不同种类托槽对儿童口腔微生态环境的影响
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摘要
目的:探讨不同种类的托槽正畸治疗对儿童口腔微生态环境的影响。方法:选取郑州大学附属儿童医院2016年2月至2017年9月口腔门诊治疗的90例需要实施固定矫正的儿童,根据代用矫正器的类型分为传统组45例(采用传统托槽矫正治疗)、研究组45例(采用自锁托槽矫正治疗);检测并对比两组儿童矫正治疗前(T0)、矫正治疗8周(T1)、矫正治疗12周(T2)时刻的龈沟液中IL-1β,TNF-α,IL-17A,IL-35水平;对比两组矫正前、矫正12周后的菌斑指数(plaqueindex,PLI)、牙龈指数(gingival index,GI)、龈沟出血指数(sulcus bleeding index,SBI)、龈沟液量及口腔寄生菌的情况。结果:矫正治疗前,研究组和传统组的PLI,GI,SBI及龈沟液量比较,差异不具有统计学意义(P>0.05);矫正治疗12周后,研究组的PLI,GI,SBI及龈沟液量均低于传统组(P<0.05);T0时刻,研究组和传统组的龈沟液IL-1β,TNF-α,IL-17A,IL-35水平比较,差异不具有统计学意义(P>0.05);T1,T2时刻,研究组的龈沟液IL-1β,TNF-α,IL-17A,IL-35水平均低于传统组(P<0.05)。治疗前,研究组和对照组的寄生菌检出率差异不具有统计学意义(P>0.05);矫正后12周,研究组的口腔寄生菌检出率低于传统组(P<0.05)。结论:自锁托槽矫正治疗与传统托槽均会对儿童口腔微生态环境造成一定的影响,但是前者影响程度较轻。
Objective: To explore the effects of different types of bracket orthodontic treatment on children's oral microecological environment. Methods: Ninety children who needed fixed correction in our dental clinic from February 2016 to September 2017 were selected and divided into a traditional group(using traditional brackets) and a study group(locking bracket correction treatment) according to the type of substitute orthosis, 45 cases in each. IL-1β, TNF-α, IL-17 A, and IL-35 levels in gingival crevicular fluid before and after treatment(T0), correction treatment for 8 weeks(T1), and correction treatment for 12 weeks(T2) were detected; plaque index(PLI), gingival index(GI), sulcus bleeding index(SBI), gingival crevicular fluid volume and oral parasites before and after 12 weeks of correctionwere compared. Results: Before the correction treatment, the difference of PLI, GI, SBI and gingival crevicular fluid between the 2 groups was not statistically significant(P>0.05). After 12 weeks of corrective treatment, PLI, GI, SBI and the amount of sulcus in the study group were significantly lower than that in the traditional group(P<0.05). At T0, the IL-1β, TNF-α, IL-17 A and IL-35 levels in the gingival crevicular fluid between the 2 groups were not statistically significant(P>0.05); at T1 and T2, the IL-1β, TNF-α, IL-17 A and IL-35 levels in the gingival crevicular fluid in the study group were lower than those in the traditional group(P<0.05). Before treatment, the difference in the detection rate of parasites between the 2 groups was not statistically significant(P>0.05). At 12 weeks after the correction, the detection rate of oral parasites in the study group was lower than that in the traditional group(P<0.05). Conclusion: Self-locking bracket correction treatment and traditional brackets will have a certain impact on children's oral micro-ecological environment, but the former is less affected.
Objective: To explore the effects of different types of bracket orthodontic treatment on children's oral microecological environment. Methods: Ninety children who needed fixed correction in our dental clinic from February 2016 to September 2017 were selected and divided into a traditional group(using traditional brackets) and a study group(locking bracket correction treatment) according to the type of substitute orthosis, 45 cases in each. IL-1β, TNF-α, IL-17 A, and IL-35 levels in gingival crevicular fluid before and after treatment(T0), correction treatment for 8 weeks(T1), and correction treatment for 12 weeks(T2) were detected; plaque index(PLI), gingival index(GI), sulcus bleeding index(SBI), gingival crevicular fluid volume and oral parasites before and after 12 weeks of correctionwere compared. Results: Before the correction treatment, the difference of PLI, GI, SBI and gingival crevicular fluid between the 2 groups was not statistically significant(P>0.05). After 12 weeks of corrective treatment, PLI, GI, SBI and the amount of sulcus in the study group were significantly lower than that in the traditional group(P<0.05). At T0, the IL-1β, TNF-α, IL-17 A and IL-35 levels in the gingival crevicular fluid between the 2 groups were not statistically significant(P>0.05); at T1 and T2, the IL-1β, TNF-α, IL-17 A and IL-35 levels in the gingival crevicular fluid in the study group were lower than those in the traditional group(P<0.05). Before treatment, the difference in the detection rate of parasites between the 2 groups was not statistically significant(P>0.05). At 12 weeks after the correction, the detection rate of oral parasites in the study group was lower than that in the traditional group(P<0.05). Conclusion: Self-locking bracket correction treatment and traditional brackets will have a certain impact on children's oral micro-ecological environment, but the former is less affected.
引文
1.孙谋远,黄清波,王孔槐,等.无托槽隐形矫治技术与传统固定矫治技术对正畸患者牙周健康的影响[J].口腔医学,2018,38(2):149-153.SUN Mouyuan,HUANG Qingbo,WANG Konghuai,et al.Impact of invisalign and fixed appliance on the periodontal health of orthodontic patients[J].Stomatology,2018,38(2):149-153.
2.刘洪,牟雁东,于晓光,等.口腔正畸治疗中微型种植体支抗的稳定和安全性[J].中国组织工程研究,2016,20(8):1159-1164.LIU Hong,MOU Yandong,YU Xiaoguang,et al.Stability and safety of mini-implant anchorage in orthodontic treatment[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2016,20(8):1159-1164.
3.Juri?i?S,Kozomara D,Juri?H,et al.The influence of different types of brackets and efficacy of two chlorhexidine mouthwashes on oral hygiene and the incidence of white spot lesions in adolescents during the orthodontic therapy[J].Psychiat Danub,2016,28(Suppl2):247-252.
4.陆一平.自锁托槽和传统托槽矫治后切牙牙根吸收差异的影像学研究[J].口腔医学,2017,37(7):635-637.LU Yiping.Imageology study of difference of root resorption after treatment of self-ligating and conventional preadjusted brackets[J].Stomatology,2017,37(7):635-637.
5.黄娣.不同给药方法治疗细菌性阴道病对阴道微生态环境及免疫因子表达的影响[J].临床检验杂志(电子版),2016,5(2):87-89.HUANG Di.Effects of different methods of administration on vaginal micro-ecological environment and immune factors in patients with bacterial vaginosis[J].Journal of Clinical Laboratory.Electronic version,2016,5(2):87-89.
6.Zheng X,He J,Wang L,et al.Ecological effect of arginine on oral microbiota[J].Sci Rep,2017,7(1):7206.
7.崔占琴,李文静,刘焕.自锁托槽矫治器对慢性广泛型牙周炎正畸治疗患者龈沟液中IL-1β和TNF-α表达的影响[J].河北医药,2016,38(10):1445-1449.CUI Zhanqin,LI Wenjing,LIU Huan.Effects of self-ligating bracket appliance on the expressions of IL-1βand TNF-αin GCF of orthodontic patients with chronic generalized periodontosis[J].Hebei Medical Journal,2016,38(10):1445-1449.
8.孙洪蕊,赵红艳,安晶涛,等.自锁托槽和传统托槽临床矫治安氏I类错牙合畸形效率的对比研究[J].中国临床研究,2016,29(5):669-671.SUN Hongrui,ZHAO Hongyan,AN Jingtao,et al.Comparative study on the efficiency of self-ligating brackets and traditional brackets for clinical correction of Class I malocclusions[J].Chinese Medicine of Factory and Mine,2016,29(5):669-671.
9.王芳,霍彦,刘艳妍,等.不同给药方法治疗细菌性阴道病对阴道微生态环境及免疫因子表达的影响[J].天津医药,2016,44(8):1029-1032.WANG Fang,HUO Yan,LIU Yanyan,et al.Influence of different administration regimens for treatment of bacterial vaginosis on vaginal microflora and the expression of immune factors[J].Tianjin Medical Journal,2016,44(8):1029-1032.
10.吴春晓,高文丽,戴玉婷,等.不同托槽设计与结扎方式对正畸弓丝表面微观结构改变研究[J].中国实用口腔科杂志,2017,10(5):309-312.WU Chunxiao,GAO Wenli,DAI Yuting,et al.Effects of ligation and bracket design on the surface of orthodontic wire[J].Chinese Journal of Practical Stomatology,2017,10(5):309-312.
11.林泽,陈军,李雪.数字化3D打印技术在口腔舌侧正畸托槽粘接中应用研究[J].中国实用口腔科杂志,2016,9(2):104-107.LIN Ze,CHEN Jun,LI Xue.Application study of digital 3D printing in individual lingual orthodontic brackets[J].Chinese Journal of Practical Stomatology,2016,9(2):104-107.
12.杨柳青,曲晓东,覃沅华.自锁托槽矫治器对慢性牙周炎正畸治疗患者牙周组织的影响[J].海南医学院学报,2017,23(4):574-576.YANG Liuqing,QU Xiaodong,QIN Yuanhua.Effect of self-ligating bracket appliance on the periodontal tissues in patients with chronic periodontitis after orthodontic treatment[J].Journal of Hainan Medical College,2017,23(4):574-576.
13.张丽雯,宋立滨,张瑾,等.不同托槽与弓丝组合滑动摩擦力的实验研究[J].中华口腔正畸学杂志,2017,24(1):10-13.ZHANG Liwen,SONG Libin,ZHANG Jin,et al.Study on the frictional resistance of different archwires to sliding of different brackets[J].Chinese Journal of Orthodontics,2017,24(1):10-13.
14.牟胤赫,杨陆一,吴嫣然,等.不同条件下3种正畸粘接剂粘结强度的比较及其意义[J].吉林大学学报(医学版),2016,42(3):512-516.MOU Yinhe,YANG Luyi,WU Yanran,et al.Comparison among bonding strengths of three kinds of orthodontic adhesives under different conditions and their significances[J].Journal of Jilin University.Medical Edition,2016,42(3):512-516.
15.苏奇志,王君香.Mini Uni-Twin托槽系统治疗中重度牙列拥挤患者的临床研究[J].中华口腔正畸学杂志,2016,23(3):132-135.SU Qizhi,WANG Junxiang.Clinical study of treating moderate to severe crowding patients with mini uni-twin brackets[J].Chinese Journal of Orthodontics,2016,23(3):132-135.
2.刘洪,牟雁东,于晓光,等.口腔正畸治疗中微型种植体支抗的稳定和安全性[J].中国组织工程研究,2016,20(8):1159-1164.LIU Hong,MOU Yandong,YU Xiaoguang,et al.Stability and safety of mini-implant anchorage in orthodontic treatment[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2016,20(8):1159-1164.
3.Juri?i?S,Kozomara D,Juri?H,et al.The influence of different types of brackets and efficacy of two chlorhexidine mouthwashes on oral hygiene and the incidence of white spot lesions in adolescents during the orthodontic therapy[J].Psychiat Danub,2016,28(Suppl2):247-252.
4.陆一平.自锁托槽和传统托槽矫治后切牙牙根吸收差异的影像学研究[J].口腔医学,2017,37(7):635-637.LU Yiping.Imageology study of difference of root resorption after treatment of self-ligating and conventional preadjusted brackets[J].Stomatology,2017,37(7):635-637.
5.黄娣.不同给药方法治疗细菌性阴道病对阴道微生态环境及免疫因子表达的影响[J].临床检验杂志(电子版),2016,5(2):87-89.HUANG Di.Effects of different methods of administration on vaginal micro-ecological environment and immune factors in patients with bacterial vaginosis[J].Journal of Clinical Laboratory.Electronic version,2016,5(2):87-89.
6.Zheng X,He J,Wang L,et al.Ecological effect of arginine on oral microbiota[J].Sci Rep,2017,7(1):7206.
7.崔占琴,李文静,刘焕.自锁托槽矫治器对慢性广泛型牙周炎正畸治疗患者龈沟液中IL-1β和TNF-α表达的影响[J].河北医药,2016,38(10):1445-1449.CUI Zhanqin,LI Wenjing,LIU Huan.Effects of self-ligating bracket appliance on the expressions of IL-1βand TNF-αin GCF of orthodontic patients with chronic generalized periodontosis[J].Hebei Medical Journal,2016,38(10):1445-1449.
8.孙洪蕊,赵红艳,安晶涛,等.自锁托槽和传统托槽临床矫治安氏I类错牙合畸形效率的对比研究[J].中国临床研究,2016,29(5):669-671.SUN Hongrui,ZHAO Hongyan,AN Jingtao,et al.Comparative study on the efficiency of self-ligating brackets and traditional brackets for clinical correction of Class I malocclusions[J].Chinese Medicine of Factory and Mine,2016,29(5):669-671.
9.王芳,霍彦,刘艳妍,等.不同给药方法治疗细菌性阴道病对阴道微生态环境及免疫因子表达的影响[J].天津医药,2016,44(8):1029-1032.WANG Fang,HUO Yan,LIU Yanyan,et al.Influence of different administration regimens for treatment of bacterial vaginosis on vaginal microflora and the expression of immune factors[J].Tianjin Medical Journal,2016,44(8):1029-1032.
10.吴春晓,高文丽,戴玉婷,等.不同托槽设计与结扎方式对正畸弓丝表面微观结构改变研究[J].中国实用口腔科杂志,2017,10(5):309-312.WU Chunxiao,GAO Wenli,DAI Yuting,et al.Effects of ligation and bracket design on the surface of orthodontic wire[J].Chinese Journal of Practical Stomatology,2017,10(5):309-312.
11.林泽,陈军,李雪.数字化3D打印技术在口腔舌侧正畸托槽粘接中应用研究[J].中国实用口腔科杂志,2016,9(2):104-107.LIN Ze,CHEN Jun,LI Xue.Application study of digital 3D printing in individual lingual orthodontic brackets[J].Chinese Journal of Practical Stomatology,2016,9(2):104-107.
12.杨柳青,曲晓东,覃沅华.自锁托槽矫治器对慢性牙周炎正畸治疗患者牙周组织的影响[J].海南医学院学报,2017,23(4):574-576.YANG Liuqing,QU Xiaodong,QIN Yuanhua.Effect of self-ligating bracket appliance on the periodontal tissues in patients with chronic periodontitis after orthodontic treatment[J].Journal of Hainan Medical College,2017,23(4):574-576.
13.张丽雯,宋立滨,张瑾,等.不同托槽与弓丝组合滑动摩擦力的实验研究[J].中华口腔正畸学杂志,2017,24(1):10-13.ZHANG Liwen,SONG Libin,ZHANG Jin,et al.Study on the frictional resistance of different archwires to sliding of different brackets[J].Chinese Journal of Orthodontics,2017,24(1):10-13.
14.牟胤赫,杨陆一,吴嫣然,等.不同条件下3种正畸粘接剂粘结强度的比较及其意义[J].吉林大学学报(医学版),2016,42(3):512-516.MOU Yinhe,YANG Luyi,WU Yanran,et al.Comparison among bonding strengths of three kinds of orthodontic adhesives under different conditions and their significances[J].Journal of Jilin University.Medical Edition,2016,42(3):512-516.
15.苏奇志,王君香.Mini Uni-Twin托槽系统治疗中重度牙列拥挤患者的临床研究[J].中华口腔正畸学杂志,2016,23(3):132-135.SU Qizhi,WANG Junxiang.Clinical study of treating moderate to severe crowding patients with mini uni-twin brackets[J].Chinese Journal of Orthodontics,2016,23(3):132-135.