摘要
目的:探讨慢性鼻-鼻窦炎(CRS)的病因与变应性因素的关系。方法:选取97例CRS患者为试验组,并按照1997年海口标准进行分型(Ⅰ型30例,Ⅱ型32例,Ⅲ型35例);20例鼻中隔偏曲患者为对照组。两组之间分别进行血清学指标检测,以SPSS20.0统计软件进行统计学分析。结果:(1)与对照组相比,外周血嗜酸性粒细胞、血清总IgE(TIgE)、血清特异性IgE(sIgE)在Ⅰ型CRS患者中的表达差异无统计学意义(P>0.05),在Ⅱ、Ⅲ型CRS患者中表达差异有统计学意义(P<0.05);(2)97例CRS患者中变应原检测阳性结果 53例;(3)67例Ⅱ、Ⅲ型CRS患者鼻息肉组织切片结果显示有52例为嗜酸性粒细胞浸润,其中Ⅲ型患者居多。结论:CRS与变态反应有一定的相关性,抗过敏治疗可能预防或降低CRS的发生。
Objective: To investigate the correlation between the etiology of chronic rhinosinusitis(CRS) and allergic factors.Methods: Ninety-seven cases of patients with CRS as the experimental group were selected and classified by the Haikou standard in1997(type Ⅰ 30 cases,type Ⅱ 32 cases, type Ⅲ 35 cases), 20 cases of patients with nasal septum deviation(except allergy history) as the control group,and related serology testing was performed. SPSS20.0 software was used to analyze the data. Results:(1)Compared with control group, the peripheral blood eosinophilia, serum total IgE, serum specific Ig E expression in type Ⅰ CRS were not significantly different(P >0.05), but expression in type Ⅱ and Ⅲ patients showed significant difference(P < 0.05).(2) In 97 cases of patients with CRS, the positive detection of allergen was 53 cases.(3) In 67 cases of type Ⅱ and Ⅲ CRS,pathological results showed that there were 52 cases of eosinophilic infiltration, and the majority of patients were type Ⅲ patients. Conclusion: CRS has certain correlation with allergic reaction and appropriate allergic treatment may prevent or reduce the occurrence of CRS.
引文
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