福建闽南地区汉族女性指长比与子宫肌瘤的关系
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摘要
目的:研究福建闽南地区汉族女性指长比与子宫肌瘤的关系。方法:采用体质测量法,分析福建闽南地区汉族女性303例(子宫肌瘤患者组152例,对照组151例)指长比(2D∶3D、2D∶4D、2D∶5D、3D∶4D、3D∶5D、4D∶5D)的差异性。结果:子宫肌瘤组指长比均值高于对照组,其中左侧2D∶3D、2D∶4D及右侧2D∶4D差异有统计学意义;子宫肌瘤组与对照组2D∶4D指长比分布构成比差异有统计学意义,子宫肌瘤组两侧2D∶4D指长比以高2D∶4D为主,对照组以低2D∶4D为主;子宫肌瘤组及对照组的2D∶4D指长比与年龄之间无相关关系。结论:福建闽南地区汉族女性两侧2D∶4D指长比可能是子宫肌瘤早期筛选的重要参考指标之一。
Objective:To investigate the relationship between digit ratio and uterine leiomyoma among females of Han nationality in southern Fujian.Methods:Using anthropometry,we calculated the digit ratio of 152 uterine leiomyoma patients and 151 controls among female Han nationality in southern Fujian,with digit ratio of 2 D∶3 D,2 D∶4 D,2 D∶5 D,3 D∶4 D,3 D∶5 Dand 4 D∶5 D,followed by the analysis of their relationship.Results:The mean value of digit ratio was higher in the uterine leiomyoma group than that of the control group.Significant differences in digit ratio for 2 D∶3 Dand 2 D∶4 Dof the left hand and 2 D∶4 Dof the right hand were observed in the uterine leiomyoma group and control group.There were also obvious differences in the proportion of distribution of 2 D∶4 Dbetween two groups.The uterine leiomyoma patients mainly showed high 2 D∶4 Dwith the opposite tendency in control group.There was no correlation between the digit ratio of 2 D∶4 D and the age in both uterine leiomyoma patients and the control groups.Conclusion:The digit ratio of 2 D∶4 Dof both hands could be considered as one of the important indexes in diagnosing early-stage uterine leiomyoma among females of Han nationality in southern Fujian.
Objective:To investigate the relationship between digit ratio and uterine leiomyoma among females of Han nationality in southern Fujian.Methods:Using anthropometry,we calculated the digit ratio of 152 uterine leiomyoma patients and 151 controls among female Han nationality in southern Fujian,with digit ratio of 2 D∶3 D,2 D∶4 D,2 D∶5 D,3 D∶4 D,3 D∶5 Dand 4 D∶5 D,followed by the analysis of their relationship.Results:The mean value of digit ratio was higher in the uterine leiomyoma group than that of the control group.Significant differences in digit ratio for 2 D∶3 Dand 2 D∶4 Dof the left hand and 2 D∶4 Dof the right hand were observed in the uterine leiomyoma group and control group.There were also obvious differences in the proportion of distribution of 2 D∶4 Dbetween two groups.The uterine leiomyoma patients mainly showed high 2 D∶4 Dwith the opposite tendency in control group.There was no correlation between the digit ratio of 2 D∶4 D and the age in both uterine leiomyoma patients and the control groups.Conclusion:The digit ratio of 2 D∶4 Dof both hands could be considered as one of the important indexes in diagnosing early-stage uterine leiomyoma among females of Han nationality in southern Fujian.
引文
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[14]Wu X L,Yang D Y,Chai W H,et al.The ratio of second to fourth digit length(2D∶4D)and coronary artery disease in a Han Chinese population[J].Int J Med Sci,2013,10(11):1584-1588.
[15]Zheng Z,Cohn M J.Developmental basis of sexually dimorphic digit ratios[J].Proc Natl Acad Sci USA,2011,108(39):16289-16294.
[16]Lutchmaya S,Baron-Cohen S,Raggatt P.2nd to 4th digit ratios,fetal testosterone and estradiol[J].Early Hum Dev,2004,77(1-2):23-28.
[2]Kondo T,Zákány J,Innis JW,et al.Of fingers,toes and penises[J].Nature,1997,390(29):185-198.
[3]Manning J T,Bundred P E.The ratio of 2nd to 4th digit length:a new predictor of disease predisposition?[J].Med Hypoth,2000,54(5):855-857.
[4]Manning J T,Barley L,Walton J,et al.The 2nd∶4th digit ratio,sexual dimorphism,population differences,and reproductive success.Evidence for sexually antagonistic genes?[J].Evol Hum Behav,2000,21(3):163-183.
[5]乐杰.妇产科学[M].第7版.北京:人民卫生出版社,2008:269-272.
[6]Manning J T,Callow M,Bundred P E.Finger and toe ratios in humans and mice:implications for the aetiology of diseases influenced by HOX genes[J].Med Hypotheses,2003,60(3):340-343.
[7]Hong L,Zhan-Bing M,Zhi-Yun S,et al.Digit ratio(2D∶4D)in Chinese women with breast cancer[J].Am J Hum Biol,2014,26(4):562-564.
[8]Kasielska-Trojan A,Stabry'a P,Antoszewski B.Can body proportions serve as a predictor of risk-taking behaviours in women and men?[J].J Biosoc Sci,2017,49(5):567-577.
[9]邵象清.人体测量手册[M].上海:上海辞书出版社,1985.
[10]Sabry M,Al-Hendy A.Medical treatment of uterine leiomyoma[J].Reprod Sci,2012,19(4):339-353.
[11]Hewitt S C,Harrell J C,Korach K S.Lessons in estrogen biology from knockout and transgenic animals[J].Annu Rev Physiol,2005,67:285-308.
[12]于皓臣,盛优静,耿芝,等.男性不育患者指长比与BMI相关性分析[J].中华男科学杂志,2015,21(11):977-981.
[13]Abbo O,Ferdynus C,Kalfa N,et al.Male infants with hypospadias and/or cryptorchidism show a lower 2D/4Ddigit ratio than normal boys[J].Arch Dis Child,2015,100(7):643-647.
[14]Wu X L,Yang D Y,Chai W H,et al.The ratio of second to fourth digit length(2D∶4D)and coronary artery disease in a Han Chinese population[J].Int J Med Sci,2013,10(11):1584-1588.
[15]Zheng Z,Cohn M J.Developmental basis of sexually dimorphic digit ratios[J].Proc Natl Acad Sci USA,2011,108(39):16289-16294.
[16]Lutchmaya S,Baron-Cohen S,Raggatt P.2nd to 4th digit ratios,fetal testosterone and estradiol[J].Early Hum Dev,2004,77(1-2):23-28.