左旋甲状腺素钠联合小金胶囊治疗结节性甲状腺肿的临床疗效
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摘要
目的:观察左旋甲状腺素钠(优甲乐)联合小金胶囊治疗结节性甲状腺肿的效果。方法:收集2017年8月—2018年8月收治的结节性甲状腺肿患者88例,随机分为试验组和对照组各44例。对照组口服左旋甲状腺素钠50μg/次,1次/d,试验组口服小剂量(25μg/次,1次/d)左旋甲状腺素钠和小金胶囊4粒/次,2次/d。两组均持续3个月。观察两组临床疗效、治疗前后的高敏促甲状腺激素(s TSH)水平及肿块最大直径变化情况和治疗期间不良反应发生率。结果:试验组总有效率为81.82%(36/44),高于对照组的61.36%(27/44,P<0.05)。治疗3个月后,试验组肿块最大直径和sTSH水平分别为(1.04±0.34)cm和(2.95±0.45)μU/ml,对照组分别为(1.57±0.69)cm和(1.97±0.32)μU/ml,组间差异有统计学意义(P均<0.05)。治疗期间,试验组不良反应发生率为6.82%(3/44),对照组为22.73%(10/44),组间差异有统计学意义(P<0.05)。结论:优甲乐联合小金胶囊治疗结节性甲状腺肿临床效果好,不良反应发生率低,安全性高。
Objective: To observe the effect of levothyroxine sodium(euthyrox) combined with Xiaojin capsule in the treatment of nodular goiter. Method: Eighty-eight patients with nodular goiter admitted from August 2017 to August 2018 were collected and randomly divided into an experimental group and a control group with 44 cases each. The control group was given levothyroxine sodium 50 μg/time, once a day, and the experimental group received oral low-dose levothyroxine sodium(25 μg/time, 1 time/d) and 4 Xiaojin capsules per time, twice a day. Both groups were treated for 3 months. The clinical efficacy of the two groups, the level of high-sensitivity thyroid stimulating hormone(sTSH) and the maximum diameter of the tumor before and after treatment and the incidence of adverse reactions during treatment were observed. Results: The total effective rate of the experimental group was 81.82%(36/44), which was higher than that of the control group 61.36%(27/44, P<0.05). After 3 months of treatment, the maximum diameter and sTSH level of the experimental group were(1.04±0.34) cm and(2.95±0.45)μU/ml, respectively, and those of the control group were(1.57±0.69) cm and(1.97±0.32) μU/ml, respectively and the difference between the groups was statistically significant(P<0.05). During the treatment period, the incidence of adverse reactions of the experimental group was 6.82%(3/44), that of the control group was 22.73%(10/44), and the difference between the groups was statistically significant(P<0.05). Conclusion: Euthyrox combined with Xiaojin capsule has good clinical effect, low incidence of adverse reactions and high safety in the treatment of nodular goiter.
Objective: To observe the effect of levothyroxine sodium(euthyrox) combined with Xiaojin capsule in the treatment of nodular goiter. Method: Eighty-eight patients with nodular goiter admitted from August 2017 to August 2018 were collected and randomly divided into an experimental group and a control group with 44 cases each. The control group was given levothyroxine sodium 50 μg/time, once a day, and the experimental group received oral low-dose levothyroxine sodium(25 μg/time, 1 time/d) and 4 Xiaojin capsules per time, twice a day. Both groups were treated for 3 months. The clinical efficacy of the two groups, the level of high-sensitivity thyroid stimulating hormone(sTSH) and the maximum diameter of the tumor before and after treatment and the incidence of adverse reactions during treatment were observed. Results: The total effective rate of the experimental group was 81.82%(36/44), which was higher than that of the control group 61.36%(27/44, P<0.05). After 3 months of treatment, the maximum diameter and sTSH level of the experimental group were(1.04±0.34) cm and(2.95±0.45)μU/ml, respectively, and those of the control group were(1.57±0.69) cm and(1.97±0.32) μU/ml, respectively and the difference between the groups was statistically significant(P<0.05). During the treatment period, the incidence of adverse reactions of the experimental group was 6.82%(3/44), that of the control group was 22.73%(10/44), and the difference between the groups was statistically significant(P<0.05). Conclusion: Euthyrox combined with Xiaojin capsule has good clinical effect, low incidence of adverse reactions and high safety in the treatment of nodular goiter.
引文
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[4]蔡军波,张强,方芳,等.小剂量优甲乐联合小金胶囊治疗结节性甲状腺肿的临床疗效及对甲状腺功能的影响[J]实用药物与临床,2014,17(6):711-714.
[5]郑雅娟,仲妙春,孟可馨,等.小金丸配合优甲乐治疗结节性甲状腺肿的临床观察[J].中国中西医结合外科杂志2013,19(3):297-298.
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