茵栀黄口服液联合布拉氏酵母菌散治疗新生儿黄疸的临床观察
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摘要
目的:探讨茵栀黄口服液联合布拉氏酵母菌散对新生儿黄疸的治疗效果。方法:选择2016年6月—2017年5月医院儿科进行新生儿黄疸治疗的患儿130例作为研究对象,按照新生儿黄疸的治疗方法分为对照组和观察组,每组65例新生儿,对照组新生儿使用对照组新生儿使用蓝光照射加布拉氏酵母菌散进行治疗,观察组新生儿在对照组治疗方法的基础上,加用茵栀黄口服液,对比两组治疗效果。结果:对照组和观察组治疗前的转铁蛋白,乳酸脱氢酶,肌酸激酶,肌酸激酶同工酶,总胆汁酸,总胆红素和直接胆红素比较差异无统计学意义(t=0.259,0.179,0.014,0.968,0.139,0.125,0.211,P>0.05)。治疗后,两组新生儿的转铁蛋白均高于治疗前,乳酸脱氢酶,肌酸激酶,肌酸激酶同工酶,总胆汁酸,总胆红素和直接胆红素均低于治疗前,数据差异具有统计学意义(t=8.069,15.439,9.882,13.640,5.836,14.934,19.752,14.071,13.238,47.049,32.510,29.480,54.550,41.650,P<0.05),两组间比较,观察组的转铁蛋白高于对照组,乳酸脱氢酶,肌酸激酶,肌酸激酶同工酶,总胆汁酸,总胆红素和直接胆红素均低于对照组,数据差异具有统计学意义(t=6.929,4.612,7.226,7.867,16.696,42.066,37.776,P<0.05),对照组的治疗有效率为81.54%,观察组的治疗有效率为100.00%,两组治疗有效率比较差异具有统计学意义(χ~2=13.220,P<0.05),两个组别治疗效果分级的数据差异也具有统计学意义(z=8.271,P<0.05),观察组的治疗效果显著优于对照组。结论:利用布拉氏酵母菌辅助茵栀黄口服液治疗新生儿黄疸,可以显著降低黄疸的程度,使转铁蛋白,心肌酶谱和血清胆红素的指标明显改善,提升治疗的有效率,值得在临床范围内进行推广。
Objective:To investigate the therapeutic effect of Yinzhihuang Oral Liquid combined with Saccharomyces brucella powder on neonatal jaundice. Methods:Between June 2016 and May 2017, 130 children with neonatal jaundice were studied in the pediatric department of our hospital,according to the treatment of neonatal jaundice, were divided into the control group and the observation group, with 65 neonates in each group. The control group used blue light and Saccharomyces boulardii powder treatment. The newborns of the observation group additionally used Yinzhihuang Oral Liquid. We compared two groups' treatment effect. Result: There was no significant difference in transferrin, lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme, total bile acid, total bilirubin or direct bilirubin before treatment in two groups(t=0.259, 0.179, 0.014, 0.968, 0.139, 0.125, 0.211, P>0.05). After treatment, the two groups' neonatal transferrin were higher;lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme, total bile acid, total bilirubin and direct bilirubin were lower(t=8.069,15.439,9.882,13.640,5.836,14.934,19.752,14.071,13.238,47.049,32.510,29.480, 54.550,41.650, P<0.05) and the difference was statistically significant. Compared with the control group, lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme, total bile acid, total bilirubin and direct bilirubin were lower in the observation group. The difference was statistically significant(t=6.929, 4.64, 7.226, 7.867, 16.696, 4.2066, 37.776, P<0.05). The effective rate of treatment was 81.54% in the control group and 100.00% in the observation group. The difference between the two groups was statistically significant(χ~2=13.220, P<0.05). The data of the two groups was statistically significant(z=8.271, P<0.05). The therapeutic effect of the observation group was significantly better than that of the control group. Conclusion:Using Saccharomyces boulardii assisted Yinzhihuang Oral Liquid in the treatment of neonatal jaundice can significantly reduce the degree of jaundice, significantly improve the transferrin, myocardial enzymes and serum bilirubin index and improve the treatment efficiency. It is worth promoting in the clinical range.
Objective:To investigate the therapeutic effect of Yinzhihuang Oral Liquid combined with Saccharomyces brucella powder on neonatal jaundice. Methods:Between June 2016 and May 2017, 130 children with neonatal jaundice were studied in the pediatric department of our hospital,according to the treatment of neonatal jaundice, were divided into the control group and the observation group, with 65 neonates in each group. The control group used blue light and Saccharomyces boulardii powder treatment. The newborns of the observation group additionally used Yinzhihuang Oral Liquid. We compared two groups' treatment effect. Result: There was no significant difference in transferrin, lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme, total bile acid, total bilirubin or direct bilirubin before treatment in two groups(t=0.259, 0.179, 0.014, 0.968, 0.139, 0.125, 0.211, P>0.05). After treatment, the two groups' neonatal transferrin were higher;lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme, total bile acid, total bilirubin and direct bilirubin were lower(t=8.069,15.439,9.882,13.640,5.836,14.934,19.752,14.071,13.238,47.049,32.510,29.480, 54.550,41.650, P<0.05) and the difference was statistically significant. Compared with the control group, lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme, total bile acid, total bilirubin and direct bilirubin were lower in the observation group. The difference was statistically significant(t=6.929, 4.64, 7.226, 7.867, 16.696, 4.2066, 37.776, P<0.05). The effective rate of treatment was 81.54% in the control group and 100.00% in the observation group. The difference between the two groups was statistically significant(χ~2=13.220, P<0.05). The data of the two groups was statistically significant(z=8.271, P<0.05). The therapeutic effect of the observation group was significantly better than that of the control group. Conclusion:Using Saccharomyces boulardii assisted Yinzhihuang Oral Liquid in the treatment of neonatal jaundice can significantly reduce the degree of jaundice, significantly improve the transferrin, myocardial enzymes and serum bilirubin index and improve the treatment efficiency. It is worth promoting in the clinical range.
引文
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[13] 章浙忠,张航,陈琳,等.新生儿脐带血对病理性黄疸的早期预测[J].浙江临床医学,2017,19(2):318-319.
[14] 刘大伟,孟琳,朱太芳,等.探讨不同蓝光照射方法治疗新生儿黄疸的疗效及不良反应[J].中国医药导刊,2017,19(2):193-194.
[15] 孙晓琳.白蛋白联合蓝光照射治疗新生儿黄疸的疗效及临床指标分析[J].中国医药指南,2017,15(9):139-140.
[16] 唐红装,梁丽清,谢映梅.短时多次蓝光疗法在新生儿黄疸治疗中的效果观察与护理[J].广东医学,2010,31(23):3154-3155.
[17] 邱青春.布拉氏酵母菌散对新生儿病理性黄疸患儿血清胆红素水平的影响[J].医药前沿,2017,7(11):194-195.
[18] 付芬芬.新生儿黄疸中西医预防及护理干预研究进展[J].全科护理,2017,15(4):409-411.
[19] 林艾.茵栀黄颗粒、蓝光照射联合双岐三联活菌胶囊治疗新生儿黄疸的机制研究[J].海南医学院学报,2017,23(3):397-400.
[20] 王欢,谢进,何惠芳,等.茵栀黄颗粒作为肝病辅助用药作用机制的网络药理学研究[J].中国医院用药评价与分析,2016,16(12):1585-1587.
[21] Beken S,Aydin B,Dilli D,et al.Can biochemical markers predict the severity of hypoxic-ischemic encephalopathy[J].Turk JPediatr,2014,56(1):62-68.
[2] 王正兰.菌栀黄结合蓝光治疗法治疗新生儿黄疸的疗效观察及护理体会[J].中国妇幼健康研究,2016,27(1):484-485.
[3] Armanian AM,Barekatain B,Hoseinzadeh M,et al.Prebiotics for the management of hyperbilirubinemia in preterm neonates [J].J Matern Fetal Neonatal Med,2016,29(18):3009-3013.
[4] 刘大伟,孟琳,朱太芳,等.探讨不同蓝光照射方法治疗新生儿黄疸的疗效及不良反应[J].中国医药导刊,2017,19(2):193-194.
[5] Olusanya BO,Osibanjo FB,Mabogunje CA,et al. The burden and management of neonatal jaundice in Nigeria:a scoping review of the literature[J]. Niger J Clin Pract,2016,19(1):1-17.
[6] 张苏红,徐晓妮,王亚萍,等.抚触护理联合早期游泳对新生儿黄疸的影响[J].中国医药导报,2016,13(17):161-164.
[7] Chiang MC,Lien R,Chu SM,et al.Serum lactate,brain magnetic resonance imaging and outcome of neonatal hypoxic is chemic encephalopathy after therapeutic hypothermia[J].Pediatr Neonatol,2016,57(1):35-40.
[8] 刘静,张鸾,王二艳,等.茵栀黄联合蓝光照射治疗新生儿黄疸的疗效及对患儿生长发育的影响[J].医学综述,2016,22(20):4114-4116.
[9] Johnson CT,Burd I,Raghunathan R,et al.Perinatal inflammation infection and its association with correction of metabolic acidosis in hypoxic-ischemic encephalopathy[J].J Perinatol,2016,36(6):448-452.
[10] 徐睿霞,王甫琴,吴亚臻,等.茵栀黄口服液联合清蛋白治疗新生儿病理性黄疸疗效及安全性研究[J].重庆医学,2017,46(4):530-532.
[11] 孙立平,王助衡,底建辉,等.足月显性黄疸新生儿TcB与血清TSB测定的比较[J].中国妇幼健康研究,2016,27(7):789-795.
[12] 郭小兰,白琳.经皮胆红素联合脐血胆红素检测预测新生儿病理性黄疸的价值[J].陕西医学杂志,2017,46(3):385-386.
[13] 章浙忠,张航,陈琳,等.新生儿脐带血对病理性黄疸的早期预测[J].浙江临床医学,2017,19(2):318-319.
[14] 刘大伟,孟琳,朱太芳,等.探讨不同蓝光照射方法治疗新生儿黄疸的疗效及不良反应[J].中国医药导刊,2017,19(2):193-194.
[15] 孙晓琳.白蛋白联合蓝光照射治疗新生儿黄疸的疗效及临床指标分析[J].中国医药指南,2017,15(9):139-140.
[16] 唐红装,梁丽清,谢映梅.短时多次蓝光疗法在新生儿黄疸治疗中的效果观察与护理[J].广东医学,2010,31(23):3154-3155.
[17] 邱青春.布拉氏酵母菌散对新生儿病理性黄疸患儿血清胆红素水平的影响[J].医药前沿,2017,7(11):194-195.
[18] 付芬芬.新生儿黄疸中西医预防及护理干预研究进展[J].全科护理,2017,15(4):409-411.
[19] 林艾.茵栀黄颗粒、蓝光照射联合双岐三联活菌胶囊治疗新生儿黄疸的机制研究[J].海南医学院学报,2017,23(3):397-400.
[20] 王欢,谢进,何惠芳,等.茵栀黄颗粒作为肝病辅助用药作用机制的网络药理学研究[J].中国医院用药评价与分析,2016,16(12):1585-1587.
[21] Beken S,Aydin B,Dilli D,et al.Can biochemical markers predict the severity of hypoxic-ischemic encephalopathy[J].Turk JPediatr,2014,56(1):62-68.