福建闽南地区汉族女性指长比与多囊卵巢综合征关系研究
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摘要
目的研究福建闽南地区汉族女性指长比与多囊卵巢综合征(PCOS)的关系。方法选择福建闽南地区汉族女性208例(对照组106例、多囊卵巢综合征患者组102例)为研究对象,用人体测量学方法测量其左右手2~5指长度(掌侧),计算各手指间的指长比比值,对比两组间指长比(2D∶3D、2D∶4D、2D∶5D、3D∶4D、3D∶5D、4D∶5D)的差异性。结果对照组和多囊卵巢综合征组两侧指长比均值呈现3D∶5D>4D∶5D>2D∶5D>3D∶4D>2D∶4D>2D∶3D的趋势;多囊卵巢综合征组左侧2D∶3D、2D∶4D指长比均值和右侧2D∶4D、3D∶4D指长比均值低于对照组,差异有统计学意义(P<0.01);对照组与多囊卵巢综合征组2D∶4D指长比均值分布构成比差异有统计学意义(P<0.01或P<0.05),多囊卵巢综合征组两侧2D∶4D指长比以低、中2D∶4D为主,对照组以中2D∶4D为主。结论福建闽南地区汉族女性两侧2D∶4D指长比与多囊卵巢综合征有一定的关系。
Objective To investigate the relationship between the digit ratio and polycystic ovary syndrome(PCOS)among female Han nationality in the southern Fujian. Methods We selected 208 Han nationality females in the southern Fujian as study subjects(106 cases as control group and 102 patients with PCOS as PCOS group).The anthropometry methods were adopted to measure the length of the 2 nd to the 5 th digit of left and right hand(palmar aspect),and we calculated the digit ratio among digits of each case.We compared the difference of the digit ratio of 2D∶3D ,2D∶4D,2D∶5D,3D ∶4D,3D ∶5D,4D∶5Dbetween control group and PCOS group. Results The average digit ratio in both aspects of the control group and the PCOS group presented the tendency of 3D ∶5D>4D∶5D>2D∶5D>3D ∶4D>2D∶4D>2D∶3D .The mean digit ratio of 2D∶3D and 2D∶4Dof the left hands as well as the mean digit ratio of 2D∶4Dand 3D ∶4Dof the right hands in the PCOS group were lower than those of the control group,there were statistically significant differences by comparison(P <0.01).There were obvious differences in the distribution proportion of the average digit ratio of 2D∶4D between the control group and the PCOS group(P <0.01 or P <0.05).The digit ratio of both aspects in the PCOS group mainly showed low and medium 2D∶4D,and the control group mainly had medium digit ratio of 2D∶4Din both aspects. Conclusion There is a correlation between the digit ratio of 2D∶4Dof both hands and PCOS among Han nationality females in southern Fujian.
Objective To investigate the relationship between the digit ratio and polycystic ovary syndrome(PCOS)among female Han nationality in the southern Fujian. Methods We selected 208 Han nationality females in the southern Fujian as study subjects(106 cases as control group and 102 patients with PCOS as PCOS group).The anthropometry methods were adopted to measure the length of the 2 nd to the 5 th digit of left and right hand(palmar aspect),and we calculated the digit ratio among digits of each case.We compared the difference of the digit ratio of 2D∶3D ,2D∶4D,2D∶5D,3D ∶4D,3D ∶5D,4D∶5Dbetween control group and PCOS group. Results The average digit ratio in both aspects of the control group and the PCOS group presented the tendency of 3D ∶5D>4D∶5D>2D∶5D>3D ∶4D>2D∶4D>2D∶3D .The mean digit ratio of 2D∶3D and 2D∶4Dof the left hands as well as the mean digit ratio of 2D∶4Dand 3D ∶4Dof the right hands in the PCOS group were lower than those of the control group,there were statistically significant differences by comparison(P <0.01).There were obvious differences in the distribution proportion of the average digit ratio of 2D∶4D between the control group and the PCOS group(P <0.01 or P <0.05).The digit ratio of both aspects in the PCOS group mainly showed low and medium 2D∶4D,and the control group mainly had medium digit ratio of 2D∶4Din both aspects. Conclusion There is a correlation between the digit ratio of 2D∶4Dof both hands and PCOS among Han nationality females in southern Fujian.
引文
[1]Li R,Zhang Q,Yang D,et al.Prevalence of polycystic ovary syndrome in women in China:a large communitybased study[J].Hum Reprod,2013,28(9):2562-2569.
[2]Homburg R,Gudi A,Shah A,et al.A novel method to demonstrate that pregnant women with polycystic ovary syndrome hyper-expose their fetus to androgens as a possible stepping stone for the developmental theory of PCOS.A pilot study[J].Reprod Biol Endocrinol,2017,15(1):61.
[3]Brown WM,Hines M,Fane BA,et al.Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia[J].Horm Behav,2002,42(4):380-386.
[4]Abbo O,Ferdynus C,Kalfa N,et a1.Male infants with hypospadias and/or cryptorchidism show a lower 2D/4D digit ratio than normal boys[J].Arch Dis Child,2015,100(7):643-647.
[5]Hong L,Zhan-Bing M,Zhi-Yun S,et a1.Digit ratio(2D:4D)in Chinese women with breast cancer[J].Am J Hum Biol,2014,26(4):562-564.
[6]Kasielska-Trojan A,Stabrya P,Antoszewski B.Can body proportions serve as a predictor of risk-taking behaviours in women and men?[J].J Biosoc Sci,2017,49(5):567-577.
[7]Rotterdam ESHRE/ASRM-Sponsored PCOS consensus work shop group.Revised 2003consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome(PCOS)[J].Hum Reprod,2004,19:41-47.
[8]舒方义,王金花,黄秀峰,等.广西瑶族中小学生示指和环指长与身高的关系及指长比特点[J].右江民族医学院学报,2014,37(4):523-526.
[9]Zheng Z,Cohn MJ.Developmental basis of sexually dimorphic digit ratios[J].Proc Natl Acad Sci USA,2011,108(39):16289-16294.
[10]Mclntyre MH.The use of digit ratios as markers for perinatal androgen action[J].Reprod Biol Endocrinol,2006,4:10.
[11]邓海萍,莫可良,徐利.达英-35联合二甲双胍治疗多囊卵巢综合征伴不孕62例临床分析[J].右江民族医学院学报,2009,31(3):430-431.
[12]曾碧冰,陈明春,杨婷,等.女性痤疮患者胰岛素抵抗的临床分析[J].右江民族医学院学报,2016,38(3):285-287.
[13]罗小琼,凌燕兰,罗小花,等.1834例女性不孕症病因分析[J].右江医学,2017,45(4):483-486.
[14]Abbott DH,Barnett DK,Bruns CM,et al.Androgen excess fetal programming of female reproduction:a developmental aetiology for polycystic ovary syndrome?[J].Hum Reprod Update,2005,11(4):357-374.
[15]钱文莉,盛优静,耿芝,等.宁夏590例回族青年大学生指长比特点分析[J].宁夏医科大学学报,2016,38(10):1156-1160.
[16]Cattrall FR,BJ Vollenhoven,Weston GC.Anatomical evidence for in utero androgen exposure in women with polycystic ovary syndrome[J].FertilSteril,2005,84(6):1689-1692.
[17]赵君利,李彩艳,刘蔚,等.指长比与PCOS及其并发症的相关性研究[J].宁夏医科大学学报,2012,34(5):438-443.
[18]汤挺兵,叶先才,范晓文,等.浙江汉族群体指长比与寻常性痤疮的相关性[J].解剖学报,2016,47(5):693-696.
[2]Homburg R,Gudi A,Shah A,et al.A novel method to demonstrate that pregnant women with polycystic ovary syndrome hyper-expose their fetus to androgens as a possible stepping stone for the developmental theory of PCOS.A pilot study[J].Reprod Biol Endocrinol,2017,15(1):61.
[3]Brown WM,Hines M,Fane BA,et al.Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia[J].Horm Behav,2002,42(4):380-386.
[4]Abbo O,Ferdynus C,Kalfa N,et a1.Male infants with hypospadias and/or cryptorchidism show a lower 2D/4D digit ratio than normal boys[J].Arch Dis Child,2015,100(7):643-647.
[5]Hong L,Zhan-Bing M,Zhi-Yun S,et a1.Digit ratio(2D:4D)in Chinese women with breast cancer[J].Am J Hum Biol,2014,26(4):562-564.
[6]Kasielska-Trojan A,Stabrya P,Antoszewski B.Can body proportions serve as a predictor of risk-taking behaviours in women and men?[J].J Biosoc Sci,2017,49(5):567-577.
[7]Rotterdam ESHRE/ASRM-Sponsored PCOS consensus work shop group.Revised 2003consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome(PCOS)[J].Hum Reprod,2004,19:41-47.
[8]舒方义,王金花,黄秀峰,等.广西瑶族中小学生示指和环指长与身高的关系及指长比特点[J].右江民族医学院学报,2014,37(4):523-526.
[9]Zheng Z,Cohn MJ.Developmental basis of sexually dimorphic digit ratios[J].Proc Natl Acad Sci USA,2011,108(39):16289-16294.
[10]Mclntyre MH.The use of digit ratios as markers for perinatal androgen action[J].Reprod Biol Endocrinol,2006,4:10.
[11]邓海萍,莫可良,徐利.达英-35联合二甲双胍治疗多囊卵巢综合征伴不孕62例临床分析[J].右江民族医学院学报,2009,31(3):430-431.
[12]曾碧冰,陈明春,杨婷,等.女性痤疮患者胰岛素抵抗的临床分析[J].右江民族医学院学报,2016,38(3):285-287.
[13]罗小琼,凌燕兰,罗小花,等.1834例女性不孕症病因分析[J].右江医学,2017,45(4):483-486.
[14]Abbott DH,Barnett DK,Bruns CM,et al.Androgen excess fetal programming of female reproduction:a developmental aetiology for polycystic ovary syndrome?[J].Hum Reprod Update,2005,11(4):357-374.
[15]钱文莉,盛优静,耿芝,等.宁夏590例回族青年大学生指长比特点分析[J].宁夏医科大学学报,2016,38(10):1156-1160.
[16]Cattrall FR,BJ Vollenhoven,Weston GC.Anatomical evidence for in utero androgen exposure in women with polycystic ovary syndrome[J].FertilSteril,2005,84(6):1689-1692.
[17]赵君利,李彩艳,刘蔚,等.指长比与PCOS及其并发症的相关性研究[J].宁夏医科大学学报,2012,34(5):438-443.
[18]汤挺兵,叶先才,范晓文,等.浙江汉族群体指长比与寻常性痤疮的相关性[J].解剖学报,2016,47(5):693-696.