An RNA-sequencing transcriptome and splicing database of glia,neurons,and vascular cells of the cerebral cortex[J]. J Neurosci,2014,34(36):11929-11947
6 Imamura O,Arai M,Dateki M,et al. Nicotinic acetylcholine receptors mediate donepezil-induced oligodendrocyte differentiation[J]. J Neurochem,2015,135(6):1086-1098
7 De Angelis F,Bernardo A,Magnaghi V,et al. Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival,proliferation,and differentiation[J]. Dev Neurobiol,2012,72(5):713-728
8 Zonouzi M,Scafidi J,Li P,et al. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury[J].Nat Neurosci,2015,18(5):674-682
9 Spitzer S,Volbracht K,Lundgaard I,et al. Glutamate signalling:A multifaceted modulator of oligodendrocyte lineage cells in health and disease[J]. Neuropharmacology,2016,110(Pt B):574-585
10 Gibson EM,Purger D,Mount CW,et al. Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain[J]. Science,2014,344(6183):1252304
11 Mc Kenzie IA,Ohayon D,Li H,et al. Motor skill learning requires active central myelination[J]. Science,2014,346(6207):318-322
12 Emery B. Regulation of oligodendrocyte differentiation and myelination[J]. Science,2010,330(6005):779-782
13 Brinkmann BG,Agarwal A,Sereda MW,et al. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system[J]. Neuron,2008,59(4):581-595
14 Shi H,Hu X,Leak RK,et al. Demyelination as a rational therapeutic target for ischemic or traumatic brain injury[J]. Exp Neurol,2015,272:17-25
15 Arai K,Lo EH. An oligovascular niche:cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells[J]. J Neurosci,2009,29(14):4351-4355
16 Hayakawa K,Seo JH,Pham LD,et al. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro[J]. Neurosci Lett,2012,513(1):42-46
17 Hayakawa K,Pham LD,Katusic ZS,et al. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery[J]. Proc Natl Acad Sci U S A,2012,109(19):7505-7510
18 Seo JH,Miyamoto N,Hayakawa K,et al. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury[J]. J Clin Invest,2013,123(2):782-786
19 Kato S,Aoyama M,Kakita H,et al. Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury[J]. J Neurosci Res,2011,89(10):1566-1574
20 Orthmann-Murphy JL,Abrams CK,Scherer SS. Gap junctions couple astrocytes and oligodendrocytes[J]. J Mol Neurosci,2008,35(1):101-116
21 Corley SM,Ladiwala U,Besson A,et al. Astrocytes attenuate oligodendrocyte death in vitro through an alpha(6)integrin-laminin-dependent mechanism[J]. Glia,2001,36(3):281-294
22 Fok-Seang J,Di Prospero NA,Meiners S,et al. Cytokine-induced changes in the ability of astrocytes to support migration of oligodendrocyte precursors and axon growth[J]. Eur J Neurosci,1998,10(7):2400-2415
23 Fulmer CG,Von Dran MW,Stillman AA,et al. Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination[J]. J Neurosci,2014,34(24):8186-8196
24 Rodriguez JP,Coulter M,Miotke J,et al. Abrogation of beta-catenin signaling in oligodendrocyte precursor cells reduces glial scarring and promotes axon regeneration after CNS injury[J]. J Neurosci,2014,34(31):10285-10297
25 Zhou Y,Zhang J,Wang L,et al. Interleukin-1beta impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion[J]. Brain Behav Immun,2017,60:93-105
26 Butovsky O,Landa G,Kunis G,et al. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis[J]. J Clin Invest,2006,116(4):905-915
27 Miron VE,Boyd A,Zhao JW,et al. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination[J].Nat Neurosci,2013,16(9):1211-1218