肺炎支原体感染与儿童慢性鼻窦炎及腺样体肥大的相关性研究
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摘要
目的研究儿童肺炎支原体感染与慢性鼻窦炎及腺样体肥大的相关性,探讨肺炎支原体在儿童慢性鼻窦炎和腺样体肥大发病中的作用。方法对2015年1月-2016年12月153例因慢性鼻窦炎及慢性鼻窦炎合并腺样体肥大的患儿血清学标本及鼻咽部抽吸物(NPA)进行肺炎支原体(MP)检测,分析肺炎支原体感染与儿童慢性鼻窦炎、腺样体肥大的关系。结果慢性鼻窦炎及慢性鼻窦炎合并腺样体肥大患儿肺炎支原体检出率均高于单纯慢性鼻窦炎患儿,腺样体重度增生儿童阳性率高于慢性鼻窦炎组及慢性鼻窦炎合并轻中度腺样体增生组儿童。结论肺炎支原体是儿童慢性鼻窦炎及腺样体肥大的重要病原体,其长期蓄积于鼻咽部可能与腺样体增生的发病有关。
Objective To analyze the role of Mycoplasma pneumonia(Mp.) infection in children with chronic rhinosinusitis and adenoid hypertrophy. Methods A prospective study was conducted on 153 children in hospital admitted with chronic rhinosinusitis and adenoid hypertrophy from January 2015 to December 2016. Mycoplasma pneumonia-DNA was investigated in nasopharyngeal aspirates(NPA) and Ig M antibodies was detected by ELISA. The correlation between Mycoplasma pneumonia and the rhinosinusitis,adenoid hypertrophy was analyzed. Results There was a high positive rate among the children with chronic rhinosinusitis and adenoid hypertrophy,and specially in the children with chronic rhinosinusitis with severe adenoid hypertrophy. Conclusion Mycoplasma pneumonia could be considered as a majorpathogen associated with chronicrhinosinusitis,adenoid hypertrophy in children. Adenoid hypertrophy may be associated with the infiltration of Mycoplasma pneumonia in pharynx nasalischronically.
Objective To analyze the role of Mycoplasma pneumonia(Mp.) infection in children with chronic rhinosinusitis and adenoid hypertrophy. Methods A prospective study was conducted on 153 children in hospital admitted with chronic rhinosinusitis and adenoid hypertrophy from January 2015 to December 2016. Mycoplasma pneumonia-DNA was investigated in nasopharyngeal aspirates(NPA) and Ig M antibodies was detected by ELISA. The correlation between Mycoplasma pneumonia and the rhinosinusitis,adenoid hypertrophy was analyzed. Results There was a high positive rate among the children with chronic rhinosinusitis and adenoid hypertrophy,and specially in the children with chronic rhinosinusitis with severe adenoid hypertrophy. Conclusion Mycoplasma pneumonia could be considered as a majorpathogen associated with chronicrhinosinusitis,adenoid hypertrophy in children. Adenoid hypertrophy may be associated with the infiltration of Mycoplasma pneumonia in pharynx nasalischronically.
引文
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[2]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会小儿学组、鼻科学组.儿童鼻-鼻窦炎诊断和治疗建议[J].中华医学会耳鼻咽喉头颈外科杂志,2013,48(3):177-179.
[3]王德云.上气道咳嗽综合征[J].解放军医学杂志,2014,39(5):354-357.
[4]石伟先,崔淑娟,黄芳,等.北京地区肺炎病例呼吸道病毒及肺炎支原体感染调查[J].中国卫生检验杂志,2012,22(10):2453-2456.
[5]徐小娟,方彩文,茅慧萍,等.难治性肺炎支原体肺炎患儿C反应蛋白检测的临床意义[J].中国卫生检验杂志,2015,25(12):1972-1974.
[6] Giulia B,Luisa A,Concetta S,et al. Procalcitonin andcommunityacquiredpneumonia(CAP)inchildren[J]. Clin Chim Acta,2015,451(Pt B):215-218.
[7]刘雅莉.支原体属感染与慢性鼻窦炎及鼻息肉相关性研究[J].中华医院感染学杂志,2013,23(2):361-363.
[8] Marseglia GL,Caimmi D,Pagella F,et al. Adenoids during childhood:the facts[J]. Int J Immunopathol Pharmacol,2011,24(4):1-5.
[9] Piacentini GL,Peroni DG,Blasi F,et al. Atypical bacteria inadenoidsand tonsils of children requiring adenotonsillectomy[J]. Acta Otolaryngol,2010,130(5):620-625.
[10]李晓品,李艳红,许凤勤,等.阿奇霉素对肺炎支原体肺炎感染患儿Th1/Th2指标的影响研究[J].中华医院感染学杂志,2016,26(16):3797-3799.
[11]丁斌,李小兵,李雷雷. Th17/Treg细胞在儿童支原体肺炎发病中的作用[J].中国卫生检验杂志,2017,27(12):1758-1760.
[12]段桂开,何植华,李俊祥.支原体肺炎患儿免疫功能检测及临床意义[J].中国卫生检验杂志,2017,27(9):1290-1292.
[13]张丽净,宋西成,贾传亮,等.血清中炎症介质和细胞因子与儿童腺样体肥大相关性研究[J].山东大学耳鼻喉眼学报,2014,28(2):58-61.
[14]刘翔,严海燕,邹华,等. Th17细胞在慢性鼻窦炎伴鼻息肉患者外周血中的表达及临床意义[J].中国卫生检验杂志,2013,23(15):3075-3077.
[15]钟华敏,谢永强,关小珊,等.儿童腺样体、扁桃体肥大病原菌分布及药物敏感性分析[J].中国卫生检验杂志,2016,26(19):2868-2870.
[16]李旭,黄群.非手术方法治疗儿童腺样体肥大的临床观察[J].临床耳鼻咽喉头颈外科杂志,2013,27(8):432-433.
[2]中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会小儿学组、鼻科学组.儿童鼻-鼻窦炎诊断和治疗建议[J].中华医学会耳鼻咽喉头颈外科杂志,2013,48(3):177-179.
[3]王德云.上气道咳嗽综合征[J].解放军医学杂志,2014,39(5):354-357.
[4]石伟先,崔淑娟,黄芳,等.北京地区肺炎病例呼吸道病毒及肺炎支原体感染调查[J].中国卫生检验杂志,2012,22(10):2453-2456.
[5]徐小娟,方彩文,茅慧萍,等.难治性肺炎支原体肺炎患儿C反应蛋白检测的临床意义[J].中国卫生检验杂志,2015,25(12):1972-1974.
[6] Giulia B,Luisa A,Concetta S,et al. Procalcitonin andcommunityacquiredpneumonia(CAP)inchildren[J]. Clin Chim Acta,2015,451(Pt B):215-218.
[7]刘雅莉.支原体属感染与慢性鼻窦炎及鼻息肉相关性研究[J].中华医院感染学杂志,2013,23(2):361-363.
[8] Marseglia GL,Caimmi D,Pagella F,et al. Adenoids during childhood:the facts[J]. Int J Immunopathol Pharmacol,2011,24(4):1-5.
[9] Piacentini GL,Peroni DG,Blasi F,et al. Atypical bacteria inadenoidsand tonsils of children requiring adenotonsillectomy[J]. Acta Otolaryngol,2010,130(5):620-625.
[10]李晓品,李艳红,许凤勤,等.阿奇霉素对肺炎支原体肺炎感染患儿Th1/Th2指标的影响研究[J].中华医院感染学杂志,2016,26(16):3797-3799.
[11]丁斌,李小兵,李雷雷. Th17/Treg细胞在儿童支原体肺炎发病中的作用[J].中国卫生检验杂志,2017,27(12):1758-1760.
[12]段桂开,何植华,李俊祥.支原体肺炎患儿免疫功能检测及临床意义[J].中国卫生检验杂志,2017,27(9):1290-1292.
[13]张丽净,宋西成,贾传亮,等.血清中炎症介质和细胞因子与儿童腺样体肥大相关性研究[J].山东大学耳鼻喉眼学报,2014,28(2):58-61.
[14]刘翔,严海燕,邹华,等. Th17细胞在慢性鼻窦炎伴鼻息肉患者外周血中的表达及临床意义[J].中国卫生检验杂志,2013,23(15):3075-3077.
[15]钟华敏,谢永强,关小珊,等.儿童腺样体、扁桃体肥大病原菌分布及药物敏感性分析[J].中国卫生检验杂志,2016,26(19):2868-2870.
[16]李旭,黄群.非手术方法治疗儿童腺样体肥大的临床观察[J].临床耳鼻咽喉头颈外科杂志,2013,27(8):432-433.