围绝经期抑郁症动物模型制备规范(草案)
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摘要
围绝经期抑郁症是女性从性成熟期到老年期过渡阶段最常见的一种情感障碍性精神疾病,其发病率呈逐年上升趋势。对围绝经期抑郁症发病机制及治疗的研究已成为现代医学研究的热点。突出病理特点的围绝经期抑郁症模型以西医指标为主,神经系统变化、内分泌系统变化是重点。突出病因特点的围绝经期抑郁症模型兼顾中医指标,精神症状、躯体症状的变化是重点。基于对围绝经期抑郁症中西医临床病症特点分析及对现有动物模型大量实验研究,形成如下围绝经期抑郁症模型制备规范(草案)。
Perimenopausal depression is one of the most common emotional disorders in women during the transition from sexual maturity to old age, and its incidence is increasing year by year. Research on the pathogenesis and treatment of perimenopausal depression has become a hot topic in modern medical research. The perimenopausal depression model with prominent pathological characteristics is mainly based on western medicine. The changes of nervous system and endocrine system are the key points. The model of perimenopausal depression with prominent etiological characteristics takes into account both traditional Chinese medicine indicators and the changes of mental and physical symptoms are the key points. Based on the analysis of clinical symptoms of perimenopausal depression and a large number of experimental studies on existing animal models, the following criteria for the preparation of perimenopausal depression model(draft).
Perimenopausal depression is one of the most common emotional disorders in women during the transition from sexual maturity to old age, and its incidence is increasing year by year. Research on the pathogenesis and treatment of perimenopausal depression has become a hot topic in modern medical research. The perimenopausal depression model with prominent pathological characteristics is mainly based on western medicine. The changes of nervous system and endocrine system are the key points. The model of perimenopausal depression with prominent etiological characteristics takes into account both traditional Chinese medicine indicators and the changes of mental and physical symptoms are the key points. Based on the analysis of clinical symptoms of perimenopausal depression and a large number of experimental studies on existing animal models, the following criteria for the preparation of perimenopausal depression model(draft).
引文
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[3]曹利华,苗明三.基于围绝经期抑郁症临床病症特点的动物模型分析.中华中医药杂志,2016,31(5):1643-1647
[4]Mingsan Miao,Xiaoli Yan,Lin Guo,et al.Effect of Cynomorium total flavone on depression model of perimenopausal rat.Saudi Journal of Biological Sciences,2017,24(1):139-148
[5]苗明三.常用医药研究动物模型.北京:人民卫生出版社,2007:13-14
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[11]岳利峰,刘佳,王文慧,等.基于汉密尔顿焦虑抑郁量表评价加味逍遥散两种剂型调节围绝经期情绪障碍的疗效差异.中华中医药杂志,2019,34(4):1796-1798
[12]山书玲,刘暖,张慧珍,等.二仙益坤汤对围绝经期抑郁模型大鼠行为学和内分泌代谢调节的作用研究.中国妇幼保健,2015,30(13):2077-2080
[13]周胜红,孙付军,陈忠,等.补肾针刺法对围绝经期抑郁模型大鼠单胺类神经递质含量的调节.时珍国医国药,2015,26(9):2299-2301
[14]蒋希荣,任路,李春日.电针对围绝经期抑郁症大鼠下丘脑-垂体-卵巢轴的影响.针刺研究,2017,42(1):45-49
[15]Tan Wang,Mingsan Miao,Yan Li,et al.Effect of cynomorium flavonoids on morphology of perimenopausal depression mice model.Saudi Pharmaceutical Journal,2016,24(3):322-328
[16]Mingsan Miao,Tan Wang,Yan Li,et al.Effect of Cynomorium flavonoids on mouse model of perimenopausal depression.Bangladesh Journal of Pharmacology,2016,11:S31-S35
[17]Miao Mingsan,Guo Lin,Wang Tan,et al.Effect of cynomorium songaricum total flavonoids on perimenopausal syndrome mice model.Basic&Clinical Pharmacology&Toxicology,2015,117(Suppl1):9
[18]王睿,王琪,金明顺,等.白藜芦醇对围绝经期抑郁症模型小鼠行为学影响及机制分析.中国实验方剂学杂志,2017,23(4):132-139
[19]蒋希荣,任路.电针疗法对围绝经期抑郁症模型大鼠下丘脑-垂体-肾上腺轴及β-内啡肽的影响.中华中医药学刊,2016,34(8):1923-1925
[20]俞洁,丁珊珊,康洁,等.围绝经期综合征肝郁兼杂与单胺类神经递质的相关性研究.中华中医药杂志,2018,33(1):58-61
[21]马瑞雪,苗明三.一种中药药效的多指标评价新方法--综合权重法.中药新药与临床药理,2011,22(5):569-572
[2]Ramos M F,Mota L M.Perimenopause and affective disorders:basic and clinical topics.SALUD MENTAL,2012,35(3):231-240
[3]曹利华,苗明三.基于围绝经期抑郁症临床病症特点的动物模型分析.中华中医药杂志,2016,31(5):1643-1647
[4]Mingsan Miao,Xiaoli Yan,Lin Guo,et al.Effect of Cynomorium total flavone on depression model of perimenopausal rat.Saudi Journal of Biological Sciences,2017,24(1):139-148
[5]苗明三.常用医药研究动物模型.北京:人民卫生出版社,2007:13-14
[6]苗明三.实验动物与动物实验技术.北京:中国中医药出版社,2010:78-87
[7]中华人民共和国国家标准.实验动物环境及设施.GB14925-2010.北京:国家质量监督检验检疫总局,2011
[8]全国实验动物标准化技术委员会.实验动物环境与设施.GB14925-2010.北京:中国标准出版社,2010
[9]乐杰.妇产科学.5版.北京:人民卫生出版社,2001:382-386
[10]中华医学会精神分会.中国精神疾病分类方案与诊断标准.3版.济南:山东科学技术出版社版,2001:86-87
[11]岳利峰,刘佳,王文慧,等.基于汉密尔顿焦虑抑郁量表评价加味逍遥散两种剂型调节围绝经期情绪障碍的疗效差异.中华中医药杂志,2019,34(4):1796-1798
[12]山书玲,刘暖,张慧珍,等.二仙益坤汤对围绝经期抑郁模型大鼠行为学和内分泌代谢调节的作用研究.中国妇幼保健,2015,30(13):2077-2080
[13]周胜红,孙付军,陈忠,等.补肾针刺法对围绝经期抑郁模型大鼠单胺类神经递质含量的调节.时珍国医国药,2015,26(9):2299-2301
[14]蒋希荣,任路,李春日.电针对围绝经期抑郁症大鼠下丘脑-垂体-卵巢轴的影响.针刺研究,2017,42(1):45-49
[15]Tan Wang,Mingsan Miao,Yan Li,et al.Effect of cynomorium flavonoids on morphology of perimenopausal depression mice model.Saudi Pharmaceutical Journal,2016,24(3):322-328
[16]Mingsan Miao,Tan Wang,Yan Li,et al.Effect of Cynomorium flavonoids on mouse model of perimenopausal depression.Bangladesh Journal of Pharmacology,2016,11:S31-S35
[17]Miao Mingsan,Guo Lin,Wang Tan,et al.Effect of cynomorium songaricum total flavonoids on perimenopausal syndrome mice model.Basic&Clinical Pharmacology&Toxicology,2015,117(Suppl1):9
[18]王睿,王琪,金明顺,等.白藜芦醇对围绝经期抑郁症模型小鼠行为学影响及机制分析.中国实验方剂学杂志,2017,23(4):132-139
[19]蒋希荣,任路.电针疗法对围绝经期抑郁症模型大鼠下丘脑-垂体-肾上腺轴及β-内啡肽的影响.中华中医药学刊,2016,34(8):1923-1925
[20]俞洁,丁珊珊,康洁,等.围绝经期综合征肝郁兼杂与单胺类神经递质的相关性研究.中华中医药杂志,2018,33(1):58-61
[21]马瑞雪,苗明三.一种中药药效的多指标评价新方法--综合权重法.中药新药与临床药理,2011,22(5):569-572